Anticariogenicity of casein phosphopeptide-amorphous calcium phosphate: A review of the literature

Journal of Contemporary Dental Practice

Volumn 10, Issue 3, 2009, Pages 1-9

  Llena, Carmen ^a   Forner, Leopoldo ^a   Baca, Pilar ^b  

^a UNIVERSITY OF VALENCIA   (Spain)

^b UNIVERSITY OF GRANADA   (Spain)

Author keywords

ACP; Amorphous calcium phosphate; Caries; Casein phosphopeptide; CPP; Demineralization; Dental plaque; Remineralization

Indexed keywords

ANTICARIES AGENT; CALCIUM; CASEIN; CASEIN PHOSPHOPEPTIDE AMORPHOUS CALCIUM PHOSPHATE NANOCOMPLEX; CASEIN PHOSPHOPEPTIDE-AMORPHOUS CALCIUM PHOSPHATE NANOCOMPLEX; PHOSPHATE;

BIOFILM; CHEMISTRY; DENTAL CARE; DENTAL CARIES; DENTIN; ENAMEL; HUMAN; METABOLISM; METHODOLOGY; PHYSIOLOGY; REVIEW; SALIVA; TOOTH DISEASE; TOOTH PLAQUE; XEROSTOMIA;

BIOFILMS; CALCIUM; CARIOSTATIC AGENTS; CASEINS; DENTAL CARIES; DENTAL ENAMEL; DENTAL PLAQUE; DENTIN; HUMANS; PHOSPHATES; SALIVA; TOOTH EROSION; TOOTH REMINERALIZATION; XEROSTOMIA;

EID: 68049086676     PISSN: None     EISSN: 15263711     Source Type: Journal    
DOI: 10.5005/jcdp-10-3-1     Document Type: Review

References (31)

