In vitro sonothrombolysis with duplex ultrasound: First results using a simplified model

Cerebrovascular Diseases

Volumn 28, Issue 4, 2009, Pages 365-370

  Hölscher, Thilo ^a,b   Raman, Rema ^b,c   Ernström, Karin ^c   Parrish, Juliet ^a   Le, Dzung The ^d   Lyden, Patrick D ^b   Mattrey, Robert F ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

B mode phase inversion; Clot preparation; In vitro; Spectral Doppler; Thrombolysis; Tissue plasminogen activator; Ultrasound contrast agent microbubbles

Indexed keywords

ALTEPLASE; D DIMER; FRESH FROZEN PLASMA; PERFLUTREN; PHOSPHATE BUFFERED SALINE;

ARTICLE; BLOOD CLOT; BLOOD CLOT LYSIS; CONTROLLED STUDY; ECHOGRAPHY; HUMAN; IN VITRO STUDY; NORMAL HUMAN; PRIORITY JOURNAL; ULTRASOUND; ULTRASOUND SCANNER;

BLOOD COAGULATION; COMBINED MODALITY THERAPY; CONTRAST MEDIA; FIBRIN FIBRINOGEN DEGRADATION PRODUCTS; FIBRINOLYTIC AGENTS; FLUOROCARBONS; HUMANS; MICROBUBBLES; PILOT PROJECTS; THROMBOLYTIC THERAPY; THROMBOSIS; TIME FACTORS; TISSUE PLASMINOGEN ACTIVATOR; ULTRASONIC THERAPY; ULTRASONOGRAPHY, DOPPLER, DUPLEX;

EID: 67651218643     PISSN: 10159770     EISSN: None     Source Type: Journal    
DOI: 10.1159/000230710     Document Type: Article

References (25)

1. Alexandrov AV, Molina CA, Grotta JC, et al: Ultrasound-enhanced systemic thrombolysis for acute ischemic stroke. N Engl J Med 2004; 351: 2170-2178
2. Eggers J, Koch B, Meyer K, Konig I, Seidel G: Effect of ultrasound on thrombolysis of middle cerebral artery occlusion. Ann Neurol 2003; 53: 797-800
3. Eggers J, Konig IR, Koch B, Handler G, Seidel G: Sonothrombolysis with transcranial color- coded sonography and recombinant tissue- type plasminogen activator in acute middle cerebral artery main stem occlusion: Results from a randomized study. Stroke 2008; 39: 1470-1475
4. Braaten JV, Goss RA, Francis CW: Ultrasound reversibly disaggregates fibrin fibers. Thromb Haemost 1997; 78: 1063-1068
5. Devcic-Kuhar B, Pfaffenberger S, Gherardini L, et al: Ultrasound affects distribution of plasminogen and tissue-type plasminogen activator in whole blood clots in vitro. Thromb Haemost 2004; 92: 980-985
6. Datta S, Coussios CC, McAdory LE, et al: Correlation of cavitation with ultrasound enhancement of thrombolysis. Ultrasound Med Biol 2006; 32: 1257-1267
7. Datta S, Ammi AY, Coussios CC, Holland CK: Monitoring and simulating stable cavitation during ultrasound-enhanced thrombolysis (A). J Acoust Soc Am 2007; 122: 3052
8. Prokop AF, Soltani A, Roy RA: Cavitational mechanisms in ultrasound-accelerated fibrinolysis. Ultrasound Med Biol 2007; 33: 924-933
9. Datta S, Coussios CC, Ammi AY, Mast TD, de Courten-Myers GM, Holland CK: Ultrasound- enhanced thrombolysis using Definity as a cavitation nucleation agent. Ultrasound Med Biol 2008; 34: 1421-1433
10. Siegel RJ, Atar S, Fishbein MC, et al: Noninvasive, transthoracic, low-frequency ultrasound augments thrombolysis in a canine model of acute myocardial infarction. Circulation 2000; 101: 2026-2029
11. Siegel RJ, Atar S, Fishbein MC, et al: Noninvasive transcutaneous low frequency ultrasound enhances thrombolysis in peripheral and coronary arteries. Echocardiography 2001; 18: 247-257
12. Nedelmann M, Brandt C, Schneider F, et al: Ultrasound-induced blood clot dissolution without a thrombolytic drug is more effective with lower frequencies. Cerebrovasc Dis 2005; 20: 18-22
13. Nedelmann M, Eicke BM, Nolle F, Lierke EG, Kempski O: The ultrasound contrast medium levovist increases the thrombolytic effect of low frequency ultrasound (in German). Med Klin (Munich) 2002; 97: 216-220
14. Francis CW, Suchkova VN: Ultrasound and thrombolysis. Vasc Med 2001; 6: 181-187
15. Daffertshofer M, Gass A, Ringleb P, et al: Transcranial low-frequency ultrasound-mediated thrombolysis in brain ischemia: increased risk of hemorrhage with combined ultrasound and tissue plasminogen activator: results of a phase II clinical trial. Stroke 2005; 36: 1441-1446
16. Daffertshofer M, Huang Z, Fatar M, et al: Efficacy of sonothrombolysis in a rat model of embolic ischemic stroke. Neurosci Lett 2004; 361: 115-119
17. Pfaffenberger S, Devcic-Kuhar B, El-Rabadi K, et al: Two MHz ultrasound enhances t- PA-mediated thrombolysis: comparison of continuous versus pulsed ultrasound and standing versus travelling acoustic waves. Thromb Haemost 2003; 89: 583-589
18. Alexandrov AV: Ultrasound-enhanced thrombolysis for stroke: Clinical significance. Eur J Ultrasound 2002; 16: 131-140
19. Cintas P, Nguyen F, Boneu B, Larrue V: Enhancement of enzymatic fibrinolysis with 2-MHz ultrasound and microbubbles. J Thromb Haemost 2004; 2: 1163-1166
20. Everbach EC, Francis CW: Cavitational mechanisms in ultrasound- accelerated thrombolysis at 1 MHz. Ultrasound Med Biol 2000; 26: 1153-1160
21. Pfaffenberger S, Devcic-Kuhar B, Kollmann C, et al: Can a commercial diagnostic ultrasound device accelerate thrombolysis? An in vitro skull model. Stroke 2005; 36: 124-128
22. Molina CA, Ribo M, Rubiera M, et al: Microbubble administration accelerates clot lysis during continuous 2-MHz ultrasound monitoring in stroke patients treated with intravenous tissue plasminogen activator. Stroke 2006; 37: 425-429
23. Mizushige K, Kondo I, Ohmori K, Hirao K, Matsuo H: Enhancement of ultrasound-accelerated thrombolysis by echo contrast agents: Dependence on microbubble structure. Ultrasound Med Biol 1999; 25: 1431-1437
24. Tachibana K, Tachibana S: Albumin microbubble echo-contrast material as an enhancer for ultrasound accelerated thrombolysis. Circulation 1995; 92: 1148-1150
25. Wu Y, Unger EC, McCreery TP, et al: Binding and lysing of blood clots using MRX-408. Invest Radiol 1998; 33: 880-885