Alkylphosphocholines: A new approach to inhibit cell proliferation in proliferative vitreoretinopathy

Developments in Ophthalmology

Volumn 44, Issue , 2009, Pages 46-55

  Eibl, Kirsten H ^a   Fisher, Steven K ^b   Lewis, Geoffrey P ^b  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG DERIVATIVE; PHOSPHORYLCHOLINE;

ANIMAL; ARTICLE; CELL PROLIFERATION; DRUG EFFECT; HUMAN; INJECTION; METABOLISM; PATHOLOGY; RETINA; TREATMENT OUTCOME; VITREORETINOPATHY; VITREOUS BODY;

ANIMALS; CELL PROLIFERATION; HUMANS; INJECTIONS; PHOSPHORYLCHOLINE; RETINA; TREATMENT OUTCOME; VITREORETINOPATHY, PROLIFERATIVE; VITREOUS BODY;

EID: 67651222313     PISSN: 02503751     EISSN: 16622790     Source Type: Book Series    
DOI: 10.1159/000223945     Document Type: Article

References (41)

1. Cook B, Lewis G P, Fisher SK, Adler R: Apoptotic photoreceptor degeneration in experimental retinal detachment. Invest Ophthalmol Vis Sci 1995;36:990- 996.
2. Lewis G P, Linberg KA, Fisher SK: Neurite outgrowth from bipolar and horizontal cells following experimental retnal detachment. Invest Ophthalmol Vis Sci 1998;39:424-434.
3. Coblentz FE, Radeke MJ, Lewis G P, Fisher SK: Evidence that ganglion cells react to retinal detachment. Exp Eye Res 2003;76:333-342.
4. Fisher SK, Lewis GP: Müller cell and neuronal remodelling in retinal detachment and reattachment and their potential consequences for visual recovery: a review and reconsideration of recent data. Vis Res 2003;43:887-897.
5. Francke M, Faude F, Pannicke T, Uckermann O, Weick M, Wolburg H, Wiedemann P, Reichenbach A, Uhlmann S, Bringmann A: Glial cell-mediated spread of retinal degeneration during detachment: a hypothesis based upon studies in rabbits. Vision Res 2005;45:2256-2267.
6. Fisher SK, Erickson PA, Lewis G P, Anderson DH: Intraretinal proliferation induced by retinal detachment. Invest Ophthalmol Vis Sci 1991;32:1739- 1748.
7. Geller SF, Lewis GP, Anderson DH, Fisher SK: Use of the MIB-1 antibody for detecting proliferating cells in the retina. Invest Ophthalmol Vis Sci 1995;36:737-744.
8. Reichenbach A, Wurm A, Pannicke T, Iandiev I, Wiedemann P, Bringmann A: Müller cells as players in retinal degeneration and edema. Graefes Arch Clin Exp Ophthalmol 2007;245:627-636.
9. Sethi CS, Lewis GP, Fisher SK, Leitner W P, Mann DL, Luthert PJ, Charteris DG. Glial remodeling and neuronal plasticity in human retinal detachment with proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci 2005;46:329-342.
10. Harada C, Harada T, Mitamura Y, Quah HM, Ohtsuka K, Kotake S, Ohno S, Wada K, Takeuchi S, Tanaka K: Diverse NF-kappaB expression in epiretinal membranes after human diabetic retinopathy and proliferative vitreoretinopathy. Mol Vis 2004;10: 31-36.
11. Haritoglou C, Schumann RG, Kampik A, Gandorfer A: Glial cell proliferation under the internal limiting membrane in a patient with cellophane maculopathy. Arch Ophthalmol 2007;125:1301-1302.
12. Kampik A, Green WR, Michels RG, Nase PK: Ultrastructural features of progressive idiopathic epiretinal membrane removed by vitreous surgery. Am J Ophthalmol 1980;90:979-809.
13. Kampik A, Kenyon KR, Michels RG, Green WR, de la Cruz ZC: Epiretinal and vitreous membranes: comparative study of 56 cases. Arch Ophthalmol 1981;99:1445-1454.
14. Faude F, Francke M, Makarov F, Schuck J, Gärtner U, Reichelt W, Wiedemann P, Wolburg H, Reichenbach A: Experimental retinal detachment causes widespread and mutlilayered degeneration in the rabbit retina. J Neurocytol 2001;30:379-390.
15. Fisher SK, Lewis GP, Linberg KA, Verardo MR: Cellular remodeling in mammalial retina: results from studies of experimental retinal detachment. Prog Retin Eye Res 2005;24:395-431.
16. Anderson DH, Guerin CJ, Erickson PA, Stern WH, Fisher SK: Morphological recovery in the reattached retina. Invest Ophthalmol Vis Sci 1986;27:168-183.
17. Charteris DG, Downie J, Aylward G W, Sethi C, Luthert P: Intraretinal and periretinal pathology in anterior proliferative vitreoretinopathy. Graefes Arch Clin Exp Ophthalmol 2007;245:93-100.
18. Lewis GP, Sethi CS, Linberg KA, Charteris DG, Fisher SK: Experimental retinal reattachment: a new perspective. Mol Neurobiol 2003;28:159-175.
19. Jaynes CD, Sheedlo HJ, Agarwal N, O'Rourke K, Turner JE: Müller and retinal pigment epithelial cells (RPE) cell expression of NGFI-A and c-fos mRNA in response to medium conditioned by the RPE. Brain Res Mol Brain Res 1995;32:329-337.
