Tightly connected water wires facilitate fast proton uptake at the proton entrance of proton pumping proteins

Journal of the American Chemical Society

Volumn 131, Issue 6, 2009, Pages 2080-2081

  Gu, Wei ^a   Helms, Volkhard ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PUMPS; VEHICULAR TUNNELS; WIRE;

CHARGED RESIDUES; FAST PROTONS; LARGE POPULATION; PROTON PUMP; PROTON-PUMPING;

PROTONS;

ACETIC ACID; ADENOSINE TRIPHOSPHATASE; AMINO ACID; ASPARTIC ACID; CARBOXYL GROUP; HYDRONIUM ION; MEMBRANE PROTEIN; NANOWIRE; OXYGEN; PROTON; PROTON PUMP; PROTON PUMP PROTEIN; UNCLASSIFIED DRUG; WATER; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; SOLUTION AND SOLUBILITY;

AQUEOUS SOLUTION; ARTICLE; BIOENERGY; BULK DENSITY; CHEMICAL ENVIRONMENT; CONDUCTANCE; DIFFUSION; ELECTRICITY; ENERGY TRANSFER; HYDROGEN BOND; ION TRANSPORT; IONIC STRENGTH; LIPID MEMBRANE; MOLECULAR DYNAMICS; MOLECULAR STABILITY; MOLECULE; PROTEIN STRUCTURE; PROTON TRANSPORT; SIMULATION; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; ESCHERICHIA COLI; METABOLISM; SOLUTION AND SOLUBILITY;

ESCHERICHIA COLI; MODELS, MOLECULAR; PROTON PUMPS; PROTON-TRANSLOCATING ATPASES; SOLUTIONS; WATER;

EID: 67749114486     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja809301w     Document Type: Article

References (19)

1. (a) Luecke, H.; Schobert, B.; Richter, H. T.; Cartailler, J. P.; Lanyi, J. K. Science 1999, 286, 255-260.
2. (b) Iwata, S.; Ostermeier, C.; Ludwig, B.; Michel, H. Nature 1995, 376, 660-669.
3. (c) Michel, H. Biochemistry 1999, 38, 15129-15140.
4. Abrahams, J. P.; Leslie, A. G. W.; Lutter, R.; Walker, J. E. Nature 1994, 370, 621-628.
5. (a) Wright, C. A. Biochim. Biophys. Acta 2006, 1757, 886-912.
6. (b) Feniouk, B. A.; Kozlova, M. A.; Knorre, D. A.; Cherepanov, D. A.; Mulkidjanian, A. Y.; Junge, W. Biophys. J. 2004, 86, 4094-4109.
7. (a) Rhodes, M. M.; Reblova, K.; Sponer, J.; Walter, N. G. Proc. Natl. Acad. Sci. U.S.A. 2006, 103, 13380-13385.
8. (b) Olkhova, E.; Hutter, M. C.; Lill, M. A.; Helms, V.; Michel, H. Biophys. J. 2004, 86, 1873-1889.
9. (c) Braun- Sand, S.; Strajbl, M.; Warshel, A. Biophys. J. 2004, 87, 2221-2239.
10. Marx, D. ChemPhysChem 2006, 7, 1848-1870.
11. (e) Swanson, J. M. J.; Maupin, C. M.; Chen, H.; Petersen, M. K.; Xu, J.; Wu, Y.; Voth, G. A. J. Phys. Chem. B 2007, 111, 4300-4314.
12. Dellago, C.; Naor, M.; Hummer, G. Phys. Rev. Lett. 2003, 90 (1-4), 105902.
13. Gutman, M.; Nachliel, E. Annu. Rev. Phys. Chem. 1997, 48, 329-356.
14. Girvin, M. E.; Rastogi, V. K.; Abildgaard, F.; Markley, J. L.; Fillingame, R. H. Biochemistry 1998, 37, 8817-8824.
15. Lill, M. A; Helms, V. J. Chem. Phys. 2001, 115, 7993-8005.
16. Gu, W.; Frigato, T.; Straatsma, T. P.; Helms, V. Angew. Chem., Int. Ed. 2007, 46, 2939-2943.
17. Raschke, T. M.; Levitt, M. Proc. Natl. Acad. Sci. U.S.A. 2005, 102, 6777-6782.
18. Van Der Spoel, D.; Lindahl, E.; Hess, B.; Groenhof, G.; Mark, A. E.; Berendsen, H. J. C. J. Comput. Chem. 2005, 26, 1701-1718.
19. Siu, S. W. I.; Vacha, R.; Jungwirth, P.; Bockmann, R. A. J. Chem. Phys. 2008, 128, 125103.