The effects of geometry on airflow in the acinar region of the human lung

Journal of Biomechanics

Volumn 42, Issue 11, 2009, Pages 1635-1642

  Kumar, Haribalan ^a   Tawhai, Merryn H ^c   Hoffman, Eric A ^a,b   Lin, Ching Long ^a  

^a UNIVERSITY OF IOWA   (United States)

^b IA United States   (United States)

^c UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Acinar fluid dynamics; Finite Element; Low Reynolds number flow; Open cavity flow; Recirculation

Indexed keywords

ACINAR FLUID DYNAMICS; FINITE ELEMENT; LOW REYNOLDS NUMBER FLOW; OPEN CAVITY FLOW; RECIRCULATION;

BIOLOGICAL ORGANS; DRUG DELIVERY; FLUID DYNAMICS;

REYNOLDS NUMBER;

ARTICLE; BIOMECHANICS; BREATHING; BRONCHIOLE; GEOMETRY; HUMAN; LUNG ALVEOLUS WALL; LUNG MECHANICS; LUNG STRUCTURE; PREDICTION; PRIORITY JOURNAL; RESPIRATORY AIRFLOW;

BIOMECHANICS; COMPUTER SIMULATION; FINITE ELEMENT ANALYSIS; HUMANS; LUNG; MODELS, ANATOMIC; MODELS, STATISTICAL; PULMONARY ALVEOLI; PULMONARY VENTILATION; RESPIRATION; RESPIRATORY MECHANICS; TIME FACTORS;

EID: 67651158810     PISSN: 00219290     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiomech.2009.04.046     Document Type: Article

References (37)

