메뉴 건너뛰기




Volumn 26, Issue 6, 2009, Pages 547-558

Prediction of breast cancer metastasis by genomic profiling: Where do we stand?

Author keywords

Angiogenesis; Breast cancer; Gene expression profiling; Metastasis; Stroma

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN; DNA; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; MICRORNA;

EID: 68049120432     PISSN: 02620898     EISSN: 15737276     Source Type: Journal    
DOI: 10.1007/s10585-009-9254-y     Document Type: Article
Times cited : (30)

References (77)
  • 1
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • 10.1016/S0092-8674(00)81683-9
    • D Hanahan RA Weinberg 2000 The hallmarks of cancer Cell 100 1 57 70 10.1016/S0092-8674(00)81683-9
    • (2000) Cell , vol.100 , Issue.1 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 0017704436 scopus 로고
    • Metastasis results from preexisting variant cells within a malignant tumor
    • 10.1126/science.887927
    • IJ Fidler ML Kripke 1977 Metastasis results from preexisting variant cells within a malignant tumor Science 197 4306 893 895 10.1126/science.887927
    • (1977) Science , vol.197 , Issue.4306 , pp. 893-895
    • Fidler, I.J.1    Kripke, M.L.2
  • 3
    • 0023261211 scopus 로고
    • Clonal analysis of human colorectal tumors
    • 10.1126/science.2889267
    • ER Fearon SR Hamilton B Vogelstein 1987 Clonal analysis of human colorectal tumors Science 238 4824 193 197 10.1126/science.2889267
    • (1987) Science , vol.238 , Issue.4824 , pp. 193-197
    • Fearon, E.R.1    Hamilton, S.R.2    Vogelstein, B.3
  • 4
    • 0017167185 scopus 로고
    • The clonal evolution of tumor cell populations
    • 10.1126/science.959840
    • PC Nowell 1976 The clonal evolution of tumor cell populations Science 194 4260 23 28 10.1126/science.959840
    • (1976) Science , vol.194 , Issue.4260 , pp. 23-28
    • Nowell, P.C.1
  • 5
    • 0024514647 scopus 로고
    • Allelotype of colorectal carcinomas
    • 10.1126/science.2565047
    • B Vogelstein ER Fearon SE Kern 1989 Allelotype of colorectal carcinomas Science 244 4901 207 211 10.1126/science.2565047
    • (1989) Science , vol.244 , Issue.4901 , pp. 207-211
    • Vogelstein, B.1    Fearon, E.R.2    Kern, S.E.3
  • 6
    • 0025083071 scopus 로고
    • Critical factors in the biology of human cancer metastasis: Twenty-eighth G.H.A. Clowes memorial award lecture
    • IJ Fidler 1990 Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture Cancer Res 50 19 6130 6138
    • (1990) Cancer Res , vol.50 , Issue.19 , pp. 6130-6138
    • Fidler, I.J.1
  • 7
    • 0038670576 scopus 로고    scopus 로고
    • Genomic analysis of primary tumors does not address the prevalence of metastatic cells in the population
    • 10.1038/ng0503-23a (author reply 5)
    • IJ Fidler ML Kripke 2003 Genomic analysis of primary tumors does not address the prevalence of metastatic cells in the population Nat Genet 34 1 23 10.1038/ng0503-23a (author reply 5)
    • (2003) Nat Genet , vol.34 , Issue.1 , pp. 23
    • Fidler, I.J.1    Kripke, M.L.2
  • 8
    • 0037158692 scopus 로고    scopus 로고
    • A progression puzzle
    • DOI 10.1038/418823a
    • R Bernards RA Weinberg 2002 A progression puzzle Nature 418 6900 823 10.1038/418823a (Pubitemid 34966286)
    • (2002) Nature , vol.418 , Issue.6900 , pp. 823
    • Bernards, R.1    Weinberg, R.A.2
  • 9
    • 18744402722 scopus 로고    scopus 로고
    • Modelling a new angle on understanding cancer
    • 10.1038/420462b
    • RA Gatenby P Maini 2002 Modelling a new angle on understanding cancer Nature 420 6915 462 10.1038/420462b
    • (2002) Nature , vol.420 , Issue.6915 , pp. 462
    • Gatenby, R.A.1    Maini, P.2
  • 10
    • 0037057698 scopus 로고    scopus 로고
    • Metastasis: The role of chance in malignancy
    • 10.1038/419559b (author reply 60)
