메뉴 건너뛰기




Volumn 81, Issue 2, 2009, Pages 388-395

Porcine hypothalamic aromatase cytochrome P450: Isoform characterization, sex-dependent activity, regional expression, and regulation by enzyme inhibition in neonatal boars

Author keywords

Aromatase; Brain; Brain sexual differentiation; Hypothalamus; Isoform; Neuroendocrinology; Porcine; Regional expression; Regulation; Sexual dimorphism; Steroid hormones; Testis

Indexed keywords

1 HYDROXYTESTOSTERONE; AROMATASE; ESTRADIOL; ETOMIDATE; LETROZOLE; TESTOSTERONE; TESTOSTERONE DERIVATIVE; UNCLASSIFIED DRUG;

EID: 68049136112     PISSN: 00063363     EISSN: 15297268     Source Type: Journal    
DOI: 10.1095/biolreprod.109.076331     Document Type: Article
Times cited : (28)

References (64)
  • 1
    • 0001121604 scopus 로고
    • Sexual differences of the hypophyses and their determination by the gonads
    • Pfeiffer CA. Sexual differences of the hypophyses and their determination by the gonads. Am J Anat 1936; 58:195-223.
    • (1936) Am J Anat , vol.58 , pp. 195-223
    • Pfeiffer, C.A.1
  • 2
    • 0018151188 scopus 로고
    • Evidence for a morphological sex difference within the medial preoptic area of the rat brain
    • Gorski RA, Gordon JH, Shryne JE, Southam AM. Evidence for a morphological sex difference within the medial preoptic area of the rat brain. Brain Res 1978; 148:333-346.
    • (1978) Brain Res , vol.148 , pp. 333-346
    • Gorski, R.A.1    Gordon, J.H.2    Shryne, J.E.3    Southam, A.M.4
  • 3
    • 0036308456 scopus 로고    scopus 로고
    • Wired for reproduction: Organization and development of sexually dimorphic circuits in the mammalian forebrain
    • Simerly RB. Wired for reproduction: organization and development of sexually dimorphic circuits in the mammalian forebrain. Annu Rev Neurosci 2002; 25:507-536.
    • (2002) Annu Rev Neurosci , vol.25 , pp. 507-536
    • Simerly, R.B.1
  • 4
    • 33644537379 scopus 로고    scopus 로고
    • Cell death and sexual differentiation of the nervous system
    • Forger NG. Cell death and sexual differentiation of the nervous system. Neuroscience 2006; 138:929-938.
    • (2006) Neuroscience , vol.138 , pp. 929-938
    • Forger, N.G.1
  • 5
    • 0000104755 scopus 로고
    • Organizing action of prenatally administered testosterone propionate on the tissues mediating mating behavior in the female guinea pig
    • Phoenix CH, Goy RW, Gerall AA, Young WC. Organizing action of prenatally administered testosterone propionate on the tissues mediating mating behavior in the female guinea pig. Endocrinology 1959; 65:369-382.
    • (1959) Endocrinology , vol.65 , pp. 369-382
    • Phoenix, C.H.1    Goy, R.W.2    Gerall, A.A.3    Young, W.C.4
  • 7
    • 0024694384 scopus 로고
    • Differentiation of sexual behavior in cattle, sheep and swine
    • Ford JJ, D'Occhio MJ. Differentiation of sexual behavior in cattle, sheep and swine. J Anim Sci 1989; 67:1816-1823.
    • (1989) J Anim Sci , vol.67 , pp. 1816-1823
    • Ford, J.J.1    D'Occhio, M.J.2
  • 8
    • 84995972777 scopus 로고
    • Copulatory behavior in prepuberally castrated male rats and its modification by estrogen administration
    • Beach FA. Copulatory behavior in prepuberally castrated male rats and its modification by estrogen administration. Endocrinology 1942; 31:679-683.
