Central acetylcholinesterase inhibition improves hemodynamic counterregulation to severe blood loss in alcohol-intoxicated rats

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 297, Issue 2, 2009, Pages

  Mathis, Keisa W ^a   Molina, Patricia E ^a  

^a LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Ethanol; Mean arterial blood pressure; Sympathetic nervous system

Indexed keywords

ACETYLCHOLINE; ACETYLCHOLINESTERASE; ALCOHOL; ARGIPRESSIN; CATECHOLAMINE; CHOLINE; NEOSTIGMINE;

ADRENERGIC SYSTEM; ALCOHOL INTOXICATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLEEDING; CATECHOLAMINE RELEASE; CONTROLLED STUDY; FLUID RESUSCITATION; HEMODYNAMICS; HEMORRHAGIC SHOCK; HYPOTENSION; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; NORADRENALIN RELEASE; PRIORITY JOURNAL; RAT; SPRAGUE DAWLEY RAT;

ALCOHOLIC INTOXICATION; ANIMALS; ARGININE VASOPRESSIN; BLOOD GLUCOSE; BLOOD PRESSURE; CHOLINESTERASE INHIBITORS; EPINEPHRINE; ETHANOL; HEART RATE; HEMODYNAMICS; HEMORRHAGE; HYPOTENSION; INSULIN; LATERAL VENTRICLES; MALE; NEOSTIGMINE; NOREPINEPHRINE; PRAZOSIN; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, VASOPRESSIN; SHOCK, HEMORRHAGIC; SURVIVAL ANALYSIS; SYMPATHETIC NERVOUS SYSTEM;

EID: 68049084843     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00170.2009     Document Type: Article

References (46)

