Protective role of alpha-ketoglutarate against massive doses of cyanide in rats

Journal of Environmental Biology

Volumn 30, Issue 4, 2009, Pages 515-520

  Bhattacharya, R ^a   Tulsawani, Rajkumar ^a  

^a DEFENCE RESEARCH AND DEVELOPMENT ESTABLISHMENT   (India)

Author keywords

Alpha ketoglutarate; Cyanide; Protection; Toxicity

Indexed keywords

2 OXOGLUTARIC ACID; CYANIDE; POTASSIUM CYANIDE; SODIUM NITRITE; SODIUM THIOSULFATE;

CYANIDE; DOSE-RESPONSE RELATIONSHIP; NITRITE; RODENT; SODIUM; SULFATE; TOXICITY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYANIDE POISONING; DRUG EFFICACY; EXPERIMENTAL ANIMAL; EXPOSURE; FEMALE; MORTALITY; NONHUMAN; RAT; REPEATED DRUG DOSE; TREATMENT RESPONSE;

ANIMALIA; RATTUS;

EID: 67749113402     PISSN: 02548704     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Adewusi, S.R.A. and A.A. Akindahunsi. Cassava processing, consumption, and cyanide toxicity. J. Toxicol. Environ. Hlth., 43, 13-23 (1994).
2. Alarie, Y.: Toxicity of fire smoke. Crit. Rev. Toxicol., 2, 259-289 (2002).
3. Barillo, D.J., R. Goode and V. Esh: Cyanide poisoning in victims of fire: Analysis of 364 cases and review of literature. J. Burn. Care Rehabil., 15, 46-57 (1994).
4. Baskin, S.I. and T.G. Brewer: Cyanide poisoning. In: Medical aspects of chemical and biological warfare: Textbook of military medicine (Eds.: F.R. Sidell, E.T. Takafuji and D.R. Franz). US Department of the Army, Office of the Surgeon General and Borden Institute, Washington, DC. pp. 271-286 (1997).
5. Baskin, S.I., A.M. Horowitz and E.W. Nealley: The antidotal action of sodium nitrite and sodium thiosulphate against cyanide poisoning. J. Clin. Pharmacol., 32, 368-375 (1992).
6. Baud, F.J.: Cyanide: Critical issues in diagnosis and treatment. Human Exp. Toxicol., 26, 191-201 (2007).
7. Berlin, C.M.: The treatment of cyanide poisoning in children. Pediatrics, 46, 193-196 (1970).
8. Bhattacharya, R.: α-ketoglutarate: A promising antidote to cyanide poisoning. In: Pharmacological perspectives of toxic chemicals and their antidotes (Eds.: S.J.S. Flora, J.A. Romano, S.I. Baskin and K. Sekhar). Narosa Publishers, Delhi. pp. 411-430 (2004).
9. Bhattacharya, R. and R. Vijayaraghavan: Cyanide intoxication in mice through different routes and its prophylaxis by α-ketoglutarate. Biomed. Environ. Sci., 4, 452-460 (1991).
10. Bhattacharya, R. and R. Vijayaraghavan: Promising role of α-ketoglutarate in protecting against the lethal effects of cyanide. Human Exp. Toxicol., 21, 297-303 (2002).
11. Bhattacharya, R., D. Kumar, K. Sugendran, S.C. Pant, R.K. Tulsawani and R. Vijayaraghavan: Acute toxicity studies of α-ketoglutarate: A promising antidote for cyanide poisoning. J. Appl. Toxicol., 21, 495-499 (2001).
12. Bhattacharya, R., P.V. Lakshmana Rao and R. Vijayaraghavan: In vitro and in vivo attenuation of experimental cyanide poisoning by α-ketoglutarate. Toxicol. Letts., 128, 185-195 (2002).
13. Borowitz, J.L., A.G. Kanthasamy and G.E. Isom: Toxicodynamics of cyanide. In: Chemical warfare agents (Ed.: S.M. Somani). Academic Press, CA, USA. pp. 209-236 (1992).
