Transgenic mice expressing porcine prion protein resistant to classical scrapie but susceptible to sheep bovine spongiform encephalopathy and atypical scrapie

Emerging Infectious Diseases

Volumn 15, Issue 8, 2009, Pages 1214-1221

  Espinosa, Juan Carlos ^a   Herva, María Eugenia ^a   Andréoletti, Olivier ^b   Padilla, Danielle ^a   Lacroux, Caroline ^b   Cassard, Hervé ^b   Lantier, Isabelle ^c   Castilla, Joaquin ^a   Torres, Juan María ^a  

^a Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria   (Spain)

^b UNIVERSITÉ DE TOULOUSE   (France)

^c CEMAGREF   (France)

Author keywords

[No Author keywords available]

Indexed keywords

PRION PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BOVINE SPONGIFORM ENCEPHALOPATHY; CONTROLLED STUDY; INFECTION SENSITIVITY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SCRAPIE; SHEEP; SWINE; TRANSGENIC MOUSE; VIRUS ISOLATION; VIRUS STRAIN; VIRUS TRANSMISSION;

ANIMALS; BRAIN; BRAIN CHEMISTRY; CATTLE; COMMUNICABLE DISEASES, EMERGING; DISEASE MODELS, ANIMAL; ENCEPHALOPATHY, BOVINE SPONGIFORM; MICE; MICE, TRANSGENIC; PRIONS; RECOMBINANT PROTEINS; SCRAPIE; SHEEP; SHEEP DISEASES; SPECIES SPECIFICITY; SWINE;

EID: 68049099286     PISSN: 10806040     EISSN: 10806059     Source Type: Journal    
DOI: 10.3201/eid1508.081218     Document Type: Article

References (39)

