Regulation of myometrial contractivity during pregnancy in the rat: Potential role for DDAH

Molecular Human Reproduction

Volumn 15, Issue 8, 2009, Pages 507-512

  Ito, Emiko ^a   Obayashi, Satoshi ^a   Nagai, Akiko ^a   Imamura, Masatoshi ^a   Azuma, Hiroshi ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

DDAH 1 and DDAH 2; Endothelin 1; MMA and ADMA; NO dependent cyclic GMP; NOS

Indexed keywords

CYCLIC GMP; DIMETHYLARGININASE; DIMETHYLARGININE DIMETHYLAMINOHYDROLASE 1; DIMETHYLARGININE DIMETHYLAMINOHYDROLASE 2; ENDOTHELIN 1; HYDROLASE; NITRIC OXIDE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; GESTATION PERIOD; MYOMETRIUM; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; RAT; UPREGULATION; UTERUS CONTRACTION; WESTERN BLOTTING;

AMIDOHYDROLASES; ANIMALS; ARGININE; BLOTTING, WESTERN; CYCLIC GMP; ENDOTHELIN-1; FEMALE; MYOMETRIUM; PREGNANCY; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; UTERINE CONTRACTION;

RATTUS;

EID: 67651152832     PISSN: 13609947     EISSN: 14602407     Source Type: Journal    
DOI: 10.1093/molehr/gap041     Document Type: Article

References (29)