    • PA Edwards 2002 Metastasis: the role of chance in malignancy Nature 419 6907 559 560 10.1038/419559b (author reply 60)
    • (2002) Nature , vol.419 , Issue.6907 , pp. 559-560
    • Edwards, P.A.1
  • 11
    • 8444252062 scopus 로고    scopus 로고
    • Laser capture microdissection, microarrays and the precise definition of a cancer cell
    • DOI 10.1586/14737159.4.6.831
    • A Player JC Barrett ES Kawasaki 2004 Laser capture microdissection, microarrays and the precise definition of a cancer cell Expert Rev Mol Diagn 4 6 831 840 10.1586/14737159.4.6.831 (Pubitemid 39487587)
    • (2004) Expert Review of Molecular Diagnostics , vol.4 , Issue.6 , pp. 831-840
    • Player, A.1    Barrett, J.C.2    Kawasaki, E.S.3
  • 12
    • 34250857019 scopus 로고    scopus 로고
    • Tumor cell-organ microenvironment interactions in the pathogenesis of cancer metastasis
    • DOI 10.1210/er.2006-0027
    • RR Langley IJ Fidler 2007 Tumor cell-organ microenvironment interactions in the pathogenesis of cancer metastasis Endocr Rev 28 3 297 321 10.1210/er.2006-0027 (Pubitemid 46984829)
    • (2007) Endocrine Reviews , vol.28 , Issue.3 , pp. 297-321
    • Langley, R.R.1    Fidler, I.J.2
  • 13
    • 0036990103 scopus 로고    scopus 로고
    • The organ microenvironment and cancer metastasis
    • DOI 10.1046/j.1432-0436.2002.700904.x
    • IJ Fidler 2002 The organ microenvironment and cancer metastasis Differentiation 70 9-10 498 505 10.1046/j.1432-0436.2002.700904.x (Pubitemid 36194315)
    • (2002) Differentiation , vol.70 , Issue.9-10 , pp. 498-505
    • Fidler, I.J.1
  • 14
    • 0035005758 scopus 로고    scopus 로고
    • Seed and soil revisited: Contribution of the organ microenvironment to cancer metastasis
    • (vii-viiii)
    • IJ Fidler 2001 Seed and soil revisited: contribution of the organ microenvironment to cancer metastasis Surg Oncol Clin N Am 10 2 257 269 (vii-viiii)
    • (2001) Surg Oncol Clin N Am , vol.10 , Issue.2 , pp. 257-269
    • Fidler, I.J.1
  • 15
    • 33846531356 scopus 로고    scopus 로고
    • The tumour microenvironment as a target for chemoprevention
    • 10.1038/nrc2067
    • A Albini MB Sporn 2007 The tumour microenvironment as a target for chemoprevention Nat Rev Cancer 7 2 139 147 10.1038/nrc2067
    • (2007) Nat Rev Cancer , vol.7 , Issue.2 , pp. 139-147
    • Albini, A.1    Sporn, M.B.2
  • 16
    • 0035902141 scopus 로고    scopus 로고
    • The microenvironment of the tumour - Host interface
    • DOI 10.1038/35077241
    • LA Liotta EC Kohn 2001 The microenvironment of the tumour-host interface Nature 411 6835 375 379 10.1038/35077241 (Pubitemid 32467047)
    • (2001) Nature , vol.411 , Issue.6835 , pp. 375-379
    • Liotta, L.A.1    Kohn, E.C.2
  • 17
    • 36349025372 scopus 로고    scopus 로고
    • New concepts in breast cancer metastasis: Tumor initiating cells and the microenvironment
    • DOI 10.1007/s10585-007-9122-6
    • JP Sleeman N Cremers 2007 New concepts in breast cancer metastasis: tumor initiating cells and the microenvironment Clin Exp Metastasis 24 8 707 715 10.1007/s10585-007-9122-6 (Pubitemid 50000183)
    • (2007) Clinical and Experimental Metastasis , vol.24 , Issue.8 , pp. 707-715
    • Sleeman, J.P.1    Cremers, N.2
  • 18
    • 0037226593 scopus 로고    scopus 로고
    • A molecular signature of metastasis in primary solid tumors
    • DOI 10.1038/ng1060
    • S Ramaswamy KN Ross ES Lander 2003 A molecular signature of metastasis in primary solid tumors Nat Genet 33 1 49 54 10.1038/ng1060 (Pubitemid 36068681)
    • (2003) Nature Genetics , vol.33 , Issue.1 , pp. 49-54
    • Ramaswamy, S.1    Ross, K.N.2    Lander, E.S.3    Golub, T.R.4
  • 19
    • 38549141895 scopus 로고    scopus 로고
    • Metastasis signatures: Genes regulating tumor-microenvironment interactions predict metastatic behavior
