The G18V CRYGS mutation associated with human cataracts increases γS-crystallin sensitivity to thermal and chemical stress

Biochemistry

Volumn 48, Issue 30, 2009, Pages 7334-7341

  Ma, Zhiwei ^a   Piszczek, Grzegorz ^b   Wingfield, Paul T ^c   Sergeev, Yuri V ^a   Hejtmancik, J Fielding ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^c NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANALYTICAL ULTRACENTRIFUGATION; AUTOSOMAL DOMINANTS; BIOPHYSICAL CHARACTERISTICS; CATARACT FORMATION; CHEMICAL STRESS; CRYSTALLIN; GUANIDINE HYDROCHLORIDE; HIGH STABILITY; INTERMEDIATE STATE; LENS TRANSPARENCY; MOLECULAR MECHANISM; MUTANT PROTEINS; PROTEIN SURFACE; RED SHIFT; REFOLDING; RELATIVE INSTABILITY; SECONDARY STRUCTURES; SITE DIRECTED MUTAGENESIS; TRYPTOPHAN FLUORESCENCE; TWO-STATE TRANSITIONS; WILD TYPES;

AMINO ACIDS; CENTRIFUGATION; CHROMATOGRAPHIC ANALYSIS; DATA STORAGE EQUIPMENT; ESCHERICHIA COLI; ION EXCHANGE; SIZE EXCLUSION CHROMATOGRAPHY;

FLUORESCENCE;

COMPLEMENTARY DNA; GAMMA CRYSTALLIN; GUANIDINE; RECOMBINANT PROTEIN; TRYPTOPHAN;

ARTICLE; CATARACT; CHEMICAL STRESS; ESCHERICHIA COLI; GEL PERMEATION CHROMATOGRAPHY; GENE EXPRESSION SYSTEM; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN PURIFICATION; PROTEIN SECONDARY STRUCTURE; SITE DIRECTED MUTAGENESIS; TEMPERATURE STRESS; ULTRACENTRIFUGATION;

CATARACT; CIRCULAR DICHROISM; GAMMA-CRYSTALLINS; GUANIDINE; HOT TEMPERATURE; HUMANS; LENS, CRYSTALLINE; POINT MUTATION; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN FOLDING; SPECTROMETRY, FLUORESCENCE; THERMODYNAMICS;

ESCHERICHIA COLI;

EID: 68049104001     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi900467a     Document Type: Article

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