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Volumn 16, Issue 4, 2009, Pages 316-320

Dopamine agonists and valvular heart disease

Author keywords

Cabergoline; Cardiac valve disease; Dopamine agonists; Prolactinomas

Indexed keywords

APOMORPHINE; BROMOCRIPTINE; CABERGOLINE; DOPAMINE RECEPTOR STIMULATING AGENT; LEVODOPA; LISURIDE; PERGOLIDE; PRAMIPEXOLE; ROPINIROLE; SELEGILINE; SEROTONIN 2B RECEPTOR;

EID: 67651122085     PISSN: 1752296X     EISSN: None     Source Type: Journal    
DOI: 10.1097/MED.0b013e32832d9f64     Document Type: Review
Times cited : (12)

References (27)
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    • Colao A, Galderisi M, Sarno A, Pardo M, et al. Increased prevalence of tricuspid regurgitation in patients with prolactinomas chronically treated with cabergoline. JCEM 2008; 93:3777-3784. This paper is the first study that showed increased moderate tricuspid regurgitation in patients being treated with the dopamine agonist (cabergoline) for prolactinomas. It highlights that the risk of cardiac valve disease is not limited to dopamine agonist use in Parkinson's disease.
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    • A recent review that illustrates that the use of ergot-derived dopamine agonists (cabergoline and pergolide) in patients with Parkinson's disease is associated with increased risk of cardiac valve regurgitation, but not with the use of nonergot dopamine agonists. This observation may have important clinical significance, in supporting the use of nonergot dopamine agonist, to avoid the adverse effect of cardiac valve disease
    • Steiger M, Jost W, Grandas F, Van Camp F. Risk of valvular heart disease associated with the use of dopamine agonists in Parkinson's disease: a systematic review. J Neural Transm 2009; 116:179-191. A recent review that illustrates that the use of ergot-derived dopamine agonists (cabergoline and pergolide) in patients with Parkinson's disease is associated with increased risk of cardiac valve regurgitation, but not with the use of nonergot dopamine agonists. This observation may have important clinical significance, in supporting the use of nonergot dopamine agonist, to avoid the adverse effect of cardiac valve disease.
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    • Cabergoline and cardiac valve disease in prolactinoma patients: Additional studies during long-term treatment are required
    • This review illustrates that although there have beenmany studies showing significant cardiac valve regurgitation in patients with Parkinson's disease on cabergoline (eight studies), only one of six studies in cabergoline-treated patients for prolactinomas reported significant moderate regurgitation. The authors emphasized that in prolactinoma patients requiring higher cumulative doses and longer duration of treatment, evaluation with echocardiograms should be considered
    • Kars M, Pereira M, Bax JJ, Romijn JA. Cabergoline and cardiac valve disease in prolactinoma patients: additional studies during long-term treatment are required. Eur Endocrinol 2008; 159:363-367. This review illustrates that although there have beenmany studies showing significant cardiac valve regurgitation in patients with Parkinson's disease on cabergoline (eight studies), only one of six studies in cabergoline-treated patients for prolactinomas reported significant moderate regurgitation. The authors emphasized that in prolactinoma patients requiring higher cumulative doses and longer duration of treatment, evaluation with echocardiograms should be considered.
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    • Low dose cabergoline for hyperprolactinaemia is not associated with clinically significant valvular heart disease
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    • Valvular heart disease and the use of cabergoline for the treatment of prolactinoma
    • The results of this study show that the commonly used doses of cabergoline (0.25-3 mg/week) to treat prolactinomas were not associated with significant valvulopathy
    • Herring N, Szmigielski C, Becher H, et al. Valvular heart disease and the use of cabergoline for the treatment of prolactinoma. Clin Endocrin 2009; 70:104-108. The results of this study show that the commonly used doses of cabergoline (0.25-3 mg/week) to treat prolactinomas were not associated with significant valvulopathy.
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    • Prospective study of high-dose cabergoline treatment in prolactinomas of 150 patients
    • This study reports that of 150 patients on cabergoline, 84% of patients achieved normalization of prolactin at 3 mg/week, reaching 97.3% at doses of 9 mg/week, with complete normalization in the entire group at doses of 11 mg/week
    • Ono M, Miki N, Kawamata T, et al. Prospective study of high-dose cabergoline treatment in prolactinomas of 150 patients. JCEM 2008; 93:4721-4727. This study reports that of 150 patients on cabergoline, 84% of patients achieved normalization of prolactin at 3 mg/week, reaching 97.3% at doses of 9 mg/week, with complete normalization in the entire group at doses of 11 mg/week.
    • (2008) JCEM , vol.93 , pp. 4721-4727
    • Ono, M.1    Miki, N.2    Kawamata, T.3
  • 27
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    • The cabergoline-resistant prolactinoma patient: New challenges
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    • Molitch ME. The cabergoline-resistant prolactinoma patient: new challenges. JCEM 2008; 93:4643-4645. This editorial reviews the literature on cardiac valvulopathy risk in cabergoline-treated patients and concludes that conventional doses (≤2 mg/week) are not likely to increase the risk of valvular disease.
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    • Molitch, M.E.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.