Comparison of two doses of the gnrh antagonist, acyline, for pregnancy termination in bitches

Reproduction in Domestic Animals

Volumn 44, Issue SUPPL. 2, 2009, Pages 156-159

  Valiente, C ^a   Corrada, Y ^a   De La Sota, P E ^a   Blanco, P G ^a   Arias, D ^a   Gobello, C ^a  

^a UNIVERSIDAD NACIONAL DE LA PLATA   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

ABORTIVE AGENT; ACYLINE; OLIGOPEPTIDE;

ANIMAL; ANIMAL DISEASE; BREEDING; CHEMICALLY INDUCED DISORDER; CLINICAL TRIAL; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOG; DOSE RESPONSE; DRUG EFFECT; FEMALE; INDUCED ABORTION; MALE; PREGNANCY; RANDOMIZED CONTROLLED TRIAL; VETERINARY ABORTION;

ABORTIFACIENT AGENTS; ABORTION, INDUCED; ABORTION, VETERINARY; ANIMALS; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; MALE; OLIGOPEPTIDES; PREGNANCY; PREGNANCY, ANIMAL;

ANIMALIA; CANIDAE; CANIS FAMILIARIS;

EID: 67651227459     PISSN: 09366768     EISSN: 14390531     Source Type: Journal    
DOI: 10.1111/j.1439-0531.2009.01397.x     Document Type: Conference Paper

References (21)

1. Bagatell CJ, Conn PM, Bremmer WJ, 1993: Single dose administrations of the gonadotropin releasing hormone antagonists, Nal-Lys (antide) to healthy men. Fertil Steril 60, 680 685.
2. Concannon PW, 2000: Canine pregnancy: predicting parturition and timing events of gestation. In: Concannon PW, England G, Verstegen J (eds Recent Advances in Small Animal Reproduction. International Veterinary Information Service (http://www.ivis.org) A1223.0802, Ithaca.
3. Corrada Y, Hermo G, Arias D, Tortora M, Esquivel C, Gobello C, 2005: Use of the GnRH antagonist, acyline, on pregnancy termination in the bitch. In: Proceedings CD 30th World Small Animal Veterinary Association Congress (WSAVA). Mexico (abstract).
4. England GCW, Russo M, 2006: Ultrasonographic characteristics of early pregnancy failure in bitches. Theriogenology 66, 1694 1698.
5. Fernandes PA, Bowen R, Kostas AC, Sawyer HR, Nett T, 1987: Luteal function in the bitch: Changes during diestrus in pituitary concentrations of and number of luteal receptors for luteinizing hormones and prolactin. Biol Reprod 37, 804 811.
6. Gobello C, 2007: New GnRH analogs in canine reproduction: a review. Anim Reprod Sci 100, 1 13.
7. Gobello C, Hermo G, Rodriguez R, Tortora M, Corrada Y, 2005: Use of the GnRH antagonist, acyline, on estrous cycle interruption in the bitch: a preliminary report. Theriogenology 64, 809 (abstract).
8. Heber D, Dobson R, Swerdloff RS, Channabasavaiah K, Stewart JM, 1982: Pituitary receptor site blockade by a gonadotropin-releasing antagonist in vivo: mechanism of action. Science 216, 420 421.
9. Herbst KL, 2003: Gonadotropin-releasing hormone antagonists. Curr Opin Pharmacol 3, 1 7.
10. Herbst KL, Anawalt BD, Amory JK, Bremner WJ, 2002: Acyline: the first study in humans of a potent, new gonadotropin-releasing hormone antagonist. J Clin Endocrinol Metab 87, 3215 3220.
11. Herbst KL, Coviello AD, Page S, Amory JK, Anawalt BD, Bremner WJ, 2004: A single dose of the potent gonadotropin-releasing hormone antagonist acyline suppresses gonadotropins and testosterone for 2 weeks in healthy young men. J Clin Endocrinol Metab 89, 5959 5965.
12. Hull ME, Kenigsberg DJ, 1987: Gonadotropin releasing hormone: function and clinical use. Lab Manag 25, 51 58.
13. Karten MJ, Rivier JE, 1986: Gonadotropin releasing hormone analog design. Structure function studies toward the development of agonists and antagonists, rationale and perspective. Endocr Rev 44 66.
14. Mattoon JS, Nyland TG, 1995: Ultrasonography of the genital system. In: Nyland JS, Mattoon TG (eds Veterinary Diagnostic Ultrasound. WB Saunders, Philadelphia, pp. 141 164.
15. ®, 1989: User's Guide, Version 6, 4th edn. SAS Institute Inc., Cary, p. 189.
16. Tarlatzis BC, Bili H, 2004: Safety of GnRH agonists and antagonists. Expert Opin Drug Saf 3, 39 46.
17. Valiente C, Corrada Y, de la Sota PE, Galassi Gerez P, Gobello C, 2007: Effect of the GnRH antagonist, acyline, on canine testicular characteristics. Theriogenology 68, 687 692.
18. Vickery BH, 1985: Comparisons of the potential utility of LHRH agonists and antagonists for fertility control. J Steroid Biochem 23, 779 791.
19. Vickery BH, Bergstrom K, Hiller M, Goodpasture JC 1987: Effect of detirelix, a long acting LHRH antagonist on luteal function and pregnancy in beagle bitches. Biol Reprod 1, 45 (abstract).
20. Vickery BH, Mc Rae GI, Goodpasture JC, Sanders LM, 1989: Use of potent LHRH analogues for chronic contraception and pregnancy termination. J Reprod Fertil 39, 175 187.
21. Wanke MM, Romagnoli S, Verstegen J, Concannon PW, 2002: Pharmacological approaches to pregnancy termination in dogs and cats including the use of prostaglandins, dopamine agonists, and dexamethasone. In: Concannon PW, England G, Verstegen J (eds Recent Advances in Small Animal Reproduction. International Veterinary Information Service (http://www.ivis.org), A1223.0802, Ithaca.