Safety and tolerability of 3-week and 6-month dosing of Deramaxx ® (Deracoxib) chewable tablets in dogs

Journal of Veterinary Pharmacology and Therapeutics

Volumn 32, Issue 4, 2009, Pages 329-337

  Roberts, E S ^a   Van Lare, K A ^a   Marable, B R ^a   Salminen, W F ^a  

^a Novaitis Animal Health US Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CORTICOSTEROID; CREATININE; DERACOXIB; GAMMA GLUTAMYLTRANSFERASE; PLACEBO; PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CHEEK MUCOSA; CONTROLLED STUDY; DOG; DOSE TIME EFFECT RELATION; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; HISTOPATHOLOGY; INFLAMMATION; KIDNEY NECROSIS; MALE; NONHUMAN; OSTEOARTHRITIS; PAIN; PRIORITY JOURNAL; RELATIVE DENSITY; UREA NITROGEN BLOOD LEVEL; WEIGHT CHANGE;

ANALYSIS OF VARIANCE; ANIMALS; BLOOD UREA NITROGEN; CYCLOOXYGENASE 2 INHIBITORS; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; EUTHANASIA, ANIMAL; FEMALE; KIDNEY TUBULES; LIVER FUNCTION TESTS; MALE; PLACEBOS; SULFONAMIDES; TABLETS;

ANIMALIA; CANIS FAMILIARIS;

EID: 67651253092     PISSN: 01407783     EISSN: 13652885     Source Type: Journal    
DOI: 10.1111/j.1365-2885.2008.01043.x     Document Type: Article

References (28)

