Growth suppression by ursodeoxycholic acid involves caveolin-1 enhanced degradation of EGFR

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1793, Issue 8, 2009, Pages 1387-1394

  Feldman, Rebecca ^a,b   Martinez, Jesse D ^b  

^a UNIVERSITY OF ARIZONA   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

Author keywords

Bile acid; c Cbl; Chemoprevention; Colon cancer; Endocytosis

Indexed keywords

BILE ACID; CAVEOLIN 1; CBL PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN TYROSINE KINASE; UBIQUITIN PROTEIN LIGASE; URSODEOXYCHOLIC ACID;

ADENOCARCINOMA; ARTICLE; CANCER CELL CULTURE; CELL GROWTH; CELL MEMBRANE; CELL PROLIFERATION; COLORECTAL CARCINOMA; CONTROLLED STUDY; DRUG ACTIVITY; ENZYME ACTIVITY; GROWTH INHIBITION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN INTERACTION; RECEPTOR INTRINSIC ACTIVITY; UBIQUITINATION;

CAVEOLIN 1; CELL LINE, TUMOR; CELL PROLIFERATION; DOWN-REGULATION; ENDOCYTOSIS; HUMANS; MODELS, BIOLOGICAL; PROTO-ONCOGENE PROTEINS C-CBL; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECOMBINANT PROTEINS; RNA, SMALL INTERFERING; TRANSFECTION; UBIQUITINATION; URSODEOXYCHOLIC ACID;

ANIMALIA;

EID: 67651119898     PISSN: 01674889     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2009.05.003     Document Type: Article

References (38)