20. Hollborn M, Tenckhoff S, Jahn K, Iandiev I, Biedermann B, Schnurrbusch UE, Limb GA, Reichenbach A, Wolf S, Wiedemann P, Kohen L, Bringmann A: Changes in retinal gene expression in proliferative vitreoretinopathy: glial cell expression of HB-EGF. Mol Vis 2005;11:397-413.
21. Lewis G P, Erickson PA, Guerin CJ, Anderson DH, Fisher SK. Basic fibroblast growth factor: a potential regulator of proliferation and intermediate filament expression in the retina. J Neurosci 1992;12:3968- 3978.
22. Shen WG, Peng WX, Shao Y, Xu JF, Dai G, Zhang Y, Pan F Y, Li CJ: Localization and activity of calmodulin is involved in cell-cell adhesion of tumor cells and endothelial cells in response to hypoxic stress. Cell Biol Toxicol 2007;23:323-335.
23. Lewis G P, Mervin K, Valter K, Maslim J, Kappel PJ, Stone J, Fisher S: Limiting the proliferation and reactivity of retinal Müller cells during experimental retinal detachment: the value of oxygen supplementation. Am J Ophthalmol 1999;128:165-172.
24. Kirchhof B: Strategies to influence PVR development. Graefes Arch Clin Exp Ophthalmol 2004;242: 699-703.
25. Cai J, Wei R, Ma X, Zhu H, Li Y: Cytotoxic effects of antiproliferative agents on human retinal glial cells in vitro. Int Ophthalmol 2001:24:225-231
26. Charteris DG, Aylward G W, Wong D, Groenewald C, Asaria RH, Bunce C, PVR Study Group: A randomised controlled trial of combined 5-fluouracil and low-molecular weight heparin in management of established proliferative vitreoretinopathy. Ophthalmology 2004;111:2240-2245.
27. Wickham L, Bunce C, Wong D, McGurn D, Charteris DG: Randomized controlled trial of combined 5-fluouracil and low-molecular weight heparin in the management of unselected rhegmatogenous retinal detachments undergoing primary vitrectomy. Ophthalmology 2007;114:698-704.
28. Sundar S, Jha TK, Thakur CP, Engel J, Sindermann H, Fischer C, Junge K, Bryceson A, Berman J: Oral miltefosine for Indian visceral leishmaniasis. N Engl J Med 2002;347:1739-1746.
29. Leonard R, Hardy J, van Tienhoven G, Houston S, Simmonds P, David M and Mansi J. Randomized, double-blind, placebo-controlled, multicenter trial of 6% miltefosine solution, a topical chemotherapy in cutaneous metastases from breast cancer. J Clin Oncol. 2001;21:4150-4159.
30. Eibl KH, Lewis G P, Betts K, Linberg KA, Gandorfer A, Kampik A, Fisher SK: The effect of alkylphosphocholines on intraretinal proliferation initiated by experimental retinal detachment. Invest Ophthalmol Vis Sci 2007;48:1305-1311.
31. Eibl KH, Banas B, Kook D, Ohlmann AV, Priglinger S, Kampik A, Welge-Luessen UC: Alkylphosphocholines: a new therapeutic option in glaucoma filtration surgery. Invest Ophthalmol Vis Sci 2004;45:2619-2624.
32. Eibl KH, Banas B, Schoenfeld CL, Neubauer AS, Priglinger S, Kampik A, Welge-Luessen U: Alkylphosphocholines inhibit proliferation of human retinal pigment epithelium. Invest Ophthalmol Vis Sci 2003;44:3556-3561.
33. Shoji M, Raynor RL, Fleer EA, Eibl H, Vogler WR, Kuo JF: Effects of hexadecylphosphocholine on protein kinase C and TPA-induced differentiation of HL60 cells. Lipids 1991;26:145-149.
34. Wu T T, Hsieh YH, Hsieh YS, Liu JY: Reduction of PKCalpha decreases cell proliferation, migration, and invasion of human malignant hepatocellular carcinoma. J Cell Biochem 2008;103:9-20.
35. Lipinski CA, Tran NL, Bay C, Kloss J, McDonough WS, Beaudry C, Berens ME, Loftus JC: Differential role of praline-rich tyrosine kinase 2 and focal adhesion kinase in determining glioblastoma migration and proliferation. Mol Cancer Res 2003;1:323-332.
36. Shen TL, Guan JL: Differential regulation of cell migration and cell cycle progression by FAK complexes with Src, PI3K, Grb7 and Grb2 in focal contacts. FEBS Lett 2001;499:176-181.
37. Ruiter GA, Zerp S F, Bartelink H, van Blitterswijk WJ, Verheij M: Anti-cancer alkyl-lysophospholipids inhibit the phosphatidylinositol 3-kinase-Akt/PKB survival pathway. Anticancer Drugs 2003;14:167- 173.
38. Ozaki M, Ogita H, Takai Y: Involvement of integrin-induced activation of protein kinase C in the formation of adherens junctions. Genes Cells 2007;12: 651-662.
39. Eibl KH, Kook D, Priglinger S, Haritoglou C, Kampik A, Welge-Luessen U: Human retinal pigment epithelial cell attachment, spreading and migration inhibition by alkylphosphocholines. Invest Ophthalmol Vis Sci 2006, 47:364-370.
40. Schuettauf F, Eibl KH, Thaler S, Shinoda K, Rejdak R, May CA, Blatsios G, Welge-Luessen U: Toxicity study of erucylphosphocholine in a rat model. Curr Eye Res 2005;30:813-820.
41. Eibl KH, Schwabe K, Welge-Luessen U, Kampik A, Eichler W. The role of alkylphosphocholines in retinal Müller glial cell proliferation. Curr Eye Res 2008;33:385-393.