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Volumn , Issue , 2008, Pages 139-152

SOST/Sclerostin: An Osteocyte-Derived Inhibitor of Bone Formation that Antagonizes Canonical Wnt Signaling

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EID: 67651141761     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-373884-4.00014-8     Document Type: Chapter
Times cited : (8)

References (79)
  • 1
    • 20344398197 scopus 로고    scopus 로고
    • Reduced affinity to and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutations in LRP5 affect canonical Wnt signaling
    • M. Ai, S.L. Holmen, W. Van Hul, B.O. Williams and M.L. Warman (2005) Reduced affinity to and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutations in LRP5 affect canonical Wnt signaling. Mol. Cell Biol 25 4946-4955.
    • (2005) Mol. Cell Biol , vol.25 , pp. 4946-4955
    • Ai, M.1    Holmen, S.L.2    Van Hul, W.3    Williams, B.O.4    Warman, M.L.5
  • 2
    • 0347916881 scopus 로고    scopus 로고
    • Comparative genomic analysis of the eight-membered ring cystine knot-containing bone morphogenetic protein antagonists
    • O. Avsian-Kretchmer and A.J. Hsueh (2004) Comparative genomic analysis of the eight-membered ring cystine knot-containing bone morphogenetic protein antagonists. Mol. Endocrinol 18 1-12.
    • (2004) Mol. Endocrinol , vol.18 , pp. 1-12
    • Avsian-Kretchmer, O.1    Hsueh, A.J.2
  • 3
    • 20444383901 scopus 로고    scopus 로고
    • A generalized skeletal hyperostosis in two siblings caused by a novel mutation in the SOST gene
    • W. Balemans, E. Cleiren, U. Siebers, J. Horst and W. Van Hul (2005) A generalized skeletal hyperostosis in two siblings caused by a novel mutation in the SOST gene. Bone 36 943-947.
    • (2005) Bone , vol.36 , pp. 943-947
    • Balemans, W.1    Cleiren, E.2    Siebers, U.3    Horst, J.4    Van Hul, W.5
  • 4
    • 34447526757 scopus 로고    scopus 로고
    • Novel LRP5 missense mutation in a patient with a high bone mass phenotype results in decreased DKK1-mediated inhibition of Wnt signaling
    • W. Balemans, J.P. Devogelaer, E. Cleiren, E. Piters, E. Caussin and W. Van Hul (2007) Novel LRP5 missense mutation in a patient with a high bone mass phenotype results in decreased DKK1-mediated inhibition of Wnt signaling. J. Bone Miner. Res 22 708-716.
    • (2007) J. Bone Miner. Res , vol.22 , pp. 708-716
    • Balemans, W.1    Devogelaer, J.P.2    Cleiren, E.3    Piters, E.4    Caussin, E.5    Van Hul, W.6
  • 7
    • 34250840514 scopus 로고    scopus 로고
    • The genetics of low-density lipoprotein receptor-related protein 5 in bone: a story of extremes
    • W. Balemans and W. Van Hul (2007) The genetics of low-density lipoprotein receptor-related protein 5 in bone: a story of extremes. Endocrinology 148 2622-2629.
    • (2007) Endocrinology , vol.148 , pp. 2622-2629
    • Balemans, W.1    Van Hul, W.2
  • 9
    • 0023970128 scopus 로고
    • Sclerosteosis
    • P. Beighton (1988) Sclerosteosis. J. Med. Genet 25 200-203.
    • (1988) J. Med. Genet , vol.25 , pp. 200-203
    • Beighton, P.1
  • 10
    • 0021289072 scopus 로고
    • The syndromic status of sclerosteosis and van Buchem disease
    • P. Beighton, A. Barnard, H. Hamersma and W.A. van der (1984) The syndromic status of sclerosteosis and van Buchem disease. Clin. Genet 25 175-181.
