A case of suspected isotretinoin-induced malformation in a baby of a mother who became pregnant one month after discontinuation of the drug

Yonsei Medical Journal

Volumn 50, Issue 3, 2009, Pages 445-447

  Lee, Soon Min ^a   Kim, He Min ^a   Lee, Jun Seok ^a   Yoon, Choon Sik ^a   Park, Min Soo ^a   Park, Kook In ^a   Namgung, Ran ^a   Lee, Chul ^a  

^a Yonsei University College of Medicine   (South Korea)

Author keywords

Isotretinoin; Malformation

Indexed keywords

ISOTRETINOIN; RO ACCUTANE; UNCLASSIFIED DRUG;

ACNE; ADULT; ANAMNESIS; ANOTIA; ARTICLE; ATRESIA; AUDITORY OSSICLE; CASE REPORT; COMPUTER ASSISTED TOMOGRAPHY; DRUG WITHDRAWAL; EAR MALFORMATION; EXTERNAL AUDITORY CANAL; EXTERNAL EAR CANAL ATRESIA; FEMALE; FETUS ECHOGRAPHY; FIRST TRIMESTER PREGNANCY; HUMAN; MICROTIA; NEWBORN; NEWBORN INTENSIVE CARE; PRENATAL CARE; PRENATAL DIAGNOSIS; PRENATAL DRUG EXPOSURE; VESTIBULE;

ABNORMALITIES, DRUG-INDUCED; ADULT; FEMALE; HUMANS; INFANT, NEWBORN; ISOTRETINOIN; MALE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS;

EID: 67651166856     PISSN: 05135796     EISSN: None     Source Type: Journal    
DOI: 10.3349/ymj.2009.50.3.445     Document Type: Article

References (10)

1. Accutane-exposed pregnancies - California, 1999. MMWR Morb Mortal Wkly Rep 2000;49:28-31.
2. Brinker A, Kornegay C, Nourjah P. Trends in adherence to a revised risk management program designed to decrease or eliminate isotretinoin-exposed pregnancies: evaluation of the accutane SMART program. Arch Dermatol 2005;141:563-9.
3. Mitchell AA, Van Bennekom CM, Louik C. A pregnancy-prevention program in women of childbearing age receiving isotretinoin. N Engl J Med 1995;333:101-6.
4. Vucinovic M, Roje D, Vucinovic Z, Capkun V, Bucat M, Banovic I. Maternal and neonatal effects of substance abuse during pregnancy: our ten-year experience. Yonsei Med J 2008;49:705-13.
5. Honein MA, Lindstrom JA, Kweder SL. Can we ensure the safe use of known human teratogens?: the iPLEDGE test case. Drug Saf 2007;30:5-15.
6. Webster WS, Johnston MC, Lammer EJ, Sulik KK. Isotretinoin embryopathy and the cranial neural crest: an in vivo and in vitro study. J Craniofac Genet Dev Biol 1986;6:211-22.
7. Suutarla S, Rautio J, Ritvanen A, Ala-Mello S, Jero J, Klockars T. Microtia in Finland: comparison of characteristics in different populations. Int J Pediatr Otorhinolaryngol 2007;71:1211-7.
8. Hersh JH, Danhauer DE, Hand ME, Weisskopf B. Retinoic acid embryopathy: timing of exposure and effects on fetal development. JAMA 1985;254:909-10.
9. Dai WS, Hsu MA, Itri LM. Safety of pregnancy after discontinuation of isotretinoin. Arch Dermatol 1989;125:362-5.
10. Nulman I, Berkovitch M, Klein J, Pastuszak A, Lester RS, Shear N, et al. Steady-state pharmacokinetics of isotretinoin and its 4-oxo metabolite: implications for fetal safety. J Clin Pharmacol 1998;38:926-30.