Life-threatening Torsades de Pointes resulting from "natural" cancer treatment

Clinical Toxicology

Volumn 47, Issue 6, 2009, Pages 592-594

  Chan, C K ^a   Chan, M H M ^b   Tse, M L ^a   Chan, I H S ^b   Cheung, R C K ^b   Lam, C W K ^b   Lau, F L ^a  

^a UNITED CHRISTIAN HOSPITAL   (Hong Kong)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Cesium; Prussian blue; Torsades de pointes

Indexed keywords

ANTIDOTUM THALLII HEYL; CESIUM CHLORIDE; FERRIC FERROCYANIDE; UNCLASSIFIED DRUG; ANTIDOTE; ANTINEOPLASTIC AGENT; CESIUM; CHLORIDE; ELECTROLYTE; FERROCYANIDE;

AGED; ARTICLE; CANCER THERAPY; CARDIOTOXICITY; CASE REPORT; DRUG ELIMINATION; DRUG INTOXICATION; ELECTROCARDIOGRAPHY MONITORING; EMERGENCY WARD; FEMALE; HEART VENTRICLE TACHYCARDIA; HOSPITALIZATION; HUMAN; OUTPATIENT DEPARTMENT; PATIENT COMPLIANCE; PLASMA HALF LIFE; QT PROLONGATION; SYNCOPE; TORSADE DES POINTES; TREATMENT DURATION; ALTERNATIVE MEDICINE; CHEMICALLY INDUCED DISORDER; DRUG COMBINATION; ELECTROCARDIOGRAPHY; LIVER TUMOR; METASTASIS; PATHOLOGY; RECTUM TUMOR; TREATMENT OUTCOME;

SYNCOPE;

AGED; ANTIDOTES; ANTINEOPLASTIC AGENTS; CESIUM; CHLORIDES; COMPLEMENTARY THERAPIES; DRUG THERAPY, COMBINATION; ELECTROCARDIOGRAPHY; ELECTROLYTES; FEMALE; FERROCYANIDES; HUMANS; LIVER NEOPLASMS; RECTAL NEOPLASMS; TACHYCARDIA, VENTRICULAR; TORSADES DE POINTES; TREATMENT OUTCOME;

EID: 67651156325     PISSN: 15563650     EISSN: 15569519     Source Type: Journal    
DOI: 10.1080/15563650902997831     Document Type: Article

References (14)

1. Pinter A, Dorian P, Newman D. Cesium-induced torsades de pointes. N Engl J Med 2002; 346(5):383-384.
2. Sartori HE. Cesium therapy in cancer patients. Pharmacol Biochem Behav 1984; 21(Suppl. 1):11-13.
3. Sartori HE. Nutrients and cancer: an introduction to cesium therapy. Pharmacol Biochem Behav 1984; 21(Suppl. 1):7-10.
4. Brewer AK. The high pH therapy for cancer tests on mice and human. Pharmacol Biochem Behav 1984; 21(Suppl.):1-5.
5. Dalal AK, Harding JD, Verdino RJ. Acquired long QT syndrome and monomorphic ventricular tachycardia after alternative treatment with cesium chloride for brain cancer. Mayo Clin Proc 2004; 79(8):1065-1069.
6. Lyon AW, Mayhew WJ. Cesium toxicity: a case of self-treatment by alternate therapy gone awry. Ther Drug Monit 2003; 25(1):114-116.
7. Saliba W, Erdogan O, Niebauer M. Polymorphic ventricular tachycardia in a woman taking cesium chloride. Pacing Clin Electrophysiol 2001; 24(Pt. I):515-517.
8. Vyas H, Johnson K, Houlihan R, Bauer BA, Ackerman MJ. Acquired long QT syndrome secondary to cesium chloride supplement. J Altern Complement Med 2006; 12(10):1011-1014.
9. Samadani U, Marcotte P. Zero efficacy with cesium chloride selftreatment for brain cancer. Mayo Clin Proc 2004; 79(12):1585-1591.
10. Antidote in depth - Prussian blue. Goldfrank's Toxicologic Emergencies, 8th ed. McGraw-Hill Companies; 2006:1373-1377.
11. Lipsztein JL, Bertelli L, Oliveira CA, Dantas BM. Studies of Cs retention in human body related to body parameters and Prussian blue administration. Health Phys 1991; 60(1):57-61.
12. Zhang S. Isolation and characterization of IKr in cardiac myocytes by Cs+ permeation. Am J Physiol Heart Circ Physiol 2006; 290:H1038-H1049.
13. Centeno JA, Pestaner JP, Omalu BI, Torres NL, Field F, Wagner G, Mullick FG. Blood and tissue concentration of cesium after exposure to cesium chloride: a report of two cases. Biol Trace Elem Res 2003; 94(2):97-104.
14. Leggett RW, Williams LR, Melo DR, Lipsztein JL. A physiological based biokinetic model for cesium in the human body. Sci Total Environ 2003; 317:235-255.