Impact of prenatal exposure to testosterone in biometrics and endocrine arameters of newborn lambs;Impacto de la exposición prenatal a testosterona sobre parámetros biométricos y endocrinos en ovinos recién nacidos

Archivos de Medicina Veterinaria

Volumn 41, Issue 1, 2009, Pages 43-51

  Recabarren, S E ^a,c   Rojas Garcia P P ^a   Recabarren, M P ^a   Norambuena, K ^a   Sir Petermann, T ^b  

^a UNIVERSITY OF CONCEPCIÓN   (Chile)

^b UNIVERSITY OF CHILE   (Chile)

^c NONE   (Chile)

Author keywords

Fetal programming; Masculinization of external genitalia; Testosterone; Thyroid hormones

Indexed keywords

OVIS ARIES;

EID: 67749102210     PISSN: 0301732X     EISSN: 07176201     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Anderka M, ER Declercq, W Smith. 2000. A time to be born. Am J Public Health 90, 124-126.
2. Barker DJ. 2005. The developmental origins of insulin resistance. Harm Res 64, Suppl 3, 2-7.
3. Barker DJ, SP Bagby, MA Hanson. 2006. Mechanisms of disease: in utero programming in the pathogenesis of hypertension. Nat Clin Pract Nephrol 2, 700-707.
4. Braun T, S Li, TJ Moss, JP Newnham, JR Challis, PD Gluckman, DM Sloboda. 2007. Maternal betamethasone administration reduces binucleate cell number and placental lactogen in sheep. J Endocrinol 194, 337-347.
5. Cagnacci A, R Soldani, G Benedetto Melis, A Volpe. 1998. Diurnal rhythms of labor and delivery in women: modulation, by parity and seasons. Am J Obstet Gynecol 178, 140-145.
6. Carlsen SM, G Jacobsen, P Romundstad. 2006. Maternal testosterone levels during pregnancy are associated with offspring size at birth. Eur J Endocrinol 155, 365-370.
7. Clarke IJ, RJ Scaramuzzi, RV Short. 1976. Effects of testosterone implants in pregnant ewes on their female offspring. J Embryol Exp Morphol 36, 87-99.
8. Clarke IJ, RJ Scaramuzzi, RV Short. 1977. Ovulation in prenatally androgenized ewes. J Endocrinol 73, 385-389.
9. De Blasio MJ, KL Gatford, JS Robinson, JA Owens. 2006. Placental restriction alters circulating thyroid hormone in the young lamb postnatally. Am J Physiol Regul lntegr Comp Physiol 291, R1016-1024.
10. De Blasio MJ, M Dodic, AJ Jefferies, KM Moritz, EM Wintour, JA Owens. 2007. Maternal exposure to dexamethasone or Cortisol in early pregnancy differentially alters insulin secretion and glucose homeostasis in adult male sheep offspring. Am J Physiol Endocrinol Metab 293, E75-E82.
11. DeHaan KC, LL Berger, DJ Kesler, FK McKeith, DL Thomas, TG Nash. 1987. Effect of prenatal androgenization on lamb performance, carcass composition and reproductive function. J Anim Sci 65, 1465-1470.
12. Dwyer CM, CA Morgan. 2006. Maintenance of body temperature in the neonatal lamb: effects of breed, birth weight, and litter size. J Anim Sci 84, 1093-1101.
13. Economides DL, KH Nicolaides, EA Linton, LA Perry, T Chard. 1988. Plasma Cortisol and adrenocorticotropin in appropriate and small for gestational age fetuses. Fetal Ther 3, 158-164.
14. Eriksson J, T Forsén, J Tuomilehto, C Osmond, D Barker. 2001. Size at birth, childhood growth, and obesity in adult life. Int J Obes Relat Metab Disord 25, 735-740.
15. Fahey AJ, JM Brameld, T Parr, PJ Buttery. 2005. The effect of maternal undernutrition before muscle differentiation on the muscle fiber development of the newborn lamb. J Anim Sci 83, 2564-2571.
16. Fisher DA. 2007. Thyroid function and dysfunction in premature infants. Pediatr Endocrinol Rev 4, 317-328.
17. Foster DL. 1988. Chapter 40: Physiology of Reproduction. In: Knobil E, Neill JD (eds). Puberty in the female sheep. Raven Press, New York, USA, Pp 1739-1760.
18. Fowden AL, J Li, AJ Forhead. 1998. Glucocorticoids and the preparation for life after birth: are there long-term, consequences of the life insurance. Proc Nutr Soc 57, 113-122.
19. Fowden. AL, AJ Forhead. 2004. Endocrine mechanisms of intrauterine programming. Reproduction 127, 515-526.
20. Herbosa CG, RI Wood, DL Foster. 1995. Prenatal androgens modify the reproductive response to photoperiod in the developing sheep. Biol Reprod 52, 163-169.
21. Hernandes E, D Coelho, J Missel, D Kumpinski. 2000. Alteraciones circadianas del sistema cardiovascular. Rev Esp Cardiol 53, 117-122.
22. Josso N, JY Picard, R Rey, N di Clemente. 2006. Testicular anti-Müllerian hormone: history, genetics, regulation and clinical applications. Pediatr Endocrinol Rev 3, 347-358.
23. Kosut SS, RI Wood, C Herbosa-Encarnación, DL Foster. 1997. Prenatal androgens time neuroendocrine puberty in the sheep: effect of testosterone dose. Endocrinology 138, 1072-1077.