    • 10.1007/s10555-007-9111-x
    • A Albini V Mirisola U Pfeffer 2008 Metastasis signatures: genes regulating tumor-microenvironment interactions predict metastatic behavior Cancer Metastasis Rev 27 1 75 83 10.1007/s10555-007-9111-x
    • (2008) Cancer Metastasis Rev , vol.27 , Issue.1 , pp. 75-83
    • Albini, A.1    Mirisola, V.2    Pfeffer, U.3
  • 22
    • 2442691827 scopus 로고    scopus 로고
    • Sequence-matched probes produce increased cross-platform consistency and more reproducible biological results in microarray-based gene expression measurements
    • 10.1093/nar/gnh071
    • BH Mecham GT Klus J Strovel 2004 Sequence-matched probes produce increased cross-platform consistency and more reproducible biological results in microarray-based gene expression measurements Nucleic Acids Res 32 9 e74 10.1093/nar/gnh071
    • (2004) Nucleic Acids Res , vol.32 , Issue.9 , pp. 74
    • Mecham, B.H.1    Klus, G.T.2    Strovel, J.3
  • 23
    • 34548853750 scopus 로고    scopus 로고
    • Exon arrays provide accurate assessments of gene expression
    • DOI 10.1186/gb-2007-8-5-r82
    • K Kapur Y Xing Z Ouyang 2007 Exon arrays provide accurate assessments of gene expression Genome Biol 8 5 R82 10.1186/gb-2007-8-5-r82 (Pubitemid 351895145)
    • (2007) Genome Biology , vol.8 , Issue.5
    • Kapur, K.1    Xing, Y.2    Ouyang, Z.3    Wong, W.H.4
  • 25
    • 13844311931 scopus 로고    scopus 로고
    • Gene expression profiles derived from fine needle aspiration correlate with response to systemic chemotherapy in breast cancer
    • 10.1186/bcr433
    • C Sotiriou TJ Powles M Dowsett 2002 Gene expression profiles derived from fine needle aspiration correlate with response to systemic chemotherapy in breast cancer Breast Cancer Res 4 3 R3 10.1186/bcr433
    • (2002) Breast Cancer Res , vol.4 , Issue.3 , pp. 3
    • Sotiriou, C.1    Powles, T.J.2    Dowsett, M.3
  • 26
    • 12444326150 scopus 로고    scopus 로고
    • Gene expression profiles obtained from fine-needle aspirations of breast cancer reliably identify routine prognostic markers and reveal large-scale molecular differences between estrogen-negative and estrogen-positive tumors
    • L Pusztai M Ayers J Stec 2003 Gene expression profiles obtained from fine-needle aspirations of breast cancer reliably identify routine prognostic markers and reveal large-scale molecular differences between estrogen-negative and estrogen-positive tumors Clin Cancer Res 9 7 2406 2415
    • (2003) Clin Cancer Res , vol.9 , Issue.7 , pp. 2406-2415
    • Pusztai, L.1    Ayers, M.2    Stec, J.3
  • 30
    • 27144488136 scopus 로고    scopus 로고
    • Molecular portraits and 70-gene prognosis signature are preserved throughout the metastatic process of breast cancer
    • DOI 10.1158/0008-5472.CAN-05-2553
    • B Weigelt Z Hu X He 2005 Molecular portraits and 70-gene prognosis signature are preserved throughout the metastatic process of breast cancer Cancer Res 65 20 9155 9158 10.1158/0008-5472.CAN-05-2553 (Pubitemid 41507977)
    • (2005) Cancer Research , vol.65 , Issue.20 , pp. 9155-9158
    • Weigelt, B.1    Hu, Z.2    He, X.3    Livasy, C.4    Carey, L.A.5    Ewend, M.G.6    Glas, A.M.7    Perou, C.M.8    Van't Veer, L.J.9
  • 35
    • 0035881617 scopus 로고    scopus 로고
    • Estrogen receptor status in breast cancer is associated with remarkably distinct gene expression patterns
    • S Gruvberger M Ringner Y Chen 2001 Estrogen receptor status in breast cancer is associated with remarkably distinct gene expression patterns Cancer Res 61 16 5979 5984
    • (2001) Cancer Res , vol.61 , Issue.16 , pp. 5979-5984
    • Gruvberger, S.1    Ringner, M.2    Chen, Y.3
  • 38
    • 33845438621 scopus 로고    scopus 로고
    • Are clusters found in one dataset present in another dataset?
