CUGBP2 directly interacts with U2 17S snRNP components and promotes U2 snRNA binding to cardiac troponin T pre-mRNA

Nucleic Acids Research

Volumn 37, Issue 13, 2009, Pages 4275-7286

  Goo, Young Hwa ^a   Cooper, Thomas A ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; MESSENGER RNA; PROTEIN CUGBP2; SMALL NUCLEAR RIBONUCLEOPROTEIN; SMALL NUCLEAR RNA; TROPONIN T; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; ENZYME ACTIVATION; EXON; HUMAN; HUMAN CELL; INTRON; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN CROSS LINKING; PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN RNA BINDING; RNA SPLICING;

ANIMALS; CHICKENS; HELA CELLS; HUMANS; INTRONS; RIBONUCLEOPROTEIN, U2 SMALL NUCLEAR; RNA PRECURSORS; RNA, MESSENGER; RNA, SMALL NUCLEAR; RNA-BINDING PROTEINS; TROPONIN T;

EID: 67949097422     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkp346     Document Type: Article

References (41)

1. Jurica,M.S. and Moore,M.J. (2003) Pre-mRNA splicing: Awash in a sea of proteins. Mol. Cell, 12, 5-14.
2. Valadkhan,S. (2005) snRNAs as the catalysts of pre-mRNA splicing. Curr. Opin. Chem. Biol., 9, 603-608.
3. Will,C.L. and Lührmann,R. (2006) Spliceosome structure and function. In Gesteland,R.F., Cech, T.R. and Atkins,J.F. (eds), The RNA World 3rd edn. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, USA, pp. 369-400.
4. Berget,S.M. (1995) Exon recognition in vertebrate splicing. J. Biol. Chem., 270, 2411-2414.
5. Robberson,B.L., Cote,G.J. and Berget, (1990) Exon definition may facilitate splice site selection in RNAs with multiple exons. Mol. Cell Biol., 10, 84-94.
6. Pan,Q., Shai,O., Lee,L.J., Frey,B.J. and Blencowe,B.J. (2008) Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing. Nat. Genet., 40, 1413-1415.
7. Wang,E.T., Sandberg,R., Luo,S., Khrebtukova,I., Zhang,L., Mayr,C., Kingsmore,S.F., Schroth,G.P. and Burge,C.B. (2008) Alternative isoform regulation in human tissue transcriptomes. Nature., 456, 470-476.
8. Blencowe,B.J. (2006) Alternative splicing: New insights from global analyses. Cell, 126, 37-47.
9. Yeo,G., Holste,D., Kreiman,G. and Burge,C.B. (2004) Variation in alternative splicing across human tissues. Genome Biol., 5, R74.
10. Sugnet,C.W., Srinivasan,K., Clark, T.A., O'Brien,G., Cline,M.S., Wang,H., Williams,A., Kulp,D., Blume,J.E., Haussler,D. et al. (2006) Unusual intron conservation near tissue-regulated exons found by splicing microarrays. PLoS Comput. Biol., 2, e4.
11. Bonnal,S., Martinez,C., Forch,P., Bachi,A., Wilm,M. and Valcarcel,J. (2008) RBM5/Luca-15/H37 regulates Fas alternative splice site pairing after exon definition. Mol. Cell, 32, 81-95.
12. Sharma,S., Kohlstaedt,L.A., Damianov,A., Rio,D.C. and Black,D.L. (2008) Polypyrimidine tract binding protein controls the transition from exon definition to an intron defined spliceosome. Nat. Struct. Mol. Biol. 15, 183-191.
13. Ule,J., Stefani,G., Mele,A., Ruggiu,M., Wang,X., Taneri,B., Gaasterl, T., Blencowe,B.J. and Darnell,R.B. (2006) An RNA map predicting Nova-dependent splicing regulation. Nature, 444, 580-586.
14. Zhou,A., Ou,A.C., Cho,A., Benz,E.J. Jr and Huang,S.C. (2008) Novel splicing factor RBM25 modulates Bcl-x pre-mRNA 5′ splice site selection. Mol. Cell Biol., 28, 5924-5936.
15. Sharma,S., Falick,A.M. and Black,D.L. (2005) Polypyrimidine tract binding protein blocks the 5′ splice site-dependent assembly of U2AF and the prespliceosomal E complex. Mol. Cell, 19, 485-496.
16. House,A.E. and Lynch,K.W. (2008) Regulation of alternative splicing: more than just the ABCs. J. Biol. Chem., 283, 1217-1221.
17. Zhou,H.L. and Lou,H. (2008) Repression of prespliceosome complex formation at two distinct steps by Fox-1/Fox-2 proteins. Mol. Cell Biol., 28, 5507-5516.
18. Forch,P., Puig,O., Martinez,C., Seraphin,B. and Valcarcel,J. (2002) The splicing regulator TIA-1 interacts with U1-C to promote U1 snRNP recruitment to 5′ splice sites. EMBO J., 21, 6882-6892.
19. Charlet,B.N., Logan,P., Singh,G. and Cooper, T.A. (2002) Dynamic antagonism between ETR-3 and PTB regulates cell type-specific alternative splicing. Mol. Cell, 9, 649-658.
