The A2B-D2 receptor interaction that controls carotid body catecholamines release locates between the last two steps of hypoxic transduction cascade

Advances in Experimental Medicine and Biology

Volumn 648, Issue , 2009, Pages 161-168

  Conde, S V ^a,b   Obeso, A ^a,b   Monteiro, E C ^a,b   Gonzalez, C ^a,b  

^a UNIVERSITY OF VALLADOLID   (Spain)

^b UNIVERSIDADE NOVA DE LISBOA   (Portugal)

Author keywords

A2b adenosine receptors; Adenosine; Adenosine agonists; Adenosine antagonists; D2 dopamine receptors; Dopamine; Dopamine agonists; Dopamine antagonists

Indexed keywords

ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A2B RECEPTOR; CALCIUM ION; DOPAMINE 2 RECEPTOR; IONOMYCIN; PROPYLNORAPOMORPHINE; APOMORPHINE; CATECHOLAMINE; DOPAMINE RECEPTOR STIMULATING AGENT; DRUG DERIVATIVE; N-N-PROPYLNORAPOMORPHINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; CALCIUM CELL LEVEL; CAROTID BODY CHEMORECEPTOR; CATECHOLAMINE RELEASE; CELL HYPOXIA; CONFERENCE PAPER; CONTROLLED STUDY; EXOCYTOSIS; FEMALE; IN VITRO STUDY; INHIBITION KINETICS; MALE; MOLECULAR INTERACTION; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RAT; SIGNAL TRANSDUCTION; STIMULUS SECRETION COUPLING; ANIMAL; ANOXIA; ARTICLE; CAROTID BODY; DRUG EFFECT; DRUG POTENTIATION; METABOLISM; SECRETION; WISTAR RAT;

RATTUS;

ADENOSINE-5'-(N-ETHYLCARBOXAMIDE); ANIMALS; ANOXIA; APOMORPHINE; CAROTID BODY; CATECHOLAMINES; DOPAMINE AGONISTS; FEMALE; IONOMYCIN; MALE; RATS; RATS, WISTAR; RECEPTOR, ADENOSINE A2B; RECEPTORS, DOPAMINE D2; SIGNAL TRANSDUCTION;

EID: 67651205673     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-90-481-2259-2_18     Document Type: Conference Paper

References (16)

1. Conde S. V. & Monteiro E. C. 2004, Hypoxia induces the release of adenosine from the rat carotid body. J Neurochem, 89:1148-1156. (Pubitemid 38715832)
2. Conde S. V., Obeso A., Vicario I., Rigual R., Rocher A., & Gonzalez C. 2006, Caffeine inhibition of rat carotid body chemoreceptors is mediated by A2A and A2B adenosine receptors. J Neurochem, 98:616-628. (Pubitemid 44133163)
3. Dedkova E. N., Sigova A. A., & Zinchenko V. P. 2000, Mechanism of action of calcium ionophores on intact cells: ionophore resistant cells. Membr Cell Biol, 13:357-368. (Pubitemid 30162427)
4. Ferré S., Fredholm B. B., Morelli M., Popoli P., & Fuxe K. 1997, Adenosine-dopamine receptorreceptor interactions as an integrative mechanism in the basal ganglia. Trends Neurosci, 20:482-487. (Pubitemid 27421712)
5. Fuxe K., Canals M., Torvinen M., Marcellino D., Terasmaa A., Genedani S., Leo G., Guidolin D., Diaz-Cabiale Z., Rivera A., Lundstrom L., Langel U., Narvaez J., Tanganelli S., Lluis C., Ferré S., Woods A., Franco R., & Agnati L. F. 2007, Intramembrane receptor-receptor interactions: a novel principle in molecular medicine. J Neural Transm, 114:49-75. (Pubitemid 46018675)
6. Gonzalez C., Almaraz L., Obeso A., & Rigual R. 1992, Oxygen and acid chemoreception in the carotid body chemoreceptors. Trends Neurosci, 15:146-153.
7. Gonzalez, C., Almaraz, L., Obeso, A., & Rigual, R. 1994, Carotid body chemoreceptors: from natural stimuli to sensory discharges. Physiol Rev, 74:829-898. (Pubitemid 24328941)
8. Himmel H. M., Riehle R., Sticker K. & Siess M. 1990, Effects of the divalent cation ionophore ionomycin on the performance of isolated guinea-pig atria. Basic Res Cardiol, 85:247-256. (Pubitemid 20202403)
9. McQueen D. S. 1983, Pharmacological aspects of putative transmitters in the carotid body. In Physiology of the Peripheral Arterial Chemoreceptors, eds. Acker, H. & O'Regan, R. G., Amsterdam, Elsevier Science, pp. 149-155.
10. Monteiro E. C. & Ribeiro J. A. 1987, Ventilatory effects of adenosine mediated by carotid body chemoreceptors in the rat. Naunyn-Schmiedeberg's Arch Pharmacol, 335:143-148. (Pubitemid 17007991)
11. Monteiro E. C. & Ribeiro J. A. 2000, Adenosine-dopamine interactions and ventilation mediated through carotid body chemoreceptors. Adv Exp Med Biol, 475:671-684. (Pubitemid 32197772)
12. Runold M., Cherniak N. S. & Prabhakar N. R. 1990, Effect of adenosine on isolated and superfused cat carotid body activity. Neurosci Lett, 113:111-114. (Pubitemid 20175267)
13. Talaia C., Queiroz G., Quintas C. & Gonçalves J. 2005, Interaction between A2B-receptors and alpha2-adrenoreceptors on the modulation of noradrenaline release in the rat vas deferens: possible involvement of a group 2 adenylyl cyclase isoform. Neurochem Int, 47:418-429. (Pubitemid 41242623)
14. Uematsu T., Kozawa O., Matsuno H., Niwa M., Yoshikoshi H., Oh-uchi M., Cono K., Nagashima S., & Kanamaru M. 2000, Pharmacokinetics and tolerability of intravenous infusion of adenosine (SUNY4001) in healthy volunteers. Br J Clin Pharmacol, 50:177-181. (Pubitemid 30612037)
15. Vicario I., Rigual R., Obeso A., & Gonzalez C. 2000, Characterization of the synthesis and release of catecholamine in the rat carotid body in vitro. Am. J. Physiol. Cell Physiol., 278:C490-C499. (Pubitemid 30154928)
16. Watt A. H. & Routledge P. A. 1985, Adenosine stimulates respiration in man, Br J Pharmacol, 20:503-506. (Pubitemid 16230375)