    • (1942) Endocrinology , vol.31 , pp. 679-683
    • Beach, F.A.1
  • 10
    • 33745401919 scopus 로고    scopus 로고
    • Estrogenic encounters: How interactions between aromatase and the environment modulate aggression
    • Trainor BC, Kyomen HH, Marler CA. Estrogenic encounters: how interactions between aromatase and the environment modulate aggression. Front Neuroendocrinol 2006; 27:170-179.
    • (2006) Front Neuroendocrinol , vol.27 , pp. 170-179
    • Trainor, B.C.1    Kyomen, H.H.2    Marler, C.A.3
  • 11
    • 5444220722 scopus 로고    scopus 로고
    • Sexual partner preference, hypothalamic morphology and aromatase in rams
    • Roselli CE, Larkin K, Schrunk JM, Stormshak F. Sexual partner preference, hypothalamic morphology and aromatase in rams. Physiol Behav 2004; 83:233-245.
    • (2004) Physiol Behav , vol.83 , pp. 233-245
    • Roselli, C.E.1    Larkin, K.2    Schrunk, J.M.3    Stormshak, F.4
  • 12
    • 34548446343 scopus 로고    scopus 로고
    • Brain aromatase: Roles in reproduction and neuroprotection
    • Roselli CF. Brain aromatase: roles in reproduction and neuroprotection. J Steroid Biochem Mol Biol 2007; 106:143-150.
    • (2007) J Steroid Biochem Mol Biol , vol.106 , pp. 143-150
    • Roselli, C.F.1
  • 13
    • 5444247311 scopus 로고    scopus 로고
    • Preoptic aromatase modulates male sexual behavior: Slow and fast mechanisms of action
    • Balthazart J, Baillien M, Cornil CA, Ball GF. Preoptic aromatase modulates male sexual behavior: slow and fast mechanisms of action. Physiol Behav 2004; 83:247-270.
    • (2004) Physiol Behav , vol.83 , pp. 247-270
    • Balthazart, J.1    Baillien, M.2    Cornil, C.A.3    Ball, G.F.4
  • 14
    • 0025797245 scopus 로고
    • Sex differences in androgen receptors and aromatase activity in microdissected regions of the rat brain
    • Roselli CE. Sex differences in androgen receptors and aromatase activity in microdissected regions of the rat brain. Endocrinology 1991; 128:1310-1316.
    • (1991) Endocrinology , vol.128 , pp. 1310-1316
    • Roselli, C.E.1
  • 15
    • 1342287977 scopus 로고    scopus 로고
    • The aromatase knockout (ArKO) mouse provides new evidence that estrogens are required for the development of the female brain
    • Bakker J, Honda S, Harada N, Balthazart J. The aromatase knockout (ArKO) mouse provides new evidence that estrogens are required for the development of the female brain. Ann N Y Acad Sci 2003; 1007:251-262.
    • (2003) Ann N Y Acad Sci , vol.1007 , pp. 251-262
    • Bakker, J.1    Honda, S.2    Harada, N.3    Balthazart, J.4
  • 16
    • 0242626137 scopus 로고    scopus 로고
    • Neurological effects of aromatase deficiency in the mouse
    • Matsumoto T, Honda S, Harada N. Neurological effects of aromatase deficiency in the mouse. J Steroid Biochem Mol Biol 2003; 86:357-365.
    • (2003) J Steroid Biochem Mol Biol , vol.86 , pp. 357-365
    • Matsumoto, T.1    Honda, S.2    Harada, N.3
  • 17
    • 67649981145 scopus 로고    scopus 로고
    • Estradiol, a key endocrine signal in the sexual differentiation and activation of reproductive behavior in quail
    • Balthazart J, Cornil CA, Charlier TD, Taziaux M, Ball GF. Estradiol, a key endocrine signal in the sexual differentiation and activation of reproductive behavior in quail. J Exp Zool Part A Ecol Genet Physiol 2008; 311A:323-345.
