Reduction of pain and anxiety prior to botulinum toxin injections with a new topical anesthetic method

Ophthalmic Plastic and Reconstructive Surgery

Volumn 25, Issue 3, 2009, Pages 173-177

  Weiss, Richard A ^a,c   Lavin, Phillip T ^b  

^a Weiss Cosmetic and Laser Procedures   (United States)

^b Boston Biostatistics Research Foundation   (United States)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANESTHETIC AGENT; BOTULINUM TOXIN A; FLUORINATED HYDROCARBON; UNCLASSIFIED DRUG; VAPOCOOLANT; MUSCLE RELAXANT AGENT;

ADULT; AEROSOL; AGED; ANXIETY; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFICACY; DRUG SAFETY; FEMALE; HUMAN; HYPERPIGMENTATION; INJECTION SITE PAIN; INJECTION SITE REACTION; MAJOR CLINICAL STUDY; MALE; PAIN ASSESSMENT; PRIORITY JOURNAL; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; TECHNIQUE; CHEMICALLY INDUCED DISORDER; CRYOANESTHESIA; ESTHETIC SURGERY; INJECTION; LOCAL ANESTHESIA; METHODOLOGY; MIDDLE AGED; PAIN; PATHOPHYSIOLOGY; PSYCHOLOGICAL ASPECT; TOPICAL DRUG ADMINISTRATION; TREATMENT OUTCOME;

ADMINISTRATION, TOPICAL; AEROSOLS; AGED; ANESTHESIA, LOCAL; ANXIETY; BOTULINUM TOXIN TYPE A; COSMETIC TECHNIQUES; CRYOANESTHESIA; HUMANS; INJECTIONS; MALE; MIDDLE AGED; NEUROMUSCULAR AGENTS; PAIN; QUESTIONNAIRES; TREATMENT OUTCOME;

EID: 68049114528     PISSN: 07409303     EISSN: None     Source Type: Journal    
DOI: 10.1097/IOP.0b013e3181a145ca     Document Type: Article

References (16)

1. Carruthers JD, Carruthers JA. Treatment of glabellar frown lines with C. botulinum-A exotoxin. J Dermatol Surg Oncol 1992;18:17-21.
2. Kranz G, Sycha T, Voller B, et al. Pain sensation during intradermal injections of three different botulinum toxin preparations in different doses and dilutions. Dermatol Surg 2006;32:886-890 (Pubitemid 44034364)
3. Elibol O, Ozkan B, Hekimhan PK, Caǧlar Y. Efficacy of skin cooling and EMLA cream application for pain relief of periocular botulinum toxin injection. Ophthal Plast Reconstr Surg 2007;23:130-133 (Pubitemid 46596604)
4. Linder JS, Edmonson BC, Laquis SJ, et al. Skin cooling before periocular botulinum toxin A injection. Ophthal Plast Reconstr Surg 2002;18:441-442 (Pubitemid 35356226)
5. Sarifakioglu N, Sarifakioglu E. Evaluating the effects of ice application on the pain felt during botulinum toxin type-a injections: a prospective, randomized single-blind controlled trial. Ann Plast Surg 2004;53:543-546 (Pubitemid 39565025)
6. Kontochristopoulos G, Gregoriou S, Zakopoulou N, Rigopoulos D. Cryoanalgesia with dichlorotetrafluoroethane spray versus ice packs in patients treated with botulinum toxin-a for palmar hyperhidrosis: self-controlled study. Dermatol Surg 2006;32:873-874 (Pubitemid 43847132)
7. Bechara FG, Sand M, Altmeyer P, et al. Skin cooling or botulinum toxin A injection in patients with focal axillary hyperhidrosis: a prospective, randomized, controlled study. Ann Plast Surg 2007;58:299-302. (Pubitemid 46667877)
8. Kashkouli MB, Salimi S, Bakhtiari P, et al. EMLA cream application without occlusive dressing before upper facial botulinum toxin injection. Ann Plast Surg 2008;60:353-356
9. Söylev MF, Koçak N, Kuvaki B, et al. Anesthesia with EMLA cream for botulinum A toxin injection into eyelids. Ophthalmologica 2002;216:355-358 (Pubitemid 44858345)
10. Carruthers A, Carruthers J. Single-center, double-blind, randomized study to evaluate the efficacy of 4% lidocaine cream versus vehicle cream during botulinum toxin type A treatments. Dermatol Surg 2005;31:1655-1659 (Pubitemid 43031168)
11. Sami MS, Soparkar CN, Patrinely JR, et al. Efficacy of botulinum toxin type A after topical anesthesia. Ophthal Plast Reconst Surg 2006;22:448-452 (Pubitemid 44789584)
12. EMLA Cream (Lidocaine 2.5% and Prilocaine 2.5%) [package insert]. Wayne, PA: ASTRA Pharmaceuticals.
13. Travell J. Factors affecting pain of injection. JAMA 1955;158:368-371
14. Reis EC, Jacobson RM, Tarbell S, Weniger BG. Taking the sting out of shots: control of vaccination-associated pain and adverse reactions. Pediatr Ann 1998;27:375-386 (Pubitemid 28287846)
15. Lehmann JF, Delateur BJ. Therapeutic Heat and Cold. 4th ed. Baltimore, MD: Williams & Wilkins, 1990.
16. Pain Ease Technical Sheet. Available at: www.gebauer.com. Accessed April 15, 2008.