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Volumn 616, Issue 1-3, 2009, Pages 58-63

Possible contribution of β-glucosidase and caspases in the cytotoxicity of glufosfamide in colon cancer cells

Author keywords

glucosidase; Apoptosis; Caco 2; Caspase 3; Caspase 9; Cytotoxicity; Glufosfamide; Glycoconjugate; HT29; T84

Indexed keywords

BETA GLUCOSIDASE; CASPASE 3; CASPASE 9; ESTERASE; GLUFOSFAMIDE; GLYCOCONJUGATE; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG;

EID: 67651108804     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.06.024     Document Type: Article
Times cited : (30)

References (38)
  • 1
    • 13844320743 scopus 로고    scopus 로고
    • Glufosfamide: Beta-D-Glc-IPM, D 19575
    • ADIS R&D PROFILE
    • ADIS R&D PROFILE. Glufosfamide: Beta-D-Glc-IPM, D 19575. Drugs R. D. 6 (2005) 49-52
    • (2005) Drugs R. D. , vol.6 , pp. 49-52
  • 2
    • 34548211906 scopus 로고    scopus 로고
    • A novel alkylating agent, glufosfamide, enhances the activity of gemcitabine in vitro and in vivo
    • Ammons W.S., Wang J.W., Yang Z., Tidmarsh G.F., and Hoffman R.M. A novel alkylating agent, glufosfamide, enhances the activity of gemcitabine in vitro and in vivo. Neoplasia 9 (2007) 625-633
    • (2007) Neoplasia , vol.9 , pp. 625-633
    • Ammons, W.S.1    Wang, J.W.2    Yang, Z.3    Tidmarsh, G.F.4    Hoffman, R.M.5
  • 3
    • 0037033737 scopus 로고    scopus 로고
    • Induction of DNA breaks and apoptosis in crosslink-hypersensitive V79 cells by the cytostatic drug beta-D-glucosyl-ifosfamide mustard
    • Becker R., Ritter A., Eichhorn U., Lips J., Bertram B., Wiessler M., Zdzienicka M.Z., and Kaina B. Induction of DNA breaks and apoptosis in crosslink-hypersensitive V79 cells by the cytostatic drug beta-D-glucosyl-ifosfamide mustard. Br. J. Cancer 86 (2002) 130-135
    • (2002) Br. J. Cancer , vol.86 , pp. 130-135
    • Becker, R.1    Ritter, A.2    Eichhorn, U.3    Lips, J.4    Bertram, B.5    Wiessler, M.6    Zdzienicka, M.Z.7    Kaina, B.8
  • 4
    • 0017184389 scopus 로고
    • A rapid method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford M.M. A rapid method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72 (1976) 248-254
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 7
    • 38949192547 scopus 로고    scopus 로고
    • Targeted cancer therapy: conferring specificity to cytotoxic drugs
    • Chari R.V. Targeted cancer therapy: conferring specificity to cytotoxic drugs. Acc. Chem. Res. 41 (2008) 98-107
    • (2008) Acc. Chem. Res. , vol.41 , pp. 98-107
    • Chari, R.V.1
  • 8
    • 0042423355 scopus 로고    scopus 로고
    • Epigallocatechin-3-gallate-induced stress signals in HT-29 human colon adenocarcinoma cells
    • Chen C., Shen G., Hebbar V., Hu R., Owuor E.D., and Kong A.N. Epigallocatechin-3-gallate-induced stress signals in HT-29 human colon adenocarcinoma cells. Carcinogenesis 24 (2003) 1369-1378
    • (2003) Carcinogenesis , vol.24 , pp. 1369-1378
    • Chen, C.1    Shen, G.2    Hebbar, V.3    Hu, R.4    Owuor, E.D.5    Kong, A.N.6
  • 9
    • 67349272693 scopus 로고    scopus 로고
    • A randomized Phase III trial of glufosfamide compared with best supportive care in metastatic pancreatic adenocarcinoma previously treated with gemcitabine
    • 10.1016/j.ejca.2008.12.022
    • Ciuleanu T.E., Pavlovsky A.V., Bodoky G., Garin A.M., Langmuir V.K., Kroll S., and Tidmarsh G.T. A randomized Phase III trial of glufosfamide compared with best supportive care in metastatic pancreatic adenocarcinoma previously treated with gemcitabine. Eur. J. Cancer (2009) 10.1016/j.ejca.2008.12.022
    • (2009) Eur. J. Cancer
    • Ciuleanu, T.E.1    Pavlovsky, A.V.2    Bodoky, G.3    Garin, A.M.4    Langmuir, V.K.5    Kroll, S.6    Tidmarsh, G.T.7
  • 10
    • 0037716395 scopus 로고    scopus 로고