    • DOI 10.1093/biostatistics/kxj029
    • AV Kapp R Tibshirani 2007 Are clusters found in one dataset present in another dataset? Biostatistics (Oxford, England) 8 1 9 31 10.1093/biostatistics/ kxj029 (Pubitemid 44906101)
    • (2007) Biostatistics , vol.8 , Issue.1 , pp. 9-31
    • Kapp, A.V.1    Tibshirani, R.2
  • 40
    • 34848854801 scopus 로고    scopus 로고
    • The complexity of genotypic alterations underlying HER2-positive breast cancer: An explanation for its clinical heterogeneity
    • I Vanden Bempt M Drijkoningen C De Wolf-Peeters 2007 The complexity of genotypic alterations underlying HER2-positive breast cancer: an explanation for its clinical heterogeneity Curr Opin Oncol 19 6 552 557
    • (2007) Curr Opin Oncol , vol.19 , Issue.6 , pp. 552-557
    • Vanden Bempt, I.1    Drijkoningen, M.2    De Wolf-Peeters, C.3
  • 41
    • 0242624620 scopus 로고    scopus 로고
    • Biologic and therapeutic role of HER2 in cancer
    • 10.1038/sj.onc.1206779
    • S Menard SM Pupa M Campiglio 2003 Biologic and therapeutic role of HER2 in cancer Oncogene 22 42 6570 6578 10.1038/sj.onc.1206779
    • (2003) Oncogene , vol.22 , Issue.42 , pp. 6570-6578
    • Menard, S.1    Pupa, S.M.2    Campiglio, M.3
  • 47
    • 33846978784 scopus 로고    scopus 로고
    • Critical review of published microarray studies for cancer outcome and guidelines on statistical analysis and reporting
    • 10.1093/jnci/djk018
    • A Dupuy RM Simon 2007 Critical review of published microarray studies for cancer outcome and guidelines on statistical analysis and reporting J Natl Cancer Inst 99 2 147 157 10.1093/jnci/djk018
    • (2007) J Natl Cancer Inst , vol.99 , Issue.2 , pp. 147-157
    • Dupuy, A.1    Simon, R.M.2
  • 48
    • 35148861546 scopus 로고    scopus 로고
    • Individualized preventive and therapeutic management of hereditary breast ovarian cancer syndrome
    • DOI 10.1038/ncponc0930, PII NCPONC0930
    • DH Roukos E Briasoulis 2007 Individualized preventive and therapeutic management of hereditary breast ovarian cancer syndrome Nat Clin Pract Oncol 4 10 578 590 10.1038/ncponc0930 (Pubitemid 47534757)
    • (2007) Nature Clinical Practice Oncology , vol.4 , Issue.10 , pp. 578-590
    • Roukos, D.H.1    Briasoulis, E.2
  • 49
    • 34250217011 scopus 로고    scopus 로고
    • Expression genomics in breast cancer research: Microarrays at the crossroads of biology and medicine
    • 10.1186/bcr1662
    • LD Miller ET Liu 2007 Expression genomics in breast cancer research: microarrays at the crossroads of biology and medicine Breast Cancer Res 9 2 206 10.1186/bcr1662
    • (2007) Breast Cancer Res , vol.9 , Issue.2 , pp. 206
    • Miller, L.D.1    Liu, E.T.2
  • 52
    • 36349025365 scopus 로고    scopus 로고
    • Gene arrays for diagnosis, prognosis and treatment of breast cancer metastasis
    • DOI 10.1007/s10585-007-9110-x
    • K Driouch T Landemaine S Sin 2007 Gene arrays for diagnosis, prognosis and treatment of breast cancer metastasis Clin Exp Metastasis 24 8 575 585 10.1007/s10585-007-9110-x (Pubitemid 50000498)
    • (2007) Clinical and Experimental Metastasis , vol.24 , Issue.8 , pp. 575-585
    • Driouch, K.1    Landemaine, T.2    Sin, S.3    Wang, S.4    Lidereau, R.5
  • 53
    • 28344454000 scopus 로고    scopus 로고
    • Molecular classification and molecular forecasting of breast cancer: Ready for clinical application?