    • (1984) Clin. Genet , vol.25 , pp. 175-181
    • Beighton, P.1    Barnard, A.2    Hamersma, H.3    van der, W.A.4
  • 11
    • 85147610012 scopus 로고    scopus 로고
    • Beighton, P., Hamersma, H., Brunkow, M. E. (2004). SOST-related sclerosting bone dysplasias. In “GeneReviews Genetics Disease Online Reviews at Gene-Test-Gene-Clinics” [database online] Available at
    • Beighton, P., Hamersma, H., Brunkow, M. E. (2004). SOST-related sclerosting bone dysplasias. In “GeneReviews Genetics Disease Online Reviews at Gene-Test-Gene-Clinics” [database online] Available at http://www.geneclinics.org.
  • 12
    • 0037386102 scopus 로고    scopus 로고
    • Cell fate specification and competence by Coco, a maternal BMP, TGFbeta and Wnt inhibitor
    • E. Bell, I. Munoz-Sanjuan, C.R. Altmann, A. Vonica and A.H. Brivanlou (2003) Cell fate specification and competence by Coco, a maternal BMP, TGFbeta and Wnt inhibitor. Development 130 1381-1389.
    • (2003) Development , vol.130 , pp. 1381-1389
    • Bell, E.1    Munoz-Sanjuan, I.2    Altmann, C.R.3    Vonica, A.4    Brivanlou, A.H.5
  • 13
    • 26844521277 scopus 로고    scopus 로고
    • Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: a novel mechanism for hormonal control of osteoblastogenesis
    • T. Bellido, A.A. Ali, I. Gubrij, L.I. Plotkin, Q. Fu, C.A. O’Brien, S.C. Manolagas and R.L. Jilka (2005) Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: a novel mechanism for hormonal control of osteoblastogenesis. Endocrinology 146 4577-4583.
    • (2005) Endocrinology , vol.146 , pp. 4577-4583
    • Bellido, T.1    Ali, A.A.2    Gubrij, I.3    Plotkin, L.I.4    Fu, Q.5    O’Brien, C.A.6    Manolagas, S.C.7    Jilka, R.L.8
  • 18
    • 0242668869 scopus 로고    scopus 로고
    • Bone morphogenetic proteins, their antagonists, and the skeleton
    • E. Canalis, A.N. Economides and E. Gazzerro (2003) Bone morphogenetic proteins, their antagonists, and the skeleton. Endocr. Rev 24 218-235.
    • (2003) Endocr. Rev , vol.24 , pp. 218-235
    • Canalis, E.1    Economides, A.N.2    Gazzerro, E.3
  • 19
    • 33746808398 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling in development and disease
    • H. Clevers (2006) Wnt/beta-catenin signaling in development and disease. Cell 127 469-480.
    • (2006) Cell , vol.127 , pp. 469-480
    • Clevers, H.1
  • 21
    • 33846449190 scopus 로고    scopus 로고
    • Bone density ligand, sclerostin, directly interacts with LRP5 but not LRP5(G171V) to modulate Wnt activity
    • D.L. Ellies, B. Viviano, J. McCarthy, J.P. Rey, N. Itasaki, S. Saunders and R. Krumlauf (2006) Bone density ligand, sclerostin, directly interacts with LRP5 but not LRP5(G171V) to modulate Wnt activity. J. Bone Miner. Res 21 1738-1749.
    • (2006) J. Bone Miner. Res , vol.21 , pp. 1738-1749
    • Ellies, D.L.1    Viviano, B.2    McCarthy, J.3    Rey, J.P.4    Itasaki, N.5    Saunders, S.6    Krumlauf, R.7
  • 23
    • 34250848174 scopus 로고    scopus 로고
    • In vivo analysis of Wnt signaling in bone
    • D.A. Glass and G. Karsenty (2007) In vivo analysis of Wnt signaling in bone. Endocrinology 148 2630-2634.
    • (2007) Endocrinology , vol.148 , pp. 2630-2634
    • Glass, D.A.1    Karsenty, G.2
  • 25
    • 0041630893 scopus 로고    scopus 로고
    • The natural history of sclerosteosis
    • H. Hamersma, J. Gardner and P. Beighton (2003) The natural history of sclerosteosis. Clin. Genet 63 192-197.
