Plasmodium berghei HAP2 induces strong malaria transmission-blocking immunity in vivo and in vitro

Vaccine

Volumn 27, Issue 38, 2009, Pages 5187-5194

  Blagborough, Andrew M ^a   Sinden, Robert E ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Fertilization; HAP2; Male gamete; Plasmodium berghei; Transmission blocking

Indexed keywords

ANTISERUM; HAP2 PROTEIN; MALARIA VACCINE; PROTOZOAL PROTEIN; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; BIOASSAY; CONTROLLED STUDY; ESCHERICHIA COLI; FEEDING; FEMALE; FERTILIZATION; GAMETE; GENE DISRUPTION; GENE LOCUS; HETEROLOGOUS EXPRESSION; HOST; IMMUNITY; IMMUNIZATION; IN VITRO STUDY; IN VIVO STUDY; MALARIA; MALE; MOSQUITO; MOUSE; NONHUMAN; OOCYST; PARASITE TRANSMISSION; PLASMODIUM BERGHEI; PLASMODIUM BERGHEI INFECTION; PREVALENCE; PRIORITY JOURNAL; RABBIT; REVIEW;

ANIMALS; ANOPHELES; ANTIBODIES, PROTOZOAN; DNA, PROTOZOAN; ESCHERICHIA COLI; FEMALE; GENES, PROTOZOAN; GERM CELLS; INSECT VECTORS; MALARIA; MALARIA VACCINES; MICE; PLASMODIUM BERGHEI; PROTOZOAN PROTEINS; RABBITS;

EID: 67651151027     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2009.06.069     Document Type: Review

References (42)

