Role of the NSs protein in the zoonotic capacity of orthobunyaviruses

Zoonoses and Public Health

Volumn 56, Issue 6-7, 2009, Pages 285-296

  Hart, T J ^a,b   Kohl, A ^a,c   Elliott, R M ^a  

^a UNIVERSITY OF ST ANDREWS   (United Kingdom)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Bunyaviridae; Host cell protein shut off; Interferon antagonist; Non structural NSs protein; Orthobunyavirus; RNA polymerase II inhibition

Indexed keywords

LUCIFERASE; RNA POLYMERASE II; UNCLASSIFIED DRUG; VIRUS NONSTRUCTURAL PROTEIN; VIRUS PROTEIN;

AEDES ALBOPICTUS; ANIMAL CELL; APOPTOSIS; BUNYAMWERA VIRUS; CELL DEATH; CELL STRAIN BHK; CONFERENCE PAPER; CONTROLLED STUDY; NONHUMAN; ORTHOBUNYAVIRUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN SYNTHESIS; VIRUS CELL INTERACTION; VIRUS TRANSMISSION; VIRUS VIRULENCE; ZOONOSIS;

AEDES; ANIMALS; BUNYAVIRIDAE INFECTIONS; HUMANS; NUCLEOCAPSID PROTEINS; ORTHOBUNYAVIRUS; VIRAL NONSTRUCTURAL PROTEINS; ZOONOSES;

AEDES ALBOPICTUS; BUNYAMWERA VIRUS; BUNYAVIRIDAE; HANTAVIRUS; MAMMALIA; NAIROVIRUS; ORTHOBUNYAVIRUS; PHLEBOVIRUS; TOSPOVIRUS;

EID: 68049142565     PISSN: 18631959     EISSN: 18632378     Source Type: Journal    
DOI: 10.1111/j.1863-2378.2008.01166.x     Document Type: Conference Paper

References (54)

