Anti-inflammatory activity of Rhodiola rosea - "A second-generation adaptogen"

Phytotherapy Research

Volumn 23, Issue 8, 2009, Pages 1099-1102

  Bawa, Pooja A S ^a   Khanum, Farhath ^a  

^a DEFENCE FOOD RESEARCH LABORATORY   (India)

Author keywords

Anti inflammatory activity; Cyclooxygenases 1 and 2; Membrane stabilization; Phospholipase A2; Rhodiola rosea

Indexed keywords

CARRAGEENAN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DEXAMETHASONE; FORMALDEHYDE; NYSTATIN; PHOSPHOLIPASE A2; RHODIOLA ROSEA EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTHRITIS; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; IN VITRO STUDY; INFLAMMATION; MALE; MEMBRANE STABILIZATION; NONHUMAN; PAW EDEMA; RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ARTHRITIS, EXPERIMENTAL; CYCLOOXYGENASE INHIBITORS; EDEMA; MALE; PHOSPHOLIPASES A2; PLANT EXTRACTS; PLANT ROOTS; RATS; RATS, WISTAR; RHODIOLA;

RATTUS; RHODIOLA ROSEA;

EID: 68049093798     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2749     Document Type: Article

References (27)

1. Anilakumar PKR, Khanum F, Bawa AS. 2006. Phytoconstituents and antioxidant potency of Rhodiola rosea-a versatile adaptogen. J Food Biochem 30: 203-214.
2. Arrigoni-Martelli E, Schiatti P, Selva D. 1971. The influence of anti-inflammatory and immunosuppressant drugs on nystatin induced oedema. Pharmacology 5: 215-224.
3. 2 from Indian cobra (Naja naja naja) venom. Toxicon 27: 861-873.
4. Cochrane CG. 1991. Cellular injury by oxidants. Am J Med 91: 23s-30s.
5. Copeland RA, Williams JM, Giannaras J, Nurnberg S, Covingotn M, Pinto D, Pick S, Trzaskos JM. 1994. Mechanism of selective inhibition of the inducible isoform of Prostaglandin G/H synthase. Proc Natl Acad Sci USA 91: 11202-11206. (Pubitemid 24349654)
6. Darbiyan V, Kteyan A, Panossian A, Gabrielian E, Wikman G, Wagner H. 2000. Rhodiola rosea in stress induced fatiguea double blind cross over study of a standardized extract SHA-5 with a repeated low dose regimen on the mental performance of healthy physicians during night duty. Phytomedicine 7: 365-371. (Pubitemid 30781317)
7. Garcia D, Fernadez A, Saenz T, Ahumada C. 1996. Anti-inflammatory effects of different extracts and harpagoside isolated from scrophularia frutescens L. Farmaco 51: 443-446. (Pubitemid 26266724)
8. German G, Ramazanov Z. 1999. Arctic root of Rhodiola rosea - the powerful ginseng alternative. Kensington Press: New York.
9. Linh PT, Kim YH, Hong SP, Jian JJ, Kang JS. 2000. Quantitative determination of salidroside and tyrosol from the underground part of Rhodiola rosea by high performance liquid chromatography. Arch Pharm Res 23: 349-352.
10. Maslov LN, Lishmanov YB, Maimessulova LA, Kraslov EA. 1998. A mechanism of antiarrhythmic effect of Rhodiola rosea. Bull Exp Biol Med 125: 374-376.
11. Maslov LN, Lishmanov YB, Naumova AV, Lasukova TV. 1997. Do endogenous ligands of peripheral mu and delta-opiate receptors mediate antiarrhythmic and cardioprotective effects of Rhodiola rosea. Bull Exp Biol and Med 124: 754-756.
12. Ming DS, Hillhouse BJ, Guns ES, Eberding A, Xie S, Vimalanathan S, Towers GH. 2005. Bioactive compounds from Rhodiola rosea (Crassulaceae). Phytother Res 19: 740-743. (Pubitemid 41571421)
13. Ozaki Y. 1990. Anti-inflammatory effects of Curcuma xanthorrhiza Roxb, and its active principle. Chem Pharm. Bull. 38: 1045-1048.
14. Pairet M, Enelhardt G. 1996. Distinct isoforms (Cox-1 and Cox-2) of cyclooxygenase: Possible physiological and therapeutic implications. Fundam Clin Pharmacol 10: 101-117.
15. Petkov VD, Yonkov D, Mosharoff A, Kambourova T, Alova L, Petkov VV, Todorov I. 1986. Effects of alcohol aqueous extract from Rhodiola rosea L roots on learning and memory. Acta Physiol Pharmacol Bull 12: 13-16.
16. Rege NN, Thatte UM, Dahanukar SA. 1999. Adaptogenic properties of six rasayana herbs used in ayurvedic medicine. Phytother Res 13: 275-291.
17. Reitman S, Frankel S. 1957. Colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminase. Am J Clin Pathol 26: 56-60.
18. Sautebin L. 2000. Prostaglandins and nitricoxide as molecular targets for anti-inflammatory therapy. Fitotherapia 71: S48-S57. (Pubitemid 30621695)
19. Shinde VA, Phadke AS, Nair AM, Mungantiwar AA, Dikshit VJ, Saraf MN. 1999. Membrane stabilizing activity - a possible mechanism of action for the anti-inflammatory activity of Cedrus deodara wood oil. Fitotherapia 70: 251-257. (Pubitemid 29377040)
20. Siani AC, Ramos MF, Menezes- de- lima O Jr, Ribeirodos- Santos R, Fernadez - ferreira E, Soares RO, Rosas EC, Susunaga GS, Guimaras AC, Zoghbi MG. Henriques MG. 1999. Evaluation of anti-inflammatory related activity of essential oils from the leaves and resin of species of Protium. J Ethnopharmaco 66: 57-69.
21. Spasov AA, Wikman GK, Mandrikov VB, Mironova IA, Neumoin VV. 2000. A double blind placebo-controlled pilot study of the stimulating effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen. Phytomedicine 7: 85-89. (Pubitemid 30307605)
22. Trenam CW, Blake DR, Morris CJ. 1992. Skin inflammation: reactive oxygen species and the role of iron. J Invest Dermatol 99: 675-682. (Pubitemid 23002026)
23. Udintsev SN, Shakov VP. 1991. The role of humoral factors of regenerating liver in the development of experimental tumors and the effect of Rhodiola rosea extract on this process. Neoplasma 38: 323-331.
24. Vane JR, Botting RM. 1998. Anti-inflammatory drugs and their mechanism of action. Inflamm Res 47: 78-87.
25. Winter C, Risley E, Nuss G. 1962. Carrageenan induced oedema in hind paw of the rat as an assay for anti-inflammatory drugs. Proc Soc Exp Biol Med 111: 544-547.
26. Xu GJ. 1996. The Chinese material media, Vol.1. Chinese medicine and Technology Press: Beijing, China; 173-177, 725, 1736-1738.
27. Yoshikawa M, Shimada H, Shimada H, Murakami N, Yamahara J, Matsuda H. 1996. Bioactive constituents of Chinese natural medicine. II. Rhdiola rosea Radix. (1). Chemical structures and anti-allergic activity of Rhodiola cyannosides A and B from the underground part of Rhdiola quadrifida (pall) Fisch. Et Mey. Chem Pharmacol Bull 44: 2086-2091.