    • (2008) J Exp Zool Part A Ecol Genet Physiol , vol.311 A , pp. 323-345
    • Balthazart, J.1    Cornil, C.A.2    Charlier, T.D.3    Taziaux, M.4    Ball, G.F.5
  • 18
    • 42649133795 scopus 로고    scopus 로고
    • The role of androgen receptors in the masculinization of brain and behavior: What we've learned from the testicular feminization mutation
    • Zuloaga DG, Puts DA, Jordan CL, Breedlove SM. The role of androgen receptors in the masculinization of brain and behavior: what we've learned from the testicular feminization mutation. Horm Behav 2008; 53(5):613-626.
    • (2008) Horm Behav , vol.53 , Issue.5 , pp. 613-626
    • Zuloaga, D.G.1    Puts, D.A.2    Jordan, C.L.3    Breedlove, S.M.4
  • 20
    • 0018076843 scopus 로고
    • Phylogenetic distribution of aromatase and other androgen-converting enzymes in the central nervous system
    • Callard GV, Petro Z, Ryan KJ. Phylogenetic distribution of aromatase and other androgen-converting enzymes in the central nervous system. Endocrinology 1978; 103:2283-2290.
    • (1978) Endocrinology , vol.103 , pp. 2283-2290
    • Callard, G.V.1    Petro, Z.2    Ryan, K.J.3
  • 21
    • 33749623084 scopus 로고    scopus 로고
    • Brain aromatase: New lessons from non-mammalian model systems
    • Forlano PM, Schlinger BA, Bass AH. Brain aromatase: new lessons from non-mammalian model systems. Front Neuroendocrinol 2006; 27:247-274.
    • (2006) Front Neuroendocrinol , vol.27 , pp. 247-274
    • Forlano, P.M.1    Schlinger, B.A.2    Bass, A.H.3
  • 22
    • 0032146511 scopus 로고    scopus 로고
    • Embryonic brain-gonadal axis in temperature-dependent sex determination of reptiles: A role for P450 aromatase (CYP19)
    • Jeyasuria P, Place AR. Embryonic brain-gonadal axis in temperature-dependent sex determination of reptiles: a role for P450 aromatase (CYP19). J Exp Zool 1998; 281:428-449.
    • (1998) J Exp Zool , vol.281 , pp. 428-449
    • Jeyasuria, P.1    Place, A.R.2
  • 24
  • 26
    • 0029095016 scopus 로고
    • Functional ovarian and placental isoforms of porcine aromatase
    • Corbin CJ, Khalil MW, Conley AJ. Functional ovarian and placental isoforms of porcine aromatase. Mol Cell Endocrinol 1995; 113:29-37.
    • (1995) Mol Cell Endocrinol , vol.113 , pp. 29-37
    • Corbin, C.J.1    Khalil, M.W.2    Conley, A.J.3
  • 29
    • 0033303546 scopus 로고    scopus 로고
    • Changes in testosterone metabolism associated with the evolution of placental and gonadal isozymes of porcine aromatase cytochrome P450
    • Corbin CJ, Trant JM, Walters KW, Conley AJ. Changes in testosterone metabolism associated with the evolution of placental and gonadal isozymes of porcine aromatase cytochrome P450. Endocrinology 1999; 140:5202-5210.
    • (1999) Endocrinology , vol.140 , pp. 5202-5210
    • Corbin, C.J.1    Trant, J.M.2    Walters, K.W.3    Conley, A.J.4
  • 30
    • 0029915214 scopus 로고    scopus 로고
    • Molecular cloning of cytochrome P450 aromatase complementary deoxyribonucleic acid from periimplantation porcine and equine blastocysts identifies multiple novel 5′-untranslated exons expressed in embryos, endometrium, and placenta
    • Choi I, Simmen RC, Simmen FA. Molecular cloning of cytochrome P450 aromatase complementary deoxyribonucleic acid from periimplantation porcine and equine blastocysts identifies multiple novel 5′-untranslated exons expressed in embryos, endometrium, and placenta. Endocrinology 1996; 137:1457-1467.
