메뉴 건너뛰기




Volumn 45, Issue 3, 2009, Pages 189-197

The clinical efficacy of tocilizumab in rheumatoid arthritis

Author keywords

[No Author keywords available]

Indexed keywords

ATLIZUMAB; DISEASE MODIFYING ANTIRHEUMATIC DRUG; INTERLEUKIN 6; METHOTREXATE;

EID: 67749084409     PISSN: 16993993     EISSN: 16994019     Source Type: Journal    
DOI: 10.1358/dot.2009.45.3.1343794     Document Type: Review
Times cited : (13)

References (16)
  • 1
    • 36749030680 scopus 로고    scopus 로고
    • Tumor necrosis factor as a therapeutic target of rheumatologic disease
    • DOI 10.1517/14728222.11.11.1369
    • Ackermann, C., Kavanaugh, A. Tumor necrosis factor as a therapeutic target of rheumatologic disease. Expert Opin Ther Targets 2007,11(11): 1369-1384 (Pubitemid 350200476)
    • (2007) Expert Opinion on Therapeutic Targets , vol.11 , Issue.11 , pp. 1369-1384
    • Ackermann, C.1    Kavanaugh, A.2
  • 2
    • 33748092926 scopus 로고    scopus 로고
    • Interleukin-6 and rheumatic diseases
    • Lipsky, P.E. Interleukin-6 and rheumatic diseases. Arthritis Res Ther 2006, 8(Suppl. 2): S4.
    • (2006) Arthritis Res Ther , vol.8 , Issue.SUPPL. 2
    • Lipsky, P.E.1
  • 3
    • 0031787640 scopus 로고    scopus 로고
    • Therapy of rheumatoid arthritis by blocking IL-6 signal transduction with a humanized anti-IL-6 receptor antibody
    • DOI 10.1007/s002810050033
    • Yoshizaki, K., Nishimoto, N., Mihara, M., Kishimoto, T. Therapy of rheumatoid arthritis by blocking IL-6 signal transduction with humanized anti-IL-6 receptor antibody. Springer Semin Immunopathol 1998, 20(1-2): 247-259 (Pubitemid 28502460)
    • (1998) Springer Seminars in Immunopathology , vol.20 , Issue.1-2 , pp. 247-259
    • Yoshizaki, K.1    Nishimoto, N.2    Mihara, M.3    Kishimoto, T.4
  • 5
    • 0036899812 scopus 로고    scopus 로고
    • Therapeutic benefit of blocking interleukin-6 activity with an anti-interleukin-6 receptor monoclonal antibody in rheumatoid arthritis. a randomized, double-blind, placebo-controlled, dose-escalation trial
    • Choy, E.H.S., Isenberg, D.A., Garrood, T. et al. Therapeutic benefit of blocking interleukin-6 activity with an anti-interleukin-6 receptor monoclonal antibody in rheumatoid arthritis. A randomized, double-blind, placebo-controlled, dose-escalation trial. Arthritis Rheum 2002, 46(12): 3143-3150
    • (2002) Arthritis Rheum , vol.46 , Issue.12 , pp. 3143-3150
    • Choy, E.H.S.1    Isenberg, D.A.2    Garrood, T.3
  • 7
    • 39149135425 scopus 로고    scopus 로고
    • Long-term safety and efficacy of tocilizumab (an anti-IL-6 receptor monoclonal antibody) in monotherapy in patients with rheumatoid arthritis
    • Nishimoto, N., Miyasaka, N., Yamamoto, K., Kawai, S., Takeuchi, T., Azuma, J., Kishimoto, T. Long-term safety and efficacy of tocilizumab (an anti-IL-6 receptor monoclonal antibody) in monotherapy in patients with rheumatoid arthritis. Ann Rheum Dis 2007, 66(Suppl. 2): 122.
    • (2007) Ann Rheum Dis , vol.66 , Issue.SUPPL. 2 , pp. 122
    • Nishimoto, N.1    Miyasaka, N.2    Yamamoto, K.3    Kawai, S.4    Takeuchi, T.5    Azuma, J.6    Kishimoto, T.7
  • 9
    • 40749114497 scopus 로고    scopus 로고
    • Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): A double-blind, placebo-controlled, randomised trial
    • Smolen, J., Beaulieu, A., Rubbert-Roth, A. et al. Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): A double-blind, placebo-controlled, randomised trial. Lancet 2008, 371(9617): 987-997
    • (2008) Lancet , vol.371 , Issue.9617 , pp. 987-997
    • Smolen, J.1    Beaulieu, A.2    Rubbert-Roth, A.3
  • 10
    • 54949150604 scopus 로고    scopus 로고
    • IL-6 receptor inhibition with Tocilizumab reduces disease activity in patients with rheumatoid arthritis with inadequate response to disease-modifying antirheumatic drugs
    • Genovese, M., McKay, J., Nasonov, E. et al. IL-6 receptor inhibition with Tocilizumab reduces disease activity in patients with rheumatoid arthritis with inadequate response to disease-modifying antirheumatic drugs. Arthritis Rheum 2008, 58(10): 2968-2980
    • (2008) Arthritis Rheum , vol.58 , Issue.10 , pp. 2968-2980
    • Genovese, M.1    McKay, J.2    Nasonov, E.3
