Cardiopulmonary bypass induced microcirculatory injury of the small bowel in rats

World Journal of Gastroenterology

Volumn 15, Issue 25, 2009, Pages 3166-3172

  Dong, Guo Hua ^a   Wang, Chang Tian ^a   Li, Yun ^a   Xu, Biao ^a   Qian, Jian Jun ^a   Wu, Hai Wei ^a   Jing, Hua ^a  

^a MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

Author keywords

Cardiopulmonary bypass; Functional capillary density; Intestinal microcirculation; Intravital microscopy

Indexed keywords

ALBUMIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY CONSTRICTION; ARTICLE; BLOOD FLOW; BLOOD FLOW VELOCITY; BLOOD VESSEL PERMEABILITY; CAPILLARY DENSITY; CARDIOPULMONARY BYPASS; CONTROLLED STUDY; EXTRAVASATION; INFLAMMATION; INTESTINE INJURY; INTESTINE PERFUSION; LEUKOCYTE ADHERENCE; MALE; MICROANGIOPATHY; NONHUMAN; RAT;

EID: 67651250076     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.15.3166     Document Type: Article

References (26)

1. Kumle B, Boldt J, Suttner SW, Piper SN, Lehmann A, Blome M. Influence of prolonged cardiopulmonary bypass times on splanchnic perfusion and markers of splanchnic organ function. Ann Thorac Surg 2003; 75: 1558-1564
2. Tsunooka N, Hamada Y, Imagawa H, Nakamura Y, Shiozaki T, Suzuki H, Kikkawa H, Miyauchi K, Watanabe Y, Kawachi K. Ischemia of the intestinal mucosa during cardiopulmonary bypass. J Artif Organs 2003; 6: 149-151
3. Velissaris T, Tang A, Murray M, El-Minshawy A, Hett D, Ohri S. A prospective randomized study to evaluate splanchnic hypoxia during beating-heart and conventional coronary revascularization. Eur J Cardiothorac Surg 2003; 23: 917-924; discussion 924
4. Tsunooka N, Maeyama K, Hamada Y, Imagawa H, Takano S, Watanabe Y, Kawachi K. Bacterial translocation secondary to small intestinal mucosal ischemia during cardiopulmonary bypass. Measurement by diamine oxidase and peptidoglycan. Eur J Cardiothorac Surg 2004; 25: 275-280
5. Ohri SK, Velissaris T. Gastrointestinal dysfunction following cardiac surgery. Perfusion 2006; 21: 215-223
6. Rossi M, Sganga G, Mazzone M, Valenza V, Guarneri S, Portale G, Carbone L, Gatta L, Pioli C, Sanguinetti M, Montalto M, Glieca F, Fadda G, Schiavello R, Silveri NG. Cardiopulmonary bypass in man: role of the intestine in a self-limiting inflammatory response with demonstrable bacterial translocation. Ann Thorac Surg 2004; 77: 612-618
7. Fitzgerald T, Kim D, Karakozis S, Alam H, Provido H, Kirkpatrick J. Visceral ischemia after cardiopulmonary bypass. Am Surg 2000; 66: 623-626
8. Cox CS Jr, Allen SJ, Brennan M. Analysis of intestinal microvascular permeability associated with cardiopulmonary bypass. J Surg Res 1999; 83: 19-26
9. Booker PD, Pozzi M. A placebo-controlled study of the effects of dopexamine on gastric mucosal perfusion in infants undergoing hypothermic cardiopulmonary bypass. Br J Anaesth 2000; 84: 23-27
10. Haisjackl M, Germann R, Hasibeder W, Schwarz B, Salak N, Pajk W, Bonatti J, Nussbaumer W, Klima G, Kox W, Mutz N. Mucosal tissue oxygenation of the porcine jejunum during normothermic cardiopulmonary bypass. Br J Anaesth 1999; 82: 738-745
11. Dong GH, Xu B, Wang CT, Qian JJ, Liu H, Huang G, Jing H. A rat model of cardiopulmonary bypass with excellent survival. J Surg Res 2005; 123: 171-175
