Zn-promoted regio- and sequence-selective one-pot joining reactions of three components: vinylpyridines, alkyl iodides, and carbonyl compounds (or nitriles)

Tetrahedron

Volumn 65, Issue 36, 2009, Pages 7706-7711

  Mineyama, Kenji ^a   Maekawa, Hirofumi ^a   Kohsaka, Akihiro ^a   Yamamoto, Yoshimasa ^a   Nishiguchi, Ikuzo ^a  

^a NAGAOKA UNIVERSITY OF TECHNOLOGY   (Japan)

Author keywords

Alkyl iodide; Carbonyl compound; Nitrile; Three components coupling; Vinylpyridine

Indexed keywords

ACETONITRILE; IODINE DERIVATIVE; NITRILE; PYRIDINE DERIVATIVE;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL REACTION; DRUG STRUCTURE; DRUG SYNTHESIS; ONE POT SYNTHESIS; PRIORITY JOURNAL;

EID: 67949117329     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2009.06.073     Document Type: Article

References (22)

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19. Similar reaction was also reported by K. Takai's group. Takai K., Ueda T., Ikeda N., and Moriwaki T. J. Org. Chem. 61 (1996) 7990
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21. For expression of the products 7(a;a-g), 8(a;a,b,d-g), 10(a,b.g-i;a-d), and 11(a, g-i; a-d) in Tables 2 and 3, the first alphabets correspond to those of alkyl halides 3a,b,g-i, while the second ones are derived from those of carbonyl compounds 6a-g and nitriles 9a-d, respectively.
22. Zn powder with 99.9% purity was purchased from KOJUNDO CHEMICAL LABORATRY Co., Ltd.