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Volumn 25, Issue 3, 2009, Pages 825-833

Characterization and design of chemically selective cationic displacers using a robotic high-throughput screen

Author keywords

High throughput screening; Protein purification; Robotics; Selective displacement chromatography

Indexed keywords

CATION EXCHANGE CHROMATOGRAPHY; DISPLACER; DISPLACERS; EXPERIMENTAL CONDITIONS; HIGH-THROUGHPUT; HIGH-THROUGHPUT SCREENING; HYDROPHOBIC INTERACTIONS; PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN SYSTEM; SECONDARY INTERACTIONS; SELECTIVE DISPLACEMENT CHROMATOGRAPHY; SHORT PERIODS; SURFACE HYDROPHOBICITY;

EID: 67651111663     PISSN: 87567938     EISSN: None     Source Type: Journal    
DOI: 10.1002/btpr.159     Document Type: Article
Times cited : (7)

References (33)
  • 1
    • 0031584719 scopus 로고    scopus 로고
    • Comparison of anion-exchange and hydroxyapatite displacement chromatography for the isolation of whey proteins
    • Vogt S, Freitag R. Comparison of anion-exchange and hydroxyapatite displacement chromatography for the isolation of whey proteins. J Chromatogr A. 1997;760:125-137.
    • (1997) J Chromatogr A , vol.760 , pp. 125-137
    • Vogt, S.1    Freitag, R.2
  • 2
    • 0028855543 scopus 로고
    • Displacement chromatography in biotechnological downstream processing
    • Freitag R, Breier J. Displacement chromatography in biotechnological downstream processing. J Chromatogr A. 1995;691:101-112.
    • (1995) J Chromatogr A , vol.691 , pp. 101-112
    • Freitag, R.1    Breier, J.2
  • 4
    • 0344073997 scopus 로고    scopus 로고
    • Cation-exchange displacement chromatography for the purification of recombinant protein therapeutics from variants
    • Barnthouse KA, Trompeter W, Jones R, Inampudi P, Rupp R, Cramer SM. Cation-exchange displacement chromatography for the purification of recombinant protein therapeutics from variants. J Biotechnol. 1998;66:125-136.
    • (1998) J Biotechnol , vol.66 , pp. 125-136
    • Barnthouse, K.A.1    Trompeter, W.2    Jones, R.3    Inampudi, P.4    Rupp, R.5    Cramer, S.M.6
  • 5
    • 0028936674 scopus 로고
    • Rapid ion-exchange displacement chromatography of proteins on perfusive chromatographic supports
    • Gerstner JA, Morris J, Hunt T, Hamilton R, Afeyan NBJ. Rapid ion-exchange displacement chromatography of proteins on perfusive chromatographic supports. Chromatogr A. 1995;695:195-204.
    • (1995) Chromatogr A , vol.695 , pp. 195-204
    • Gerstner, J.A.1    Morris, J.2    Hunt, T.3    Hamilton, R.4    Afeyan, N.B.J.5
  • 7
    • 0031570359 scopus 로고    scopus 로고
    • Low-molecular-weight displacers for high resolution protein separations
    • Kundu A, Cramer SM. Low-molecular-weight displacers for high resolution protein separations. Anal Biochem. 1997;248: 111-116.
    • (1997) Anal Biochem , vol.248 , pp. 111-116
    • Kundu, A.1    Cramer, S.M.2
  • 8
    • 0027404957 scopus 로고
    • Ion-exchange displacement chromatography of proteins. Dextran-based polyelectrolytes as high affinity displacers
    • Jayaraman G, Gadam SD, Cramer SM. Ion-exchange displacement chromatography of proteins. Dextran-based polyelectrolytes as high affinity displacers. J Chromatogr A. 1993;630:53-68.
    • (1993) J Chromatogr A , vol.630 , pp. 53-68
    • Jayaraman, G.1    Gadam, S.D.2    Cramer, S.M.3
  • 9
    • 0020741160 scopus 로고
    • Ion-exchange displacement chromatography of proteins, using narrow-range carboxymethyldextrans and a new index of affinity