14. Borowitz, J.L., G.E. Isom and S.I. Baskin: Acute and chronic cyanide toxicity. In: Chemical warfare agents: Toxicity at low levels (Eds.: S.M. Somani and J.A. Romano, Jr.). CRC Press, NY, USA. pp. 301-319 (2001).
15. Borron, S.W., F.J. Baud, B. Megarbane and C. Bismuth: Hydroxocobalamine for severe acute cyanide poisoning by ingestion or inhalation. Am. J. Emerg. Med., 25, 551-558 (2007).
16. Bowden, C.A. and E.P. Krenzelok: Clinical applications of commonly used contemporary antidotes: A US perspective. Drug Saf., 16, 9-47 (1997).
17. Dalvi, R.R., S.G. Sawant and P.S. Terse: Efficacy of alpha-ketoglutaric acid as an effective antidote in cyanide poisoning in dogs. Vet. Res. Commun., 14, 411-414 (1990).
18. Dulaney, M.D. (Jr), M. Brumely, J.T. Willis and A.S. Hume: Protection against cyanide toxicity by oral alpha-ketoglutaric acid. Vet. Human Toxicol., 33, 571-575 (1991).
19. nd Edn., Raven Press, NY, USA. pp. 435-483 (1989).
20. Isom, G.E. and J.L. Borowitz: Modification of cyanide toxicodynamic: Mechanistic based antidote development. Toxicol. Letts., 82/83, 795-799 (1995).
21. Kalyanaraman, U.P., K. Kalyanaraman and S.A. Cullinan: Neuropathy of cyanide intoxication due to laetrile (amygdalin). Cancer, 51, 2126-2133 (1983).
22. Marrs, T.C., R.L. Maynard and F.R. Sidell: Cyanides. In: Chemical warfare agents. Toxicology and treatments (Eds.: T.C. Marrs, R.L. Maynard and F.R. Sidell). John Wiley, London, UK. pp. 203-219 (1996).
23. Moore, S.J., J.C. Norris, I.K. Ho and A.S. Hume: The efficacy of α-ketoglutaric acid in the antagonism of cyanide intoxication. Toxicol. Appl. Pharmacol., 82, 40-44 (1986).
24. Niknahad, H. and P.J. O'Brien: Antidotal effect of dihydroxyacetone against cyanide toxicity in vivo. Toxicol. Appl. Pharmacol., 138, 186-191 (1996).
25. Osuntokun, B.O.: A degenerative neuropathy with blindness and chronic cyanide intoxication of dietary origin. The evidence in nigerians. In: Toxicology in the tropics (Eds.: R.L. Smith and E.A. Bababunmi). Taylor and Francis, Londopn, UK. pp. 16-79 (1980).
26. Peden, N.R., A. Taha, P.D. McSorley, G.T. Bryden, I.B. Murdoch and J.M. Anderson: Industrial exposure to hydrogen cyanide: Implications for treatment. Br. Med. J., 293, 538 (1986).
27. Rotenberg, J.S.: Cyanide as a weapon of terror. Pediatr. Ann., 32, 236-240 (2003).
28. Santiago, I.: Gas poisoning. An. Sist. Sanit. Navar., 26, 173-180 (2003).
29. Silverman, S.H., G.F. Purdue, J.L. Hunt and R.O. Bost: Cyanide toxicity in burned patients. J. Trauma., 28, 171-176 (1988).
30. Van Heijst, A.N.P. and J.J. Meredith: Antidotes for cyanide poisoning. In: Basic science in toxicology (Eds:. G.N. Volanis, J. Sims, F. Sullivan and P. Turner). Taylor and Francis, Brighton, UK. pp. 558-566 (1990).
31. Van Heijst, A.N.P., J.M.C. Douze, R.G. van Kesteren, J. van Bergen and A. van Dijk: Therapeutic problems in cyanide poisoning. Clin. Toxicol., 25, 393-398 (1987).
32. Vesey, C.J. and P.V. Cole: Blood cyanide and thiocyanate concentrations produced by long-term therapy with sodiun nitroprusside. Br. J. Anaes., 57, 148-155 (1985).
33. Way, J.L.: Cyanide intoxication and its mechanism of antagonism. Ann. Rev. Pharmacol. Toxicol., 24, 451-481 (1984).