Clinical effect of purification of dialysis fluids, evidence and experience

Blood Purification

Volumn 27, Issue SUPPL. 1, 2009, Pages 20-22

  Schindler, Ralf ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Bacterial contamination; Dialysate contamination; Dialysis fluid purification; Microinflammation

Indexed keywords

GAMMA INTERFERON; HEMODIALYSIS FLUID; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ATHEROSCLEROSIS; BACTERIUM CONTAMINATION; COLONY FORMING UNIT; CONFERENCE PAPER; DIALYSATE; HEMODIALYSIS; HEMODIALYSIS PATIENT; HUMAN; INFLAMMATION; KIDNEY FAILURE; LIMULUS LYSATE TEST; PRIORITY JOURNAL; PURIFICATION;

BACTERIA; HEMODIALYSIS SOLUTIONS; HUMANS; QUALITY CONTROL; RENAL DIALYSIS; WATER MICROBIOLOGY; WATER POLLUTANTS; WATER SUPPLY;

EID: 68149125340     PISSN: 02535068     EISSN: None     Source Type: Journal    
DOI: 10.1159/000213493     Document Type: Conference Paper

References (12)

1. Ridker PM, Cannon CP, Morrow D, Rifai N, Rose LM, McCabe CH, Pfeffer MA, Braunwald E: C-reactive protein levels and outcomes after statin therapy. N Engl J Med 2005; 352:20-28.
2. Ridker PM, Cushman M, Stampfer MJ, Tracy RP, Hennekens CH: Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Engl J Med 1997; 336: 973-979. Published erratum appears in N Engl J Med 1997; 337: 356.
3. Zimmermann J, Herrlinger S, Pruy A, Metzger T, Wanner C: Inflammation enhances cardiovascular risk and mortality in hemodialysis. Kidney Int 1999; 55:648-658.
4. Schindler R, Beck W, Deppisch R, Aussieker M, Wilde A, Gohl H, Frei U: Short bacterial DNA fragments: detection in dialysate and induction of cytokines. J Am Soc Nephrol 2004; 15: 3207-3214.
5. Wagner H: Toll meets bacterial CpG-DNA. Immunity 2001; 1 4 : 499 -502.
6. Yi AK, Yoon JG, Hong SC, Redford TW, Krieg AM: Lipopolysaccharide and CpG DNA synergize for tumor necrosis factor-a production through activation of NF- kB. Int Immunol 2001; 13:1391-1404.
7. Lonnemann G, Behme TC, Lenzner B, Floege J, Schulze M, Colton CK, Koch KM, Shaldon S: Permeability of dialyzer membranes to TNF-α-inducing substances derived from water bacteria. Kidney Int 1992; 42: 61-68.
8. Schindler R, Christ-Kohlrausch F, Frei U, Shaldon S: Differences in the permeability of high-flux dialyzer membranes for bacterial pyrogens. Clin Nephrol 2003; 59:447-454.
9. Schindler R, Krautzig S, Lufft V, Lonnemann G, Mahiout A, Marra MN, Shaldon S, Koch KM: Induction of interleukin-1 and interleukin-1 receptor antagonist during contaminated in vitro dialysis with whole blood. Nephrol Dial Transplant 1996; 11:101-108.
10. Arizono K, Nomura K, Motoyama T, Matsushita Y, Matsuoka K, Miyazu R, Takeshita H, Fukui H: Use of ultrapure dialysate in reduction of chronic inflammation during hemodialysis. Blood Purif 2004; 22(suppl 2):26- 29.
11. Hsu PY, Lin CL, Yu CC, Chien CC, Hsiau TG, Sun TH, Huang LM, Yang CW: Ultrapure dialysate improves iron utilization and erythropoietin response in chronic hemodialysis patients - a prospective cross-over study. J Nephrol 2004; 17:693-700.
12. Sitter T, Bergner A, Schiffl H: Dialysate-related cytokine induction and response to recombinant human erythropoietin in haemodialysis patients. Nephrol Dial Transplant 2000; 15: 1207-1211.