Synthesis, cannabinoid receptor affinity, molecular modeling studies and in vivo pharmacological evaluation of new substituted 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides. 2. Effect of the 3-carboxamide substituent on the affinity and selectivity profile

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 15, 2009, Pages 5549-5564

  Silvestri, Romano ^a   Ligresti, Alessia ^b   Regina, Giuseppe La ^a   Piscitelli, Francesco ^a   Gatti, Valerio ^a   Brizzi, Antonella ^c   Pasquini, Serena ^c   Lavecchia, Antonio ^d   Allarà, Marco ^b   Fantini, Noemi ^b   Carai, Mauro Antonio Maria ^b   Novellino, Ettore ^d   Colombo, Giancarlo ^b   Marzo, Vincenzo Di ^b   Corelli, Federico ^c  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b CNR   (Italy)

^c UNIVERSITY OF SIENA   (Italy)

^d UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Cannabinoid; Human recombinant CB receptor type 1; Molecular modeling; Pyrrole bioisoteres; Structure activity relationships

Indexed keywords

CANNABINOID 1 RECEPTOR; N (ADAMANT 1 YL) 1 (3,4 DICHLOROPHENYL) 5 (2,5 DIMETHYL 1H PYRROL 1 YL) 4 METHYL 1H PYRAZOLE 3 CARBOXAMIDE; N [1 (1 CYCLOHEXYL)ETHYL] 1 (3,4 DICHLOROPHENYL) 4 METHYL 5 (1H PYRROL 1 YL) 1H PYRAZOLE 3 CARBOXAMIDE; N [2 (4 CHLOROPHENYL)ETHYL] 1 (2,4 DIFLUOROPHENYL) 5 (2,5 DIMETHYL 1H PYRROL 1 YL) 4 METHYL 1H PYRAZOLE 3 CARBOXAMIDE; PYRAZOLE DERIVATIVE; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; IN VIVO STUDY; MALE; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MOLECULAR MODEL; NONHUMAN; RAT; RECEPTOR AFFINITY; SIMULATION;

ANIMALS; BINDING SITES; COMPUTER SIMULATION; DRINKING; EATING; HUMANS; LIGANDS; MALE; MODELS, MOLECULAR; PROTEIN BINDING; PYRROLES; RATS; RATS, WISTAR; RECEPTOR, CANNABINOID, CB1; RECEPTOR, CANNABINOID, CB2;

RATTUS;

EID: 67849084545     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.06.027     Document Type: Article

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