Modulating the tumor microenvironment to improve radiotherapy

Retina

Volumn 29, Issue SUPPL. 6, 2009, Pages

  Maity, Amit ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Radiation; Thior microenvironment

Indexed keywords

VASCULOTROPIN;

ANTIANGIOGENIC ACTIVITY; CANCER RADIOTHERAPY; HUMAN; MICROENVIRONMENT; NEOVASCULARIZATION (PATHOLOGY); NOTE; ONCOLOGY; RADIATION; RETINA DISEASE; RETINA MACULA AGE RELATED DEGENERATION; TUMOR; UPREGULATION; VASCULAR TISSUE;

ANGIOGENESIS INHIBITORS; ANIMALS; COMBINED MODALITY THERAPY; HUMANS; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 68049132882     PISSN: 0275004X     EISSN: None     Source Type: Journal    
DOI: 10.1097/IAE.0b013e3181ad248b     Document Type: Note

References (9)

1. Moeller BJ, Cao Y, Li CY, Dewhirst MW. Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules. Cancer Cell 2004;5:429-441. (Pubitemid 38610245)
2. Gorski DH, Becket MA, Jaskowiat NT, et al. Blockage of the endothelial growth factor stress response increases the antitumor effects of ionizing radiation. Cancer Res 1999;59:3374-3378.
3. Timke C, Zieher H, Roth A, et al. Combination of vascular endothelial growth factor receptor/platelet derived growth factor receptor inhibition markedly improves radiation tumor therapy. Clin Cancer Res 2008;14:2210-2219. (Pubitemid 351551134)
4. Yuan TL, Cantley LC. P13K pathway alterations in cancer: variations on a theme. Oncogene 2008;27:5497-5510.
5. Gupta AK, Li B, Cerniglia GJ, Ahmed MS, Hahn SM, Maity A. The HIV protease inhibitor nelfinavir downregulates Akt phosphorylation by inhibiting proteasomal activity and inducing the unfolded protein response. Neoplasia 2007;9:271-278. (Pubitemid 46608294)
6. Pore N, Gupta AK, Cerniglia GJ, et al. Nelfinavir downregulates hypoxia-inducible factor 1 alpha and VEGF expression and increases tumor oxygenation: implications for radiotherapy. Cancer Res 2006;66:9252-9259. (Pubitemid 44521147)
7. Pore N, Gupta AK, Cerniglia GJ, Maity A. HIV protease inhibitors decrease VEGF/HIF-1 alpha expression and angiogenesis in glioblastoma cells. Neoplasia 2006;8:889-995. (Pubitemid 44706238)
8. Manegold PC, Paringer C, Kulka U, et al. Antiangiogenic therapy with mammalian target of rapamycin inhibitor RAD001 (Everolimus) increases radiosensitivity in solid cancer. Clin Cancer Res 2008;14:892-900. (Pubitemid 351231174)
9. Shinohara ET, Cao C, Niermann K, et al. Enhanced radiation damage of tumor vasculator by mTOR inhibitors. Oncogene 2005;24:5414-5422. (Pubitemid 43080085)