    • DOI 10.1200/JCO.2005.03.3845
    • JD Brenton LA Carey AA Ahmed 2005 Molecular classification and molecular forecasting of breast cancer: ready for clinical application? J Clin Oncol 23 29 7350 7360 10.1200/JCO.2005.03.3845 (Pubitemid 46202348)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.29 , pp. 7350-7360
    • Brenton, J.D.1    Carey, L.A.2    Ahmed, A.3    Caldas, C.4
  • 54
    • 33846896651 scopus 로고    scopus 로고
    • High-throughput genomic technology in research and clinical management of breast cancer. Molecular signatures of progression from benign epithelium to metastatic breast cancer
    • DOI 10.1186/bcr1528
    • K Rennstam I Hedenfalk 2006 High-throughput genomic technology in research and clinical management of breast cancer. Molecular signatures of progression from benign epithelium to metastatic breast cancer Breast Cancer Res 8 4 213 10.1186/bcr1528 (Pubitemid 46442932)
    • (2006) Breast Cancer Research , vol.8 , Issue.4 , pp. 213
    • Rennstam, K.1    Hedenfalk, I.2
  • 55
    • 41849084544 scopus 로고    scopus 로고
    • Gene expression profiling of breast cancer
    • 10.1146/annurev.pathmechdis.3.121806.151505
    • MC Cheang M van de Rijn TO Nielsen 2008 Gene expression profiling of breast cancer Annu Rev Pathol 3 67 97 10.1146/annurev.pathmechdis.3.121806. 151505
    • (2008) Annu Rev Pathol , vol.3 , pp. 67-97
    • Cheang, M.C.1    Van De Rijn, M.2    Nielsen, T.O.3
  • 57
    • 39149113165 scopus 로고    scopus 로고
    • Development of the 21-gene assay and its application in clinical practice and clinical trials
    • DOI 10.1200/JCO.2007.15.1068
    • JA Sparano S Paik 2008 Development of the 21-gene assay and its application in clinical practice and clinical trials J Clin Oncol 26 5 721 728 10.1200/JCO.2007.15.1068 (Pubitemid 351264384)
    • (2008) Journal of Clinical Oncology , vol.26 , Issue.5 , pp. 721-728
    • Sparano, J.A.1    Paik, S.2
  • 60
    • 3843116922 scopus 로고    scopus 로고
    • "Good Old" clinical markers have similar power in breast cancer prognosis as microarray gene expression profilers
    • DOI 10.1016/j.ejca.2004.02.025, PII S0959804904002138
    • P Eden C Ritz C Rose 2004 "Good Old" clinical markers have similar power in breast cancer prognosis as microarray gene expression profilers Eur J Cancer 40 12 1837 1841 10.1016/j.ejca.2004.02.025 (Pubitemid 39036757)
    • (2004) European Journal of Cancer , vol.40 , Issue.12 , pp. 1837-1841
    • Eden, P.1    Ritz, C.2    Rose, C.3    Ferno, M.4    Peterson, C.5
  • 66
    • 45749157664 scopus 로고    scopus 로고
    • Commercialized multigene predictors of clinical outcome for breast cancer
    • DOI 10.1634/theoncologist.2007-0248
    • JS Ross C Hatzis WF Symmans 2008 Commercialized multigene predictors of clinical outcome for breast cancer Oncol 13 5 477 493 10.1634/theoncologist. 2007-0248 (Pubitemid 351872866)
    • (2008) Oncologist , vol.13 , Issue.5 , pp. 477-493
    • Ross, J.S.1    Hatzis, C.2    Symmans, W.F.3    Pusztai, L.4    Hortobagyi, G.N.5
  • 67
    • 13444282534 scopus 로고    scopus 로고
    • Outcome signature genes in breast cancer: Is there a unique set?
