Pentoxifylline: A first line treatment option for severe alcoholic hepatitis and hepatorenal syndrome?

World Journal of Gastroenterology

Volumn 15, Issue 25, 2009, Pages 3194-3195

  Assimakopoulos, Stelios F ^a   Thomopoulos, Konstantinos C ^a   Labropoulou Karatza, Chrisoula ^a  

^a UNIVERSITY HOSPITAL OF PATRAS   (Greece)

Author keywords

Alcoholic hepatitis; Hepatorenal syndrome; Mortality; Pentoxifylline

Indexed keywords

CORTICOSTEROID; PENTOXIFYLLINE; PLACEBO; PREDNISOLONE; TUMOR NECROSIS FACTOR ALPHA;

ALCOHOL LIVER DISEASE; DISEASE SEVERITY; DRUG EFFICACY; HEPATORENAL SYNDROME; HUMAN; LETTER; PROTEIN SYNTHESIS INHIBITION; RISK BENEFIT ANALYSIS; SURVIVAL;

EID: 67651240364     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.15.3194     Document Type: Letter

References (7)

1. De BK, Gangopadhyay S, Dutta D, Baksi SD, Pani A, Ghosh P. Pentoxifylline versus prednisolone for severe alcoholic hepatitis: a randomized controlled trial. World J Gastroenterol 2009; 15: 1613-1619
2. McCullough AJ, O'Connor JF. Alcoholic liver disease: proposed recommendations for the American College of Gastroenterology. Am J Gastroenterol 1998; 93: 2022-2036
3. Rongey C, Kaplowitz N. Current concepts and controversies in the treatment of alcoholic hepatitis. World J Gastroenterol 2006; 12: 6909-6921
4. Louvet A, Diaz E, Dharancy S, Coevoet H, Texier F, Thévenot T, Deltenre P, Canva V, Plane C, Mathurin P. Early switch to pentoxifylline in patients with severe alcoholic hepatitis is inefficient in non-responders to corticosteroids. J Hepatol 2008; 48: 465-470
5. McHutchison JG, Runyon BA, Draguesku JO, Cominelli F,. Person JL, Castracane J. Pentoxifylline may prevent renal impairment (hepatorenal syndrome) in severe acute alcoholic hepatitis. Hepatology 1991; 14: 96A
6. Akriviadis E, Botla R, Briggs W, Han S, Reynolds T, Shakil O. Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis: a double-blind, placebo-controlled trial. Gastroenterology 2000; 119: 1637-1648
7. McClain CJ, Barve S, Deaciuc I, Kugelmas M, Hill D. Cytokines in alcoholic liver disease. Semin Liver Dis 1999; 19: 205-219