Silver ion unusually stabilizes the structure of a parallel-motif DNA triplex

Journal of the American Chemical Society

Volumn 131, Issue 11, 2009, Pages 3826-3827

  Ihara, Toshihiro ^a,c   Ishii, Tatsuaki ^a   Araki, Norie ^b   Wilson, Anthony W ^b   Jyo, Akinori ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b KUMAMOTO UNIVERSITY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; GENES; MELTING POINT; NUCLEIC ACIDS;

BASE-PAIRING; BASIC CONDITIONS; DNA TRIPLEXES; EQUIMOLAR AMOUNT; MELTING TEMPERATURES; SILVER IONS;

METAL IONS;

AMINO ACID; CYTOSINE; DNA; MERCURY; METAL ION; SILVER; TRIPLEX DNA;

ARTICLE; CHEMICAL STRUCTURE; DNA HELIX; DNA STRUCTURE; MASS SPECTROMETRY; MOLECULAR INTERACTION; PH; STRUCTURE ANALYSIS; THERMOSTABILITY; BASE PAIRING; BINDING SITE; CHEMISTRY; CONFORMATION; DNA DENATURATION; TRANSITION TEMPERATURE;

BASE PAIRING; BINDING SITES; CYTOSINE; DNA; NUCLEIC ACID CONFORMATION; NUCLEIC ACID DENATURATION; SILVER; TRANSITION TEMPERATURE;

EID: 67849097706     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja809702n     Document Type: Article

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17. We first attempted the melting experiments at pH 7. However, the triplex TC11/AG11/TC11 melted almost cooperatively. To evaluate both transitions (t- d and d- c) separately, the pH was raised to 8.5.
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