Extracytoplasmic function σ factors with overlapping promoter specificity regulate sublancin production in Bacillus subtilis

Journal of Bacteriology

Volumn 191, Issue 15, 2009, Pages 4951-4958

  Luo, Yun ^a   Helmann, John D ^a  

^a Department of Obstetrics Gynecology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; EXTRACYTOPLASMIC FUNCTION SIGMA FACTOR; EXTRACYTOPLASMIC FUNCTION SIGMA FACTOR M; EXTRACYTOPLASMIC FUNCTION SIGMA FACTOR W; EXTRACYTOPLASMIC FUNCTION SIGMA FACTOR X; PROTEIN ABH; PROTEIN ABRB; REGULATOR PROTEIN; SIGMA FACTOR; SUBLANCIN; UNCLASSIFIED DRUG;

ABH GENE; ABRB GENE; ANTIBIOTIC RESISTANCE; ARTICLE; BACILLUS SUBTILIS; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIOPHAGE; DRUG SYNTHESIS; GENE MUTATION; GENE REPRESSION; GENETIC ANALYSIS; GENETIC TRANSCRIPTION; MUTANT; NONHUMAN; OPERON; PRIORITY JOURNAL; PROMOTER REGION; REGULATORY MECHANISM;

BACILLUS SUBTILIS; BACTERIAL PROTEINS; BACTERIOCINS; BLOTTING, NORTHERN; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, BACTERIAL; OPERON; PEPTIDES; PROMOTER REGIONS, GENETIC; SIGMA FACTOR; TRANSCRIPTION FACTORS;

BACILLUS SUBTILIS;

EID: 67749097598     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.00549-09     Document Type: Article

References (34)

