A randomized controlled trial comparing a computer-assisted insulin infusion protocol with a strict and a conventional protocol for glucose control in critically ill patients

Journal of Critical Care

Volumn 24, Issue 3, 2009, Pages 371-378

  Cavalcanti, Alexandre B ^a,b,c   Silva, Eliezer ^a   Pereira, Adriano J ^a   Caldeira Filho, Milton ^d   Almeida, Francisca P ^a   Westphal, Glauco A ^e   Beims, Renate ^f   Fernandes, Caio C ^b   Correa, Thiago D ^a   Gouvea, Marcos R ^a   Eluf Neto, José ^c  

^a HOSPITAL ISRAELITA ALBERT EINSTEIN   (Brazil)

^b Centro de Reabilitação do Hospital Estadual Mário Covas   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d Hospital Dona Helena   (Brazil)

^e Centro Hospitalar Unimed   (Brazil)

^f Hospital Municipal Sao Jose   (Brazil)

Author keywords

Blood glucose; Critical care; Hyperglycemia; Hypoglycemia; Insulin

Indexed keywords

INSULIN;

ADULT; ARTICLE; ARTIFICIAL VENTILATION; BURN; CLINICAL PROTOCOL; CLINICAL TRIAL; COMPUTER ASSISTED DRUG THERAPY; CONTINUOUS INFUSION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CRITICAL ILLNESS; CRITICALLY ILL PATIENT; DRUG EFFICACY; DRUG INTERMITTENT THERAPY; DRUG SAFETY; FEMALE; GLYCEMIC CONTROL; HUMAN; HYPOGLYCEMIA; INJURY; INSULIN INFUSION; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

ADULT; AGED; APACHE; BLOOD GLUCOSE; CLINICAL PROTOCOLS; CRITICAL ILLNESS; DRUG THERAPY, COMPUTER-ASSISTED; FEMALE; HUMANS; HYPOGLYCEMIC AGENTS; INFUSIONS, INTRAVENOUS; INJECTIONS, SUBCUTANEOUS; INSULIN; INTENSIVE CARE UNITS; MALE; MIDDLE AGED;

EID: 67949115532     PISSN: 08839441     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jcrc.2009.05.005     Document Type: Article

References (22)

1. Van den Berghe G., Wouters P., Weekers F., et al. Intensive insulin therapy in the critically ill patients. N Engl J Med 345 (2001) 1359-1367
2. Brunkhorst F.M., Engel C., Bloos F., et al. Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med 358 (2008) 125-139
3. Preiser J.C. Intensive glycemic control in med-surg patients (European Glucontrol trial). Society of Critical Care Medicine's 36th Critical Care Congress (2007)
4. Finfer S., Chittock D.R., Su S.Y., et al. Intensive versus conventional glucose control in critically ill patients. N Engl J Med 360 (2009) 1283-1297
5. Van den Berghe G., Wilmer A., Hermans G., et al. Intensive insulin therapy in the medical ICU. N Engl J Med 354 (2006) 449-461
6. American College of Endocrinology and American Diabetes Association consensus statement on inpatient diabetes and glycemic control. Endocr Pract 12 (2006) 458-468
7. Dellinger R.P., Carlet J.M., Masur H., et al. Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Intensive Care Med 30 (2004) 536-555
8. Krinsley J.S., and Grover A. Severe hypoglycemia in critically ill patients: risk factors and outcomes. Crit Care Med 35 (2007) 2262-2267
9. Meijering S., Corstjens A.M., Tulleken J.E., et al. Towards a feasible algorithm for tight glycaemic control in critically ill patients: a systematic review of the literature. Crit Care 10 (2006) R19
10. Pachler C., Plank J., Weinhandl H., et al. Tight glycaemic control by an automated algorithm with time-variant sampling in medical ICU patients. Intensive Care Med 34 (2008) 1224-1230
11. Plank J., Blaha J., Cordingley J., et al. Multicentric, randomized, controlled trial to evaluate blood glucose control by the model predictive control algorithm versus routine glucose management protocols in intensive care unit patients. Diabetes Care 29 (2006) 271-276
12. Vogelzang M., van der Horst I., and Nijsten M.W. Hyperglycaemic index as a tool to assess glucose control: a retrospective study. Crit Care 8 (2004) R122-R127
13. Finney S.J., Zekveld C., Elia A., et al. Glucose control and mortality in critically ill patients. JAMA 290 (2003) 2041-2047
14. Knaus W.A., Draper E.A., Wagner D.P., et al. APACHE II: a severity of disease classification system. Crit Care Med 13 (1985) 818-829
15. Vincent J.L., Moreno R., Takala J., et al. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 22 (1996) 707-710
16. Matthews J.N., Altman D.G., Campbell M.J., et al. Analysis of serial measurements in medical research. BMJ 300 (1990) 230-235
17. Finkielman J.D., Oyen L.J., and Afessa B. Agreement between bedside blood and plasma glucose measurement in the ICU setting. Chest 127 (2005) 1749-1751
18. Kanji S., Buffie J., Hutton B., et al. Reliability of point-of-care testing for glucose measurement in critically ill adults. Crit Care Med 33 (2005) 2778-2785
19. Pereira A.J., Cavalcanti A.B., Correa T.D., et al. Reliability of arterial, capillary and venous point-of-care glucose measurements in the intensive care unit setting: evaluation of two glucometers. Crit Care 11 (2007) s56 [abstr]
20. Cheung N.W., Wong V.W., and McLean M. The hyperglycemia: intensive insulin infusion in infarction (HI-5) study-a randomized controlled trial of insulin infusion therapy for myocardial infarction. Diabetes Care 29 (2006) 765-770
21. Devos P., and Preiser J.C. Current controversies around tight glucose control in critically ill patients. Curr Opin Clin Nutr Metab Care 10 (2007) 206-209
22. Vriesendorp T.M., van Santen S., de Vries J.H., et al. Predisposing factors for hypoglycemia in the intensive care unit. Crit Care Med 34 (2006) 96-101