Efficacy of arbidol on lethal hantaan virus infections in suckling mice and in vitro

Acta Pharmacologica Sinica

Volumn 30, Issue 7, 2009, Pages 1015-1024

  Deng, Hai Ying ^a,b   Luo, Fan ^a   Shi, Li Qiao ^a   Zhong, Qiong ^a   Liu, Ying Juan ^a   Yang, Zhan Qiu ^a  

^a WUHAN UNIVERSITY   (China)

^b WUHAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ARBIDOL; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; HANTAVIRUS; HISTOPATHOLOGY; IC 50; LD 50; MOUSE; NONHUMAN; SUCKLING; SURVIVAL RATE; VIRUS INFECTION; VIRUS INHIBITION; VIRUS LOAD;

ANIMALS; ANIMALS, NEWBORN; ANIMALS, SUCKLING; ANTIVIRAL AGENTS; BRAIN; CELL LINE; FEMALE; HANTAAN VIRUS; HEMORRHAGIC FEVER WITH RENAL SYNDROME; HUMANS; IMMUNOLOGIC FACTORS; INDOLES; KIDNEY; LETHAL DOSE 50; LUNG; MICE; MICE, INBRED BALB C; PLACEBOS; PREGNANCY; RANDOM ALLOCATION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 67651151279     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2009.53     Document Type: Article

References (34)

