Examination of processing speed deficits in multiple sclerosis using functional magnetic resonance imaging

Journal of the International Neuropsychological Society

Volumn 15, Issue 3, 2009, Pages 383-393

  Genova, Helen M ^a,b,c   Hillary, Frank G ^d   Wylie, Glenn ^c   Rypma, Bart ^e,f   Deluca, John ^a,b,c  

^a The State University of New Jersey   (United States)

^b RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^c KESSLER FOUNDATION   (United States)

^d PENNSYLVANIA STATE UNIVERSITY   (United States)

^e UNIVERSITY OF TEXAS AT DALLAS   (United States)

^f UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Brain mapping; Cognition; fMRI; Multiple sclerosis; Processing speed; Symbol Digit Modalities Task

Indexed keywords

ACCURACY; ADULT; AGING; ARTICLE; BRAIN FUNCTION; CEREBELLUM; CINGULATE GYRUS; CLINICAL ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; FEMALE; FRONTAL CORTEX; FUNCTIONAL ASSESSMENT; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GRAY MATTER; HUMAN; MALE; MENTAL TASK; MULTIPLE SCLEROSIS; NERVE CELL NETWORK; OCCIPITAL LOBE; PARIETAL LOBE; PRIORITY JOURNAL; TASK PERFORMANCE; THALAMUS; WHITE MATTER; BLOOD; BRAIN; BRAIN MAPPING; IMAGE PROCESSING; MENTAL FUNCTION; METHODOLOGY; NEUROPSYCHOLOGICAL TEST; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; REACTION TIME; VASCULARIZATION;

OXYGEN;

ADULT; BRAIN; BRAIN MAPPING; COGNITION DISORDERS; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; MENTAL PROCESSES; MULTIPLE SCLEROSIS; NEUROPSYCHOLOGICAL TESTS; OXYGEN; REACTION TIME; YOUNG ADULT;

EID: 67651183996     PISSN: 13556177     EISSN: 14697661     Source Type: Journal    
DOI: 10.1017/S1355617709090535     Document Type: Article

References (58)