1. Aregawi M, Cibulskis R, Otten M, Williams R, Dye C. World Health Organisation. World Malaria Report; 2008.
2. Sinden R.E., Butcher G.A., Billker O., and Fleck S.L. Regulation of infectivity of Plasmodium to the mosquito vector. Adv Parasitol 38 (1996) 54-117
3. Grotendorst C.A., Carter R., Rosenberg R., and Koontz L.C. Complement effects on the infectivity of Plasmodium gallinaceum to Aedes aegypti mosquitoes. I. Resistance of zygotes to the alternative pathway of complement. J Immunol 136 11 (1986) 4270-4274
4. Kaslow D.C., Bathurst I.C., and Barr P.J. Malaria transmission-blocking vaccines. Trends Biotechnol 10 11 (1992) 388-391
5. Vermeulen A.N., Ponnudurai T., Beckers P.J., Verhave J.P., Smits M.A., and Meuwissen J.H. Sequential expression of antigens on sexual stages of Plasmodium falciparum accessible to transmission-blocking antibodies in the mosquito. J Exp Med 162 5 (1985) 1460-1476
6. Ranawaka G., Fleck S.L., Alejo-Blanco A., and Sinden R.E. Characterisation of the modes of action of anti Pbs21 malaria transmission-blocking immunity upon ookinete to oocyst differentiation in vivo. Parasitology 109 4 (1994) 403-411
7. Carter R., Mendis K.N., Miller L.H., Molineaux L., and Saul A. Malaria transmission blocking vaccines: how can their development be supported?. Nat Med 6 (2000) 241-244
8. Kaslow D.C. Transmission-blocking vaccines. Chem Immunol 80 (2002) 287-307
9. van Dijk M.R., Janse C.J., Thompson J., Waters A.P., Braks J.A., Dodemont H.J., et al. A central role for P48/45 in malaria parasite male gamete fertility. Cell 104 (2001) 153-164
10. Outchkourouv N.S., Roeffen W., Kaan A., Jansen J., Luty A., Schuiffel D., et al. Correctly folded Pfs48/45 protein of Plasmodium falciparum elicits malaria transmission blocking immunity in mice. PNAS 105 (2008) 4301-4305
11. Roeffen W., Lensen T., Mulder B., Teelen K., Sauerwein R., Van Druten J., et al. A comparison of transmission-blocking activity with reactivity in a Plasmodium falciparum 48/45-kDa molecule-specific competition enzyme-linked immunosorbent assay. Am J Trop Med Hyg 52 (1995) 60-65
12. Bousema J.T., Drakeley C.J., Kihonda J., Hendriks J.C., Akim N.I., Roeffen W., et al. A longitudinal study of immune responses to Plasmodium falciparum sexual stage antigens in Tanzanian adults. Parasite Immunol 29 (2007) 306-317
13. Eksi S., and Williamson K.C. Male-specific expression of the paralog of malaria transmission-blocking target antigen Pfs230, PfB0400w. Mol Biochem Parasitol 122 July (2) (2002) 127-130
14. Eksi S., Czesny B., van Gemert G.J., Sauerwein R.W., Eling W., and Williamson K.C. Malaria transmission-blocking antigen, Pfs230, mediates human red blood cell binding to exflagellating male parasites and oocyst production. Mol Microbiol 61 4 (2006 Aug) 991-998
15. Kaslow D.C. Transmission blocking vaccines. In: Hoffman S.L. (Ed). Malaria vaccine development (1996), ASM Press, Washington, DC 181-228
16. Tomas A.M., Marcos G., Dimopoulous G., van Lin L.H.M., de Koning-Ward T.F., Sinha R., et al. P25 and P38 proteins of the malaria ookinete surface have multiple and partially redundant functions. EMBO J 20 (2001) 3975-3983
17. Hisaeda H., Collins W.E., Saul A., and Stowers A.W. Antibodies to Plasmodium vivax transmission-blocking vaccine candidate antigens Pv25 and Pvs28 do not show synergism. Vaccine 20 5/6 (2001) 763-770
18. Malkin E.M., Durbin A.P., Diemert D.J., Sattabongkot J., Wu Y., Miura K., et al. Phase I clinical trial of Pvs25H: a transmission blocking vaccine for Plasmodium vivax malaria. Vaccine 23 (2005) 3131-3138
19. Stowers A., and Carter R. Current developments in malaria transmission-blocking vaccines. Expert Opin Biol Ther 1 (2001) 619-628
20. Johnson M.A., von Besser K., Zhou Q., Smith E., Aux G., Patton D., et al. Arabidopsis hapless mutations define essential gametophytic functions. Genetics 168 (2004) 971-982
21. Mori T., Kuroiwa H., Higashiyama T., and Kuroiwa T. Generative cell specific 1 is essential for angiosperm fertilization. Nat Cell Biol 8 (2006) 64-71
22. Liu Y., Tewari R., Ning J., Blagborough A.M., Garbom S., Pei J., et al. The conserved plant sterility gene HAP2 functions after attachment of fusogenic membranes in Chlamydomonas and Plasmodium gametes. Genes Dev 22 April (8) (2008) 1051-1068
