Phase II study of calcitriol-enhanced docetaxel in patients with previously untreated metastatic or locally advanced pancreatic cancer

Investigational New Drugs

Volumn 27, Issue 4, 2009, Pages 374-378

  Blanke, C D ^a   Beer, T M ^b   Todd, K ^b   Mori, M ^b   Stone, M ^c   Lopez, C ^b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c Hillsboro Oncology and Hematology   (United States)

Author keywords

Calcitriol; Chemotherapy; Pancreatic cancer

Indexed keywords

CALCITRIOL; CALCIUM; DEXAMETHASONE; DOCETAXEL;

ADULT; ADVANCED CANCER; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANOREXIA; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; BONE MARROW SUPPRESSION; CALCIUM INTAKE; CANCER CHEMOTHERAPY; CANCER GROWTH; CANCER SURVIVAL; CLINICAL ARTICLE; CLINICAL TRIAL; COGNITIVE DEFECT; COMPUTER ASSISTED TOMOGRAPHY; DIARRHEA; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG HYPERSENSITIVITY; DRUG INTERMITTENT THERAPY; DRUG MECHANISM; DRUG MEGADOSE; DRUG POTENTIATION; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; DYSPNEA; FATIGUE; FEBRILE NEUTROPENIA; FEMALE; FLUID INTAKE; HUMAN; HYPERCALCEMIA; HYPERGLYCEMIA; INFECTION; MALE; METASTASIS; MULTIPLE CYCLE TREATMENT; NAUSEA; NEUTROPENIA; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PANCREAS ADENOCARCINOMA; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; SIDE EFFECT; THROMBOCYTOPENIA; THROMBOSIS; TREATMENT RESPONSE;

ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS; CALCITRIOL; CALCIUM CHANNEL AGONISTS; CALCIUM, DIETARY; DISEASE PROGRESSION; DRUG THERAPY, COMBINATION; FATIGUE; FEMALE; HUMANS; HYPERGLYCEMIA; MALE; MIDDLE AGED; PANCREATIC NEOPLASMS; SURVIVAL RATE; TAXOIDS; TREATMENT OUTCOME;

EID: 67651156227     PISSN: 01676997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10637-008-9184-6     Document Type: Article

References (20)

1. MJ Moore D Goldstein J Hamm 2007 Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group J Clin Oncol 25 1960 1966. doi:10.1200/JCO.2006.07.9525
2. R Lenzi S Yalcin DB Evans 2002 Phase II study of docetaxel in patients with pancreatic cancer previously untreated with cytotoxic chemotherapy Cancer Invest 20 464 472. doi:10.1081/CNV-120002146
3. P Rougier A Adenis M Ducreux 2000 A phase II study: docetaxel as first-line chemotherapy for advanced pancreatic adenocarcinoma Eur J Cancer 36 1016 1025.doi:10.1016/S0959-8049(00)00072-1
4. S Okada Y Sakata S Matsuno 1999 Phase II study of docetaxel in patients with metastatic pancreatic cancer: a Japanese cooperative study Br J Cancer 80 438 443. doi:10.1038/sj.bjc.6690375
5. QM Wang JB Jones GP Studzinski 1996 Cyclin-dependent kinase inhibitor p27 as a mediator of the G1-S phase block induced by 1,25-dihydroxyvitamin D3 in HL60 cells Cancer Res 56 264 267 (Pubitemid 26026352)
6. M Liu MH Lee M Cohen 1996 Transcriptional activation of the Cdk inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937 Genes Dev 10 142 153. doi:10.1101/gad.10.2.142 (Pubitemid 26049905)
7. PA Hershberger WD Yu RA Modzelewski 2001 Calcitriol (1,25- dihydroxycholecalciferol) enhances paclitaxel antitumor activity in vitro and in vivo and accelerates paclitaxel-induced apoptosis Clin Cancer Res 7 1043 1051 (Pubitemid 32708744)
8. F Pettersson KW Colston AG Dalgleish 2000 Differential and antagonistic effects of 9-cis-retinoic acid and vitamin D analogues on pancreatic cancer cells in vitro Br J Cancer 83 239 245. doi:10.1054/bjoc.2000.1281 (Pubitemid 30411724)
9. TM Beer KM Hough M Garzotto 2001 Weekly high-dose calcitriol and docetaxel in advanced prostate cancer Semin Oncol 28 49 55. doi:10.1016/S0093- 7754(01)90155-1 (Pubitemid 32947552)
10. TM Beer M Munar WD Henner 2001 A phase I trial of pulse calcitriol in patients with refractory malignancies: pulse dosing permits substantial dose escalation Cancer 91 2431 2439. doi:10.1002/1097-0142(20010615)91:122431::AID- CNCR12783.0.CO;2-3 (Pubitemid 32552832)
11. TM Beer CW Ryan PM Venner 2007 Double-blinded randomized study of high-dose calcitriol plus docetaxel compared with placebo plus docetaxel in androgen-independent prostate cancer: a report from the ASCENT investigators J Clin Oncol 25 669 674. doi:10.1200/JCO.2006.06.8197
12. P Therasse SG Arbuck EA Eisenhauer 2000 New guidelines to evaluate the response to treatment in solid tumors J Natl Cancer Inst 92 205 216 (Pubitemid 30099779)
13. National Cancer Institute (1999) Cancer Therapy Evaluation Program: common toxicity criteria (version 2.0). National Cancer Institute, Bethesda
14. RC Shepard DE Levy JD Berlin 2004 Phase II study of gemcitabine in combination with docetaxel in patients with advanced pancreatic carcinoma (E1298). A trial of the Eastern Cooperative Oncology Group Oncology 66 303 309. doi:10.1159/000078331
15. JA Johnson JP Grande PC Roche 1994 Immunohistochemical localization of the 1,25(OH)2D3 receptor and calbindin D28k in human and rat pancreas Am J Physiol 267 E356 E360
16. K Iseki M Tatsuta H Uehara 1999 Inhibition of angiogenesis as a mechanism for nhibition y 1alpha-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 of colon carcinogenesis induced by zoxymethane in Wistar rats Int J Cancer 81 730 733. i:10.1002/(SICI)1097-0215(19990531)81:5730::AID-IJC113.0.CO;2-Q (Pubitemid 29214382)
17. K Wu D Feskanich CS Fuchs 2007 A nested case-control study of plasma 25-hydroxyvitamin D concentrations and risk of colorectal cancer J Natl Cancer Inst 99 1120 1129. doi:10.1093/jnci/djm038
18. JM Lappe D Travers-Gustafson KM Davies 2007 Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial Am J Clin Nutr 85 1586 1591. (Pubitemid 46890428)
19. TRJ Evans KW Colston FJ Lofts 2002 A phase II trial of the vitamin D analogue seocalcitol (EB1089) in patients with inoperable pancreatic cancer Br J Cancer 86 680 685. doi:10.1038/sj.bjc.6600162
20. Novacea (2007) Novacea halts ASCENT-2 trial in advanced prostate cancer (press release). http://www.novacea.com/610.asp?id=136&nav=news