1. Allison, J.D., Meador, K.J., Loring, D.W., Figueroa, R.E., & Wright, J.C. (2000). Functional MRI cerebral activation and deactivation during finger movement. Neurology, 54 (1), 135-142.
2. Archibald, C.J. & Fisk, J.D. (2000). Information processing efficiency in patients with multiple sclerosis. Journal of Clinical and Experimental Neuropsychology, 22, 686-701.
3. Arnett, P.A. (2004). Speed of presentation infl uences story recall in college students and persons with multiple sclerosis. Archives of Clinical Neuropsychology, 19, 507-523.
4. Arnett, P.A. (2005). Longitudinal consistency of the relationship between depression symptoms and cognitive functioning in multiple sclerosis. CNS Spectrums, 10, 372-382.
5. Arnett, P.A., Higginson, C.I., Voss, W.D., Randolph, J.J., & Grandey, A.A. (2002). Relationship between coping, cognitive dysfunction and depression in multiple sclerosis. The Clinical Neuropsychologist, 16 341-355.
6. Audoin, B., Ibarrola, D., Au Duong, M.V., Pelletier, J., Confort-Gouny, S., Malikova, I., Ali-Cherif, A., Cozzone, P.J., & Ranjeva, J.P. (2005). Functional MRI study of PASAT in normal subjects. Magma, 18, 96-102.
7. Barker-Collo, S.L. (2006). Quality of life in multiple sclerosis: Does information-processing speed have an independent effect? Archives of Clinical Neuropsychology, 21, 167-174.
8. Benedict, R.H., Bruce, J., Dwyer, M.G., Weinstock-Guttman, B., Tjoa, C., Tavazzi, E., Munschauer, F.E., & Zivadinov, R. (2007). Diffusion-weighted imaging predicts cognitive impairment in multiple sclerosis. Multiple Sclerosis, 13 (6), 722-730.
9. Benedict, R.H., Carone, D.A., & Bakshi, R. (2004). Correlating brain atrophy with cognitive dysfunction, mood disturbances, and personality disorder in multiple sclerosis. Journal of Neuroimaging, 14 (3 Suppl 1), 36S-45S.
10. Benedict, R.H., Cookfair, D., Gavett, R., Gunther, M., Munschauer, F., Garg, N., & Weinstock-Guttman, B. (2006). Validity of the minimal assessment of cognitive function in multiple sclerosis (MACFIMS). Journal of the International Neuropsychological Society, 12 (4), 549-558.
11. Brandt, J. & Benedict, R.H.B. (2001). Hopkins Verbal Learning Test - Revised Professional Manual. Odessa, FL: Psychological Assessment Resources.
12. Brittain, J.L., La Marche, J.L., Reeder, K.P., Roth, D.L., & Boll, T.S. (1991). Effects of age and IQ on paced auditory serial additional task (PASAT) performance. The Clinical Neuropsychologist, 5, 163-175.
13. Canli, T., Sivers, H., Thomason, M.E., Whitfi eld-Gabrieli, S., Gabrieli, J.D., & Gotlib, I.H. (2004). Brain activation to emotional words in depressed vs healthy subjects. Neuroreport, 15, 2585-2588.
14. Caplan, B. (1985). Stimulus effects in unilateral neglect? Cortex, 21 69-80.
15. Chiaravalloti, N., Hillary, F., Ricker, J., Christodoulou, C., Kalnin, A., Liu, W.C., Steffener, J., & DeLuca, J. (2005). Cerebral activation patterns during working memory performance in multiple sclerosis using FMRI. Journal of Clinical and Experimental Neuropsychology, 27, 33-54.
16. Christodoulou, C., Krupp, L.B., Liang, Z., Huang, W., Melville, P., Roque, C., Scherl, W.F., Morgan, T., MacAllister, W.S., Li, L., Tudorica, L.A., Li, X., Roche, P., & Peyster, R. (2003). Cognitive performance and MR markers of cerebral injury in cognitively impaired MS patients. Neurology, 60 (11), 1793-1798.
17. Cox, R.W. (1996). AFNI: Software for analysis and visualization of functional magnetic resonance neuroimages. Computers and Biomedical Research, 29, 162-173.
18. Deloire, M.S., Bonnet, M.C., Salort, E., Arimone, Y., Boudineau, M., Petry, K.G., & Brochet, B. (2006). How to detect cognitive dysfunction at early stages of multiple sclerosis? Multiple Sclerosis, 12 (4), 445-452.
19. DeLuca, J., Barbieri-Berger, S., & Johnson, S.K. (1994). The nature of memory impairments in multiple sclerosis: Acquisition versus retrieval. Journal of Clinical and Experimental Neuropsychology, 16, 183-189.
20. DeLuca, J., Chelune, G.J., Tulsky, D.S., Lengenfelder, J., & Chiaravalloti, N.D. (2004). Is speed of processing or working memory the primary information processing deficit in multiple sclerosis? Journal of Clinical and Experimental Neuropsychology, 26, 550-562.
