Risk assessment of isolated aripiprazole exposures and toxicities: A retrospective study

Clinical Toxicology

Volumn 47, Issue 6, 2009, Pages 580-583

  Young, M C ^a   Shah, N ^b   Cantrell, F L ^c   Clark, R F ^c,d  

^a SANTA CLARA VALLEY MEDICAL CENTER   (United States)

^b KAISER PERMANENTE MEDICAL CENTER   (United States)

^c California Poison Control System   (United States)

^d UCSD MEDICAL CENTER   (United States)

Author keywords

Abilify; Aripiprazole; Overdose; Poisoning; Toxicity

Indexed keywords

ARIPIPRAZOLE; NEUROLEPTIC AGENT; PIPERAZINE DERIVATIVE; QUINOLONE DERIVATIVE;

ADOLESCENT; ADULT; AGITATION; ARTICLE; CHILD; DEATH; DIZZINESS; DYSPHAGIA; DYSTONIA; ELECTROCARDIOGRAM; FEMALE; HEADACHE; HEART RATE; HUMAN; HYPOTENSION; INTOXICATION; INTUBATION; MAJOR CLINICAL STUDY; MALE; NAUSEA; PARESTHESIA; PEDIATRICS; RETROSPECTIVE STUDY; RISK ASSESSMENT; SCHOOL CHILD; SEDATION; SINUS TACHYCARDIA; SOMNOLENCE; SYMPTOM; SYNCOPE; TACHYCARDIA; TREMOR; VOMITING; ACUTE DISEASE; AGED; DOSE RESPONSE; INFANT; MIDDLE AGED; PATHOPHYSIOLOGY; POISON CENTER; PRESCHOOL CHILD;

SYNCOPE;

ACUTE DISEASE; ADOLESCENT; ADULT; AGED; ANTIPSYCHOTIC AGENTS; CHILD; CHILD, PRESCHOOL; DISORDERS OF EXCESSIVE SOMNOLENCE; DOSE-RESPONSE RELATIONSHIP, DRUG; DYSTONIA; FEMALE; HUMANS; INFANT; MALE; MIDDLE AGED; NAUSEA; PIPERAZINES; POISON CONTROL CENTERS; POISONING; QUINOLONES; RETROSPECTIVE STUDIES; RISK ASSESSMENT; TACHYCARDIA, SINUS; VOMITING; YOUNG ADULT;

EID: 67651177981     PISSN: 15563650     EISSN: 15569519     Source Type: Journal    
DOI: 10.1080/15563650902980027     Document Type: Article

References (16)

1. Baldessarini RJ, Tarazi FI. Drugs and the treatment of psychiatric disorders: psychosis and mania. In: Hardman JG, Limbird LE, Gilman AG, eds. Goodman & Gilman's The Pharmacological Basis of Therapeutics. 10th ed. New York: McGraw-Hill; 2001:485.
2. Chi JC. Drug Topics web site. http://drugtopics.modernmedicine.com/ drugtopics/data/articlestandard//drugtopics/102008/500221/article.pdf. Accessed 10 June 2008.
3. Chi JC. Drug Topics web site. http://drugtopics.modernmedicine.com/ drugtopics/data/articlestandard//drugtopics/072008/491207/article.pdf. Accessed 10 June 2008.
4. Forrester MB. Aripiprazole exposures reported to Texas poison control centers during 2002-2004. J Toxicol Environ Health A 2006; 69(18):1719-1726.
5. LoVecchio F, Watts D, Winchell J. One year experience with aripiprazole exposures. Am J Emerg Med 2005; 23(4):585-586.
6. Lai MW, Klein-Schwartz W, Rodgers GC, Abrams JY, Haber DA, Bronstein AC, Wruk KM. 2005 Annual report of the American Association of Poison Control Centers' national poisoning and exposure database. Clin Toxicol 2006; 44:803-932.
7. Marder SR, McQuade RD, Stock E, Kaplita S, Marcus R, Safferman AZ, Saha A, Ali M, Iwamoto T. Aripiprazole in the treatment of schizophrenia: safety and tolerability in short term, placebo-controlled trials. Schizophr Res 2003; 61(2-3):123-136.
8. Carstairs SD, Williams SR. Overdose of aripiprazole, a new type of antipsychotic. J Emerg Med 2005; 28(3):311-313.
9. Evicmen H, Alici-Evcimen Y, Basil B, Mania I, Mathews M, Gorman JM. Neuroleptic malignant syndrome induced by low dose aripiprazole in first episode psychosis. J Psychiatr Pract 2007; 13(2):117-119.
10. Chakraborty N, Johnston T. Aripiprazole and neuroleptic malignant syndrome. Int Clin Psychopharmacol 2004; 19(6):351-353.
11. Kang SC, Lee HJ, Lee MS, Kim L, Park JS. Atypical neuroleptic malignant syndrome associated with aripiprazole. J Clin Psychopharmacol 2006; 26(5):534.
12. Brunelle J, Guigueno S, Gouin P, Tamion F, Thibaut F. Aripiprazole and neuroleptic malignant syndrome. J Clin Psychopharmacol 2007; 27(2):212-214.
13. Egger C, Rauscher A, Muehlbacher M, Nickel M, Geretsegger C, Stuppaeck C. A case of dose-dependent aripiprazole-induced conduction disturbance. J Clin Psychopharmacol 2006; 26(4):436.
14. Leo R, Razzini C, Di Lorenzo G, Bianchi F, Tesauro M, Zanasi M, Siracusano A, Romeo F. Asymptomatic QTc prolongation during coadministration of aripiprazole and haloperidol. J Clin Psychiatry 2008; 69(2):327-328.
15. Glassman AH, Bigger JT Jr. Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death. Am J Psychiatry 2001; 158(11):1774-1782.
16. Lofton AL, Klein-Schwartz W. Atypical experience: a case series of pediatric aripiprazole exposures. Clin Toxicol 2005; 43(3):151-153.