Cardiac differentiation is driven by nkx2.5 and gata4 nuclear translocation in tissue-specific mesenchymal stem cells

Stem Cells and Development

Volumn 18, Issue 6, 2009, Pages 907-917

  Armiñán, Ana ^a   Gandía, Carolina ^a   Bartual, Macarmen ^a   García Verdugo, José M ^a,b   Lledó, Elisa ^a   Mirabet, Vicente ^c   Llop, Mauro ^a   Barea, José ^d   Montero, José A ^a,d   Sepúlveda, Pilar ^a,d  

^a CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE   (Spain)

^b UNIVERSITY OF VALENCIA   (Spain)

^c Centro de Transfusion de la Comunidad Valenciana   (Spain)

^d HOSPITAL UNIVERSITARIO LA FE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ACTININ; ATRIAL NATRIURETIC FACTOR; CONNEXIN 43; MYOSIN HEAVY CHAIN BETA; TRANSCRIPTION FACTOR GATA 4; TRANSCRIPTION FACTOR NKX2.5; TROPONIN I;

ADIPOSE TISSUE CELL; ADULT; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; COCULTURE; CONTROLLED STUDY; GAP JUNCTION; HEART MUSCLE CELL; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; MESENCHYMAL STEM CELL; MUSCLE FIBRIL; NONHUMAN; NORMAL HUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; TISSUE SPECIFICITY; TOOTH PULP;

ADOLESCENT; ADULT; ANIMALS; ANTIGENS, SURFACE; CELL DIFFERENTIATION; CELL NUCLEUS; CELLS, CULTURED; COCULTURE TECHNIQUES; CULTURE MEDIA; GAP JUNCTIONS; GATA4 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HOMEODOMAIN PROTEINS; HUMANS; MESENCHYMAL STEM CELLS; MICROFILAMENTS; MYOCARDIUM; MYOCYTES, CARDIAC; ORGAN SPECIFICITY; PROTEIN TRANSPORT; RATS; SUBCELLULAR FRACTIONS; TRANSCRIPTION FACTORS;

RATTUS;

EID: 67651121719     PISSN: 15473287     EISSN: None     Source Type: Journal    
DOI: 10.1089/scd.2008.0292     Document Type: Article

References (34)