1. Kruger DH, Urich R, Lundkvist A. Hantavirus infections and their prevention. Microbes Infect 2001; 3: 1129-44.
2. Muranyi W, Bahr U, Zeier M, van der Woude FJ. Hantavirus infection. J Am Soc Nephrol 2005; 16: 3669-79.
3. Lee HW. Epidemiology and pathogenesis of hemorrhagic fever with renal syndrome. In: Elliott RM, editor. The Bunyaviridae. New York (NY): Plenum Press; 1996. p253-67.
4. Schmaljohn C, Hjelle B. Hantaviruses-A global disease problem. Emerg Infect Dis 1997; 3: 95-104.
5. Borio L, Inglesby T, Peters CJ, Schmaljohn AL, Hughes JM, Jahrling PB, et al. Hemorrhagic fever viruses as biological weapons: medical and public health management. JAMA 2002; 287: 2391-405.
6. Kanerva M, Mustonen J, Vaheri A. Pathogenesis of Puumala and other Hantavirus infections. Rev Med Virol 1998; 8: 95-104.
7. Klempa B, Stanko M, Labuda M, Ulrich R, Meisel H, Kruger DH. Central European Dobrava Hantavirus isolate from a striped field mouse (Apodemus agrarius). J Clin Microbiol 2005; 43: 2756-63.
8. Hooper J, Li D. Vaccines against Hantaviruses. Curr Top Microbiol Immunol 2001; 256: 171-91.
9. Robert W Sidwell, Smee DF. Viruses of the Bunya- and Togaviridae families: potential as bioterrorism agents and means of control. Antiviral Res 2003; 57: 101-11.
10. Huggins JW, Hsiang CM, Cosgriff TM, Guang MY, Smith JI, Wu ZO, et al. Prospective, double-blind, concurrent, placebo-controlled clinical trial of intravenous ribavirin therapy of hemorrhagic fever with renal syndrome. J Infect Dis 1991; 164: 1119-27.
11. Chapman LE, Mertz GJ, Peters CJ. Intravenous ribavirin for hantavirus pulmonary syndrome: safety and tolerance during 1 year of open-label experience. Ribavirin Study Group. Antiviral Ther 1999; 4: 211-9.
12. Salmon-Céron D, Chauvelot-Moachon L, Abad S, Silbermann B, Sogni P. Mitochondrial toxic effects and ribavirin. Lancet 2001; 357: 1803-4.
13. Ohnson EM. Developmental toxicity and safety evaluations of ribavirin. Pediatr J Infect Dis 1990; 9: S85-7.
14. Glushkov RG, Gus'kova TA, Krylova LI, Nikolaeva IS. Mechanisms of arbidole's immunomodulating action. Vestn Ross Akad Med Nauk 1999; 3: 36-40. In Russian.
15. Shi LQ, Xiong HR, He J, Deng HY, Li Q, Zhong Q, et al. Antiviral activity of arbidol against infuenza A virus, respiratory syncytial virus, rhinovirus, coxsackie virus and adenovirus in vitro and in vivo. Arch Virol 2007; 152: 1447-55.
16. Boriskin YS, Pecheur EI, Polyak SJ. Arbidol: a broad-spectrum antiviral that inhibits acute and chronic HCV infection. Virol J 2006; 3: 56.
17. Brooks MJ, Sasadeusz JJ, Tannock GA. Antiviral chemotherapeutic agents against respiratory viruses: where are we now and what's in pipeline? Curr Opin Pulm Med 2004; 10: 197-203.
18. Denizot F, Lang R. Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. J Immunol Methods 1986; 89: 271-7.
19. Severson WE, Schmaljohn CS, Javadian A, Jonsson CB. Ribavirin causes error catastrophe during Hantaan virus replication. J Virol 2003; 77: 481-8.
20. Liu YJ, Yang ZQ, Deng HY, Xiao H, Qu CF. Separation and anti-hantaan virus activity of extracts from alternanthera philoxcroides in vitro and in vivo. J Wuhan Univ (Nat Sci) 2007; 12: 1143-7.
21. Diaz MO, Ziemin S, Lebeau MM, Pitha P, Smith SD, Chilcote RR, et al. Homozygous deletion of the alpha-interferon and beta-1-interferon genes in human leukemia and derived cell lines. Proc Natl Acad Sci USA 1988; 85: 5259-63.
22. Lee PW, Amyx HL, Gibbs CJ Jr, Gajdusek DC, Lee HW. Propagation of Korean hemorrhagic fever virus in laboratory rats. Infect Immun 1981; 31: 334-8.
23. Yoshimatsu K, Arikawa J, Ohbora S, Itakura C. Hantavirus infection in SCID mice. J Vet Med Sci 1997; 59: 863-8.
24. Brian BG, Michael RH. Animal models of highly pathogenic RNA viral infections: Hemorrhagic fever viruses. Antiviral Res 2008; 78: 79-90.
25. Gum RK, Kelly T, Mckee JR. Pathogenesis of Hantaan virus infection in suckling mice: clinical, virologic, and serologic observations. Am J Trop Med Hyg 1985; 34: 388-95.
26. Yamanouchi T, Domae K, Tanishita O, Takahashi Y, Yamanishi K, Takahashi M, et al. Experimental infection in newborn mice and rats by hemorrhagic fever with renal syndrome (HFRS) virus. Microbiol Immunol 1984; 28: 1345-53.
27. Huggins JW, Kim GR, Brand OM, McKee KT Jr. Ribavirin therapy for Hantaan virus infection in suckling mice. J Infect Dis 1986; 153: 489-97.
28. Linderholm M, Ahlm C, Settergren B, Waage A, Tarnvik A. Elevated plasma levels of tumor necrosis factor (TNF)-alpha soluble TNF receptors interleukin (IL)-6 and IL-10 in patients with hemorrhagic fever with renal syndrome. J Infect Dis 1996; 173: 38-43.
29. Niikura M, Maeda A, Ikegami T, Saijo M, Kurane I, Morikawa S. Modifcation of endothelial cell functions by Hantaan virus infection: prolonged hyper-permeability induced by TNF-alpha of Hantaan virusinfected endothelial cell monolayers. Arch Virol 2004; 149: 1279-92.
30. Wei XW, Gong JF, Zhu J, Wang PF, Li N, Zhu WM, et al. The suppressive effect of triptolide on chronic colitis and TNF-α/TNFR2 signal pathway in interleukin-10 defcient mice. Clin Immunol 2008; 129: 211-8.
31. Strandin T, Hepojoki J, Wang H, Vaheri A, Lankinen H. Hantaviruses and TNF-alpha act synergistically to induce ERK1/2 inactivation in Vero E6 cells. Virol J 2008; 5: 110.
32. Wajant H, Pfzenmaier K, Scheurich P. Tumor necrosis factor signaling. Cell Death Differ 2003; 10: 45-65.
33. Krogerus L, Soots A, Loginov R, Bruggeman C, Lautenschlager I. CMV increases tubular apoptosis through the TNF-α-TNF-R1 pathway in a rat model of chronic renal allograft rejection. Transplant Immunol 2008; 18: 232-6.
34. Temonen M, Lankinen H, Vapalahti L, Ronni T, Julkunen I, Vaheri A. Effect of interferon-α and cell differentiation on Puumala virus infection in human monocyte/macrophages. Virology 1995; 206: 8-15.