High cardiovascular event rates in patients with asymptomatic carotid stenosis: The REACH registry

European Journal of Neurology

Volumn 16, Issue 8, 2009, Pages 902-908

  Aichner, F T ^a   Topakian, R ^a   Alberts, M J ^b   Bhatt, D L ^c   Haring, H P ^a   Hill, M D ^d   Montalescot, G ^e   Goto, S ^f   Touze E ^g   Mas, J L ^g   Steg, P G ^h   Rother J ⁱ  

^a KEPLER UNIVERSITY HOSPITAL   (Austria)

^b NORTHWESTERN UNIVERSITY   (United States)

^c LERNER RESEARCH INSTITUTE   (United States)

^d FOOTHILLS HOSPITAL   (Canada)

^e SORBONNE UNIVERSITÉ   (France)

^f TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^g CENTRE HOSPITALIER SAINTE ANNE   (France)

^h UNIVERSITÉ PARIS DESCARTES   (France)

ⁱ HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Carotid artery stenosis; Outcome assessment; Prevention; Stroke; Therapy

Indexed keywords

CHOLESTEROL; GLUCOSE;

ADULT; AGED; ARTICLE; BLEEDING; BRAIN ISCHEMIA; CARDIOVASCULAR DISEASE; CAROTID ARTERY OBSTRUCTION; DISEASE ASSOCIATION; FEMALE; FOLLOW UP; HUMAN; INTERNATIONAL COOPERATION; MAJOR CLINICAL STUDY; MALE; MORTALITY; OUTCOMES RESEARCH; OUTPATIENT; PRIORITY JOURNAL; RISK FACTOR; STROKE; SYMPTOMATOLOGY; THROMBOSIS; TRANSIENT ISCHEMIC ATTACK;

AGED; BRAIN ISCHEMIA; CARDIOVASCULAR DISEASES; CAROTID STENOSIS; CEREBROVASCULAR DISORDERS; FEMALE; HUMANS; MALE; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; REGISTRIES; RISK FACTORS; STROKE;

EID: 67651241761     PISSN: 13515101     EISSN: 14681331     Source Type: Journal    
DOI: 10.1111/j.1468-1331.2009.02614.x     Document Type: Article

References (23)

1. Fine-Edelstein JS, Wolf PA, O'Leary DH, et al. Precursors of extracranial carotid atherosclerosis in the Framingham Study. Neurology 1994 44 : 1046 1050.
2. Bogousslavsky J, Despland PA, Regli F. Asymptomatic tight stenosis of the internal carotid artery: long-term prognosis. Neurology 1986 36 : 861 863.
3. Chambers BR, Norris JW. Outcome in patients with asymptomatic neck bruits. N Engl J Med 1986 315 : 860 865.
4. Autret A, Pourcelot L, Saudeau D, Marchal C, Bertrand P, de Boisvilliers S. Stroke risk in patients with carotid stenosis. Lancet 1987 1 : 888 890.
5. Hennerici M, Hülsbömer HB, Hefter H, Lammerts D, Rautenberg W. Natural history of asymptomatic extracranial arterial disease: Results of a long-term prospective study. Brain 1987 110 : 777 791.
6. Meissner I, Wiebers DO, Whisnant JP, O'Fallon WM. The natural history of asymptomatic carotid artery occlusive lesions. JAMA 1987 258 : 2704 2707.
7. Mackey AE, Abrahamowicz M, Langlois Y, et al. Outcome of asymptomatic patients with carotid disease. Neurology 1997 48 : 896 903.
8. Nadareishvili ZG, Rothwell PM, Beletsky V, Pagniello A, Norris JW. Long-term risk of stroke and other vascular events in patients with asymptomatic carotid artery stenosis. Arch Neurol 2002 59 : 1162 1166.
9. Hobson RW II., Weiss DG, Fields WS, et al. Efficacy of carotid endarterectomy for asymptomatic carotid stenosis. The Veterans Affairs Cooperative Study Group. N Engl J Med 1993 328 : 221 227.
10. Executive Committee for the Asymptomatic Carotid Atherosclerosis Study. Endarterectomy for asymptomatic carotid artery stenosis. JAMA 1995 273 : 1421 1428.
11. Halliday A, Mansfield A, Marro J, et al. Prevention of disabling and fatal strokes by successful carotid endarterectomy in patients without recent neurological symptoms: randomized controlled trial. Lancet 2004 363 : 1491 1502.
12. Rothwell PM. External validity of randomised controlled trials: "to whom do the results of this trial apply?". Lancet 2005 365 : 82 93.
13. Steg PG, López-Sendón J, Lopez de Sa E, et al. External validity of clinical trials in acute myocardial infarction. Arch Intern Med 2007 167 : 68 73.
14. Ohman EM, Bhatt DL, Steg PG, et al. The REduction of Atherothrombosis for Continued Health (REACH) Registry: An international, prospective, observational investigation in subjects at risk for atherothrombotic events-study design. Am Heart J 2006 151 : 786.
15. Bhatt DL, Steg PG, Ohman EM, et al. International prevalence, recognition, and treatment of cardiovascular risk factors in outpatients with atherothrombosis. JAMA 2006 295 : 180 189.
16. Goessens BM, Visseren FL, Kappelle LJ, Algra A, van der Graaf Y. Asymptomatic carotid artery stenosis and the risk of new vascular events in patients with manifest arterial disease: the SMART study. Stroke 2007 38 : 1470 1475.
17. Norris JW, Zhu CZ, Bornstein NM, Chambers BR. Vascular risks of asymptomatic carotid stenosis. Stroke 1991 22 : 1485 1490.
18. Bock RW, Gray-Weale AC, Mock PA, et al. The natural history of asymptomatic carotid artery disease. J Vasc Surg 1993 17 : 160 171.
19. Sabeti S, Schlager O, Exner M, et al. Progression of carotid stenosis detected by duplex ultrasonography predicts adverse outcomes in cardiovascular high-risk patients. Stroke 2007 38 : 2887 2894.
20. European Stroke Organisation (ESO) Executive Committee; ESO Writing Committee. Guidelines for management of ischaemic stroke and transient ischaemic attack 2008. Cerebrovasc Dis 2008 25 : 457 507.
21. Inzitari D, Eliasziw M, Gates P, et al. The causes and risk of stroke in patients with asymptomatic internal-carotid-artery stenosis. N Engl J Med 2000 342 : 1693 1700. (Pubitemid 30354516)
22. Steg PG, Bhatt DL, Wilson PWF, et al. One-year cardiovascular event rates in outpatients with atherothrombosis. JAMA 2007 297 : 1197 1206.
23. The European Carotid Surgery Trialists Collaborative Group. Risk of stroke in the distribution of an asymptomatic carotid artery. Lancet 1995 345 : 209 212.