1. Balkan B, Dunning BE. Muscarinic stimulation maintains in vivo insulin secretion in response to glucose after prolonged hyperglycemia. Am J Physiol Regul Integr Comp Physiol 268: R475-R479, 1995.
2. Bertolini A, Ferrari W, Guarini S. Adrenocorticotropic hormone and centrally-acting cholinomimetic drugs improve survival of rats with severe hemorrhagic shock through distinct central cholinergic mechanisms. Resuscitation 18: 289-297, 1989.
3. Bloom FE, Koda LY. Chemical circuitry and central cardiovascular regulation. Clin Exp Hypertens A 4: 529-541, 1982.
4. Blount PJ, Nguyen CD, McDeavitt JT. Clinical use of cholinomimetic agents: a review. J Head Trauma Rehabil 17: 314-321, 2002.
5. Brooks VL, Osborn JW. Hormonal-sympathetic interactions in longterm regulation of arterial pressure: an hypothesis. Am J Physiol Regul Integr Comp Physiol 268: R1343-R1358, 1995.
6. Cherpitel CJ, Bond J, Ye Y, Borges G, Macdonald S, Stockwell T, Giesbrecht N, Cremonte M. Alcohol-related injury in the ER: a cross-national meta-analysis from the Emergency Room Collaborative Alcohol Analysis Project (ERCAAP). J Studies Alcohol 64: 641-649, 2003.
7. Chien S. Role of the sympathetic nervous system in hemorrhage. Physiol Rev 47: 214-288, 1967.
8. Darlington DN, Shinsaka J, Dallman MF. Responses of ACTH, epinephrine, norepinephrine, and cardiovascular system to hemorrhage. Am J Physiol Heart Circ Physiol 251: H612-H618, 1986.
9. Foex BA. Systemic responses to trauma. Br Med Bull 55: 726-743, 1999.
10. Gmel G, Bissery A, Gammeter R, Givel JC, Calmes JM, Yersin B, Daeppen JB. Alcohol-attributable injuries in admissions to a Swiss emergency room - an analysis of the link between volume of drinking, drinking patterns, and preattendance drinking. Alcohol Clin Exp Res 30: 501-509, 2006.
11. Gotoh M, Smythe GA. Effects of intracerebroventricularly administered neostigmine on hypothalamic monoaminergic neuronal activities in awake rats. Brain Res 586: 340-343, 1992.
12. Greiffenstein P, Mathis KW, Vande Stouwe C, Molina PE. Alcohol binge before trauma/hemorrhage impairs integrity of host defense mechanisms during recovery. Alcoholism Clin Exp Res 31: 1-12, 2007.
13. Guarini S, Tagliavini S, Ferrari W, Bertolini A. Reversal of haemorrhagic shock in rats by cholinomimetic drugs. Br J Pharmacol 98: 218-224, 1989.
14. Hadfield RJH, Mercer M, Parr MJA. Alcohol and drug abuse in trauma. Resuscitation 48: 25-36, 2001.
15. Hill DA, Abraham KJ, West RH. Factors affecting outcome in resuscitation of severely injured patients. Aust NZ J Surg 63: 604-609, 1993.
16. Hori H, Hauta K, Nanki M, Sakamoto N, Uemura K, Matsubara T, Itoh K, Iguchi A. Pressor response induced by the hippocampal administration of neostigmine is suppressed by M1-muscarinic antagonist. Life Sci 57: 1853-1859, 1995.
17. Iguchi A, Gotoh M, Matsunaga H, Yatomi A, Honmura A, Yanese M, Sakamoto N. Relative contributions of the nervous system and hormones to CNS-mediated hyperglycemia. Am J Physiol Endocrinol Metab 255: E920-E927, 1988.
18. Kennedy B, Janowsky DS, Risch SC, Ziegler MG. Central cholinergic stimulation causes adrenal epinephrine release. J Clin Invest 74: 972-975, 1984.
19. Koshimizu T, Nas Y, Tanoue A, Oikawa R, Kawahara Y, Kiyono Y, Adachi T, Tanaka T, Kuwaki T, Mori T, Takeo S, Okamua H, Tsujimoto G. V1a vasopressin receptors maintain normal blood pressure by regulating circulating blood volume and baroreflex sensitivity. Proc Natl Acad Sci USA 103: 7807-7812, 2006.
20. Kung HC, Hoyert DL, Xu J, Murphy SL. Deaths: final data for 2005. Natl Vital Stat Rep 56: 1-121, 2008.
21. Li G, Keyl PM, Smith GS, Baker SP. Alcohol and injury severity: reappraisal of the continuing controversy. J Trauma 42: 562-569, 1997.
22. Li J, Brezenoff HE, Tkacs NC. Identification of pressor regions activated by central cholinergic stimulation in rat brain. Eur J Pharmacol 337: 227-233, 1997.
23. Long JP, Eckstein JW. Ganglionic actions of neostigmine methylsulfate. J Pharmacol Exp Ther 133: 216-222, 1961.
24. Madan AK, Yu K, Beech DJ. Alcohol and drug use in victims of life-threatening trauma. J Trauma 47: 568-571, 1999.
25. Mathis KW, Zambell K, Olubadewo JO, Molina PE. Altered hemodynamic counter-regulation to hemorrhage by acute moderate alcohol intoxication. Shock 26: 55-61, 2006.
26. Mathis KW, Molina PE. Transient central cholinergic activation enhances sympathetic nervous system activity but does not improve hemorrhage-induced hypotension in alcohol-intoxicated rodents. Shock. In press.
27. Miller RS, Patton M, Graham RM, Hollins D. Outcomes of trauma patients who survive prolonged lengths of stay in the intensive care unit. J Trauma 48: 229-234, 1999.
28. Molina M, Whitaker A, McDonough K, Molina PE. Alcohol does not modulate the augmented acetylcholine-induced vasodilatory response in hemorrhaged rodents. Shock. In press.
29. Molina PE, Malek S, Lang CH, Qian L, Naukam R, Abumrad NN. Early organ-specific hemorrhage-induced increases in tissue cytokine content: associated neurohormonal and opioid alterations. Neuroimmunomodulation 4: 28-36, 1997.
30. Molina PE, Zambel KL, Norenberg K, Eason J, Phelan H, Zang P, Vande Stouwe C, Carnal JW, Porretta C. Consequences of alcohol-induced early dysregulation of responses to trauma/hemorrhage. Alcohol 33: 217-227, 2004.
31. Naimi TS, Brewer RD, Mokdad A, Denny C, Serdula MK, Marks JS. Binge drinking among US adults. JAMA 289: 70-75, 2003.
32. Neukirchen M, Kienbaum P. Sympathetic nervous system: evaluation and importance for clinical general anesthesia. Anesthesiology 109: 1113-1131, 2008.
33. Phelan H, Stahls P, Hunt J, Bagby GJ, Molina PE. Impact of alcohol intoxication on hemodynamic, metabolic and cytokine responses to hemorrhagic shock. J Trauma 52: 675-682, 2002.
34. Picciotto MR, Alreja M, Jentsch JD. Acetylcholine. In: Psychopharmacology: The Fifth Generation of Progress, edited by KL Davis, D Charney, JT Coyle, and C Nemeroff. Philadelphia: Lippincott, Williams & Wilkins, 2002, p. 3-14.
35. Raber J, Bloom FE. IL-2 induces vasopressin release from the hypothalamus and the amygdala: role of nitric oxide-mediated signaling. J Neurosci 14: 6187-6195, 1994.
36. Rehm J, Room R, Graham K, Monteiro M, Gmel G, Sempos CT. The relationship of average volume of alcohol consumption and patterns of drinking to burden of disease: an overview. Addiction 98: 1209-1228, 2003.
37. Reyna TM, Hollis HW, Hulsebus RC. Alcohol-related trauma. Ann Surg 201: 194-197, 1984.
38. Rivara FP, Jurkovich GJ, Gurney JG, Seguin D, Fligner CL, Ries R, Raisys VA, Copass M. The magnitude of acute and chronic alcohol abuse in trauma patients. Arch Surg 128: 903-905, 1993.
39. Savic J, Vargic VM, Prokic DJ, Vujnov S, Prostran M, Zunic G, Stanimirovic D, Rastovac-Bogdanovic M. The life-saving effect of physostigmine in haemorrhagic shock. Resuscitation 21: 57-60, 1991.
40. Savola O. Alcohol intake and the pattern of trauma in young adults and working aged people admitted after trauma. Alcohol Alcohol 40: 269-273, 2005.
41. Shih H, Hu S, Yang C, Ko J, Wu J, Lee C. Alcohol intoxication increases morbidity in drivers involved in motor vehicle accidents. Am J Emerg Med 21: 91-94, 2003.
42. Tagliavini S, Bazzani C, Guarini S, Bertolini A. Influence of morphine on the reversal of haemorrhagic shock induced by cholinergic drugs. Pharmacol Res 22: 331-335, 1990.
43. Wang P, Zheng FB, Koo DJ, CIoffic WG, Bland KI, Chaudry IH. Continuous resuscitation after hemorrhage and acute fluid replacement improves cardiovascular responses. Surgery 129: 559-566, 2001.
44. Wilkinson DG, Francis PT, Schwam E, Payne-Parish J. Cholinesterase inhibitors used in the treatment of Alzheimer's disease: the relationship between pharmacological effects and clinical efficacy. Drugs Aging 21: 453-476, 2004.
45. 2 analog in hemorrhaged hypotensive rats: investigation of different brain areas. Pharmacology 70: 177-187, 2004.
46. 2 analog, in hemorrhaged rats. Brain Res 1118: 43-51, 2006.