    • (1996) Endocrinology , vol.137 , pp. 1457-1467
    • Choi, I.1    Simmen, R.C.2    Simmen, F.A.3
  • 31
    • 0042433312 scopus 로고    scopus 로고
    • Structural and functional differences among purified recombinant mammalian aromatases: Glycosylation, N-terminal sequence and kinetic analysis of human, bovine and the porcine placental and gonadal isozymes
    • Corbin C.J, Mapes SM, Lee YM, Conley AJ. Structural and functional differences among purified recombinant mammalian aromatases: glycosylation, N-terminal sequence and kinetic analysis of human, bovine and the porcine placental and gonadal isozymes. Mol Cell Endocrinol 2003; 206:147-157.
    • (2003) Mol Cell Endocrinol , vol.206 , pp. 147-157
    • Corbin, C.J.1    Mapes, S.M.2    Lee, Y.M.3    Conley, A.J.4
  • 32
    • 2042437718 scopus 로고    scopus 로고
    • Paralogues of porcine aromatase cytochrome P450: A novel hydroxylase activity is associated with the survival of a duplicated gene
    • Corbin CJ, Mapes SM, Marcos J, Shackleton CH, Morrow D, Safe S, Wise T, Ford JJ, Conley AJ. Paralogues of porcine aromatase cytochrome P450: a novel hydroxylase activity is associated with the survival of a duplicated gene. Endocrinology 2004; 145:2157-2164.
    • (2004) Endocrinology , vol.145 , pp. 2157-2164
    • Corbin, C.J.1    Mapes, S.M.2    Marcos, J.3    Shackleton, C.H.4    Morrow, D.5    Safe, S.6    Wise, T.7    Ford, J.J.8    Conley, A.J.9
  • 33
    • 54149114751 scopus 로고    scopus 로고
    • Reducing endogenous estrogens during the neonatal and juvenile periods affects reproductive tract development and sperm production in postpuberal boars
    • Berger T, McCarthy M, Pearl CA, At-Taras E, Roser JF, Conley A. Reducing endogenous estrogens during the neonatal and juvenile periods affects reproductive tract development and sperm production in postpuberal boars. Anim Reprod Sci 2008; 109:218-235.
    • (2008) Anim Reprod Sci , vol.109 , pp. 218-235
    • Berger, T.1    McCarthy, M.2    Pearl, C.A.3    At-Taras, E.4    Roser, J.F.5    Conley, A.6
  • 34
    • 0035857464 scopus 로고    scopus 로고
    • Porcine gonadal and placental isozymes of aromatase cytochrome P450: Sub-cellular distribution and support by NADPH-cytochrome P450 reductase
    • Corbin CJ, Trant JM, Conley AJ. Porcine gonadal and placental isozymes of aromatase cytochrome P450: sub-cellular distribution and support by NADPH-cytochrome P450 reductase. Mol Cell Endocrinol 2001; 172:115-124.
    • (2001) Mol Cell Endocrinol , vol.172 , pp. 115-124
    • Corbin, C.J.1    Trant, J.M.2    Conley, A.J.3
  • 35
    • 85047685695 scopus 로고    scopus 로고
    • Structural determinants of aromatase cytochrome P450 inhibition in substrate recognition site-1
    • Conley A, Mapes S, Corbin CJ, Greger D, Graham S. Structural determinants of aromatase cytochrome P450 inhibition in substrate recognition site-1. Mol Endocrinol 2002; 16:1456-1468.
    • (2002) Mol Endocrinol , vol.16 , pp. 1456-1468
    • Conley, A.1    Mapes, S.2    Corbin, C.J.3    Greger, D.4    Graham, S.5
  • 36
    • 0029031987 scopus 로고
    • Critical re-examination of the distribution of aromatase-immunoreactive cells in the quail forebrain using antibodies raised against human placental aromatase and against the recombinant quail, mouse or human enzyme
    • Foidart A, Reid J, Absil P, Yoshimura N, Harada N, Balthazart J. Critical re-examination of the distribution of aromatase-immunoreactive cells in the quail forebrain using antibodies raised against human placental aromatase and against the recombinant quail, mouse or human enzyme. J Chem Neuroanat 1995; 8:267-282.