1. Kinnaird T, E Stabile, MS Burnett, M Shou, CW Lee, S Barr, S Fuchs and SE Epstein. (2004). Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms. Circulation 109:1543-1549.
2. Schueller PO, C Meyer, M Brehm, P Wernet, CM Schannwell and BE Strauer. (2006). Intracoronary autologous bone marrow cell transplantation benef cially modulates heart rate variability. Int J Cardiol 119:398-399.
3. Strauer BE, M Brehm, T Zeus, M Kostering, A Hernandez, RV Sorg, G Kogler and P Wernet. (2002). Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans. Circulation 106:1913-1918.
4. Urbich C, A Aicher, C Heeschen, E Dernbach, WK Hofmann, AM Zeiher and S Dimmeler. (2005). Soluble factors released by endothelial progenitor cells promote migration of endothelial cells and cardiac resident progenitor cells. J Mol Cell Cardiol 39:733-742.
5. Lipinski MJ, GG Biondi-Zoccai, A Abbate, R Khianey, I Sheiban, J Bartunek, M Vanderheyden, HS Kim, HJ Kang, BE Strauer and GW Vetrovec. (2007). Impact of intracoronary cell therapy on left ventricular function in the setting of acute myocardial infarction: a collaborative systematic review and meta-analysis of controlled clinical trials. J Am Coll Cardiol 50:1761-1767.
6. Chen S, Z Liu, N Tian, J Zhang, F Yei, B Duan, Z Zhu, S Lin and TW Kwan. (2006). Intracoronary transplantation of autologous bone marrow mesenchymal stem cells for ischemic cardiomy-opathy due to isolated chronic occluded left anterior descending artery. J Invasive Cardiol 18:552-556.
7. Stamm C, HD Kleine, YH Choi, S Dunkelmann, JA Lauffs, B Lorenzen, A David, A Liebold, C Nienaber, D Zurakowski, M Freund and G Steinhoff. (2007). Intramyocardial delivery of CD133+ bone marrow cells and coronary artery bypass grafting for chronic ischemic heart disease: safety and eff cacy studies. J Thorac Cardiovasc Surg 133:717-725.
8. Pittenger MF, AM Mackay, SC Beck, RK Jaiswal, R Douglas, JD Mosca, MA Moorman, DW Simonetti, S Craig and DR Marshak. (1999). Multilineage potential of adult human mesenchymal stem cells. Science 284:143-147.
9. Izadpanah R, C Trygg, B Patel, C Kriedt, J Dufour, JM Gimble and BA Bunnell. (2006). Biologic properties of mesenchymal stem cells derived from bone marrow and adipose tissue. J Cell Biochem 99:1285-1297.
10. Li X, X Yu, Q Lin, C Deng, Z Shan, M Yang and S Lin. (2007). Bone marrow mesenchymal stem cells differentiate into functional cardiac phenotypes by cardiac microenvironment. J Mol Cell Cardiol 42:295-303.
11. Pierdomenico L, L Bonsi, M Calvitti, D Rondelli, M Arpinati, G Chirumbolo, E Becchetti, C Marchionni, F Alviano, V Fossati, N Staffolani, M Franchina, A Grossi and GP Bagnara. (2005). Multipotent mesenchymal stem cells with immunosuppressive activit y can be easily isolated from dental pulp. Transplantation 80:836-842.
12. Kern S, H Eichler, J Stoeve, H Kluter and K Bieback. (2006). Com parative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue. Stem Cells 24:1294-1301.
13. Lee RH, B Kim, I Choi, H Kim, HS Choi, K Suh, YC Bae and JS Jung. (2004). Characterization and expression analysis of mes-enchymal stem cells from human bone marrow and adipose tissue. Cell Physiol Biochem 14:311-324.
14. Gronthos S, M Mankani, J Brahim, PG Robey and S Shi. (2000). Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc Natl Acad Sci USA 97:13625-13630.
15. Zuk PA, M Zhu, P Ashjian, DA De Ugarte, JI Huang, H Mizuno, ZC Alfonso, JK Fraser, P Benhaim and MH Hedrick. (2002). Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell 13:4279-4295.
16. Makino S, K Fukuda, S Miyoshi, F Konishi, H Kodama, J Pan, M Sano, T Takahashi, S Hori, H Abe, J Hata, A Umezawa and S Ogawa. (1999). Cardiomyocytes can be generated from marrow stromal cells in vitro. J Clin Invest 103:697-705.
17. Leri A, J Kajstura and P Anversa. (2005). Cardiac stem cells and mechanisms of myocardial regeneration. Physiol Rev 85:1373-1416.