  • 11
    • 34447300492 scopus 로고    scopus 로고
    • Study of active controlled monotherapy used for rheumatoid arthritis, an IL-6 inhibitor (SAMURAI): Evidence of clinical and radiographic benefit from an x ray reader-blinded randomised controlled trial of tocilizumab
    • DOI 10.1136/ard.2006.068064
    • Nishimoto, N., Hashimoto, J., Miyasaka, N. et al. Study of active controlled monotherapy used for rheumatoid arthritis, and IL-6 inhibitor (SAMURAI): Evidence of clinical and radiographic benefit from an x-ray reader-blinded randomized controlled trial of tocilizumab. Ann Rheum Dis 2007, 66(9): 1162-1167 (Pubitemid 47309731)
    • (2007) Annals of the Rheumatic Diseases , vol.66 , Issue.9 , pp. 1162-1167
    • Nishimoto, N.1    Hashimoto, J.2    Miyasaka, N.3    Yamamoto, K.4    Kawai, S.5    Takeuchi, T.6    Murata, N.7    Van Heijde, D.D.8    Kishimoto, T.9
  • 12
    • 43649104094 scopus 로고    scopus 로고
    • The recombinant humanized anti-IL-6 receptor antibody tocilizumab, an innovative drug for the treatment of rheumatoid arthritis
    • Ohsugi, Y., Kishimoto, T. The recombinant humanized anti-IL-6 receptor antibody tocilizumab, an innovative drug for the treatment of rheumatoid arthritis. Expert Opin Biol Ther 2008, 8(5): 669-681
    • (2008) Expert Opin Biol Ther , vol.8 , Issue.5 , pp. 669-681
    • Ohsugi, Y.1    Kishimoto, T.2
  • 13
    • 64049115766 scopus 로고    scopus 로고
    • Tocilizumab inhibits structural joint damage in rheumatoid arthritis patients with an inadequate response to methotrexate: The LITHE study
    • Kremer, J., Fleischmann, R., Halland, A.-M. et al. Tocilizumab inhibits structural joint damage in rheumatoid arthritis patients with an inadequate response to methotrexate: the LITHE study. Arthritis Rheum 2008, 58(12): 4031.
    • (2008) Arthritis Rheum , vol.58 , Issue.12 , pp. 4031
    • Kremer, J.1    Fleischmann, R.2    Halland, A.-M.3
  • 14
    • 52149099504 scopus 로고    scopus 로고
    • IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: Results from a 24-week multicentre randomised placebo-controlled trial
    • Emery, P., Keystone, E., Tony, H.P. et al. IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: results from a 24-week multicentre randomised placebo-controlled trial Ann Rheum Dis 2008, 67(11): 1516-1523
    • (2008) Ann Rheum Dis , vol.67 , Issue.11 , pp. 1516-1523
    • Emery, P.1    Keystone, E.2    Tony, H.P.3
  • 15
    • 60149105639 scopus 로고    scopus 로고
    • Study of active controlled tocilizumab monotherapy for rheumatoid arthritis patients with an inadequate response to methotrexate (SATORI): Significant reduction in disease activity and serum vascular endothelial growth factor by IL-6 receptor inhibition therapy
    • Nishimoto, N., Miyasaka, N., Yamamoto, K., Kawai, S., Takeuchi, T., Azuma, J., Kishimoto, T. Study of active controlled tocilizumab monotherapy for rheumatoid arthritis patients with an inadequate response to methotrexate (SATORI): Significant reduction in disease activity and serum vascular endothelial growth factor by IL-6 receptor inhibition therapy. Mod Rheumatol. 2009, 19(1): 12-19
    • (2009) Mod Rheumatol , vol.19 , Issue.1 , pp. 12-19
    • Nishimoto, N.1    Miyasaka, N.2    Yamamoto, K.3    Kawai, S.4    Takeuchi, T.5    Azuma, J.6    Kishimoto, T.7
  • 16
    • 64949190561 scopus 로고    scopus 로고
    • Long-term safety and efficacy of tocilizumab, an anti-interleukin-6 receptor monoclonal antibody, in monotherapy, in patients with rheumatoid arthritis (the STREAM study): Evidence of safety and efficacy in a 5-year extension study
    • Nov 19 Epub ahead of print
    • Nishimoto, N., Miyasaka, N., Yamamoto, K., Kawai, S., Takeuchi, T., Azuma, J. Long-term safety and efficacy of tocilizumab, an anti-interleukin-6 receptor monoclonal antibody, in monotherapy, in patients with rheumatoid arthritis (the STREAM study): Evidence of safety and efficacy in a 5-year extension study. Ann Rheum Dis 2008, Nov 19 (Epub ahead of print).
    • (2008) Ann Rheum Dis
    • Nishimoto, N.1    Miyasaka, N.2    Yamamoto, K.3    Kawai, S.4    Takeuchi, T.5    Azuma, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.