1. Aranda, M. A. Maule, 1998 : Virus-induced host gene shutoff in animals and plants. Virology 243, 261 267.
2. Beaty, B. J. C. H. Calisher, 1991 : Bunyaviridae - natural history. Curr. Top. Microbiol. Immunol. 169, 27 78.
3. Blakqori, G., S. Delhaye, M. Habjan, C. D. Blair, I. Sanchez-Vargas, K. E. Olson, G. Attarzadh-Yazdi, R. Fragkoudis, A. Kohl, U. Kalinke, S. Weiss, T. Michiels, P. Staeheli F. Weber, 2007 : La Crosse bunyavirus nonstructural protein NSs serves to suppress the type I interferon system of mammalian hosts. J. Virol. 81, 4991 4999.
4. Borucki, M. K., B. J. Kempf, B. J. Blitvich, C. D. Blair B. J. Beaty, 2002 : La Crosse virus: replication in vertebrate and invertebrate hosts. Microbes Infect. 4, 341 350.
5. Bouloy, M., 1991 : Bunyaviridae: genome organization and replication strategies. Adv. Virus Res. 40, 235 275.
6. Bowen, M. D., A. O. Jackson, T. D. Bruns, D. L. Hacker J. L. Hardy, 1995 : Determination and comparative analysis of the small RNA genomic sequences of California encephalitis, Jamestown Canyon, Jerry Slough, Melao, Keystone and Trivittatus viruses (Bunyaviridae, genus Bunyavirus, California serogroup). J. Gen. Virol. 76, 559 572.
7. Bridgen, A. R. M. Elliott, 1996 : Rescue of a segmented negative-strand RNA virus entirely from cloned complementary DNAs. Proc. Natl. Acad. Sci. U.S.A. 93, 15400 15404.
8. Bridgen, A., F. Weber, J. K. Fazakerley R. M. Elliott, 2001 : Bunyamwera bunyavirus nonstructural protein NSs is a nonessential gene product that contributes to viral pathogenesis. Proc. Natl. Acad. Sci. U.S.A. 98, 664 669.
9. Buchholz, U. J., S. Finke K. K. Conzelmann, 1999 : Generation of bovine respiratory syncytial virus (BRSV) from cDNA: BRSV NS2 is not essential for virus replication in tissue culture, and the human RSV leader region acts as a functional BRSV genome promoter. J. Virol. 73, 251 259.
10. Calisher, C. H., 1996 : History, classification and taxonomy of viruses in the family Bunyaviridae. In : Elliott, R. M. (ed. The Bunyaviridae, pp. 1 17. Plenum Press, New York.
11. Carvalho, M. G., I. C. Frugulhetti M. A. Rebello, 1986 : Marituba (Bunyaviridae) virus replication in cultured Aedes albopictus cells and in L-A9 cells. Arch. Virol. 90, 325 335.
12. Colon-Ramos, D. A., P. M. Irusta, E. C. Gan, M. R. Olson, J. Song, R. I. Morimoto, R. M. Elliott, M. Lombard, R. Hollingsworth, J. M. Hardwick, G. K. Smith S. Kornbluth, 2003 : Inhibition of translation and induction of apoptosis by Bunyaviral nonstructural proteins bearing sequence similarity to reaper. Mol. Biol. Cell 14, 4162 4172.
13. Conaway, R. C., S. Sato, C. Tomomori-Sato, T. Yao J. W. Conaway, 2005 : The mammalian Mediator complex and its role in transcriptional regulation. Trends Biochem. Sci. 30, 250 255.
14. Dunn, E. F., D. C. Pritlove R. M. Elliott, 1994 : The S RNA genome segments of Batai, Cache Valley, Guaroa, Kairi, Lumbo, Main Drain and Northway bunyaviruses: sequence determination and analysis. J. Gen. Virol. 75, 597 608.
15. Elliott, R. M., 1990 : Molecular biology of the Bunyaviridae. J. Gen. Virol. 71, 501 522.
16. Elliott, R. M. (ed.) 1996 : The Bunyaviridae. Plenum Press, New York.
17. Elliott, R. M., 1997 : Emerging viruses: the Bunyaviridae. Mole Med 3, 572 577.
18. Elliott, R. M. M. L. Wilkie, 1986 : Persistent infection of Aedes albopictus C6/36 cells by Bunyamwera virus. Virology 150, 21 32.
19. Frugulhetti, I. C. M. A. Rebello, 1989 : Na+ and K+ concentration and regulation of protein synthesis in L-A9 and Aedes albopictus cells infected with Marituba virus (Bunyaviridae). J. Gen. Virol. 70, 3493 3499.
20. Hetz, C. A., M. Hunn, P. Rojas, V. Torres, L. Leyton A. F. Quest, 2002 : Caspase-dependent initiation of apoptosis and necrosis by the Fas receptor in lymphoid cells: onset of necrosis is associated with delayed ceramide increase. J. Cell Sci. 115, 4671 4683.
21. Igarashi, A., 1978 : Isolation of a Singh's Aedes albopictus cell clone sensitive to Dengue and Chikungunya viruses. J. Gen. Virol. 40, 531 544.
22. Kascsak, R. J. M. J. Lyons, 1978 : Bunyamwera virus. II. The generation and nature of defective interfering particles. Virology 89, 539 546.
23. Kohl, A., A. Bridgen, E. Dunn, J. N. Barr R. M. Elliott, 2003a : Effects of a point mutation in the 3′ end of the S genome segment of naturally occurring and engineered Bunyamwera viruses. J. Gen. Virol. 84, 789 793.
24. Kohl, A., R. F. Clayton, F. Weber, A. Bridgen, R. E. Randall R. M. Elliott, 2003b : Bunyamwera virus nonstructural protein NSs counteracts interferon regulatory factor 3-mediated induction of early cell death. J. Virol. 77, 7999 8008.
25. Kohl, A., T. J. Hart, C. Noonan, E. Royall, L. O. Roberts R. M. Elliott, 2004 : A bunyamwera virus minireplicon system in mosquito cells. J. Virol. 78, 5679 5685.
26. Kohl, A., A. C. Lowen, V. H. Leonard R. M. Elliott, 2006 : Genetic elements regulating packaging of the Bunyamwera orthobunyavirus genome. J. Gen. Virol. 87, 177 178.
27. Kornberg, R. D., 2005 : Mediator and the mechanism of transcriptional activation. Trends Biochem. Sci. 30, 235 239.
28. Kozak, M., 2002 : Pushing the limits of the scanning mechanism for initiation of translation. Gene 299, 1 34.