1. Adams, R.H. (2001) Autocoids and anti-inflammatory drugs. In Veterinary Pharmacology and Therapeutics, 8th edn. Eds Adams, R., pp. 403 412. Iowa State University Press, Ames, IA.
2. Bergh, M.S. Budsberg, S.C. (2005) The coxib NSAIDS: Potential clinical and pharmacologic importance in veterinary medicine. Journal of Veterinary Internal Medicine, 19, 633 643.
3. Bertolini, A., Ottani, A. Sandrini, M. (2001) Dual acting anti-inflammatory drugs: a reappraisal. Pharmacological Research, 44, 437 450.
4. Bertolini, A., Ottani, A. Sandrini, M. (2002) Selective COX-2 inhibitors and dual acting anti-inflammatory drugs: critical remarks. Current Medicinal Chemistry, 9, 1033 1043.
5. Blikslager, A.T., Roberts, M.C. Argenzio, R.A. (1999) Prostaglandin-induced recovery of barrier function in porcine ileum is triggered by chloride secretion. American Journal of Physiology, 276, G28 G36.
6. Botting, R.M. (2006) Inhibitors of cyclooxygenases: mechanisms, selectivity and uses. Journal of Physiology and Pharmacology, 57 (Suppl. 5 113 124.
7. Burke, A., Smyth, E. FitzGerald, G.A. (2006) Analgesic-antipyretic agents; Pharmacotherapy of Gout. In Goodman & Gilman's The Pharmacological Basis of Therapeutics, 11th edn. Eds Brunton, L.L., Lazo, J.S. Parker, K.L., pp. 671 715. McGraw-Hill Medical Publishing Division, New York, NY.
8. Cheng, H.F. Harris, R.C. (2005) Renal effects of non-steroidal anti-inflammatory drugs and selective cyclo-oxygenase-2 inhibitors. Current Pharmaceutical Design, 11, 1795 1804.
9. Collins, L.G. Tyler, D.E. (1985) Experimentally induced phenylbutazone toxicosis in ponies: Description of the syndrome and its prevention with synthetic prostaglandin E2. American Journal of Veterinary Research, 46, 1605 1615.
10. Coruzzi, G., Venturi, N. Spaggiari, S. (2007) Gastrointestinal safety of novel nonsteroidal anti-inflammatory drugs: selective COX-2 inhibitors and beyond. Acta Bio-medica, 78, 96 110.
11. Curry, S.L., Cogar, S.M. Cook, J.L. (2005) Nonsteroidal anti-inflammatory drugs: a review. Journal of the American Animal Hospital Association, 41, 298 309.
12. Hampshire, V.A., Doddy, F.M., Post, L.O., Koogler, T.L., Burgess, T.M., Batten, P.O., Hudson, R., McAdams, D.R. Brown, M.A. (2004) Adverse drug event reports at the United States Food and Drug Administration Center for Veterinary Medicine. Journal of the American Veterinary Medical Association, 225, 533 536.
13. Hinz, B. Brune, K. (2004) Pain and osteoarthritis: new drugs and mechanisms. Current Opinion in Rheumatology, 16, 628 633.
14. Jones, R.D., Baynes, R.E. Nimitz, C.T. (1992) Nonsteroidal anti-inflammatory drug toxicosis in dogs and cats: 240 cases (1989-1990). Journal of the American Veterinary Medical Association, 217, 721 729.
15. Lascelles, B.D.X., Court, M.H., Hardie, E.M. Robertson, S.A. (2007) Nonsteroidal anti-inflammatory drugs in cats: a review. Veterinary Anaesthesia and Analgesia, 34, 228 250.
16. Lathers, C.M. (2003) Challenges and opportunities in animal drug development: a regulatory perspective. Nature Reviews. Drug Discovery, 2, 915 918.
17. Marnett, L.J., Rowlinson, S.W., Goodwin, D.C., Kalgutkar, A.S. Lanzo, C.A. (1999) Arachidonic acid oxygenation by COX-1 and COX-2. Mechanisms of catalysis and inhibition. Journal of Biological Chemistry, 274, 22903 22906.
18. McCormack, K. (1994) Non-steroidal anti-inflammatory drugs and spinal nociceptive processing. Pain, 59, 9 43.
19. McMann, M.E., Andersen, D.R., Zhang, D., Brideau, C., Black, W.C., Hanson, P.D. Hickey, G.J. (2004) In vitro effects and in vivo efficacy of a novel cyclooxygenase-2 inhibitor in dogs with experimentally induced synovitis. American Journal of Veterinary Research, 65, 503 512.
20. National Research Council 1996) Guide for the Care and use of Laboratory Animals. National Academy Press, Washington, DC.
21. Renberg, W.C. (2005) Pathophysiology and management of arthritis. Veterinary Clinics of North America. Small Animal Practice, 35, 1073 1091.
22. Sellers, R.S., Senese, P.B. Khan, K.N. (2004) Interspecies differences in the nephrotoxic response to cyclooxygenase inhibition. Drug and Chemical Toxicology, 27, 111 122.
23. Silverman, L.R. Khan, K.N.M. (1999) "Have you seen this?" Nonsteriodal anti-inflammatory drug-induced renal papillary Necrosis in a dog. Toxicologic Pathology, 27, 244 245.
24. Smith, W.L. Langenbach, R. (2001) Why there are two cyclo-oxygenase isozymes. Journal of Clinical Investigation, 107, 1491 1495.
25. Smith, W.L., Garavito, R.M. DeWitt, D.L. (1996) Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2. Journal of Biological Chemistry, 271, 33157 33160.
26. Tsuchiya, T., Yabe, K., Takada, S., Ishii, Y., Jindo, T., Furuhama, K. Suzuki, K.T. (2005) Early pathophysiological features in canine renal papillary necrosis induced by nefiracetam. Toxicologic Pathology, 33, 561 569.
27. Vane, J.R., Bakhle, Y.S. Botting, R.M. (1998) Cyclooxygenases 1 and 2. Annual Review of Pharmacology and Toxicology, 38, 97 120.
28. Wooten, J.G., Blikslager, A.T., Ryan, K.A., Marks, S.L., MacLaw, J. Lascelles, D.X. (2008) Cyclooxygenase expression and prostanoids production in pyloric and duodenal mucosae in dogs after administration of nonsteroidal anti-inflammatory drugs. American Journal of Veterinary Research, 69, 457 464.