Metabotropic glutamate receptors in the control of neuronal activity and as targets for development of anti-epileptogenic drugs

Current Medicinal Chemistry

Volumn 16, Issue 17, 2009, Pages 2189-2204

  Tang, Feng Ru ^a,b   Bradford, Henry F ^c   Ling, Eng Ang ^b  

^a NATIONAL NEUROSCIENCE INSTITUTE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Agonists and antagonists; Anti epileptogenic; Anticonvulsive; Glutamate induced epileptic discharges; Metabotropic glutamate receptors (mGluRs)

Indexed keywords

1 AMINO 1,5 INDANDICARBOXYLIC ACID; 1 AMINO 3 (PHOSPHONOMETHYLENE) CYCLOBUTANE CARBOXYLIC ACID; 1 AMINOCYCLOPENTANE DICARBOXYLIC ACID; 2 (2,3 DICARBOXYCYCLOPROPYL)GLYCINE; 2 AMINO 2 (3 CARBOXYCYCLOBUTYL) 3 (9 THIOXANTHYL)PROPIONIC ACID; 2 AMINO 2 (4 CARBOXYPHENYL) 3 (9 THIOXANTHYL)PROPIONIC ACID; 2 METHYL 3 HYDROXY 4 CARBOXYPHENYLGLYCINE; 2 METHYL 6 (2 PHENYLVINYL)PYRIDINE; 2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; 3 [(2 METHYL 4 THIAZOLYL)ETHYNYL]PYRIDINE; 3 ETHYL 2 METHYL QUINOLIN 6 YL (4 METHOXY CYCLOHEXYL) METHANONE METHANESULFONATE; 3,4 DICARBOXYPHENYLGLYCINE; 4 AMINO 2 OXABICYCLO[3.1.0]HEXANE 4,6 DICARBOXYLIC ACID; 4 AMINO 2 THIABICYCLO[3.1.0]HEXANE 4,6 DICARBOXYLIC ACID; 4 AMINOPYRROLIDINE 2,4 DICARBOXYLATE; 4 CARBOXY 2 METHYLPHENYLGLYCINE; 4 CARBOXY 3 HYDROXYPHENYLGLYCINE; 4 CARBOXYPHENYLGLYCINE; 4 PHOSPHONOPHENYLGLYCINE; 6 METHYL 2 PHENYLAZO 3 PYRIDINOL; 6A NAPHTHALEN 2 YLMETHYL 5 METHYLIDENHEXAHYDROCYCLOPENTA[C]FURAN 1 ON; ANTICONVULSIVE AGENT; BAY 36 7620; GLUTAMIC ACID; IONOTROPIC RECEPTOR; LY 339840; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR AGONIST; METABOTROPIC RECEPTOR ANTAGONIST; TIAGABINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VIGABATRIN; NEUROPROTECTIVE AGENT;

ANTICONVULSANT ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; EPILEPSY; EPILEPTIC STATE; EPILEPTOGENESIS; GABAERGIC TRANSMISSION; HUMAN; NERVE CELL; NEUROPROTECTION; NEUROTRANSMITTER RELEASE; NONHUMAN; POSTSYNAPTIC POTENTIAL; PROTEIN TARGETING; PSYCHOSIS; REVIEW; SEIZURE; TEMPORAL LOBE EPILEPSY; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DISEASE MODEL; DOSE RESPONSE; DRUG ADMINISTRATION; DRUG ANTAGONISM; DRUG DESIGN; DRUG EFFECT; DRUG POTENTIATION; FRONTAL LOBE EPILEPSY; METABOLISM; SPECIES DIFFERENCE;

ANIMALS; ANTICONVULSANTS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; DRUG DESIGN; EPILEPSY; EPILEPSY, FRONTAL LOBE; HUMANS; MOLECULAR STRUCTURE; NEURONS; NEUROPROTECTIVE AGENTS; RECEPTORS, METABOTROPIC GLUTAMATE; SPECIES SPECIFICITY;

EID: 67949120460     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986709788612710     Document Type: Review

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