29. Lappin, D. F., G. W. Nakitare, J. W. Palfreyman R. M. Elliott, 1994 : Localisation of Bunyamwera bunyavirus G1 glycoprotein to the Golgi requires association with G2 but not NSm. J. Gen. Virol. 75, 3441 3451.
30. Léonard, V. H. J., A. Kohl, T. J. Hart R. M. Elliott, 2006 : Interaction of Bunyamwera orthobunyavirus NSs protein with the Mediator protein MED8: a mechanism for inhibiting the interferon response. J. Virol. 80, 9667 9675.
31. Lowen, A. C., C. Noonan, A. McLees R. M. Elliott, 2004 : Efficient bunyavirus rescue from cloned cDNA. Virology 330, 493 500.
32. Macpherson, I. M. Stoker, 1962 : Polyoma transformation of hamster cell clones - an investigation of genetic factors affecting cell competence. Virology 16, 147 151.
33. Marsden, H. S., K. MacAulay, J. Murray I. W. Smith, 1998 : Identification of an immunodominant sequential epitope in glycoprotein G of herpes simplex virus type 2 that is useful for serotype-specific diagnosis. J. Med. Virol. 56, 79 84.
34. Newton, S. E., N. J. Short L. Dalgarno, 1981 : Bunyamwera virus replication in cultured Aedes albopictus (mosquito) cells: establishment of a persistent viral infection. J. Virol. 38, 1015 1024.
35. Nichol, S., B. J. Beaty, R. M. Elliott, R. Goldbach, A. Plyusnin, C. S. Schmaljohn R. B. Tesh, 2005 : Bunyaviridae. In : Fauquet, C. M., M. A. Mayo, J. Maniloff, U. Desselberger L. A. Ball (eds Virus Taxonomy. VIIIth Report of the International Committee on Taxonomy of Viruses, pp. 695 716. Elsevier Academic Press, Amsterdam.
36. Nunes, M. R., A. P. Travassos da Rosa, S. C. Weaver, R. B. Tesh P. F. Vasconcelos, 2005 : Molecular epidemiology of group C viruses (Bunyaviridae, Orthobunyavirus) isolated in the Americas. J. Virol. 79, 10561 10570.
37. Posnett, D. N., H. McGrath J. P. Tam, 1988 : A novel method for producing anti-peptide antibodies. Production of site-specific antibodies to the T cell antigen receptor beta-chain. J. Biol. Chem. 263, 1719 1725.
38. Raju, R. D. Kolakofsky, 1988 : La Crosse virus infection of mammalian cells induces mRNA instability. J. Virol. 62, 27 32.
39. Randall, R. S. Goodbourn, 2008 : Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures. J. Gen. Virol. 89, 1 27.
40. Rossier, C., J. Patterson D. Kolakofsky, 1986 : La Crosse virus small genome mRNA is made in the cytoplasm. J. Virol. 58, 647 650.
41. Rossier, C., R. Raju D. Kolakofsky, 1988 : LaCrosse virus gene expression in mammalian and mosquito cells. Virology 165, 539 548.
42. Saeed, M. F., H. Wang, M. Suderman, D. W. Beasley, A. Travassos da Rosa, L. Li, R. E. Shope, R. B. Tesh A. D. Barrett, 2001 : Jatobal virus is a reassortant containing the small RNA of Oropouche virus. Virus Res. 77, 25 30.
43. Saelens, X., M. Kalai P. Vandenabeele, 2001 : Translation inhibition in apoptosis: caspase-dependent PKR activation and eIF2-alpha phosphorylation. J. Biol. Chem. 276, 41620 41628.
44. Scallan, M. F. R. M. Elliott, 1992 : Defective RNAs in mosquito cells persistently infected with Bunyamwera virus. J. Gen. Virol. 73, 53 60.
45. Schmaljohn, C. S. J. W. Hooper, 2001 : Bunyaviridae: the viruses and their replication. In : Knipe, D. M., and P. M. Howley (eds Fields Virology, 4th edn, pp. 1581 1602. Lippincott Williams & Wilkins, Philadelphia.
46. Shi, X., D. F. Lappin R. M. Elliott, 2004 : Mapping the Golgi targeting and retention signal of Bunyamwera virus glycoproteins. J. Virol. 78, 10793 10802.
47. Shi, X., K. Brauburger R. M. Elliott, 2005 : Role of N-linked glycans on Bunyamwera virus glycoproteins in intracellular trafficking, protein folding and virus viability. J. Virol. 79, 13725 13734.
48. Shi, X., A. Kohl, V. H. J. Léonard, P. Li, A. McLees R. M. Elliott, 2006 : Requirement of the N-terminal region of the orthobunyavirus non-structural protein NSm for virus assembly and morphogenesis. J. Virol. 80, 8089 8099.
49. Streitenfeld, H., A. Boyd, J. K. Fazakerley, A. Bridgen, R. M. Elliott F. Weber, 2003 : Activation of PKR by Bunyamwera virus is independent of the viral interferon antagonist NSs. J. Virol. 77, 5507 5511.
50. Tait, S. W., A. B. Werner, E. de Vries J. Borst, 2004 : Mechanism of action of Drosophila Reaper in mammalian cells: reaper globally inhibits protein synthesis and induces apoptosis independent of mitochondrial permeability. Cell Death Differ. 11, 800 811.
51. Tam, J. P., 1988 : Synthetic peptide vaccine design: synthesis and properties of a high-density multiple antigenic peptide system. Proc. Natl. Acad. Sci. U.S.A. 85, 5409 5413.
52. Thomas, D., G. Blakqori, V. Wagner, M. Banholzer, N. Kessler, R. M. Elliott, O. Haller F. Weber, 2004 : Inhibition of RNA polymerase II phosphorylation by a viral interferon antagonist. J. Biol. Chem. 279, 31471 31477.
53. Weber, F., E. F. Dunn, A. Bridgen R. M. Elliott, 2001 : The Bunyamwera virus nonstructural protein NSs inhibits viral RNA synthesis in a minireplicon system. Virology 281, 67 74.
54. Weber, F., A. Bridgen, J. K. Fazakerley, H. Streitenfeld, N. Kessler, R. E. Randall R. M. Elliott, 2002 : Bunyamwera bunyavirus nonstructural protein NSs counteracts the induction of alpha/beta interferon. J. Virol. 76, 7949 7955.