24. Manikkam M, EJ Crespi, DD Doop, C Herkimer, JS Lee, S Yu, MB Brown, DL Foster, V Padmanabhan. 2004. Fetal programming: prenatal testosterone excess leads to fetal growth retardation and postnatal catch-up growth in sheep. Endocrinol 145, 790-798.
25. Mellor DJ, RA Pearson. 1977. Some changes in the composition of blood during the first 24 hours after birth, in normal and growth retarded lambs. Ann Rech Vet 8, 460-467.
26. New MI. 2004. An update of congenital adrenal hyperplasia. Ann N Y Acad Sci 1038, 14-43.
27. Nimkarn S, MI New. 2007. Prenatal diagnosis and treatment of congenital adrenal hyperplasia owing to 21-hydroxylase deficiency. Nat Clin Pract Endocrinol Metab 3, 405-413.
28. Orgeur P. 1995. Sexual play behavior in lambs androgenized in utero. Physiol Behav 57, 185-187.
29. Padmanabhan V, M Manikkan, S Recabarren, D Foster. 2006. Prenatal testosterone excess programs reproductive and metabolic dysfunction. in the female. Moll Cell Endocrinolol 246, 165-174.
30. Parraguez VH, V Vergara, R Riquelme, R Arriman, AJ Llanos, M SerónFerré. 1989. Ontogeny of the circadian. rhythm of Cortisol in sheep. Biol Reprod 40, 1137-1143.
31. Recabarren SE, A Lobos, C Schneider, J Cox, J Pařilo. 2000. Sensibilidad tisular a la insulina antes, durante y después de un ayuno en ovejas prepúberes. Arch Med Vet 32, 139-146.
32. Recabarren SE, A Lobos, V Torres, R Oyarzo, T Sir-Petermann. 2004. Secretory patterns of leptin and luteinizing hormone in food-restricted ewe lambs. Biol Res 37, 371-384.
33. a. Postnatal consequences of altered insulin sensitivity in female sheep treated prenatally with testosterone. Am J Physiol Endocrinol Metab 289, 801-806.
34. b. Response to the gonadotropin releasing hormone agonist leuprolide in immature female sheep androgenized in utero. Biol Res 38, 235-244.
35. Recabarren SE, T Sir-Petermann, M Maliqueo, A Lobos, P Rojas-García. 2006. La exposición prenatal a andrógenos como factor de reprogramación fetal. Rev Med Chile 134, 101-108.
36. Recabarren SE, A Lobos, Y Figueroa, V Padmanabhan, DL Foster, T Sir-Petermann. 2007. Prenatal testosterone treatment alters LH and testosterone responsiveness to GnRH agonist in male sheep. Biol Res 40, 329-338.
37. Robinson JE, RA Forsdike, JA Taylor. 1999. In utero exposure of female lambs to testosterone reduces the sensivity of the gonadotropinreleasing hormone neuronal network to inhibition by progesterone. Endocrinology 140, 5797-5805.
38. Rojas-García PP, CI Abarca, CE Ulloa, V Alfaro, MP Recabarren, DA Sandoval, T Sir-Petermann, SE Recabarren. 2006. Estudio preliminar de la histología oválica en ovejas adultas con exposición prenatal a testosterona (EPT). XVII Reunión Anual Sociedad Chilena de. Reproducción y Desarrollo, Reñaca, Chile.
39. Savabieasfahani M, JS Lee, C Herkimer, TP Sharma, DL Foster, V Padmanabhan. 2005. Fetal programming: testosterone exposure of the female sheep during midgestation disrupts the dynamics of its adult gonadotropin secretion, during the periovulatory period. Biol Reprod 72, 221-229.
40. Sharma TP, C Herkimer, C West, W Ye, R Birch, JE Robinson, DL Foster, V Padmanabhan. 2002. Fetal programming: prenatal androgen disrupts positive feedback actions of estradiol but does not affect timing of puberty in female sheep. Biol Reprod 66, 924-933.
41. Sir-Petermann T, M Maliqueo, B Angel, HE Lara, F Pérez-Bravo, SE Recabarren. 2002. Maternal serum androgens in pregnant women with polycystic ovarian syndrome: possible implications in. prenatal androgenization. Hum Reprod 17, 2573-2579.
42. Unsworth WP, JA Taylor, JE Robinson. 2005. Prenatal programming of reproductive neuroendocrine function: the effect of prenatal androgens on the development of estrogen positive feedback and ovarian cycles in the ewe. Biol Reprod 72, 619-627.
43. Vergara F. 2007. Caracterización de los perfiles de LH, Estradiol y Progesterona del ciclo estral durante la segunda estación reproductiva en ovejas Suffolk con exposición prenatal a testosterona. Memoria de título, Facultad de Medicina Veterinaria, Universidad de Concepción, Chillan, Chile.
44. Ward JW, FB Wooding, AL Fowden. 2002. The effects of Cortisol on the binucleate cell population in the ovine placenta during late gestation. Placenta 23, 451-458.
45. Wolf CJ, A Hotchkiss, JS Osthy, GA LeBlanc, LE Gray Jr. 2002. Effects of prenatal testosterone propionate on the sexual development of male and female rats: a dose-response study. Toxicol Sci 65, 71-86.
46. Wood RI, DL Foster. 1998. Sexual differentiation of reproductive neuroendocrine function in sheep. Rev. Reprod 3, 130-140.