    • (1995) J Chem Neuroanat , vol.8 , pp. 267-282
    • Foidart, A.1    Reid, J.2    Absil, P.3    Yoshimura, N.4    Harada, N.5    Balthazart, J.6
  • 37
    • 0034119433 scopus 로고    scopus 로고
    • Distribution of aromatase mRNA in the ram hypothalamus: An in situ hybridization study
    • Roselli CE, Stormshak F, Resko JA. Distribution of aromatase mRNA in the ram hypothalamus: an in situ hybridization study. J Neuroendocrinol 2000; 12:656-664.
    • (2000) J Neuroendocrinol , vol.12 , pp. 656-664
    • Roselli, C.E.1    Stormshak, F.2    Resko, J.A.3
  • 38
    • 30344483659 scopus 로고    scopus 로고
    • Reducing estrogen synthesis does not affect gonadotropin secretion in the developing boar
    • At-Taras EE, Conley AJ, Berger T, Roser JF. Reducing estrogen synthesis does not affect gonadotropin secretion in the developing boar. Biol Reprod 2006; 74:58-66.
    • (2006) Biol Reprod , vol.74 , pp. 58-66
    • At-Taras, E.E.1    Conley, A.J.2    Berger, T.3    Roser, J.F.4
  • 41
    • 0036879348 scopus 로고    scopus 로고
    • Genomics of steroid hormones: In silico analysis of nucleotide sequence variants (polymorphisms) of the enzymes involved in the biosynthesis and metabolism of steroid hormones
    • Igaz P, Pap E, Patocs A, Falus A, Tulassay Z, Racz K. Genomics of steroid hormones: in silico analysis of nucleotide sequence variants (polymorphisms) of the enzymes involved in the biosynthesis and metabolism of steroid hormones. J Steroid Biochem Mol Biol 2002; 82:359-367.
    • (2002) J Steroid Biochem Mol Biol , vol.82 , pp. 359-367
    • Igaz, P.1    Pap, E.2    Patocs, A.3    Falus, A.4    Tulassay, Z.5    Racz, K.6
  • 42
    • 0035064795 scopus 로고    scopus 로고
    • Two Cyp19 (P450 aromatase) genes on duplicated zebrafish chromosomes are expressed in ovary or brain
    • Chiang EF, Yan YL, Guiguen Y, Postlethwait J, Chung B. Two Cyp19 (P450 aromatase) genes on duplicated zebrafish chromosomes are expressed in ovary or brain. Mol Biol Evol 2001; 18:542-550.
    • (2001) Mol Biol Evol , vol.18 , pp. 542-550
    • Chiang, E.F.1    Yan, Y.L.2    Guiguen, Y.3    Postlethwait, J.4    Chung, B.5
  • 43
    • 0031734593 scopus 로고    scopus 로고
    • Identification of multiple CYP19 genes encoding different cytochrome P450 aromatase isozymes in brain and ovary
    • Tchoudakova A, Callard GV. Identification of multiple CYP19 genes encoding different cytochrome P450 aromatase isozymes in brain and ovary. Endocrinology 1998; 139:2179-2189.
    • (1998) Endocrinology , vol.139 , pp. 2179-2189
    • Tchoudakova, A.1    Callard, G.V.2
  • 44
    • 0034925290 scopus 로고    scopus 로고
    • Different catalytic properties and inhibitor responses of the goldfish brain and ovary aromatase isozymes
    • Zhao J, Mak P, Tchoudakova A, Callard G, Chen S. Different catalytic properties and inhibitor responses of the goldfish brain and ovary aromatase isozymes. Gen Comp Endocrinol 2001; 123:180-191.
    • (2001) Gen Comp Endocrinol , vol.123 , pp. 180-191
    • Zhao, J.1    Mak, P.2    Tchoudakova, A.3    Callard, G.4    Chen, S.5
  • 45
    • 0022612917 scopus 로고
    • Hypothalamic aromatase activity in young and old male rats
    • Roselli CE, Kaler LW, Resko JA. Hypothalamic aromatase activity in young and old male rats. Neurobiol Aging 1986; 7:121-125.