    • (2003) Clin. Genet , vol.63 , pp. 192-197
    • Hamersma, H.1    Gardner, J.2    Beighton, P.3
  • 26
    • 9344258590 scopus 로고    scopus 로고
    • Mechanotransduction and strain amplification in osteocyte cell processes
    • Y. Han, S.C. Cowin, M.B. Schaffler and S. Weinbaum (2004) Mechanotransduction and strain amplification in osteocyte cell processes. Proc. Natl. Acad. Sci. USA 101 16689-16694.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 16689-16694
    • Han, Y.1    Cowin, S.C.2    Schaffler, M.B.3    Weinbaum, S.4
  • 27
    • 20844449569 scopus 로고    scopus 로고
    • TOPGAL mice show that the canonical Wnt signaling pathway is active during bone development and growth and is activated by mechanical loading in vitro
    • J.R. Hens, K.M. Wilson, P. Dann, X. Chen, M.C. Horowitz and J.J. Wysolmerski (2005) TOPGAL mice show that the canonical Wnt signaling pathway is active during bone development and growth and is activated by mechanical loading in vitro. J. Bone Miner. Res 20 1103-1113.
    • (2005) J. Bone Miner. Res , vol.20 , pp. 1103-1113
    • Hens, J.R.1    Wilson, K.M.2    Dann, P.3    Chen, X.4    Horowitz, M.C.5    Wysolmerski, J.J.6
  • 32
    • 0034868049 scopus 로고    scopus 로고
    • Establishment of an osteoid preosteocyte-like cell MLO-A5 that spontaneously mineralizes in culture
    • Y. Kato, A. Boskey, L. Spevak, M. Dallas, M. Hori and L.F. Bonewald (2001) Establishment of an osteoid preosteocyte-like cell MLO-A5 that spontaneously mineralizes in culture. J. Bone Miner. Res 16 1622-1633.
    • (2001) J. Bone Miner. Res , vol.16 , pp. 1622-1633
    • Kato, Y.1    Boskey, A.2    Spevak, L.3    Dallas, M.4    Hori, M.5    Bonewald, L.F.6
  • 33
    • 21844467220 scopus 로고    scopus 로고
    • SOST is a target gene for PTH in bone
    • H. Keller and M. Kneissel (2005) SOST is a target gene for PTH in bone. Bone 37 148-158.
    • (2005) Bone , vol.37 , pp. 148-158
    • Keller, H.1    Kneissel, M.2
  • 34
    • 33846566222 scopus 로고    scopus 로고
    • Genetic variation at the low-density lipoprotein receptor-related protein 5 (LRP5) locus modulates Wnt signaling and the relationship of physical activity with bone mineral density in men
    • D.P. Kiel, S.L. Ferrari, L.A. Cupples, D. Karasik, D. Manen, A. Imamovic, A.G. Herbert and J. Dupuis (2007) Genetic variation at the low-density lipoprotein receptor-related protein 5 (LRP5) locus modulates Wnt signaling and the relationship of physical activity with bone mineral density in men. Bone 40 587-596.
    • (2007) Bone , vol.40 , pp. 587-596
    • Kiel, D.P.1    Ferrari, S.L.2    Cupples, L.A.3    Karasik, D.4    Manen, D.5    Imamovic, A.6    Herbert, A.G.7    Dupuis, J.8
  • 36
    • 0038267120 scopus 로고    scopus 로고
    • Sclerostin is a novel secreted osteoclast-derived bone morphogenetic protein antagonist with unique ligand specificity
    • N. Kusu, J. Laurikkala, M. Imanishi, H. Usui, M. Konishi, A. Miyake, I. Thesleff and N. Itoh (2003) Sclerostin is a novel secreted osteoclast-derived bone morphogenetic protein antagonist with unique ligand specificity. J. Biol. Chem. 278 24113-24117.
    • (2003) J. Biol. Chem. , vol.278 , pp. 24113-24117
    • Kusu, N.1    Laurikkala, J.2    Imanishi, M.3    Usui, H.4    Konishi, M.5    Miyake, A.6    Thesleff, I.7    Itoh, N.8
  • 37
    • 34548419640 scopus 로고    scopus 로고
    • Whole genome expression profiling reveals a significant role for immune function in human abdominal aortic aneurysms
    • G.M. Lenk, G. Tromp, S. Weinsheimer, Z. Gatalica, R. Berguer and H. Kuivaniemi (2007) Whole genome expression profiling reveals a significant role for immune function in human abdominal aortic aneurysms. BMC Genomics 8 237.