21. Demaree, H.A., DeLuca, J., Gaudino, E.A., & Diamond, B.J. (1999). Speed of information processing as a key deficit in multiple sclerosis: Implications for rehabilitation. Journal of Neurology, Neurosurgery, and Psychiatry, 67, 661-663.
22. Denney, D.R., Lynch, S.G., Parmenter, B.A., & Horne, N. (2004). Cognitive impairment in relapsing and primary progressive multiple sclerosis: Mostly a matter of speed. Journal of the International Neuropsychological Society, 10, 948-956.
23. Gaudino, E.A., Chiaravalloti, N.D., DeLuca, J., & Diamond, B.J. (2001). A comparison of memory performance in relapsing-remitting, primary progressive and secondary progressive, multiple sclerosis. Neuropsychiatry, Neuropsychology, and Behavioral Neurology, 14, 32-44.
24. Greicius, M.D. & Menon, V. (2004). Default-mode activity during a passive sensory task: Uncoupled from deactivation but impacting activation. Journal of Cognitive Neuroscience, 16 (9), 1484-1492.
25. Harvey, P.O., Fossati, P., Pochon, J.B., Levy, R., Lebastard, G., Lehericy, S., Allilaire, J.F., & Dubois, B. (2005). Cognitive control and brain resources in major depression: An fMRI study using the n-back task. NeuroImage, 26, 860-869.
26. Henry, J.D. & Beatty, W.W. (2006). Verbal fluency deficits in multiple sclerosis. Neuropsychologia, 44, 1166-1174.
27. Hester, R., Fassbender, C., & Garavan, H. (2004). Individual differences in error processing: A review and reanalysis of three event-related fMRI studies using the GO/NOGO task. Cerebral Cortex, 14, 986-994.
28. Hillary, F.G., Chiaravalloti, N.D., Ricker, J.H., Steffener, J., Bly, B.M., Lange, G., Liu, W.C., Kalnin, A.J., & DeLuca, J. (2003). An investigation of working memory rehearsal in multiple sclerosis using fMRI. Journal of Clinical and Experimental Neuropsychology, 25, 965-978.
29. Kim, H.J., Park, H.K., Park, J.R., Choi, M.H., Lee, H.W., & Chung, S.C. (2008). Effects of aging on visuospatial performance and cerebral activation and lateralization: An FMRI study. The International Journal of Neuroscience, 118 (6), 781-791.
30. Landro, N.I., Celius, E.G., & Sletvold, H. (2004). Depressive symptoms account for deficient information processing speed but not for impaired working memory in early phase multiple sclerosis (MS). Journal of the Neurological Sciences, 217, 211-216.
31. Lazeron, R.H., Rombouts, S.A., de Sonneville, L., Barkhof, F., & Scheltens, P. (2003). A paced visual serial addition test for fMRI. Journal of the Neurological Sciences, 213, 29-34.
32. Lengenfelder, J., Bryant, D., Diamond, B.J., Kalmar, J.H., Moore, N.B., & DeLuca, J. (2006). Processing speed interacts with working memory efficiency in multiple sclerosis. Archives of Clinical Neuropsychology, 21, 229-238.
33. Litvan, I., Grafman, J., Vendrell, P., & Martinez, J.M. (1988). Slowed information processing in multiple sclerosis. Archives of Neurology, 45, 281-285.
34. Madden, D.J., Whiting, W.L., Huettel, S.A., White, L.E., MacFall, J.R., & Provenzale, J.M. (2004 a). Diffusion tensor imaging of adult age differences in cerebral white matter: Relation to response time. NeuroImage, 21 (3), 1174-1181.
35. Madden, D.J., Whiting, W.L., Provenzale, J.M., & Huettel, S.A. (2004 b). Age-related changes in neural activity during visual target detection measured by fMRI. Cerebral Cortex, 14 (2), 143-155.
36. Mainero, C., Caramia, F., Pozzilli, C., Pisani, A., Pestalozza, I., Borriello, G., Bozzao, L., & Pantano, P. (2004). fMRI evidence of brain reorganization during attention and memory tasks in multiple sclerosis. NeuroImage, 21, 858-867.
37. Morgen, K., Sammer, G., Courtney, S.M., Wolters, T., Melchior, H., Blecker, C.R., Oschmann, P., Kaps, M., & Vaitl, D. (2007). Distinct mechanisms of altered brain activation in patients with multiple sclerosis. NeuroImage, 37 (3), 937-946.
38. Nocentini, U., Pasqualetti, P., Bonavita, S., Buccafusca, M., De Caro, M.F., Farina, D., Girlanda, P., Le Pira, F., Lugaresi, A., Quattrone, A., Reggio, A., Salemi, G., Savettieri, G., Tedeschi, G., Trojano, M., Valentino, P., & Caltagirone, C. (2006). Cognitive dysfunction in patients with relapsing-remitting multiple sclerosis. Multiple Sclerosis, 12, 77-87.