20. Leroy,O., Dhaenens,C.M., Schraen-Maschke,S., Belarbi,K., Delacourte,A., Andreadis,A., Sablonniere,B., Buee,L., Sergeant,N. et al. (2006) ETR-3 represses Tau exons 2/3 inclusion, a splicing event abnormally enhanced in myotonic dystrophy type I. J. Neurosci. Res., 84 852-859.
21. Faustino,N.A. and Cooper, T.A. (2005) Identification of putative new splicing targets for ETR-3 using sequences identified by systematic evolution of ligands by exponential enrichment. Mol. Cell Biol., 25, 879-887.
22. Zhang, W., Liu,H., Han,K. and Grabowski,P.J. (2002) Region-specific alternative splicing in the nervous system: Implications for regulation by the RNA-binding protein NAPOR. RNA, 8, 671-685.
23. Anderson,P.A., Malouf,N.N., Oakeley,A.E., Pagani,E.D. and Allen,P.D. (1991) Troponin T isoform expression in humans. A comparison among normal and failing adult heart, fetal heart, and adult and fetal skeletal muscle. Circ. Res., 69, 1226-1233.
24. Cooper, T.A. and Ordahl,C.P. (1985) A single cardiac troponin T gene generates embryonic and adult isoforms via developmentally regulated alternate splicing. J. Biol. Chem., 260, 11140-11148.
25. Ladd,A.N., Charlet,N. and Cooper, T.A. (2001) The CELF family of RNA binding proteins is implicated in cell-specific and developmentally regulated alternative splicing. Mol. Cell Biol., 21, 1285-1296.
26. Dignam,J.D., Martin,P.L., Shastry,B.S. and Roeder,R.G. (1983) Eukaryotic gene transcription with purified components. Methods Enzymol., 101, 582-598.
27. Seiwert,S.D. and Steitz,J.A. (1993) Uncoupling two functions of the U1 small nuclear ribonucleoprotein particle during in vitro splicing. Mol. Cell Biol., 13, 3135-3145.
28. Gould,K.L., Ren,L., Feoktistova,A.S., Jennings,J.L. and Link,A.J. (2004) Tandem affinity purification and identification of protein complex components. Methods, 33, 239-244.
29. Strathdee,C.A., McLeod,M.R. and Hall,J.R. (1999) Efficient control of tetracycline-responsive gene expression from an autoregulated bi-directional expression vector. Gene, 229, 21-29.
30. Reed,R. (2000) Mechanisms of fidelity in pre-mRNA splicing. Curr. Opin. Cell Biol., 12, 340-345.
31. Puig,O., Caspary,F., Rigaut,G., Rutz,B., Bouveret,E., Bragado-Nilsson,E., Wilm,M. and Seraphin,B. (2001) The tandem affinity purification (TAP) method: A general procedure of protein complex purification. Methods, 24, 218-229.
32. Izquierdo,J.M., Majos,N., Bonnal,S., Martinez,C., Castelo,R., Guigo,R., Bilbao,D. and Valcarcel,J. (2005) Regulation of Fas alternative splicing by antagonistic effects of TIA-1 and PTB on exon definition. Mol. Cell, 19, 475-484.
33. Izquierdo,J.M. (2008) Hu antigen R (HuR) functions as an alternative pre-mRNA splicing regulator of Fas apoptosis-promoting receptor on exon definition. J. Biol. Chem., 283, 19077-19084.
34. Shen,H. and Green,M.R. (2004) A pathway of sequential arginineserine-rich domain-splicing signal interactions during mammalian spliceosome assembly. Mol. Cell, 16, 363-373.
35. Shen,H. and Green,M.R. (2006) RS domains contact splicing signals and promote splicing by a common mechanism in yeast through humans. Genes Dev., 20, 1755-1765.
36. Han,J. and Cooper, T.A. (2005) Identification of CELF splicing activation and repression domains in vivo. Nucleic Acids Res., 33, 2769-2780.
37. Ho,T.H., Charlet,B.N., Poulos,M.G., Singh,G., Swanson,M.S. and Cooper,T.A. (2004) Muscleblind proteins regulate alternative splicing. EMBO J., 23, 3103-3112.
38. Feng,Y., Chen,M. and Manley,J.L. (2008) Phosphorylation switches the general splicing repressor SRp38 to a sequence-specific activator. Nat. Struct. Mol. Biol., 15, 1040-1048.
39. Kalsotra,A., Xiao,X., Ward,A., Castle,J.C., Johnson,J.M., Burge,C.B. and Cooper,T.A. (2008) A post natal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart. Proc. Natl Acad. Sci. USA, 105, 20333-20338.
40. Zhang,C., Zhang,Z., Castle,J., Sun,S., Johnson,J., Krainer,A.R. and Zhang,M.Q. (2008) Defining the regulatory network of the tissue-specific splicing factors Fox-1 and Fox-2. Genes Dev., 22, 2550-2563.
41. Castle,J.C., Zhang,C., Shah,J.K., Kulkarni,A.V., Kalsotra,A., Cooper,T.A. and Johnson,J.M. (2008) Expression of 24,426 human alternative splicing events and predicted cis regulation in 48 tissues and cell lines. Nat. Genet., 40, 1416-1425.