    • (1986) Neurobiol Aging , vol.7 , pp. 121-125
    • Roselli, C.E.1    Kaler, L.W.2    Resko, J.A.3
  • 46
    • 0842269869 scopus 로고    scopus 로고
    • The volume of a sexually dimorphic nucleus in the ovine medial preoptic area/anterior hypothalamus varies with sexual partner preference
    • Roselli CE, Larkin K, Resko JA, Stellflug JN, Stormshak F. The volume of a sexually dimorphic nucleus in the ovine medial preoptic area/anterior hypothalamus varies with sexual partner preference. Endocrinology 2004; 145:478-483.
    • (2004) Endocrinology , vol.145 , pp. 478-483
    • Roselli, C.E.1    Larkin, K.2    Resko, J.A.3    Stellflug, J.N.4    Stormshak, F.5
  • 48
    • 0018942724 scopus 로고
    • Oestrogens, compared to other steroids of testicular origin, in blood plasma of boars
    • Claus R, Hoffmann B. Oestrogens, compared to other steroids of testicular origin, in blood plasma of boars. Acta Endocrinol (Copenh) 1980; 94:404-411.
    • (1980) Acta Endocrinol (Copenh) , vol.94 , pp. 404-411
    • Claus, R.1    Hoffmann, B.2
  • 49
    • 0021071610 scopus 로고
    • Serum estrogen concentrations during postnatal development in male pigs
    • Ford JJ. Serum estrogen concentrations during postnatal development in male pigs. Proc Soc Exp Biol Med 1983; 174:160-164.
    • (1983) Proc Soc Exp Biol Med , vol.174 , pp. 160-164
    • Ford, J.J.1
  • 50
    • 0027546823 scopus 로고
    • Plasma levels of several androgens and estrogens from birth to puberty in male domestic pigs
    • Schwarzenberger F, Toole GS, Christie HL, Raeside JI. Plasma levels of several androgens and estrogens from birth to puberty in male domestic pigs. Acta Endocrinol (Copenh) 1993; 128:173-177.
    • (1993) Acta Endocrinol (Copenh) , vol.128 , pp. 173-177
    • Schwarzenberger, F.1    Toole, G.S.2    Christie, H.L.3    Raeside, J.I.4
  • 51
    • 0015317751 scopus 로고
    • Plasma estrogen, progesterone and luteinizing hormone levels during the estrous cycle in pigs
    • Henricks DM, Guthrie HD, Handlin DL. Plasma estrogen, progesterone and luteinizing hormone levels during the estrous cycle in pigs. Biol Reprod 1972; 6:210-218.
    • (1972) Biol Reprod , vol.6 , pp. 210-218
    • Henricks, D.M.1    Guthrie, H.D.2    Handlin, D.L.3
  • 52
    • 0036721554 scopus 로고    scopus 로고
    • Regulation of microsomal P450, redox partner proteins and steroidogenesis in the developing testes of the neonatal pig
    • Moran FM, Ford JJ, Corbin CJ, Mapes S, Njar VC, Brodie AM, Conley AJ. Regulation of microsomal P450, redox partner proteins and steroidogenesis in the developing testes of the neonatal pig. Endocrinology 2002; 143:3361-3369.
    • (2002) Endocrinology , vol.143 , pp. 3361-3369
    • Moran, F.M.1    Ford, J.J.2    Corbin, C.J.3    Mapes, S.4    Njar, V.C.5    Brodie, A.M.6    Conley, A.J.7
  • 53
    • 0020209512 scopus 로고
    • Pubertal development of the boar: Testosterone, estradiol-17 beta, cortisol and LH concentrations before and after castration at various ages
    • Allrich RD, Christenson RK, Ford JJ, Zimmerman DR. Pubertal development of the boar: testosterone, estradiol-17 beta, cortisol and LH concentrations before and after castration at various ages. J Anim Sci 1982; 55:1139-1146.
