Yoked Delivery of Cocaine Is Aversive and Protects Against the Motivation for Drug in Rats

Behavioral Neuroscience

Volumn 123, Issue 4, 2009, Pages 913-925

  Twining, Robert C ^a   Bolan, Matthew ^a   Grigson, Patricia S ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

addiction; compensatory; craving; devaluation; tolerance

Indexed keywords

COCAINE; SACCHARIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASSOCIATION; AVERSIVE BEHAVIOR; AVOIDANCE BEHAVIOR; COCAINE DEPENDENCE; CONTROLLED STUDY; INSTRUMENTAL CONDITIONING; MOTIVATION; NONHUMAN; RAT; REINFORCEMENT; TASK PERFORMANCE; WATER DEPRIVATION; WITHDRAWAL SYNDROME;

ANIMALS; CATHETERIZATION; COCAINE; CONDITIONING, CLASSICAL; CONDITIONING, OPERANT; CUES; DOPAMINE UPTAKE INHIBITORS; DRINKING BEHAVIOR; MALE; MOTIVATION; NEUROPSYCHOLOGICAL TESTS; PHYSICAL STIMULATION; RATS; RATS, SPRAGUE-DAWLEY; REINFORCEMENT SCHEDULE; SACCHARIN; SELF ADMINISTRATION; TASTE PERCEPTION; WATER;

EID: 67949122019     PISSN: 07357044     EISSN: None     Source Type: Journal    
DOI: 10.1037/a0016498     Document Type: Article

References (68)