1. Anderson P.D., Galaktionov O.S., Peters G.W.M., Van De Vosse F.N., and Meijer H.E.H. Analysis of mixing in three-dimensional time-periodic cavity flows. Journal of Fluid Mechanics 386 (1999) 149-166
2. Burrowes K.S. An anatomically based mathematical model of the human pulmonary circulation (2005), The University of Auckland (PhD. Thesis)
3. Carney D., DiRocco J., and Nieman G. Dynamic alveolar mechanics and ventilator-induced lung injury. Critical Care Medicine 33 (2005) S122-S128
4. Choi H.G., Choi H., and Yoo J.Y. A fractional four-step finite element formulation of the unsteady incompressible Navier-Stokes equations using SUPG and linear equal-order element methods. Computer Methods in Applied Mechanics and Engineering 143 (1997) 333-348
5. Dailey H.L., and Ghadiali S.N. Fluid-structure analysis of microparticle transport in deformable pulmonary alveoli. Journal of Aerosol Science 38 (2007) 269-288
6. Darquenne C., and Paiva M. Two- and three-dimensional simulations of aerosol transport and deposition in alveolar zone of the human lung. Journal of Applied Physiology 80 (1996) 1401-1414
7. Darquenne C., and Prisk G.K. Aerosols in the study of convective acinar mixing. Respiratory Physiology and Neurobiology 148 (2005) 207-216
8. Davidson M.R., and Fitz-Gerald J.M. Flow patterns in models of small airway units of the lung. Journal of Fluid mechanics 52 (1972) 161-177
9. Finlay W.H. The Mechanics of Pharmaceutical Aerosols: An introduction (2001), Academic Press, London
10. Fung Y.C. A model of the lung structure and its validation. Journal of Applied Physiology 64 (1988) 2132-2141
11. Gatto L.A., Fluck R.R., and Nieman G.F. Alveolar mechanics in the acutely injured lung: role of alveolar instability in the pathogenesis of ventilator-induced lung injury. Respiratory Care 49 (2004) 1044-1055
12. Haber S., Butler J.P., Brenner H., Emanuel I., and Tsuda A. Shear flow over a self-similar expanding pulmonary alveolus during rhythmical breathing. Journal of Fluid Mechanics 405 (2000) 243-268
13. Haber S., Yitzhak D., and Tsuda A. Gravitational deposition in a rhythmically expanding and contracting alveolus. Journal of Applied Physiology 95 (2003) 657-671
14. Haefeli-Bleuer B., and Weibel E.R. Morphometry of the human pulmonary acinus. The Anatomical Record 220 (1988) 401-414
15. Harrington L., Prisk G.K., and Darquenne C. Importance of the bifurcation zone and branch orientation in simulated aerosol deposition in the alveolar zone of the human lung. Journal of Aerosol Science 37 (2006) 37-62
16. Henry F.S., Butler J.P., and Tsuda A. Kinematically irreversible acinar flow: a departure from classical dispersive aerosol transport theories. Journal of Applied Physiology 92 (2002) 835-845
17. Heyder J., Blanchard J.D., Feldman H.A., and Brain J.D. Convective mixing in human respiratory tract: estimates with aerosol boli. Journal of Applied Physiology 64 (1988) 1273-1278
18. Horner M., Metcalfe G., Wiggins S., and Ottino J.M. Transport enhancement mechanism in open cavities. Journal of Fluid Mechanics 452 (2002) 199-229
19. Lin C.-L., Lee H., Lee T., and Weber L.J. A level set characteristic Galerkin finite element method for free surface flows. International Journal of Numerical Methods in Fluids 49 (2005) 521-547
20. Namati, E., Thiesse, J., De Ryk, J., McLennan, G., 2007. Dynamic in vivo alveolar morphology using a novel laser scanning confocal microscope, 9th Biennial Conference of the Australian Pattern Recognition Society, DICTA 99-105.
21. Ottino, J.M., 1989. The kinematics of mixing: stretching, chaos and transport. Cambridge texts in applied mathematics.
22. Popp A., Wendel M., Knels L., Koch T., and Koch E. Imaging of the three-dimensional alveolar structure and the alveolar mechanics of a ventilated and perfused isolated rabbit lung with Fourier domain optical coherence tomography. Journal of Biomedical Optics 11 (2006) 14015
23. Pozrikidis C. Shear flow over a plane wall with an axisymmetric cavity or a circular orifice of finite thickness. Physics of Fluids 6 (1994) 68-79
24. Pozrikidis C. Effect of pressure gradient on viscous shear flow past an axisymmetric depression or protuberance on a plane wall. Computers and Fluids 29 (2000) 617-637
25. Quarteroni M., Tuveri M., and Venexiani A. Computational vascular fluid dynamics: problems, models and methods. Computing and Visualization in Science 2 (2000) 163-197
26. Sarangapani R., and Wexler A.S. The role of dispersion in particle deposition in human airways. Toxicological Sciences 54 (2000) 229-236
27. Sung J., Choi H.G., and Yoo J.Y. Time-accurate computation of unsteady free surface flows using an ALE-segregated equal-order FEM. Computer Methods in Applied Mechanics and Engineering 190 (2000) 1425-1440
28. Sznitman J., Heimsch F., Heimsch T., Rusch D., and Rösgen T. Three-dimensional convective alveolar flow induced by rhythmic breathing motion of the pulmonary acinus. Journal of Biomechanical Engineering 129 (2007) 658-665
29. Sznitman, J., Schmuki, S., Sutter, R., Tsuda, A., Rösgen, T., 2007b. CFD investigation of respiratory flows in a space-filling pulmonary acinus model, In: Brebbia, C.A. (Eds.), Modelling in Medicine and Biology VII, WIT Transactions on Biomedicine and Health 12, pp. 147-156.
30. Sznitman J., Heimsch T., Wildhaber J.H., Tsuda A., and Rosgen T. Respiratory flow phenomena and gravitational deposition in a three-dimensional space-filling model of the pulmonary acinar tree. Journal of Biomechanical Engineering 131 (2009) 031010-031116
31. Shen C., and Floryan J.M. Low Reynolds flow over cavities. Physics of Fluids 28 (1985) 3191-3202
32. Tawhai M.H., and Burrowes K.S. Developing integrative computational models of pulmonary structure. The Anatomical Record-Part B 275B (2003) 207-218
33. Tsuda A., Henry F.S., and Butler J.P. Chaotic mixing of alveolated duct flow in rhythmically expanding pulmonary acinus. Journal of Applied Physiology 79 (1995) 1055-1063
34. Tsuda A., Filipovic N., Haberthur D., Dickie R., Matsui Y., Stampanoni M., and Schittny J.C. Finite element 3D reconstruction of the pulmonary acinus imaged by synchrotron X-ray tomography. Journal of Applied, Physiology 105 (2008) 964-976
35. Weibel E.R., Sapoval B., and Filoche M. Design of peripheral airways for efficient gas exchange. Respiratory Physiology and Neurobiology 148 (2005) 3-21
36. Xia G., and Lin C.-L. An unstructured finite volume approach for structural dynamics in response to fluid motions. Computers and Structures 86 (2008) 684-701
37. Yue W., Lin C.-L., and Patel V.C. Numerical simulation of unsteady multidimensional free surface motions by level set method. International Journal for Numerical Methods in Fluids 42 (2003) 853-884