1. Anusavice KJ. Present and future approaches for the control of caries. J Dent Educ. 2005 May; 69(5):538-54.
2. Vitorino R, Calheiros-Lobo MJ, Duarte JA, Domingues P, Amado F. Salivary clinical data and dental caries susceptibility: is there a relationship? Bull Group Int Rech Sci Stomatol Odontol. 2006 Mar; 47(1):27-33.
3. Owens BM, Kitchens M. The erosive potential of soft drinks on enamel surface substrate: an in vitro scanning electron microscopy investigation. J Contemp Dent Pract. 2007 Nov; 18(7):11-20.
4. Marshall TA, Eichenberger-Gilmore JM, Broffitt BA, Warren JJ, Levy SM. Dental caries and childhood obesity: roles of diet and socioeconomic status. Community Dent Oral Epidemiol. 2007 Dec; 35(6):449-58.
5. Aimutis WR. Bioactive properties of milk proteins focus on anticariogenesis. J Nutr. 2004 Apr; 134(4):989S-95S.
6. Reynolds EC. The prevention of sub-surface demineralization of bovine enamel and change in plaque composition by casein in an intra-oral model. J Dent Res. 1987 Jun; 66(6):1120-7.
7. Llena-Puy C.The rôle of saliva in maintaining oral health and as an aid to diagnosis. Med Oral Patol Oral Cir Bucal. 2006 Aug; 11(5):E449-55.
8. Vitorino R, Lobo MJ, Duarte JR, Ferrer-Correia AJ, Domingues PM, Amado FM. The role of salivary peptides in dental caries. Biomed Chromatogr. 2005 Apr; 19(3):214-22.
9. Drobni M, Li T, Krüger C, Loimaranta V, Kilian M, Hammarström L, Jörnvall H, Bergman T, Strömberg N. Host-derived pentapeptide affecting adhesion, proliferation, and local pH in biofilm communities composed of Streptococcus and Actinomyces species. Infect Immun. 2006 Nov; 74(11):6293-9.
10. Cross KJ, Huq NL, Reynolds EC. Casein phosphopeptides in oral health-chemistry and clinical applications. Curr Pharm Des. 2007; 13(8):793-800.
11. Schüpbach P, Neeser JR, Golliard M, Rouvet M, Guggenheim B. Incorporation of caseinoglycomacropeptide and caseinophosphopeptide into the salivary pellicle inhibits adherence of mutans streptococci. J Dent Res. 1996 Oct; 75(10):1779-88.
12. Cross KJ, Huq NL, Palamara JE, Perich JW, Reynolds EC. Physicochemical characterization of casein phosphopeptide-amorphous calcium phosphate nanocomplexes. J Biol Chem. 2005 Apr 15;280(15):15362-9.
13. Reynolds EC. Anticariogenic complexs of amorphous calcium phosphate stabilized by casein phosphopeptides: a review. Spec Care Dentis. 1998 Jan-Feb; 18(1):8-16.
14. Reynolds EC. Remineralization of enamel subsurface lesions by casein phosphopeptide-stabilized calcium phosphate solutions. J Dent Res. 1997 Sep; 76(9):1587-95.
15. Rees J, Loyn T, Chadwick B. Pronamel and tooth mousse: an initial assessment of erosion prevention in vitro. J Dent. 2007 Apr; 35(4):355-7.
16. Tantbirojn D, Huang A, Ericson MD,. Change in surface hardness of enamel by a cola drink and a CPP-ACP paste. J Dent. 2008 Jan; 36(1):74-9.
17. Ramalingam L, Messer LB, Reynolds EC. Adding casein phosphopeptide-amorphous calcium phosphate to sports drinks to eliminate in vitro erosion. Pediatr Dent. 2005 Jan-Feb; 27(1):61-7.
18. Brostek AM, Bochenek AJ, Walsh LJ. Minimally invasive dentistry: a review and update. Shanghai Kou Qiang Yi Xue. 2006 Jun; 15(3):225-49.
19. Oshiro M, Yamaguchi K, Takamizawa T, Inage H, Watanabe T, Irokawa A, Ando S, Miyazaki M. Effect of CPP-ACP paste on tooth mineralization: an FE-SEM study. J Oral Sci. 2007 Jun; 49(2):115-20.
20. Rahiotis C, Vougiouklakis G. Effect of a CPP-ACP agent on the demineralization and remineralization of dentine in vitro. J Dent. 2007 Aug; 35(8):695-8.
21. Sudjalim TR, Woods MG, Manton DJ, Reynolds EC. Prevention of demineralization around orthodontic brackets in vitro. Am J Orthod Dentofacial Orthop. 2007 Jun; 131(6):705.e1-9.
22. Shen P, Cai F, Nowicki A, Vincent J, Reynolds EC. Remineralization of enamel subsurface lesions by sugar-free chewing gum containing casein phosphopeptide-amorphous calcium phosphate. J Dent Res. 2001 Dec; 80(12):2066-70.
23. Itthagarun A, King NM, Yiu C, Dawes C. The effect of chewing gums containing calcium phosphates on the remineralization of artificial caries-like lesions in situ. Caries Res. 2005 May-Jun; 39(3):251-4.
24. Cai F, Shen P, Morgan MV, Reynolds EC. Remineralization of enamel subsurface lesions in situ by sugar-free lozenges containing casein phosphopeptide-amorphous calcium phosphate. Aust Dent J. 2003 Dec; 48(4):240-3.
25. Andersson A, Sköld-Larsson K, Hallgren A, Petersson LG, Twetman S. Effect of a dental cream containing amorphous cream phosphate complexes on white spot lesion regression assessed by laser fluorescence. Oral Health Prev Dent. 2007 5;(3):229-33.
26. Vlacic J, Meyers IA, Walsh LJ. Combined CPP-ACP and photoactivated disinfection (PAD) therapy in arresting root surface caries: a case report. Br Dent J. 2007 Oct 27;203(8):457-9.
27. Ardu S, Castioni NV, Benbachir N, Krejci I. Minimally invasive treatment of white spot enamel lesions. Quintessence Int. 2007 Sep; 38(8):633-6.
28. Reynolds EC, Cai F, Shen P, Walker GD. Retention in plaque and remineralization of enamel lesions by various forms of calcium in a mouthrinse or sugar-free chewing gum. J Dent Res. 2003 Mar; 82(3):206-11.
29. Rose RK. Effects of an anticariogenic casein phosphopeptide on calcium diffusion in streptococcal model dental plaques. Arch Oral Biol. 2000 Jul; 45(7):569-75.
30. Hay KD, Thomson WM. A clinical trial of the anticaries efficacy of casein derivatives complexed with calcium phosphate in patients with salivary gland dysfunction. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002 Mar; 93(3):271-5.
31. Reynolds EC, Cai F, Cochrane NJ, Shen P, Walker GD, Morgan MV, Reynolds C. Fluoride and casein phosphopeptide-amorphous calcium phosphate. J Dent Res. 2008 Apr; 87(4):344-8.