1. Arnold J.M., and Roberts D.C. A critique of fixed and progressive ratio schedules used to examine the neural substrates of drug reinforcement. Pharmacology, Biochemistry and Behavior 57 (1997) 441-447
2. Baker T.B., Brandon T.H., and Chassin L. Motivational influences on cigarette smoking. Annual Review of Psychology 55 (2004) 463-491
3. Baker T.B., Piper M.E., McCarthy D.E., Majeskie M.R., and Fiore M.C. Addiction motivation reformulated: An affective processing model of negative reinforcement. Psychological Review 111 (2004) 33-51
4. Blanchard D.C., and Blanchard R.J. Cocaine potentiates defensive behaviors related to fear and anxiety. Neuroscience and Biobehavioral Reviews 23 (1999) 981-991
5. Cappell H., and LeBlanc A.E. Conditioned aversion to saccharin by single administrations of mescaline and d-amphetamine. Psychopharmacologia 22 (1971) 352-356
6. Cappell H., and Le Blanc A.E. Punishment of saccharin drinking by amphetamine in rats and its reversal by chlordiazepoxide. Journal of Comparative and Physiological Psychology 85 (1973) 97-104
7. Cappell H., LeBlanc A.E., and Endrenyi L. Aversive conditioning by psychoactive drugs: Effects of morphine, alcohol and chlordiazepoxide. Psychopharmacologia 29 (1973) 239-246
8. Carlezon Jr. W.A., and Chartoff E.H. Intracranial self-stimulation (ICSS) in rodents to study the neurobiology of motivation. Nature Protocols 2 (2007) 2987-2995
9. Carroll M.E., and Smith J.C. Tme course of radiation-induced taste aversion conditioning. Physiology and Behavior 13 (1974) 809-812
10. Dworkin S.I., Mirkis S., and Smith J.E. Response-dependent versus response-independent presentation of cocaine: Differences in the lethal effects of the drug. Psychopharmacology (Berl) 117 (1995) 262-266
11. Ettenberg A. Opponent process properties of self-administered cocaine. Neuroscience and Biobehavioral Reviews 27 (2004) 721-728
12. Everitt B.J., and Robbins T.W. Neural systems of reinforcement for drug addiction: From actions to habits to compulsion. Nature Neuroscience 8 (2005) 1481-1489
13. Flaherty C.F. Incentive relativity (1996), Cambridge University Press, New York
14. Flaherty C.F., and Checke S. Anticipation of incentive gain. Animal Learning and Behavior 10 (1982) 177-182
15. Garcia J., Kimmeldorf K.J., and Koelling R.A. Conditioned aversions to saccharin resulting from exposure to gamma radiation. Science 122 (1955) 157-158
16. Glowa J.R., Shaw A.E., and Riley A.L. Cocaine-induced conditioned taste aversions: Comparisons between effects in LEW/N and F344/N rat strains. Psychopharmacology (Berl) 114 (1994) 229-232
17. Grigson, P. S. (in press). Reward comparison: The Achilles' heel and hope for addiction. Drug Discovery Today: Disease Models
18. Grigson P.S., and Twining R.C. Cocaine-induced suppression of saccharin intake: A model of drug-induced devaluation of natural rewards. Behavioral Neuroscience 116 (2002) 321-333
19. Grigson P.S., Twining R.C., and Carelli R.M. Heroin-induced suppression of saccharin intake in water-deprived and water-replete rats. Pharmacology, Biochemistry and Behavior 66 (2000) 603-608
20. Grigson P.S., Twining R.C., Freet C.S., Wheeler R.A., and Geddes R.I. Drug-induced suppression of CS intake: Reward, aversion, and addiction. In: Reilly S., and Schachtman T. (Eds). Conditioned taste aversion: Behavioral and neural processes (2008), Oxford University Press, New York
21. Hinson R.E., and Siegel S. Nonpharmacological bases of drug tolerance and dependence. Journal of Psychosomatic Research 26 (1982) 495-503
22. Hinson R.E., and Siegel S. Pavlovian inhibitory conditioning and tolerance to pentobarbital-induced hypothermia in rats. Journal of Experimental Psychology: Animal Behavior Processes 12 (1986) 363-370
23. Horger B.A., Shelton K., and Schenk S. Preexposure sensitizes rats to the rewarding effects of cocaine. Pharmacology, Biochemistry and Behavior 37 (1990) 707-711
24. Kenny P.J., Chen S.A., Kitamura O., Markou A., and Koob G.F. Conditioned withdrawal drives heroin consumption and decreases reward sensitivity. Journal of Neuroscience 26 (2006) 5894-5900
25. Kenny P.J., and Markou A. Conditioned nicotine withdrawal profoundly decreases the activity of brain reward systems. Journal of Neuroscience 25 (2005) 6208-6212
26. Kippin T.E., Fuchs R.A., and See R.E. Contributions of prolonged contingent and noncontingent cocaine exposure to enhanced reinstatement of cocaine seeking in rats. Psychopharmacology (Berl) 187 (2006) 60-67
27. Kollins S.H. ADHD, substance use disorders, and psychostimulant treatment: Current literature and treatment guidelines. Journal of Attention Disorders 12 (2008) 115-125
28. Koob G.F., Vaccarino F.J., Amalric M., and Swerdlow N.R. Neural substrates for cocaine and opiate reinforcement. In: Fischer S., Raskin A., and Uhlenhuth E.H. (Eds). Cocaine: Clinical and biobehavioral aspects (1987), Oxford University Press, New York 80-108
29. Krank M.D., Hinson R.E., and Siegel S. Effect of partial reinforcement on tolerance to morphine-induced analgesia and weight loss in the rat. Behavioral Neuroscience 98 (1984) 72-78
30. Krank M.D., O'Neill S., Squarey K., and Jacob J. Goal- and signal-directed incentive: Conditioned approach, seeking, and consumption established with unsweetened alcohol in rats. Psychopharmacology (Berl) 196 (2008) 397-405
31. Kuntz K.L., Patel K.M., Grigson P.S., Freeman W.M., and Vrana K.E. Heroin self-administration: II. CNS gene expression following withdrawal and cue-induced drug-seeking behavior. Pharmacology, Biochemistry and Behavior 90 (2008) 349-356
32. Kuntz K.L., Twining R.C., Baldwin A.E., Vrana K.E., and Grigson P.S. Heroin self-administration: I. Incubation of goal-directed behavior in rats. Pharmacology, Biochemistry and Behavior 90 (2008) 344-348
33. Lecca D., Cacciapaqlia F., Valentini V., Acquas E., and Di Chiara G. Differential neurochemical and behavioral adaptation to cocaine after response contingent and noncontingent exposure in the rat. Psychopharmacology 191 (2007) 653-667
34. Lenoir M., Serre F., Cantin L., and Ahmed S.H. Intense sweetness surpasses cocaine reward. PLoS ONE 2 1 (2007) e698