    • Peterson EA, Torres AR. Ion-exchange displacement chromatography of proteins, using narrow-range carboxymethyldextrans and a new index of affinity. Anal Biochem. 1983;130:271-282.
    • (1983) Anal Biochem , vol.130 , pp. 271-282
    • Peterson, E.A.1    Torres, A.R.2
  • 10
    • 0029016506 scopus 로고
    • Ion-exchange displacement chromatography of proteins. Dendritic polymers as novel displacers
    • Jayaraman G, Li YF, Moore JA, Cramer SM. Ion-exchange displacement chromatography of proteins. Dendritic polymers as novel displacers. J Chromatogr A. 1995;702:143-155.
    • (1995) J Chromatogr A , vol.702 , pp. 143-155
    • Jayaraman, G.1    Li, Y.F.2    Moore, J.A.3    Cramer, S.M.4
  • 11
    • 0344073997 scopus 로고    scopus 로고
    • Cation-exchange displacement chromatography for the purification of recombinant protein therapeutics from variants
    • Barnthouse KA, Trompeter W, Jones R, Inampudi P, Rupp R, Cramer SM. Cation-exchange displacement chromatography for the purification of recombinant protein therapeutics from variants. J Biotechnol. 1998;66:125-136.
    • (1998) J Biotechnol , vol.66 , pp. 125-136
    • Barnthouse, K.A.1    Trompeter, W.2    Jones, R.3    Inampudi, P.4    Rupp, R.5    Cramer, S.M.6
  • 12
    • 0034523761 scopus 로고    scopus 로고
    • Purification of oligonucleotides by high affinity, low molecular weight displacers
    • Shukla AA, Deshmukh RR, Moore JA, Cramer SM. Purification of oligonucleotides by high affinity, low molecular weight displacers. Biotechnol Prog. 2000;16:1064-1070.
    • (2000) Biotechnol Prog , vol.16 , pp. 1064-1070
    • Shukla, A.A.1    Deshmukh, R.R.2    Moore, J.A.3    Cramer, S.M.4
  • 13
    • 0035919598 scopus 로고    scopus 로고
    • Purification of an oligonucleotide at high column loading by high affinity, low-molecular-mass displacers
    • Tugcu N, Deshmukh RR, Sanghvi YS, Moore JA, Cramer SM. Purification of an oligonucleotide at high column loading by high affinity, low-molecular-mass displacers. J Chromatogr A. 2001;923:65-73.
    • (2001) J Chromatogr A , vol.923 , pp. 65-73
    • Tugcu, N.1    Deshmukh, R.R.2    Sanghvi, Y.S.3    Moore, J.A.4    Cramer, S.M.5
  • 14
    • 27544472256 scopus 로고    scopus 로고
    • Multidimensional highthroughput screening of displacers
    • Rege K, Ladiwala A, Cramer SM. Multidimensional highthroughput screening of displacers. Anal Chem. 2005;77:6818-6827.
    • (2005) Anal Chem , vol.77 , pp. 6818-6827
    • Rege, K.1    Ladiwala, A.2    Cramer, S.M.3
  • 15
    • 0037226821 scopus 로고    scopus 로고
    • Displacement chromatography of anti-sense oligonucleotide and proteins using saccharin as a non-toxic displacer
    • Tugcu N, Deshmukh RR, Sanghvi YS, Cramer SM. Displacement chromatography of anti-sense oligonucleotide and proteins using saccharin as a non-toxic displacer. React Funct Polym. 2003;54:37-47.
    • (2003) React Funct Polym , vol.54 , pp. 37-47
    • Tugcu, N.1    Deshmukh, R.R.2    Sanghvi, Y.S.3    Cramer, S.M.4
  • 16
    • 33846230875 scopus 로고    scopus 로고
    • The effect of displacer chemistry on dispalcer efficacy for a sugar-based anion exchange displacer library
    • Liu J, Park SK, Moore JA, Cramer SM. The effect of displacer chemistry on dispalcer efficacy for a sugar-based anion exchange displacer library. Ind Eng Chem Res. 2006;45:9107-9114.
    • (2006) Ind Eng Chem Res , vol.45 , pp. 9107-9114
    • Liu, J.1    Park, S.K.2    Moore, J.A.3    Cramer, S.M.4
  • 17
    • 0029637152 scopus 로고
    • Protected amino acids as novel low-molecular-weight displacers in cationexchange displacement chromatography