39. Parmenter, B.A., Weinstock-Guttman, B., Garg, N., Munschauer, F., & Benedict, R.H. (2007). Screening for cognitive impairment in multiple sclerosis using the Symbol Digit Modalities Test. Multiple Sclerosis, 13 (1), 52-57.
40. Penner, I.K., Rausch, M., Kappos, L., Opwis, K., & Radü, E.W. (2003). Analysis of impairment related functional architecture in MS patients during performance of different attention tasks. Journal of Neurology, 250 (4), 461-472.
41. Polman, C.H., Reingold, S.C., Edan, G., Filippi, M., Hartung, H.P., Kappos, L., Lublin, F.D., Metz, L.M., McFarland, H.F., O'Connor, P.W., Sandberg-Wollheim, M., Thompson, A.J., Weinshenker, B.G., & Wolinsky, J.S. (2005). Diagnostic criteria for multiple sclerosis: 2005 revisions to the "McDonald Criteria". Annals of Neurology, 58 (6), 840-846.
42. Rabbitt, P., Scott, M., Lunn, M., Thacker, N., Lowe, C., Pendleton, N., Horan, M., & Jackson, A. (2007). White matter lesions account for all age-related declines in speed but not in intelligence. Neuropsychology, 21 (3), 363-370.
43. Raichle, M.E., MacLeod, A.M., Snyder, A.Z., Powers, W.J., Gusnard, D.A., & Shulman, G.L. (2001). A default mode of brain function. Proceedings of the National Academy of Sciences of the United States of America, 98 (2), 676-682.
44. Reitan, R. (1958). Validity of TMT as an indication of organic brain damage. Perceptual and Motor Skills, 8, 271-276.
45. Robb, R.A. (2001). The biomedical imaging resource at Mayo Clinic. IEEE Transactions on Medical Imaging, 20, 854-867.
46. Rose, E.J., Simonotto, E., & Ebmeier, K.P. (2006). Limbic over-activity in depression during preserved performance on the nback task. NeuroImage, 29, 203-215.
47. Rypma, B., Berger, J.S., Genova, H.M., Rebbechi, D., & D'Esposito, M. (2005). Dissociating age-related changes in cognitive strategy and neural efficiency using event-related fMRI. Cortex, 41, 582-594.
48. Rypma, B., Berger, J.S., Prabhakaran, V., Bly, B.M., Kimberg, D.Y., Biswal, B.B., & D'Esposito, M. (2006). Neural correlates of cognitive efficiency. NeuroImage, 33, 969-979.
49. Rypma, B., Eldreth, D.A., & Rebbechi, D. (2007). Age-related differences in activation-performance relations in delayed-response tasks: A multiple component analysis. Cortex, 43 (1), 65-76.
50. Rypma, B., Prabhakaran, V., Desmond, J.E., Glover, G.H., & Gabrieli, J.D. (1999). Load-dependent roles of frontal brain regions in the maintenance of working memory. NeuroImage, 9 (2), 216-226.
51. Sanfi lipo, M.P., Benedict, R.H., Weinstock-Guttman, B., & Bakshi, R. (2006). Gray and white matter brain atrophy and neuropsychological impairment in multiple sclerosis. Neurology, 66 (5), 685-692.
52. Sepulcre, J., Vanotti, S., Hernandez, R., Sandoval, G., Caceres, F., Garcea, O., & Villoslada, P. (2006). Cognitive impairment in patients with multiple sclerosis using the Brief Repeatable Battery-Neuropsychology test. Multiple Sclerosis, 12, 187-195.
53. Shmuel, A., Augath, M., Oeltermann, A., & Logothetis, N.K. (2006). Negative functional MRI response correlates with decreases in neuronal activity in monkey visual area V1. Nature Neuroscience, 9 (4), 569-577.
54. Shum, D.H.K., McFarland, K.A., & Bain, J.D. (1990). Construct validity of eight tests of attention: Comparison of normal and closed head injured samples. The Clinical Neuropsychologist, 4, 151-162.
55. Smith, A. (1982). Symbol Digits Modalities Test. Los Angeles, CA: Western Psychological Services.
56. Staffen, W., Mair, A., Zauner, H., Unterrainer, J., Niederhofer, H., Kutzelnigg, A., Ritter, S., Golaszewski, S., Iglseder, B., & Ladurner, G. (2002). Cognitive function and fMRI in patients with multiple sclerosis: Evidence for compensatory cortical activation during an attention task. Brain, 125, 1275-1282.
57. Wechsler, D. (1997). Wechsler Adult Intelligence Scale - Third Addition. San Antonio, TX: Psychological Corporation.
58. Wilkinson, G.S. (1993). Wide Range Achievement Test-3, Administration Manual. Wilmington, DE: Wide Range.