    • (1982) J Anim Sci , vol.55 , pp. 1139-1146
    • Allrich, R.D.1    Christenson, R.K.2    Ford, J.J.3    Zimmerman, D.R.4
  • 54
    • 2942521779 scopus 로고    scopus 로고
    • Relationships between aromatase activity in the brain and gonads and behavioural deficits in homozygous and heterozygous aromatase knockout mice
    • Bakker J, Baillien M, Honda S, Harada N, Balthazart J. Relationships between aromatase activity in the brain and gonads and behavioural deficits in homozygous and heterozygous aromatase knockout mice. J Neuroendocrinol 2004; 16:483-490.
    • (2004) J Neuroendocrinol , vol.16 , pp. 483-490
    • Bakker, J.1    Baillien, M.2    Honda, S.3    Harada, N.4    Balthazart, J.5
  • 55
    • 0028833979 scopus 로고
    • Sex differences in the distribution of estrogen receptors in the septal area and hypothalamus of the domestic pig (Sus scrofa)
    • van Leeuwen FW, Chouham S, Axelson JF, Swaab DF, van Eerdenburg FJ. Sex differences in the distribution of estrogen receptors in the septal area and hypothalamus of the domestic pig (Sus scrofa). Neuroscience 1995; 64:261-275.
    • (1995) Neuroscience , vol.64 , pp. 261-275
    • van Leeuwen, F.W.1    Chouham, S.2    Axelson, J.F.3    Swaab, D.F.4    van Eerdenburg, F.J.5
  • 56
    • 0019797807 scopus 로고
    • Sexual differentiation of the central nervous system
    • MacLusky NJ, Naftolin F. Sexual differentiation of the central nervous system. Science 1981; 211:1294-1302.
    • (1981) Science , vol.211 , pp. 1294-1302
    • MacLusky, N.J.1    Naftolin, F.2
  • 57
    • 0024369696 scopus 로고
    • Sexual differentiation of reproductive behavior in pigs: Defeminizing effects of prepubertal estradiol
    • Adkins-Regan E, Orgeur P, Signoret JP. Sexual differentiation of reproductive behavior in pigs: defeminizing effects of prepubertal estradiol. Horm Behav 1989; 23:290-303.
    • (1989) Horm Behav , vol.23 , pp. 290-303
    • Adkins-Regan, E.1    Orgeur, P.2    Signoret, J.P.3
  • 58
    • 0025106888 scopus 로고
    • Differentiation of sexual behaviour in pigs
    • Ford JJ. Differentiation of sexual behaviour in pigs. J Reprod Fertil Suppl 1990; 40:311-321.
    • (1990) J Reprod Fertil Suppl , vol.40 , pp. 311-321
    • Ford, J.J.1
  • 59
    • 0030199501 scopus 로고    scopus 로고
    • Paradoxical effect of an aromatase inhibitor, CGS 20267, on aromatase activity in guinea pig brain
    • Choate JV, Resko JA. Paradoxical effect of an aromatase inhibitor, CGS 20267, on aromatase activity in guinea pig brain. J Steroid Biochem Mol Biol 1996; 58:411-415.
    • (1996) J Steroid Biochem Mol Biol , vol.58 , pp. 411-415
    • Choate, J.V.1    Resko, J.A.2
  • 64
    • 40849087859 scopus 로고    scopus 로고
    • Inhibition of luteinizing hormone secretion by testosterone in men requires aromatization for its pituitary but not its hypothalamic effects: Evidence from the tandem study of normal and gonadotropin-releasing hormone-deficient men
    • Pitteloud N, Dwyer AA, DeCruz S, Lee H, Boepple PA, Crowley WF Jr, Hayes FJ. Inhibition of luteinizing hormone secretion by testosterone in men requires aromatization for its pituitary but not its hypothalamic effects: evidence from the tandem study of normal and gonadotropin-releasing hormone-deficient men. J Clin Endocrinol Metab 2008; 93:784-791.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 784-791
    • Pitteloud, N.1    Dwyer, A.A.2    DeCruz, S.3    Lee, H.4    Boepple, P.A.5    Crowley Jr, W.F.6    Hayes, F.J.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.