    • Kundu A, Vunnum S, Jayaraman G, Cramer SM. Protected amino acids as novel low-molecular-weight displacers in cationexchange displacement chromatography. Biotechnol Bioeng. 1995;48:452-460.
    • (1995) Biotechnol Bioeng , vol.48 , pp. 452-460
    • Kundu, A.1    Vunnum, S.2    Jayaraman, G.3    Cramer, S.M.4
  • 18
    • 0029003303 scopus 로고
    • Antibiotics as low-molecularmass displacers in ion-exchange displacement chromatography
    • Kundu A, Vunnum S, Cramer SM. Antibiotics as low-molecularmass displacers in ion-exchange displacement chromatography. J Chromatogr A. 1995;707:57-67.
    • (1995) J Chromatogr A , vol.707 , pp. 57-67
    • Kundu, A.1    Vunnum, S.2    Cramer, S.M.3
  • 19
    • 4744357239 scopus 로고    scopus 로고
    • Chemoenzymatic synthesis and high-throughput screening of an aminoglycoside-polyamine library: Identification of high-affinity displacers and DNA-binding ligands
    • Rege K, Hu S, Moore JA, Dordick JS, Cramer SM. Chemoenzymatic synthesis and high-throughput screening of an aminoglycoside-polyamine library: identification of high-affinity displacers and DNA-binding ligands. J Am Chem Soc. 2004; 126:12306-12315.
    • (2004) J Am Chem Soc , vol.126 , pp. 12306-12315
    • Rege, K.1    Hu, S.2    Moore, J.A.3    Dordick, J.S.4    Cramer, S.M.5
  • 20
    • 0030969458 scopus 로고    scopus 로고
    • Productivity and operating regimes in protein chromatography using low-molecular-mass displacers
    • Gallant SR, Cramer SM. Productivity and operating regimes in protein chromatography using low-molecular-mass displacers. J Chromatogr A. 1997;771:9-22.
    • (1997) J Chromatogr A , vol.771 , pp. 9-22
    • Gallant, S.R.1    Cramer, S.M.2
  • 21
    • 0026799147 scopus 로고
    • Steric mass-action ion exchange: Displacement profiles and induced salt gradients
    • Brooks CA, Cramer SM. Steric mass-action ion exchange: displacement profiles and induced salt gradients. AIChE J. 1992;38:1969-1978.
    • (1992) AIChE J , vol.38 , pp. 1969-1978
    • Brooks, C.A.1    Cramer, S.M.2
  • 22
    • 0242322756 scopus 로고    scopus 로고
    • Identification of chemically selective displacers using parallel batch screening experiments and quantitative structure efficacy relationship models
    • Tugcu N, Ladiwala A, Breneman CM, Cramer SM. Identification of chemically selective displacers using parallel batch screening experiments and quantitative structure efficacy relationship models. Anal Chem. 2003;75:5806-5816.
    • (2003) Anal Chem , vol.75 , pp. 5806-5816
    • Tugcu, N.1    Ladiwala, A.2    Breneman, C.M.3    Cramer, S.M.4
  • 23
    • 11344291787 scopus 로고    scopus 로고
    • The effect of multi-component adsorption on selectivity in ion exchange displacement systems
    • Tugcu N, Cramer SM. The effect of multi-component adsorption on selectivity in ion exchange displacement systems. J Chromatogr A. 2005;1063:15-23.
    • (2005) J Chromatogr A , vol.1063 , pp. 15-23
    • Tugcu, N.1    Cramer, S.M.2
  • 24
    • 42949093161 scopus 로고    scopus 로고
    • Chemically selective displacers for high resolution protein separations in ion-exchange systems: Effect of displacer-protein interactions
    • Liu J, Hilton ZA, Cramer SM. Chemically selective displacers for high resolution protein separations in ion-exchange systems: effect of displacer-protein interactions. Anal Chem. 2008;80: 3357-3364.
    • (2008) Anal Chem , vol.80 , pp. 3357-3364
    • Liu, J.1    Hilton, Z.A.2    Cramer, S.M.3
  • 25
