α2,6-hyposialylation of c-Met abolishes cell motility of ST6Gal-I-knockdown HCT116 cells

Acta Pharmacologica Sinica

Volumn 30, Issue 7, 2009, Pages 1039-1045

  Qian, Jin ^a   Zhu, Cai Hua ^a   Tang, Shuai ^b   Shen, Ai Jun ^a   Ai, Jing ^b   Li, Jing ^b   Geng, Mei Yu ^a,b   Ding, Jian ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b OCEAN UNIVERSITY OF CHINA   (China)

Author keywords

C Met; hyposialylation; Cell motility; ST6Gal I

Indexed keywords

BETA GALACTOSIDE ALPHA 2,6 SIALYLTRANSFERASE; CARBOHYDRATE DERIVATIVE; LECTIN; MESSENGER RNA; SCATTER FACTOR RECEPTOR; SIALIC ACID DERIVATIVE; SIALYLTRANSFERASE; SMALL INTERFERING RNA; STAT3 PROTEIN; TYROSINE; UNCLASSIFIED DRUG; BETA D GALACTOSIDE ALPHA 2 6 SIALYLTRANSFERASE; BETA-D-GALACTOSIDE ALPHA 2-6-SIALYLTRANSFERASE;

ARTICLE; CELL ADHESION; CELL MIGRATION; CELL MOTILITY; CELL STRAIN HCT116; COLON CANCER; CONTROLLED STUDY; ENZYME ACTIVITY; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; HYPOSIALYLATION; KNOCKOUT GENE; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN MODIFICATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIALYLATION; SIGNAL TRANSDUCTION; ST 6 GAL 1 GENE; WESTERN BLOTTING; ANIMAL; CELL MOTION; CHEMISTRY; GENE SILENCING; GENETICS; METABOLISM; PHYSIOLOGY;

ANIMALS; CELL ADHESION; CELL MOVEMENT; GENE KNOCKDOWN TECHNIQUES; HCT116 CELLS; HUMANS; PROTO-ONCOGENE PROTEINS C-MET; RNA, SMALL INTERFERING; SIALIC ACIDS; SIALYLTRANSFERASES; STAT3 TRANSCRIPTION FACTOR; TYROSINE;

EID: 67651172997     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2009.84     Document Type: Article

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