1. Albano, M., W. K. Smits, L. T. Ho, B. Kraigher, I. Mandic-Mulec, O. P. Kuipers, and D. Dubnau. 2005. The Rok protein of Bacillus subtilis represses genes for cell surface and extracellular functions. J. Bacteriol. 187:2010-2019.
2. Banse, A. V., A. Chastanet, L. Rahn-Lee, E. C. Hobbs, and R. Losick. 2008. Parallel pathways of repression and antirepression governing the transition to stationary phase in Bacillus subtilis. Proc. Natl. Acad. Sci. USA 105:15547-15552.
3. W-dependent genes that provide intrinsic resistance to antimicrobial compounds produced by bacilli. Mol. Microbiol. 60:765-782.
4. W, an extracytoplasmic function σ factor in Bacillus subtilis. J. Bacteriol. 183:2380-2383.
5. Cao, M., and J. D. Helmann. 2002. Regulation of the Bacillus subtilis bcrC bacitracin resistance gene by two extracytoplasmic function σ factors. J. Bacteriol. 184:6123-6129.
6. X factor regulates modification of the cell envelope and resistance to cationic antimicrobial peptides. J. Bacteriol. 186:1136-1146.
7. M, an extracytoplasmic function σ factor, and is conferred by YqjL and BcrC. J. Bacteriol. 187:2948-2956.
8. Y and its target promoters. J. Bacteriol. 185:4883-4890.
9. Dorenbos, R., T. Stein, J. Y. Dubois, J. Weiland, W. J. Quax, and J. M. van Dijl. 2004. Thiol-disulfide oxidoreductases in Bacillus subtilis. Ph.D. dissertation. University of Groningen, Groningen, The Netherlands.
10. Dorenbos, R., T. Stein, J. Kabel, C. Bruand, A. Bolhuis, S. Bron, W. J. Quax, and J. M. Van Dijl. 2002. Thiol-disulfide oxidoreductases are essential for the production of the lantibiotic sublancin 168. J. Biol. Chem. 277:16682-16688.
11. Dubois, J. Y., T. R. Kouwen, A. K. Schurich, C. R. Reis, H. T. Ensing, E. N. Trip, J. C. Zweers, and J. M. van Dijl. 2009. Immunity to the bacteriocin sublancin 168 is determined by the SunI (YolF) protein of Bacillus subtilis. Antimicrob. Agents Chemother. 53:651-661.
12. M regulon and its contribution to cell envelope stress responses. Mol. Microbiol. 67:830-848.
13. Ellermeier, C. D., E. C. Hobbs, J. E. Gonzalez-Pastor, and R. Losick. 2006. A three-protein signaling pathway governing immunity to a bacterial cannibalism toxin. Cell 124:549-559.
14. Fujita, M., J. E. Gonzalez-Pastor, and R. Losick. 2005. High- and lowthreshold genes in the Spo0A regulon of Bacillus subtilis. J. Bacteriol. 187: 1357-1368.
15. Fujita, M., and R. Losick. 2005. Evidence that entry into sporulation in Bacillus subtilis is governed by a gradual increase in the level and activity of the master regulator Spo0A. Genes Dev. 19:2236-2244.
16. Hambraeus, G., C. von Wachenfeldt, and L. Hederstedt. 2003. Genome-wide survey of mRNA half-lives in Bacillus subtilis identifies extremely stable mRNAs. Mol. Genet. Genomics 269:706-714.
17. Harwood, C. R., and S. M. Cutting. 1990. Molecular biological methods for Bacillus. John Wiley & Sons Ltd., Chichester, United Kingdom.
18. Helmann, J. D. 2002. The extracytoplasmic function (ECF) σ factors. Adv. Microb. Physiol. 46:47-110.
19. X factor using a consensus-directed search. J. Mol. Biol. 279:165-173.
20. Kleerebezem, M. 2004. Quorum sensing control of lantibiotic production; nisin and subtilin autoregulate their own biosynthesis. Peptides 25:1405-1414.
21. Kouwen, T. R., E. N. Trip, E. L. Denham, M. J. Sibbald, J. Y. Dubois, and J. M. van Dijl. 2009. Protein secretion and disulfide bond handling in Bacillus subtilis. Ph.D. dissertation. University of Groningen, Groningen, The Netherlands.
22. Mascher, T., A. B. Hachmann, and J. D. Helmann. 2007. Regulatory overlap and functional redundancy among Bacillus subtilis extracytoplasmic function σ factors. J. Bacteriol. 189:6919-6927.
23. Mascher, T., N. G. Margulis, T. Wang, R. W. Ye, and J. D. Helmann. 2003. Cell wall stress responses in Bacillus subtilis: the regulatory network of the bacitracin stimulon. Mol. Microbiol. 50:1591-1604.
24. Mathews, D. H., J. Sabina, M. Zuker, and D. H. Turner. 1999. Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure. J. Mol. Biol. 288:911-940.
25. McAuliffe, O., R. P. Ross, and C. Hill. 2001. Lantibiotics: structure, biosynthesis and mode of action. FEMS Microbiol. Rev. 25:285-308.
26. Miller, J. H. 1972. Experiments in molecular genetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
27. Paik, S. H., A. Chakicherla, and J. N. Hansen. 1998. Identification and characterization of the structural and transporter genes for, and the chemical and biological properties of, sublancin 168, a novel lantibiotic produced by Bacillus subtilis 168. J. Biol. Chem. 273:23134-23142.
28. Phillips, Z. E., and M. A. Strauch. 2002. Bacillus subtilis sporulation and stationary phase gene expression. Cell Mol. Life Sci. 59:392-402.
29. W regulon in Bacillus subtilis. FEMS Microbiol. Lett. 211:219-223.
30. Salzberg, L. I., and J. D. Helmann. 2007. An antibiotic-inducible cell wall-associated protein that protects Bacillus subtilis from autolysis. J. Bacteriol. 189:4671-4680.
31. Serizawa, M., K. Kodama, H. Yamamoto, K. Kobayashi, N. Ogasawara, and J. Sekiguchi. 2005. Functional analysis of the YvrGHb two-component system of Bacillus subtilis: identification of the regulated genes by DNA microarray and northern blot analyses. Biosci. Biotechnol. Biochem. 69:2155-2169.
32. Stein, T. 2005. Bacillus subtilis antibiotics: structures, syntheses and specific functions. Mol. Microbiol. 56:845-857.
33. Strauch, M. A., B. G. Bobay, J. Cavanagh, F. Yao, A. Wilson, and Y. Le Breton. 2007. Abh and AbrB control of Bacillus subtilis antimicrobial gene expression. J. Bacteriol. 189:7720-7732.
34. Zuker, M. 2003. Mfold web server for nucleic acid folding and hybridization prediction. Nucleic Acids Res. 31:3406-3415.