    • (2007) BMC Genomics , vol.8 , pp. 237
    • Lenk, G.M.1    Tromp, G.2    Weinsheimer, S.3    Gatalica, Z.4    Berguer, R.5    Kuivaniemi, H.6
  • 39
    • 17844411475 scopus 로고    scopus 로고
    • LRP5 mutations in osteoporosis-pseudoglioma syndrome and high-bone-mass disorders
    • R. Levasseur, D. LaCombe and M.C. De Vernejoul (2005) LRP5 mutations in osteoporosis-pseudoglioma syndrome and high-bone-mass disorders. Joint Bone Spine 72 207-214.
    • (2005) Joint Bone Spine , vol.72 , pp. 207-214
    • Levasseur, R.1    LaCombe, D.2    De Vernejoul, M.C.3
  • 44
    • 0035902050 scopus 로고    scopus 로고
    • LDL-receptor-related protein 6 is a receptor for Dickkopf proteins
    • B. Mao, W. Wu, Y. Li, D. Hoppe, P. Stannek, A. Glinka and C. Niehrs (2001) LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature 411 321-325.
    • (2001) Nature , vol.411 , pp. 321-325
    • Mao, B.1    Wu, W.2    Li, Y.3    Hoppe, D.4    Stannek, P.5    Glinka, A.6    Niehrs, C.7
  • 46
    • 4644227529 scopus 로고    scopus 로고
    • Spaciotemporal association and bone morphogenetic protein regulation of sclerostin and osterix expression during embryonic osteogenesis
    • Y. Ohyama, A. Nifuji, Y. Maeda, T. Amagasa and M. Noda (2004) Spaciotemporal association and bone morphogenetic protein regulation of sclerostin and osterix expression during embryonic osteogenesis. Endocrinology 145 4685-4692.
    • (2004) Endocrinology , vol.145 , pp. 4685-4692
    • Ohyama, Y.1    Nifuji, A.2    Maeda, Y.3    Amagasa, T.4    Noda, M.5
  • 51
    • 0026654149 scopus 로고
    • Expression of cell growth and bone specific genes at single cell resolution during development of bone tissue-like organization in primary osteoblast cultures
    • S.M. Pockwinse, L.G. Wilming, D.M. Conlon, G.S. Stein and J.B. Lian (1992) Expression of cell growth and bone specific genes at single cell resolution during development of bone tissue-like organization in primary osteoblast cultures. J. Cell Biochem. 49 310-323.
    • (1992) J. Cell Biochem. , vol.49 , pp. 310-323
    • Pockwinse, S.M.1    Wilming, L.G.2    Conlon, D.M.3    Stein, G.S.4    Lian, J.B.5
  • 54
    • 22844445934 scopus 로고    scopus 로고
    • SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor
    • M. Semenov, K. Tamai and X. He (2005) SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor. J. Biol. Chem. 280 26770-26775.
    • (2005) J. Biol. Chem. , vol.280 , pp. 26770-26775
    • Semenov, M.1    Tamai, K.2    He, X.3
  • 55
    • 33845994036 scopus 로고    scopus 로고
    • LRP5 mutations linked to high bone mass diseases cause reduced LRP5 binding and inhibition by SOST
    • M.V. Semenov and X. He (2006) LRP5 mutations linked to high bone mass diseases cause reduced LRP5 binding and inhibition by SOST. J. Biol. Chem. 281 38276-38284.
    • (2006) J. Biol. Chem. , vol.281 , pp. 38276-38284
    • Semenov, M.V.1    He, X.2
  • 56
    • 1842690566 scopus 로고    scopus 로고
    • Cbfa1/RUNX2 directs specific expression of the sclerosteosis gene (SOST)
    • B. Sevetson, S. Taylor and Y. Pan (2004) Cbfa1/RUNX2 directs specific expression of the sclerosteosis gene (SOST). J. Biol. Chem. 279 13849-13858.
