In thrombin stimulated human platelets citalopram, promethazine, risperidone, and ziprasidone, but not diazepam, may exert their pharmacological effects also through intercalation in membrane phospholipids in a receptor-independent manner

Journal of Chemical Biology

Volumn 2, Issue 2, 2009, Pages 89-103

  Oruch, Ramadhan ^a   Hodneland, Erlend ^a   Pryme, Ian F ^a   Holmsen, Holm ^a  

^a UNIVERSITY OF BERGEN   (Norway)

Author keywords

Diazepam; Human platelets; Intercalation; Langmuir technique; MLC; PLA2; PPI cycle; Psychotrophic drugs; Substrate availability

Indexed keywords

CITALOPRAM; DIAZEPAM; GLYCEROPHOSPHOLIPID; MEMBRANE PHOSPHOLIPID; PHOSPHOLIPASE A2; PHOSPHOLIPASE C; POLYPHOSPHOINOSITIDE; PROMETHAZINE; RISPERIDONE; THROMBIN; ZIPRASIDONE;

ARTICLE; CELL STIMULATION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; ENZYME METABOLISM; HUMAN; INTERCALATION COMPLEX; LIPID MONOLAYER; METABOLISM; PRIORITY JOURNAL; THROMBOCYTE; THROMBOCYTE MEMBRANE;

EID: 67651160348     PISSN: 18646158     EISSN: 18646166     Source Type: Journal    
DOI: 10.1007/s12154-009-0018-6     Document Type: Article

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