1. Pattison IH, Jones KM. The possible nature of the transmissible agent of scrapie. Vet Rec. 1967;80:2-9.
2. Detwiler LA, Baylis M. The epidemiology of scrapie. Rev Sci Tech. 2003;22:121-43.
3. Bruce ME. TSE strain variation. Br Med Bull. 2003;66:99-108. DOI: 10.1093/bmb/66.1.99
4. Benestad SL, Sarradin P, Thu B, Schonheit J, Tranulis MA, Bratberg B. Cases of scrapie with unusual features in Norway and designation of a new type, Nor98. Vet Rec. 2003;153:202-8.
5. Buschmann A, Biacabe AG, Ziegler U, Bencsik A, Madec JY, Erhardt G, et al. Atypical scrapie cases in Germany and France are identified by discrepant reaction patterns in BSE rapid tests. J Virol Methods. 2004;117:27-36. DOI: 10.1016/j.jviromet.2003.11.017
6. Wilesmith JW, Wells GA, Cranwell MP, Ryan JB. Bovine spongiform encephalopathy: epidemiological studies. Vet Rec. 1988;123:638-44.
7. Ironside JW, Sutherland K, Bell JE, McCardle L, Barrie C, Estebeiro K, et al. A new variant of Creutzfeldt-Jakob disease: neuropathological and clinical features. Cold Spring Harb Symp Quant Biol. 1996;61:523-30.
8. Castilla J, Gutierrez-Adan A, Brun A, Doyle D, Pintado B, Ramirez MA, et al. Subclinical bovine spongiform encephalopathy infection in transgenic mice expressing porcine prion protein. J Neurosci. 2004;24:5063-9. DOI: 10.1523/JNEUROSCI.5400-03.2004
9. Wells GA, Hawkins SA, Austin AR, Ryder SJ, Done SH, Green RB, et al. Studies of the transmissibility of the agent of bovine spongi-form encephalopathy to pigs. J Gen Virol. 2003;84:1021-31. DOI: 10.1099/vir.0.18788-0
10. Heath CA, Barker RA, Esmonde TF, Harvey P, Roberts R, Trend P, et al. Dura mater-associated Creutzfeldt-Jakob disease: experience from surveillance in the UK. J Neurol Neurosurg Psychiatry. 2006;77:880-2.
11. Foster JD, Dickinson AG. The unusual properties of CH1641, a sheep-passaged isolate of scrapie. Vet Rec. 1988;123:5-8.
12. Hope J, Wood SC, Birkett CR, Chong A, Bruce ME, Cairns D, et al. Molecular analysis of ovine prion protein identifies similarities between BSE and an experimental isolate of natural scrapie, CH1641. J Gen Virol. 1999;80:1-4.
13. Baron T, Biacabe AG. Molecular behaviors of "CH1641-like" sheep scrapie isolates in ovine transgenic mice (TgOvPrP4). J Virol. 2007;81:7230-7. DOI: 10.1128/JVI.02475-06
14. Baylis M, Goldmann W, Houston F, Cairns D, Chong A, Ross A, et al. Scrapie epidemic in a fully PrP-genotyped sheep flock. J Gen Virol. 2002;83:2907-14.
15. Houston F, Goldmann W, Chong A, Jeffrey M, Gonzalez L, Foster J, et al. Prion diseases: BSE in sheep bred for resistance to infection. Nature. 2003;423:498. DOI: 10.1038/423498a
16. Hunter N. Prion protein (prnp) genotypes and natural scrapie in closed flocks of Cheviot and Suffolk sheep in Britain. In: Court LDB, editor. Transmissible subacute spongiform encephalopathies: prion diseases. Paris: Elsevier; 1996. p. 47-50.
17. European Food Safety Authority. Opinion of the Scientific Panel of the European Food Safety Authority on the biological hazards on the breeding programme for TSE resistance in sheep. The EFSA Journal. 2006;382:1-46.
18. Andreoletti O, Morel N, Lacroux C, Rouillon V, Barc C, Tabouret G, et al. Bovine spongiform encephalopathy agent in spleen from an ARR/ARR orally exposed sheep. J Gen Virol. 2006;87:1043-6. DOI: 10.1099/vir.0.81318-0
19. Groschup MH, Lacroux C, Buschmann A, Luhken G, Mathey J, Eiden M, et al. Classic scrapie in sheep with the ARR/ARR prion genotype in Germany and France. Emerg Infect Dis. 2007;13:1201-7.
20. Le Dur A, Beringue V, Andréoletti O, Reine F, Laï TL, Baron T, et al. A newly identified type of scrapie agent can naturally infect sheep with resistant PrP genotypes. Proc Natl Acad Sci U S A. 2005;102:16031-6.
21. European Union Directorate General for Health and Consumers. Preliminary report on the monitoring and testing of ruminants for the presence of transmissible spongiform encephalopathy (TSE) in the EU in 2007 [cited 2009 May 10] Available from http://ec.europa.eu/ food/food/biosafety/bse/preliminary- annual-report-tse2007-en.pdf
22. Eloit M, Adjou K, Coulpier M, Fontaine JJ, Hamel R, Lilin T, et al. BSE agent signatures in a goat. Vet Rec. 2005;156:523-4.
23. The TSE community reference laboratory strain typing expert group (STEG). MEMO/06/113. 2006 9/3/2006 [cited 2009 May 10]. Available from http://europa.eu/rapid/pressReleasesAction. do?reference=MEMO/06/113
24. Espinosa JC, Andreoletti O, Castilla J, Herva ME, Morales M, Alamillo E, et al. Sheep-passaged bovine spongiform encephalopathy agent exhibits altered pathobiological properties in bovine-PrP transgenic mice. J Virol. 2007;81:835-43. DOI: 10.1128/JVI.01356-06
25. Scott M, Foster D, Mirenda C, Serban D, Coufal F, Walchli M, et al. Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques. Cell. 1989;59:847-57. DOI: 10.1016/0092-8674(89)90608-9
26. Manson JC, Clarke AR, Hooper ML, Aitchison L, McConnell I, Hope J. 129/Ola mice carrying a null mutation in PrP that abolishes mRNA production are developmentally normal. Mol Neurobiol. 1994;8:121-7. DOI: 10.1007/BF02780662
27. Féraudet C, Morel N, Simon S, Volland H, Frobert Y, Créminon C, et al. Screening of 145 anti-PrP monoclonal antibodies for their capacity to inhibit PrPSc replication in infected cells. J Biol Chem. 2005;280:11247-58.
28. Yull HM, Ritchie DL, Langeveld JP, van Zijderveld FG, Bruce ME, Ironside JW, et al. Detection of type 1 prion protein in variant Creutzfeldt-Jakob disease. Am J Pathol. 2006;168:151-7. DOI: 10.2353/ajpath.2006.050766
29. Andreoletti O, Lacroux C, Chabert A, Monnereau L, Tabouret G, Lantier F, et al. PrP(Sc) accumulation in placentas of ewes exposed to natural scrapie: influence of foetal PrP genotype and effect on ewe-to-lamb transmission. J Gen Virol. 2002;83:2607-16.
30. Fraser H, Dickinson AG. The sequential development of the brain lesion of scrapie in three strains of mice. J Comp Pathol. 1968;78:301-11. DOI: 10.1016/0021-9975(68)90006-6
31. Andreoletti O, Simon S, Lacroux C, Morel N, Tabouret G, Chabert A, et al. PrP(Sc) accumulation in myocytes from sheep incubating natural scrapie. Nat Med. 2004;10:591-3. DOI: 10.1038/nm1055
32. Thuring CM, Erkens JH, Jacobs JG, Bossers A, Van Keulen LJ, Garssen GJ, et al. Discrimination between scrapie and bovine spongiform encephalopathy in sheep by molecular size, immunoreactivity, and glycoprofile of prion protein. J Clin Microbiol. 2004;42:972-80. DOI: 10.1128/JCM.42.3.972-980.2004
33. Saunders GC, Cawthraw S, Mountjoy SJ, Hope J, Windl O. PrP genotypes of atypical scrapie cases in Great Britain. J Gen Virol. 2006;87:3141-9. DOI: 10.1099/vir.0.81779-0
34. Moum T, Olsaker I, Hopp P, Moldal T, Valheim M, Benestad SL. Polymorphisms at codons 141 and 154 in the ovine prion protein gene are associated with scrapie Nor98 cases. J Gen Virol. 2005;86:231-5. DOI: 10.1099/vir.0.80437-0
35. Arsac JN, Andreoletti O, Bilheude JM, Lacroux C, Benestad SL, Baron T. Similar biochemical signatures and prion protein genotypes in atypical scrapie and Nor98 cases, France and Norway. Emerg Infect Dis. 2007;13:58-65.
36. Gonzalez L, Chianini F, Martin S, Siso S, Gibbard L, Reid HW, et al. Comparative titration of experimental ovine BSE infectivity in sheep and mice. J Gen Virol. 2007;88:714-7. DOI: 10.1099/vir.0.82426-0
37. Bartz JC, Marsh RF, McKenzie DI, Aiken JM. The host range of chronic wasting disease is altered on passage in ferrets. Virology. 1998;251:297-301. DOI: 10.1006/viro.1998.9427
38. Scott MR, Groth D, Tatzelt J, Torchia M, Tremblay P, DeArmond SJ, et al. Propagation of prion strains through specific conformers of the prion protein. J Virol. 1997;71:9032-44.
39. Bartz JC, Bessen RA, McKenzie D, Marsh RF, Aiken JM. Adaptation and selection of prion protein strain conformations following interspecies transmission of transmissible mink encephalopathy. J Virol. 2000;74:5542-7. DOI: 10.1128/JVI.74.12.5542-5547.2000