Virtual histology and optical coherence tomography: From research to a broad clinical application

Heart

Volumn 95, Issue 16, 2009, Pages 1362-1374

  Garcia Garcia, Hector M ^a   Gonzalo, Nieves ^a   Regar, Evelyn ^a   Serruys, Patrick W ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DARAPLADIB; EVEROLIMUS; PACLITAXEL; PLACEBO; RAPAMYCIN;

ARTICLE; ARTIFICIAL EMBOLISM; ATHEROMA; ATHEROSCLEROTIC PLAQUE; BLOOD VESSEL INJURY; CLINICAL ASSESSMENT; CLINICAL EVALUATION; CLINICAL FEATURE; CORONARY ARTERY ATHEROSCLEROSIS; CORONARY ARTERY THROMBOSIS; DRUG ELUTING STENT; FOLLOW UP; HISTOLOGY; HUMAN; INTRAVASCULAR ULTRASOUND; MACROPHAGE; NONHUMAN; OPTICAL COHERENCE TOMOGRAPHY; PRIORITY JOURNAL; RADIOFREQUENCY; RESTENOSIS; RISK ASSESSMENT; STENT; VIRTUAL HISTOLOGY;

BLOOD VESSEL PROSTHESIS; BLOOD VESSEL PROSTHESIS IMPLANTATION; COMPUTER SIMULATION; CORONARY DISEASE; CORONARY RESTENOSIS; CORONARY VESSELS; EMBOLIZATION, THERAPEUTIC; HUMANS; NECROSIS; STENTS; TOMOGRAPHY, OPTICAL COHERENCE;

EID: 68049126396     PISSN: 13556037     EISSN: 1468201X     Source Type: Journal    
DOI: 10.1136/hrt.2008.151159     Document Type: Article

References (17)

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2. Nair A, Kuban BD, Tuzcu EM, et al. Coronary plaque classification with intravascular ultrasound radiofrequency data analysis. Circulation 2002;106:2200-6. ▶ Landmark study reporting the first validation against pathology of VH.
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4. Rodriguez-Granillo GA, Garcia-Garcia HM, Mc Fadden EP, et al. In vivo intravascular ultrasound-derived thin-cap fibroatheroma detection using ultrasound radiofrequency data analysis. J Am Coll Cardiol 2005;46:2038-42. ▶ First study reporting the definition of IVUS derived TCFAs.
5. Garcia-Garcia HM, Goedhart D, Schuurbiers JC, et al. Virtual histology and remodeling index allow in vivo identification of allegedly high risk coronary plaques in patients with acute coronary syndromes: a three vessel intravascular ultrasound radiofrequency data analysis. Eurointervention 2006;2:338-44. ▶ Three-vessel IVUS study looking at the frequency of IVUS derived TCFAs and its relation with expansive remodelling in patients with ACS.
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13. Manfrini O, Mont E, Leone O, et al. Sources of error and interpretation of plaque morphology by optical coherence tomography. Am J Cardiol 2006;98:156-9. ▶ In some cases, OCT is not able to distinguish calcium deposits from lipid pools or the opposite, due to its low signal penetration.
14. Kubo T, Imanishi T, Takarada S, et al. Assessment of culprit lesion morphology in acute myocardial infarction: ability of optical coherence tomography compared with intravascular ultrasound and coronary angioscopy. J Am Coll Cardiol 2007;50:933-9. ▶ OCT is feasible in patients with acute myocardial infarction and allows identification of plaque rupture, fibrous cap erosion, intracoronary thrombus, and TCFAs in vivo more frequently compared with IVUS and angioscopy.
15. Tearney GJ, Yabushita H, Houser SL, et al. Quantification of macrophage content in atherosclerotic plaques by optical coherence tomography. Circulation 2003;107:113-9. ▶ There was a high degree of positive correlation between OCT and histological measurements of fibrous cap macrophage density.
16. Sawada T, Shite J, Garcia-Garcia HM, et al. Feasibility of combined use of intravascular ultrasound radiofrequency data analysis and optical coherence tomography for detecting thin-cap fibroatheroma. Eur Heart J 2008;29:1136-46. ▶ The combined use of OCT and IVUS-VH allows better characterisation of TCFAs.
17. Gonzalo N, Garcia-Garcia HM, Regar E, et al. In vivo assessment of high-risk coronary plaques at bifurcations with combined intravascular ultrasound virtual histology and optical coherence tomography. J Am Coll Cardiol Img 2009;2:473-82. ▶ The proximal rim of the ostium of the side branch has been identified as a region more likely to contain a thin fibrous cap and a greater proportion of necrotic core.