1. Ayling LJ, Whitley GS, Aplin JD, Cartwright JE. Dimethylarginine dimethylaminohydrolase (DDAH) regulates trophoblast invasion and motility through effects on nitric oxide. Hum Reprod 2006;21 2530-2537.
2. Azuma H, Sato J, Hamasaki H, Sugimoto A, Isotani E, Obayashi S. Accumulation of endogenous inhibitors for nitric oxide synthesis and decreased content of L-arginine in regenerated endothelial cells. Br J Pharmacol 1995;115:1001-1004.
3. Azuma H, Masuda H, Sato J, Niwa K, Tokoro T. A possible role of endogenous inhibitors for nitric oxide synthesis in the bovine ciliary muscle. Exp Eye Res 1997;64:823-830.
4. Beppu M, Obayashi S, Aso T, Goto M, Azuma H. Endogenous nitric oxide synthase inhibitors in endothelial cells, endothelin-1 within the vessel wall and intimal hyperplasia in perimenopausal human uterine arteries. J Cardiovasc Pharmacol 2002;39:192-200.
5. 2alpha) are controlled by progesterone in the rat uterus during pregnancy. J Steroid Biochem Mol Biol 2004;91:211-218.
6. Hamasaki H, Sato J, Masuda H, Tamaoki S, Isotani E, Obayashi S, Udagawa T, Azuma H. Effect of nicotine on the intimal hyperplasia after endothelial removal of the rabbit carotid artery. Gen Pharmacol 1997;28:653-659.
7. Hennan JK, Diamond J. Evidence that spontaneous contractile activity in the rat myometrium is not inhibited by NO-mediated increases in tissue level of cyclic GMP. Br J Pharmacol 1998;123:959-967.
8. Hennan JK, Diamond J. Effect of NO donors on protein phosphorylation in intact vascular and nonvascular smooth muscles. Am J Physiol 2001; 280:H1565-H1580.
9. Hirata M, Obayashi S, Sakamoto S, Aso T, Imamura M, Azuma H. Involvement of arginase in regulating myometrial contractions during gestation in the rat. Mol Hum Reprod 2006;12:513-518.
10. Holden DP, Cartwright JE, Nussey SS, Whitley G. Estrogen stimulates dimethylarginine dimethylaminohydrolase activity and the metabolism of asymmetric dimethylarginine. Circulation 2003;108:1575-1580.
11. Ito A, Tsao PS, Adimoolam S, Kimoto M, Ogawa T, Cooke JP. Novel mechanism for endothelial dysfunction: Dysregulation of dimethylarginine dimethylaminohydrolase. Circulation 1999;99:3092-3095.
12. Izumi H, Yallampalli C, Gar.eld RE. Gestational changes in L-arginine-induced relaxation of pregnant rat and human myometrial smooth muscle. Am J Obstet Gynecol 1993;169:1327-1337.
13. Jiang JL, Zhang XH, Li NS, Rang WQ, Feng Y, Hu CP, Li YJ, Deng HW. Probucol decreases asymmetric dimethylarginine levels by alteration of protein arginine methyltransferase I and dimethylarginine dimethylaminohydrolase activity. Cardiovasc Drugs Ther 2006;20 281-294.
14. Kaya T, Cetin A, Sarioglu Y. Changes in the nitric oxide system of rat myometrium during mid-gestation and delivery at term. Pharmacol Res 1998;37:403-408.
15. Leiper JM, MacAllister RJ, Whitley GS, Santa Maria J, Chubb A, Charles I, Vallance P. Identification of two human dimethylarginine dimethylaminohydrolase with distinct tissue distributions and homology with microbial arginine deiminases. Biochem J 1999;343 209-214.
16. MacAllister RJ, Parry H, Kimoto M, Ogawa T, Russel RJ, Hodson H, Whitley GS, Vallance P. Regulation of nitric oxide synthesis by dimethylarginine dimethylaminohydrolase. Br J Pharmacol 1996;11: 2449-2452.
17. Momohara Y, Sakamoto S, Obayashi S, Aso T, Goto M, Azuma H. Roles of endogenous nitric oxide synthase inhibitors and endothelin-1 for regulating myometrial contractions during gestation in the rat. Mol Hum Reprod 2004;10:505-512.
18. Monsalve E, Oviedo PJ, Garcia-Perez MA, Tarin JJ, Cano A, Hermenegildo C. Estradiol counteracts oxidized LDL-induced asymmetric dimethylarginine production by cultured human endothelial cells. Cardiovasc Res 2007;73:66-72.
19. Nijveldt RJ, Teerlink T, Siroen MPC, van Lambalgen AA, Rauwerda JA, van Leeuwen PAM. The liver is an important organ in the metabolism of asymmetric dimethylarginine (ADMA). Clin Nutr 2003; 22:17-22.
20. G-dimethylarginine dimethylaminohydrolase, from rat kidney. J Biol Chem 1989;264:10205-10209.
21. Sakamoto S, Aso T, Masuda H, Goto M, Tamaoki S, Azuma H. Gestational changes in endothelin-1-induced receptors and myometrial contractions in rat. Mol Hum Reprod 1999;5:270-276.
22. Sakurada M, Shichiri M, Imamura M, Azuma H, Hirata Y. Nitric oxide upregulates dimethylarginine dimethylaminohydrolase-2 via cyclic GMP induction in endothelial cells. Hypertension 2008;52:903-909.
23. Sasaki A, Doi S, Mizutani S, Azuma H. Roles of accumulated endogenous nitric oxide synthase inhibitors, enhanced arginase activity, and attenuated nitric oxide synthase activity in endothelial cells for pulmonary hypertension in rats. Am J Physiol 2007;292 L1480-L1487.
24. Sorrenti V, Mazza F, Campisi A, Vanella L, Volti G, Di Giacomo C. High glucose-mediated imbalance of nitric oxide synthase and dimethylarginine dimethylaminohydrolase expression in endothelial cells. Curr Neurovasc Res 2006;3:49-54.
25. Tojo A, Welch WJ, Bremer V, Kimoto M, Kimura K, Omata M, Ogawa T, Vallance P, Wilcox CS. Colocalozation of dimethylating enzymes and NOS and functional effects of methylarginines in rat kidney. Kidney Int 1997;52:1593-1601.
26. Watson J, Anderson FB, Alam M, O'Grady JE, Heald PJ. Plasma hormones and pituitary luteinizing hormone in the rat during the early stages of pregnancy and after post-coital treatment with tamoxifen. J Endocrinol 1975;65:7-17.
27. Word RA, Cornwell TL. Regulation of cGMP-induced relaxation and cGMP-dependent protein kinase in rat myometrium during pregnancy. Am J Physiol 1998;274:C748-C756.
28. Xin HY, Jiang DJ, Jia SJ, Song K, Wang GP, Li YJ, Chen FP. Regulation by DDAH/ADMA pathway of lipopolysaccharide-induced tissue factor expression in endothelial cells. Thromb Haemost 2007;97: 830-838.
29. Yang TL, Chen MF, Luo BL, Xie QY, Jiang JL, Li YJ. Fenofibrate decreases asymmetric dimethylarginine level in cultured endothelial cells by inhibiting NF-kappaB activity. Naunyn Schmiedebergs Arch Pharmacol 2005;371:401-407.