12. Kalia N, Pockley AG, Wood RF, Brown NJ. Effects of hypothermia and rewarming on the mucosal villus microcirculation and survival after rat intestinal ischemia-reperfusion injury. Ann Surg 2002; 236: 67-74
13. Massberg S, Gonzalez AP, Leiderer R, Menger MD, Messmer K. In vivo assessment of the influence of cold preservation time on microvascular reperfusion injury after experimental small bowel transplantation. Br J Surg 1998; 85: 127-133
14. Levy JH, Tanaka KA. Inflammatory response to cardiopulmonary bypass. Ann Thorac Surg 2003; 75: S715-S720
15. Byhahn C, Strouhal U, Martens S, Mierdl S, Kessler P, Westphal K. Incidence of gastrointestinal complications in cardiopulmonary bypass patients. World J Surg 2001; 25: 1140-1144
16. Baue AE. Sepsis, systemic inflammatory response syndrome, multiple organ dysfunction syndrome, and multiple organ failure: are trauma surgeons lumpers or splitters? J Trauma 2003; 55: 997-998
17. Pimenta MB, Aguilar-Nascimento JE, Martins DC, Silva DR, Bacelo KL, Bocchese IC, Zaffani S, Zaffani E, Silveira EA, Carmo AV, Ferreira SS. The intestinal tract as the major source of interleukin 6 production during abdominal aortic clamping and hind limb ischaemia-reperfusion injury. Acta Cir Bras 2007; 22 Suppl 1: 34-39
18. Geissler HJ, Fischer UM, Grunert S, Kuhn-Régnier F, Hoelscher A, Schwinger RH, Mehlhorn U, Hekmat K. Incidence and outcome of gastrointestinal complications after cardiopulmonary bypass. Interact Cardiovasc Thorac Surg 2006; 5: 239-242
19. Filsoufi F, Rahmanian PB, Castillo JG, Scurlock C, Legnani PE, Adams DH. Predictors and outcome of gastrointestinal complications in patients undergoing cardiac surgery. Ann Surg 2007; 246: 323-329
20. Bastien O, Piriou V, Aouifi A, Flamens C, Evans R, Lehot JJ. Relative importance of flow versus pressure in splanchnic perfusion during cardiopulmonary bypass in rabbits. Anesthesiology 2000; 92: 457-464
21. Bastien O, Piriou V, Aouifi A, Evans R, Lehot JJ. Effects of dopexamine on blood flow in multiple splanchnic sites measured by laser Doppler velocimetry in rabbits undergoing cardiopulmonary bypass. Br J Anaesth 1999; 82: 104-109
22. Anthoni C, Rijcken EJ, Laukoetter MG, Spiegel HU, Senninger N, Schurmann G, Krieglstein CF. Submucosal collecting venules: a reliable site for intestinal intravital microscopy in rats. J Invest Surg 2002; 15: 259-267
23. Kurose I, Anderson DC, Miyasaka M, Tamatani T, Paulson JC, Todd RF, Rusche JR, Granger DN. Molecular determinants of reperfusion-induced leukocyte adhesion and vascular protein leakage. Circ Res 1994; 74: 336-343
24. Modine T, Azzaoui R, Fayad G, Lacroix D, Bordet R, Warembourg H, Gourlay T. A recovery model of minimally invasive cardiopulmonary bypass in the rat. Perfusion 2006; 21: 87-92
25. Ohri SK. Systemic inflammatory response and the splanchnic bed in cardiopulmonary bypass. Perfusion 1996; 11: 200-212
26. Tao W, Zwischenberger JB, Nguyen TT, Vertrees RA, McDaniel LB, Nutt LK, Herndon DN, Kramer GC. Gut mucosal ischemia during normothermic cardiopulmonary bypass results from blood flow redistribution and increased oxygen demand. J Thorac Cardiovasc Surg 1995; 110: 819-828