23. Sinden R.E. Molecular interactions between Plasmodium and its insect vectors. Cell Microbiol 4 (2002) 713-724
24. Beetsma A.L., van de Wiel T.J., Sauerwein R.W., and Eling W.M. Plasmodium berghei ANKA: purification of large numbers of infectious gametocytes. Exp Parasitol 88 January (1) (1998) 69-72
25. Billker O., Shaw M.K., Margo G., and Sinden R.E. The roles of temperature, pH and mosquito factors as triggers of male and female gametogenesis of Plasmodium berghei in vitro. Parasitology 115 (2007) 1-7
26. Carter R., and Chen D.H. Malaria transmission blocked by immunisation with gametes of the malaria parasite. Nature 263 September (5572) (1976) 57-60
27. Donnelly M.I., Zhou M., Millard C.S., Clancy S., Stols L., Eschenfeldt W.H., et al. An expression vector tailored for large-scale, high-throughput purification of recombinant proteins. Protein Exp Purif 47 June (2) (2006) 446-454
28. Vaid A., and Sharma P. PfPKB, a protein kinase B-like enzyme from Plasmodium falciparum: II. Identification of calcium/calmodulin as its upstream activator and dissection of a novel signaling pathway. J Biol Chem 281 September (37) (2006) 27126-27133
29. Reininger L., Billker O., Tewari R., Mukhopadhyay A., Fennell C., Dorin-Semblat D., et al. A 38 nima-related protein kinase is essential for completion of the sexual cycle of malaria parasites. J Biol Chem 280 (2005) 31957-31964
30. Sinden R.E. Infection of mosquitoes with rodent malaria. In: Crampton J.M., Beard C.B., and Louis C. (Eds). Molecular biology of inset disease vectors: a methods manual (1996), Chapman & Hall, London, UK 67-91
31. Cinquin O., Christopherson R.I., and Menz R.I. A hybrid plasmid for expression of toxic malarial proteins in Escherichia coli. Mol Biochem Parasitol 117 October (2) (2001) 245-247
32. Peiris J.S., Premawansa S., Ranawaka M.B., Udagama P.V., Munasinghe Y.D., Nanayakkara M.V., et al. Monoclonal and polyclonal antibodies both block and enhance transmission of human Plasmodium vivax malaria. Am J Trop Med Hyg 39 July (1) (1988) 26-32
33. Tirawanchai N., Winger L.A., Nicholas J., and Sinden R.E. Analysis of immunity induced by the affinity-purified 21-kilodalton zygote-ookinete surface antigen of Plasmodium berghei. Infect Immun 59 January (1) (1991) 36-44
34. Scholz S.M., Simon N., Lavazec C., Dude M.A., Templeton T.J., and Pradel G. PfCCp proteins of Plasmodium falciparum: gametocyte-specific expression and role in complement-mediated inhibition of exflagellation. Int J Parasitol 38 March (3/4) (2008) 327-340
35. Munesinghe Y.D., Mendis K.N., and Carter R. Anti-gamete antibodies block transmission of human vivax malaria to mosquitoes. Parasite Immunol 8 May (3) (1986) 231-238
36. Outchkourov N., Vermunt A., Jansen J., Kaan A., Roeffen W., Teelen K., et al. Epitope analysis of the malaria surface antigen Pfs48/45 identifies a subdomain that elicits transmission blocking antibodies. J Biol Chem 282 June (23) (2007) 17148-17156
37. Williamson K.C., Keister D.B., Muratova O., and Kaslow D.C. Recombinant Pfs230, a Plasmodium falciparum gametocyte protein, induces antisera that reduce the infectivity of Plasmodium falciparum to mosquitoes. Mol Biochem Parasitol 75 December (1) (1995) 33-42
38. Carter R. Transmission blocking malaria vaccines. Vaccine 19 March (17/19) (2001) 2309-2314
39. Tirawanchai N., Winger L.A., Nicholas J., and Sinden R.E. Analysis of immunity induced by the affinity-purified 21-kilodalton zygote-ookinete surface antigen of Plasmodium berghei. Infect Immun 59 1 (1991) 36-44
40. Winger L.A., Tirawanchai N., Nicholas J., Carter H.E., Smith J.E., and Sinden R.E. Ookinete antigens of Plasmodium berghei. Appearance on the zygote surface of an Mr 21 kDa determinant identified by transmission-blocking monoclonal antibodies. Parasite Immunol 10 March (2) (1988) 193-207
41. Healer J., McGuinness D., Hopcroft P., Haley S., Carter R., and Riley E. Complement-mediated lysis of Plasmodium falciparum gametes by malaria-immune human sera is associated with antibodies to the gamete surface antigen Pfs230. Infect Immun 65 August (8) (1997) 3017-3023
42. Wu Y., Ellis R.D., Shaffer D., Fontes E., Malkin E.M., Mahanty S., et al. Phase 1 trial of malaria transmission blocking vaccine candidates Pfs25 and Pvs25 formulated with montanide ISA 51. PLoS ONE 3 July (7) (2008) e2636