Vancomycin analogs: Seeking improved binding of d-Ala-d-Ala and d-Ala-d-Lac peptides by side-chain and backbone modifications

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 16, 2009, Pages 5874-5886

  Leung, Siegfried S F ^a   Tirado Rives, Julian ^a   Jorgensen, William L ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

Antibiotic resistance; Free energy perturbation; Structure based design; Vancomycin

Indexed keywords

PEPTIDE DERIVATIVE; VANCOMYCIN DERIVATIVE;

ARTICLE; BINDING AFFINITY; CHEMICAL MODIFICATION; DRUG BINDING; DRUG STRUCTURE; HYDROPHOBICITY; MONTE CARLO METHOD; PEPTIDE ANALYSIS; PROTEIN STRUCTURE;

ANTI-BACTERIAL AGENTS; CELL WALL; COMPUTER SIMULATION; MODELS, CHEMICAL; MOLECULAR CONFORMATION; MONTE CARLO METHOD; PEPTIDES; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS; VANCOMYCIN; VANCOMYCIN RESISTANCE;

BACTERIA (MICROORGANISMS);

EID: 68149112480     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.07.006     Document Type: Article

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