    • 34948906395 scopus 로고    scopus 로고
    • High-throughput screening of packed-bed chromatography coupled with SELDI-TOF MS analysis: Monoclonal antibodies versus host cell protein
    • Wierling PS, Bogumil R, Knieps-Grunhagen E, Hubbuch J. High-throughput screening of packed-bed chromatography coupled with SELDI-TOF MS analysis: monoclonal antibodies versus host cell protein. Biotechnol Bioeng. 2007;98:440-450.
    • (2007) Biotechnol Bioeng , vol.98 , pp. 440-450
    • Wierling, P.S.1    Bogumil, R.2    Knieps-Grunhagen, E.3    Hubbuch, J.4
  • 27
    • 67651133556 scopus 로고    scopus 로고
    • Booth J, Coffman J, Kelley B. High throughput screening of protein A resin for purification process development. Abstracts 234th ACS National Meeting, August 19-23, Boston, MA, 2007, BIOT-471.
    • Booth J, Coffman J, Kelley B. High throughput screening of protein A resin for purification process development. Abstracts 234th ACS National Meeting, August 19-23, Boston, MA, 2007, BIOT-471.
  • 28
    • 67651130448 scopus 로고    scopus 로고
    • Teeters M, Bezila D, Alred P, Velayudhan A. Development and application of an automated, small-chromatography system for resin and condition screening. Abstracts 234th ACS National Meeting, August 19-23, Boston, MA, 2007, BIOT-468.
    • Teeters M, Bezila D, Alred P, Velayudhan A. Development and application of an automated, small-volume chromatography system for resin and condition screening. Abstracts 234th ACS National Meeting, August 19-23, Boston, MA, 2007, BIOT-468.
  • 29
    • 1542298909 scopus 로고    scopus 로고
    • Parallel screening of selective and high-affinity displacers for proteins in ion-exchange systems
    • Rege K, Ladiwala A, Tugcu N, Breneman CM, Cramer SM. Parallel screening of selective and high-affinity displacers for proteins in ion-exchange systems. J Chromatogr A. 2004;1033: 19-28.
    • (2004) J Chromatogr A , vol.1033 , pp. 19-28
    • Rege, K.1    Ladiwala, A.2    Tugcu, N.3    Breneman, C.M.4    Cramer, S.M.5
  • 30
    • 0037026928 scopus 로고    scopus 로고
    • High-throughput screening and quantitative structureefficacy relationship models of potential displacer molecules for ion-exchange systems
    • Mazza CB, Rege K, Breneman CM, Sukumar N, Dordick JS, Cramer SM. High-throughput screening and quantitative structureefficacy relationship models of potential displacer molecules for ion-exchange systems. Biotechnol Bioeng. 2002;80:60-72.
    • (2002) Biotechnol Bioeng , vol.80 , pp. 60-72
    • Mazza, C.B.1    Rege, K.2    Breneman, C.M.3    Sukumar, N.4    Dordick, J.S.5    Cramer, S.M.6
  • 31
    • 0037625875 scopus 로고    scopus 로고
    • Predicting column performance in displacement chromatography from high throughput screening batch experiments
    • Rege K, Tugcu N, Cramer SM. Predicting column performance in displacement chromatography from high throughput screening batch experiments. Sep Sci Technol. 2003;38:1499-1517.
    • (2003) Sep Sci Technol , vol.38 , pp. 1499-1517
    • Rege, K.1    Tugcu, N.2    Cramer, S.M.3
  • 32
    • 33749561120 scopus 로고    scopus 로고
    • High throughput determination and QSER modeling of displacer DC-50 values for ion exchange systems
    • Liu J, Yang T, Ladiwala A, Cramer SM. High throughput determination and QSER modeling of displacer DC-50 values for ion exchange systems. Sep Sci Technol. 2006;41:3079-3107.
    • (2006) Sep Sci Technol , vol.41 , pp. 3079-3107
    • Liu, J.1    Yang, T.2    Ladiwala, A.3    Cramer, S.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.