18. Badorff C, RP Brandes, R Popp, S Rupp, C Urbich, A Aicher, I Fleming, R Busse, AM Zeiher and S Dimmeler. (2003). Transdifferentiation of blood-derived human adult endothe-lial progenitor cells into functionally active cardiomyocytes. Circu lat ion 107:1024-1032.
19. Xaymardan M, L Tang, L Zagreda, B Pallante, J Zheng, JL Chazen, A Chin, I Duignan, P Nahirney, S Raf i, T Mikawa and JM Edelberg. (2004). Platelet-derived growth factor-AB promotes the generation of adult bone marrow-derived cardiac myocytes. Circ Res 94:E39-E45.
20. Shim WS, S Jiang, P Wong, J Tan, YL Chua, YS Tan, YK Sin, CH Lim, T Chua, M Teh, TC Liu and E Sim. (2004). Ex vivo differentiation of human adult bone marrow stem cells into cardiomyocyte-like cells. Biochem Biophys Res Commun 324:481-488.
21. Lowry WE, L Richter, R Yachechko, AD Pyle, J Tchieu, R Sridharan, AT Clark and K Plath. (2008). Generation of human induced pluripotent stem cells from dermal f broblasts. Proc Natl Acad Sci USA 105:2883-2888.
22. Fukuhara S, S Tomita, S Yamashiro, T Morisaki, C Yutani, S Kitamura and T Nakatani. (2003). Direct cell-cell interaction of cardiomyocytes is key for bone marrow stromal cells to go into cardiac lineage in vitro. J Thorac Cardiovasc Surg 125:1470-1480.
23. Rangappa S, JW Entwistle, AS Wechsler and JY Kresh. (2003). Cardiomyocyte-mediated contact programs human mesen-chymal stem cells to express cardiogenic phenotype. J Thorac Cardiovasc Surg 126:124-132.
24. Xu M, M Wani, YS Dai, J Wang, M Yan, A Ayub and M Ashraf. (2004). Differentiation of bone marrow stromal cells into the cardiac phenotype requires intercellular communication with myocytes. Circulation 110:2658-2565.
25. Pasquinelli G, P Tazzari, F Ricci, C Vaselli, M Buzzi, R Conte, C Orrico, L Foroni, A Stella, F Alviano, GP Bagnara and E Lucarelli. (2007). Ultrastructural characteristics of human mes-enchymal stromal (stem) cells derived from bone marrow and term placenta. Ultrastruct Pathol 31:23-31.
26. Faustino RS, A Behfar, C Perez-Terzic and A Terzic. (2008). Genomic chart guiding embryonic stem cell cardiopoiesis. Genome Biol 9:R6.
27. Chen CY and RJ Schwartz. (1997). Competition between negative acting YY1 versus positive acting serum response factor and tinman homologue Nkx-2.5 regulates cardiac alpha-actin promoter activity. Mol Endocrinol 11:812-822.
28. Morkin E. (2000). Control of cardiac myosin heavy chain gene expression. Microsc Res Tech 50:522-531.
29. Nagaya N, T Fujii, T Iwase, H Ohgushi, T Itoh, M Uematsu, M Yamagishi, H Mori, K Kangawa and S Kitamura. (2004). Intravenous administration of mesenchymal stem cells improves cardiac function in rats with acute myocardial infarction through angiogenesis and myogenesis. Am J Physiol Heart Circ Physiol 287:H2670-H2676.
30. Gandia C, A Arminan, JM Garcia-Verdugo, E Lledo, A Ruiz, MD Minana, J Sanchez-Torrijos, R Paya, V Mirabet, F Carbonell-Uberos, M Llop, JA Montero and P Sepulveda. (2008). Human dental pulp stem cells improve left ventricular function, induce angiogenesis, and reduce infarct size in rats with acute myocar-dial infarction. Stem Cells 26:638-645.
31. Miyahara Y, N Nagaya, M Kataoka, B Yanagawa, K Tanaka, H Hao, K Ishino, H Ishida, T Shimizu, K Kangawa, S Sano, T Okano, S Kitamura and H Mori. (2006). Monolayered mesen-chymal stem cells repair scarred myocardium after myocardial infarction. Nat Med 12:459-465.
32. Behfar A, C Perez-Terzic, RS Faustino, DK Arrell, DM Hodgson, S Yamada, M Puceat, N Niederlander, AE Alekseev, LV Zingman and A Terzic. (2007). Cardiopoietic programming of embryonic stem cells for tumor-free heart repair. J Exp Med 204:405-420.
33. Perez-Terzic C, RS Faustino, BJ Boorsma, DK Arrell, NJ Niederlander, A Behfar and A Terzic. (2007). Stem cells transform into a cardiac phenotype with remodeling of the nuclear transport machinery. Nat Clin Pract Cardiovasc Med 4 (Suppl. 1):S68-S76.
34. Behfar A and A Terzic. (2006). Derivation of a cardiopoietic population from human mesenchymal stem cells yields cardiac progeny. Nat Clin Pract Cardiovasc Med 3 (Suppl. 1):S78-S82.