35. Liu Y., Morgan D., and Roberts D.C. Cross-sensitization of the reinforcing effects of cocaine and amphetamine in rats. Psychopharmacology (Berl) 195 (2007) 369-375
36. MacRae J.R., Scoles M.T., and Siegel S. The contribution of Pavlovian conditioning to drug tolerance and dependence. British Journal of Addiction 82 (1987) 371-380
37. Mark G.P., Hajnal A., Kinney A.E., and Keys A.S. Self-administration of cocaine increases the release of acetylcholine to a greater extent than response-independent cocaine in the nucleus accumbens of rats. Psychopharmacology (Berl) 143 (1999) 47-53
38. Melchior C.L. Conditioned tolerance provides protection against ethanol lethality. Pharmacology, Biochemistry and Behavior 37 (1990) 205-206
39. Mutschler N.H., and Miczek K.A. Withdrawal from a self-administered or non-contingent cocaine binge: Differences in ultrasonic distress vocalizations in rats. Psychopharmacology (Berl) 136 (1998) 402-408
40. Mutschler N.H., and Miczek K.A. Withdrawal from i.v. cocaine "binges" in rats: Ultrasonic distress calls and startle. Psychopharmacology (Berl) 135 (1998) 161-168
41. Nachman M., and Ashe J.H. Learned taste aversions in rats as a function of dosage, concentration, and route of administration of LiCl. Physiology and Behavior 10 (1973) 73-78
42. Nachman M., Lester D., and Le Magnen J. Alcohol aversion in the rat: Behavioral assessment of noxious drug effects. Science 168 (1970) 1244-1246
43. Poulos C.X., Hinson R.E., and Siegel S. The role of Pavlovian processes in drug tolerance and dependence: Implications for treatment. Addictive Behaviors 6 (1981) 205-211
44. Ramos B.M., Siegel S., and Bueno J.L. Occasion setting and drug tolerance. Integrative Physiological and Behavioral Science 37 (2002) 165-177
45. Reicher M.A., and Holman E.W. Location preference and flavor aversion reinforced by amphetamine in rats. Animal Learning & Behavior 5 (1977) 343-346
46. Riley A.L., and Tuck D.L. Conditioned taste aversions: A behavioral index of toxicity. Annals of the New York Academy of Sciences 443 (1985) 272-292
47. Sayette M.A., Wertz J.M., Martin C.S., Cohn J.F., Perrott M.A., and Hobel J. Effects of smoking opportunity on cue-elicited urge: A facial coding analysis. Experimental and Clinical Psychopharmacology 11 (2003) 218-227
48. Siegel S. Evidence from rats that morphine tolerance is a learned response. Journal of Comparative Physiology: A. Sensory, Neural, and Behavioral Physiology 89 (1975) 498-506
49. Siegel S. Tolerance to the hyperthermic effect of morphine in the rat is a learned response. Journal of Comparative Physiology: A. Sensory, Neural, and Behavioral Physiology 92 (1978) 1137-1149
50. Siegel S. Opioid expectation modifies opioid effects. Fed Proc 41 (1982) 2339-2343
51. Siegel S., Baptista M.A., Kim J.A., McDonald R.V., and Weise-Kelly L. Pavlovian psychopharmacology: The associative basis of tolerance. Experimental and Clinical Psychopharmacology 8 (2000) 276-293
52. Siegel S., Hinson R.E., and Krank M.D. The role of predrug signals in morphine analgesic tolerance: Support for a Pavlovian conditioning model of tolerance. Journal of Experimental Psychology: Animal Behavior Processes 4 (1978) 188-196
53. Siegel S., Hinson R.E., Krank M.D., and McCully J. Heroin "overdose" death: Contribution of drug-associated environmental cues. Science 216 (1982) 436-437
54. Siegel S., and Ramos B.M. Applying laboratory research: Drug anticipation and the treatment of drug addiction. Experimental and Clinical Psychopharmacology 10 (2002) 162-183
55. Sizemore G.M., Co C., and Smith J.E. Ventral pallidal extracellular fluid levels of dopamine, serotonin, gamma amino butyric acid, and glutamate during cocaine self-administration in rats. Psychopharmacology (Berl) 150 (2000) 391-398
56. Smith J.E., Koves T.R., and Co C. Brain neurotransmitter turnover rates during rat intravenous cocaine self-administration. Neuroscience 117 (2003) 461-475
57. Smith J.E., Vaughn T.C., and Co C. Acetylcholine turnover rates in rat brain regions during cocaine self-administration. Journal of Neurochemistry 88 (2004) 502-512
58. Smith M.A., Ward S.J., and Roberts D.C. Lesions of the dorsomedial frontal cortex block sensitization to the positive-reinforcing effects of cocaine. Pharmacology, Biochemistry and Behavior 88 (2008) 238-246
59. van der Kooy D., Swerdlow N.R., and Koob G.F. Paradoxical reinforcing properties of apomorphine: Effects of nucleus accumbens and area postrema lesions. Brain Research 259 (1983) 111-118
60. Vila J. Protection from pentobarbital lethality mediated by Pavlovian conditioning. Pharmacology, Biochemistry and Behavior 32 (1989) 365-366
61. Vogel J.R., and Nathan B.A. Learned taste aversions induced by hypnotic drugs. Pharmacology, Biochemistry and Behavior 3 (1975) 189-194
62. Walker B.M., and Ettenberg A. Intra-ventral tegmental area heroin-induced place preferences in rats are potentiated by peripherally administered alprazolam. Pharmacology, Biochemistry and Behavior 82 (2005) 470-477
63. Weise-Kelly L., and Siegel S. Self-administration cues as signals: Drug self-administration and tolerance. Journal of Experimental Psychology: Animal Behavior Processes 27 (2001) 125-136
64. Wheeler D.S., and Miller R.R. Contrasting reduced overshadowing and blocking. Journal of Experimental Psychology: Animal Behavior Processes 33 (2007) 349-359
65. Wheeler R.A., Twining R.C., Jones J.L., Slater J.M., Grigson P.S., and Carelli R.M. Behavioral and electrophysiological indices of negative affect predict cocaine self-administration. Neuron 57 (2008) 774-785
66. White N., Sklar L., and Amit Z. The reinforcing action of morphine and its paradoxical side effect. Psychopharmacology (Berl) 52 (1977) 63-66
67. Wilson S.J., Sayette M.A., Delgado M.R., and Fiez J.A. Effect of smoking opportunity on responses to monetary gain and loss in the caudate nucleus. Journal of Abnormal Psychology 117 (2008) 428-434
68. Wise R.A., Yokel R.A., and DeWit H. Both positive reinforcement and conditioned aversion from amphetamine and from apomorphine in rats. Science 191 (1976) 1273-1275