1. Vlahcevic Z.R., Heuman D.M., and Hylemon P.B. Regulation of bile acid synthesis. Hepatology 13 (1991) 590-600
2. Armstrong B., and Doll R. Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practices. Int. J. Cancer 15 (1975) 617-631
3. Bayerdorffer E., Mannes G.A., Richter W.O., Ochsenkuhn T., Wiebecke B., Kopcke W., and Paumgartner G. Increased serum deoxycholic acid levels in men with colorectal adenomas. Gastroenterology 104 (1993) 145-151
4. Reddy B.S., Watanabe K., Weisburger J.H., and Wynder E.L. Promoting effect of bile acids in colon carcinogenesis in germ-free and conventional F344 rats. Cancer Res. 37 (1977) 3238-3242
5. Earnest D.L., Holubec H., Wali R.K., Jolley C.S., Bissonette M., Bhattacharyya A.K., Roy H., Khare S., and Brasitus T.A. Chemoprevention of azoxymethane-induced colonic carcinogenesis by supplemental dietary ursodeoxycholic acid. Cancer Res. 54 (1994) 5071-5074
6. Wali R.K., Frawley Jr. B.P., Hartmann S., Roy H.K., Khare S., Scaglione-Sewell B.A., Earnest D.L., Sitrin M.D., Brasitus T.A., and Bissonnette M. Mechanism of action of chemoprotective ursodeoxycholate in the azoxymethane model of rat colonic carcinogenesis: potential roles of protein kinase C-alpha,-beta II, and -zeta. Cancer Res. 55 (1995) 5257-5264
7. Ikegami T., Matsuzaki Y., Shoda J., Kano M., Hirabayashi N., and Tanaka N. The chemopreventive role of ursodeoxycholic acid in azoxymethane-treated rats: suppressive effects on enhanced group II phospholipase A2 expression in colonic tissue. Cancer Lett. 134 (1998) 129-139
8. Alberts D.S., Martinez M.E., Hess L.M., Einspahr J.G., Green S.B., Bhattacharyya A.K., Guillen J., Krutzsch M., Batta A.K., Salen G., Fales L., Koonce K., Parish D., Clouser M., Roe D., and Lance P. Phase III trial of ursodeoxycholic acid to prevent colorectal adenoma recurrence. J. Natl. Cancer Inst. 97 (2005) 846-853
9. Martinez J.D., Stratagoules E.D., LaRue J.M., Powell A.A., Gause P.R., Craven M.T., Payne C.M., Powell M.B., Gerner E.W., and Earnest D.L. Different bile acids exhibit distinct biological effects: the tumor promoter deoxycholic acid induces apoptosis and the chemopreventive agent ursodeoxycholic acid inhibits cell proliferation. Nutr. Cancer 31 (1998) 111-118
10. Qiao D., Stratagouleas E.D., and Martinez J.D. Activation and role of mitogen-activated protein kinases in deoxycholic acid-induced apoptosis. Carcinogenesis 22 (2001) 35-41
11. Cheng K., and Raufman J.P. Bile acid-induced proliferation of a human colon cancer cell line is mediated by transactivation of epidermal growth factor receptors. Biochem. Pharmacol. 70 (2005) 1035-1047
12. Qiao D., Chen W., Stratagoules E.D., and Martinez J.D. Bile acid-induced activation of activator protein-1 requires both extracellular signal-regulated kinase and protein kinase C signaling. J. Biol. Chem. 275 (2000) 15090-15098
13. Akare S., and Martinez J.D. Bile acid induces hydrophobicity-dependent membrane alterations. Biochim. Biophys. Acta 1735 (2005) 59-67
14. Powell A.A., LaRue J.M., Batta A.K., and Martinez J.D. Bile acid hydrophobicity is correlated with induction of apoptosis and/or growth arrest in HCT116 cells. Biochem. J. 356 (2001) 481-486
15. Im E., Akare S., Powell A., and Martinez J.D. Ursodeoxycholic acid can suppress deoxycholic acid-induced apoptosis by stimulating Akt/PKB-dependent survival signaling. Nutr. Cancer 51 (2005) 110-116
16. Im E., and Martinez J.D. Ursodeoxycholic acid (UDCA) can inhibit deoxycholic acid (DCA)-induced apoptosis via modulation of EGFR/Raf-1/ERK signaling in human colon cancer cells. J. Nutr. 134 (2004) 483-486
17. Jean-Louis S., Akare S., Ali M.A., Mash Jr. E.A., Meuillet E., and Martinez J.D. Deoxycholic acid induces intracellular signaling through membrane perturbations. J. Biol. Chem. 281 (2006) 14948-14960
18. Lisanti M.P., Scherer P.E., Vidugiriene J., Tang Z., Hermanowski-Vosatka A., Tu Y.H., Cook R.F., and Sargiacomo M. Characterization of caveolin-rich membrane domains isolated from an endothelial-rich source: implications for human disease. J. Cell Biol. 126 (1994) 111-126
19. Liu P., Rudick M., and Anderson R.G. Multiple functions of caveolin-1. J. Cell Biol. 277 (2002) 41295-41298
20. Bender F.C., Reymond M.A., Bron C., and Quest A.F. Caveolin-1 levels are down-regulated in human colon tumors, and ectopic expression of caveolin-1 in colon carcinoma cell lines reduces cell tumorigenicity. Cancer Res. 60 (2000) 5870-5878
21. Williams T.M., Cheung M.W., Park D.S., Razani B., Cohen A.W., Muller W.J., Di Vizio D., Chopra N.G., Pestell R.G., and Lisanti M.P. Loss of caveolin-1 gene expression accelerates the development of dysplastic mammary lesions in tumor-prone transgenic mice. Mol. Biol. Cell 14 (2003) 1027-1042
22. Song K.S., Li S., Okamoto T., Quilliam L.A., Sargiacomo M., and Lisanti M.P. Co-purification and direct interaction of Ras with caveolin, an integral membrane protein of caveolae microdomains. Detergent-free purification of caveolae microdomains. J. Biol. Chem. 271 (1996) 9690-9697
23. Waterman H., Levkowitz G., Alroy I., and Yarden Y. The RING finger of c-Cbl mediates desensitization of the epidermal growth factor receptor. J. Biol. Chem. 274 (1999) 22151-22154
24. Engelman J.A., Chu C., Lin A., Jo H., Ikezu T., Okamoto T., Kohtz D.S., and Lisanti M.P. Caveolin-mediated regulation of signaling along the p42/44 MAP kinase cascade in vivo.A role for the caveolin-scaffolding domain. FEBS Lett. 428 (1998) 205-211
25. Marmor M.D., and Yarden Y. Role of protein ubiquitylation in regulating endocytosis of receptor tyrosine kinases. Oncogene 23 (2004) 2057-2070
26. Di Fiore P.P., and Gill G.N. Endocytosis and mitogenic signaling. Curr. Opin. Cell Biol. 11 (1999) 483-488
27. Brown W.J., Goodhouse J., and Farquhar M.G. Mannose-6-phosphate receptors for lysosomal enzymes cycle between the Golgi complex and endosomes. J. Cell Biol. 103 (1986) 1235-1247
28. Ravid T., Heidinger J.M., Gee P., Khan E.M., and Goldkorn T. c-Cbl-mediated ubiquitinylation is required for epidermal growth factor receptor exit from the early endosomes. J. Biol. Chem. 279 (2004) 37153-37162
29. Couet J., Sargiacomo M., and Lisanti M.P. Interaction of a receptor tyrosine kinase, EGF-R, with caveolins. Caveolin binding negatively regulates tyrosine and serine/threonine kinase activities. J. Biol. Chem. 272 (1997) 30429-30438
30. Galbiati F., Volonte D., Brown A.M., Weinstein D.E., Ben-Ze'ev A., Pestell R.G., and Lisanti M.P. Caveolin-1 expression inhibits Wnt/beta-catenin/Lef-1 signaling by recruiting beta-catenin to caveolae membrane domains. J. Biol. Chem. 275 (2000) 23368-23377
31. Vieira A.V., Lamaze C., and Schmid S.L. Control of EGF receptor signaling by clathrin-mediated endocytosis. Science 274 (1996) 2086-2089
32. Di Fiore P.P., and De Camilli P. Endocytosis and signaling. an inseparable partnership. Cell 106 (2001) 1-4
33. Dikic I. Mechanisms controlling EGF receptor endocytosis and degradation. Biochem. Soc. Trans. 31 (2003) 1178-1181
34. Yarden Y., and Ullrich A. Growth factor receptor tyrosine kinases. Annu. Rev. Biochem. 57 (1988) 443-478
35. Ceresa B.P., and Schmid S.L. Regulation of signal transduction by endocytosis. Curr. Opin. Cell Biol. 12 (2000) 204-210
36. Powell A.A., Akare S., Qi W., Herzer P., Jean-Louis S., Feldman R.A., and Martinez J.D. Resistance to ursodeoxycholic acid-induced growth arrest can also result in resistance to deoxycholic acid-induced apoptosis and increased tumorgenicity. BMC Cancer 6 (2006) 219
37. Adachi S., Nagao T., Ingolfsson H.I., Maxfield F.R., Andersen O.S., Kopelovich L., and Weinstein I.B. The inhibitory effect of (-)-epigallocatechin gallate on activation of the epidermal growth factor receptor is associated with altered lipid order in HT29 colon cancer cells. Cancer Res. 67 (2007) 6493-6501
38. Felley-Bosco E., Bender F.C., Courjault-Gautier F., Bron C., and Quest A.F. Caveolin-1 down-regulates inducible nitric oxide synthase via the proteasome pathway in human colon carcinoma cells. Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 14334-14339