    • (2004) J. Biol. Chem. , vol.279 , pp. 13849-13858
    • Sevetson, B.1    Taylor, S.2    Pan, Y.3
  • 57
    • 33947537963 scopus 로고    scopus 로고
    • Update in osteoporosis and metabolic bone disorders
    • D. Shoback (2007) Update in osteoporosis and metabolic bone disorders. J. Clin. Endocrinol. Metab. 92 747-753.
    • (2007) J. Clin. Endocrinol. Metab. , vol.92 , pp. 747-753
    • Shoback, D.1
  • 61
    • 5344234448 scopus 로고    scopus 로고
    • Sclerostin promotes the apoptosis of human osteoblastic cells: A novel regulation of bone formation
    • M.K. Sutherland, J.C. Geoghegan, C. Yu, E. Turcott, J.E. Skonier, D.G. Winkler and J.A. Latham (2004) Sclerostin promotes the apoptosis of human osteoblastic cells: A novel regulation of bone formation. Bone 35 828-835.
    • (2004) Bone , vol.35 , pp. 828-835
    • Sutherland, M.K.1    Geoghegan, J.C.2    Yu, C.3    Turcott, E.4    Skonier, J.E.5    Winkler, D.G.6    Latham, J.A.7
  • 62
    • 0034284970 scopus 로고    scopus 로고
    • Bone resorption by osteoclasts
    • S.L. Teitelbaum (2000) Bone resorption by osteoclasts. Science 289 1504-1508.
    • (2000) Science , vol.289 , pp. 1504-1508
    • Teitelbaum, S.L.1
  • 63
    • 78651038254 scopus 로고
    • Osteopetrosis with syndactyly; a morphological variant of Albers-Schonberg’s disease
    • A.S. Truswell (1958) Osteopetrosis with syndactyly; a morphological variant of Albers-Schonberg’s disease. J. Bone Joint Surg. Br. 40B 209-218.
    • (1958) J. Bone Joint Surg. Br. , vol.40B , pp. 209-218
    • Truswell, A.S.1
  • 65
    • 34250019537 scopus 로고
    • Bone: formation by autoinduction
    • M.R. Urist (1965) Bone: formation by autoinduction. Science 150 893-899.
    • (1965) Science , vol.150 , pp. 893-899
    • Urist, M.R.1
  • 72
    • 0001049651 scopus 로고
    • An uncommon familial systemic disease of the skeleton: hyperostosis corticalis generalisata familiaris
    • F.S. van Buchem, H.N. Hadders and R. Ubbens (1955) An uncommon familial systemic disease of the skeleton: hyperostosis corticalis generalisata familiaris. Acta Radiol. 44 109-120.
    • (1955) Acta Radiol. , vol.44 , pp. 109-120
    • van Buchem, F.S.1    Hadders, H.N.2    Ubbens, R.3
  • 75
    • 9144265626 scopus 로고    scopus 로고
    • Patients with Van Buchem disease, an osteosclerotic genetic disease, have elevated bone formation markers, higher bone density, and greater derived polar moment of inertia than normal
    • J.E. Wergedal, K. Veskovic, M. Hellan, C. Nyght, W. Balemans, C. Libanati, F.M. Vanhoenacker, J. Tan, D.J. Baylink and W. Van Hul (2003) Patients with Van Buchem disease, an osteosclerotic genetic disease, have elevated bone formation markers, higher bone density, and greater derived polar moment of inertia than normal. J. Clin. Endocrinol. Metab. 88 5778-5783.
    • (2003) J. Clin. Endocrinol. Metab. , vol.88 , pp. 5778-5783
    • Wergedal, J.E.1    Veskovic, K.2    Hellan, M.3    Nyght, C.4    Balemans, W.5    Libanati, C.6    Vanhoenacker, F.M.7    Tan, J.8    Baylink, D.J.9    Van Hul, W.10
  • 79
    • 0030598829 scopus 로고    scopus 로고
    • The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4
    • L.B. Zimmerman, J.M. Jesus-Escobar and R.M. Harland (1996) The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4. Cell 86 599-606.
    • (1996) Cell , vol.86 , pp. 599-606
    • Zimmerman, L.B.1    Jesus-Escobar, J.M.2    Harland, R.M.3


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