    • DOI 10.1093/bioinformatics/bth469
    • L Ein-Dor I Kela G Getz 2005 Outcome signature genes in breast cancer: is there a unique set? Bioinformatics (Oxford, England) 21 2 171 178 10.1093/bioinformatics/bth469 (Pubitemid 40202018)
    • (2005) Bioinformatics , vol.21 , Issue.2 , pp. 171-178
    • Ein-Dor, L.1    Kela, I.2    Getz, G.3    Givol, D.4    Domany, E.5
  • 68
    • 33645825183 scopus 로고    scopus 로고
    • Thousands of samples are needed to generate a robust gene list for predicting outcome in cancer
    • 10.1073/pnas.0601231103
    • L Ein-Dor O Zuk E Domany 2006 Thousands of samples are needed to generate a robust gene list for predicting outcome in cancer Proc Natl Acad Sci USA 103 15 5923 5928 10.1073/pnas.0601231103
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.15 , pp. 5923-5928
    • Ein-Dor, L.1    Zuk, O.2    Domany, E.3
  • 69
    • 34447632167 scopus 로고    scopus 로고
    • Gene expression profiling spares early breast cancer patients from adjuvant therapy: Derived and validated in two population-based cohorts
    • 10.1186/bcr1325
    • Y Pawitan J Bjohle L Amler 2005 Gene expression profiling spares early breast cancer patients from adjuvant therapy: derived and validated in two population-based cohorts Breast Cancer Res 7 6 R953 R964 10.1186/bcr1325
    • (2005) Breast Cancer Res , vol.7 , Issue.6
    • Pawitan, Y.1    Bjohle, J.2    Amler, L.3
  • 73
    • 41649092988 scopus 로고    scopus 로고
    • Gene expression signatures, clinicopathological features, and individualized therapy in breast cancer
    • 10.1001/jama.299.13.1574
    • CR Acharya DS Hsu CK Anders 2008 Gene expression signatures, clinicopathological features, and individualized therapy in breast cancer J Am Med Assoc 299 13 1574 1587 10.1001/jama.299.13.1574
    • (2008) J Am Med Assoc , vol.299 , Issue.13 , pp. 1574-1587
    • Acharya, C.R.1    Hsu, D.S.2    Anders, C.K.3
  • 74
    • 33750370444 scopus 로고    scopus 로고
    • MicroRNA signatures in human cancers
    • DOI 10.1038/nrc1997, PII NRC1997
    • GA Calin CM Croce 2006 MicroRNA signatures in human cancers Nat Rev Cancer 6 11 857 866 10.1038/nrc1997 (Pubitemid 44629897)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.11 , pp. 857-866
    • Calin, G.A.1    Croce, C.M.2
  • 75
    • 38949111440 scopus 로고    scopus 로고
    • MicroRNAs as prognostic indicators and therapeutic targets: Potential effect on breast cancer management
    • DOI 10.1158/1078-0432.CCR-07-0992
    • AJ Lowery N Miller RE McNeill 2008 MicroRNAs as prognostic indicators and therapeutic targets: potential effect on breast cancer management Clin Cancer Res 14 2 360 365 10.1158/1078-0432.CCR-07-0992 (Pubitemid 351226101)
    • (2008) Clinical Cancer Research , vol.14 , Issue.2 , pp. 360-365
    • Lowery, A.J.1    Miller, N.2    McNeill, R.E.3    Kerin, M.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.