    • Cytosolic beta-glycosidases for activation of glycoside prodrugs of daunorubicin
    • de Graaf M., Pinedo H.M., Quadir R., Haisma H.J., and Boven E. Cytosolic beta-glycosidases for activation of glycoside prodrugs of daunorubicin. Biochem. Pharmacol. 65 (2003) 1875-1881
    • (2003) Biochem. Pharmacol. , vol.65 , pp. 1875-1881
    • de Graaf, M.1    Pinedo, H.M.2    Quadir, R.3    Haisma, H.J.4    Boven, E.5
  • 11
    • 37849014621 scopus 로고    scopus 로고
    • Apoptotic caspase activation and activity
    • Denault J.B., and Salvesen G.S. Apoptotic caspase activation and activity. Methods Mol. Biol. 414 (2008) 191-220
    • (2008) Methods Mol. Biol. , vol.414 , pp. 191-220
    • Denault, J.B.1    Salvesen, G.S.2
  • 12
    • 0028154911 scopus 로고
    • Targeting enzymes for cancer therapy: old enzymes in new roles
    • Deonarain M.P., and Epenetos A.A. Targeting enzymes for cancer therapy: old enzymes in new roles. Br. J. Cancer 70 (1994) 786-794
    • (1994) Br. J. Cancer , vol.70 , pp. 786-794
    • Deonarain, M.P.1    Epenetos, A.A.2
  • 13
    • 34347376957 scopus 로고    scopus 로고
    • Beta-galactoside prodrugs of doxorubicin for application in antibody directed enzyme prodrug therapy/prodrug monotherapy
    • Devalapally H., Navath R.S., Yenamandra V., Akkinepally R.R., and Devarakonda R.K. Beta-galactoside prodrugs of doxorubicin for application in antibody directed enzyme prodrug therapy/prodrug monotherapy. Arch. Pharm. Res. 30 (2007) 723-732
    • (2007) Arch. Pharm. Res. , vol.30 , pp. 723-732
    • Devalapally, H.1    Navath, R.S.2    Yenamandra, V.3    Akkinepally, R.R.4    Devarakonda, R.K.5
  • 14
    • 50249135564 scopus 로고    scopus 로고
    • Multivalency: the hallmark of antibodies used for optimization of tumor targeting by design
    • Deyev S.M., and Lebedenko E.N. Multivalency: the hallmark of antibodies used for optimization of tumor targeting by design. Bioessays 30 (2008) 904-918
    • (2008) Bioessays , vol.30 , pp. 904-918
    • Deyev, S.M.1    Lebedenko, E.N.2
  • 15
    • 6444227432 scopus 로고    scopus 로고
    • Ex vivo responsiveness of head and neck squamous cell carcinoma to glufosfamide, a novel alkylating agent
    • Dollner R., Dietz A., Kopun M., Helbig M., Wallner F., and Granzow C. Ex vivo responsiveness of head and neck squamous cell carcinoma to glufosfamide, a novel alkylating agent. Anticancer Res. 24 (2004) 2947-2951
    • (2004) Anticancer Res. , vol.24 , pp. 2947-2951
    • Dollner, R.1    Dietz, A.2    Kopun, M.3    Helbig, M.4    Wallner, F.5    Granzow, C.6
  • 16
    • 12144285603 scopus 로고    scopus 로고
    • Glufosfamide administered by 1-hour infusion as a second-line treatment for advanced non-small cell lung cancer; a phase II trial of the EORTC-New Drug Development Group
    • EORTC-New Drug Development Group
    • Giaccone G., Smit E.F., de Jonge M., Dansin E., Briasoulis E., Ardizzoni A., Douillard J.Y., Spaeth D., Lacombe D., Baron B., Bachmann P., Fumoleau P., and EORTC-New Drug Development Group. Glufosfamide administered by 1-hour infusion as a second-line treatment for advanced non-small cell lung cancer; a phase II trial of the EORTC-New Drug Development Group. Eur. J. Cancer 40 (2004) 667-672
    • (2004) Eur. J. Cancer , vol.40 , pp. 667-672
    • Giaccone, G.1    Smit, E.F.2    de Jonge, M.3    Dansin, E.4    Briasoulis, E.5    Ardizzoni, A.6    Douillard, J.Y.7    Spaeth, D.8    Lacombe, D.9    Baron, B.10    Bachmann, P.11    Fumoleau, P.12
  • 17
    • 52249083014 scopus 로고    scopus 로고
    • Peptide-targeted polyglutamic acid doxorubicin conjugates for the treatment of alpha(v)beta(6)-positive cancers
    • Guan H., McGuire M.J., Li S., and Brown K.C. Peptide-targeted polyglutamic acid doxorubicin conjugates for the treatment of alpha(v)beta(6)-positive cancers. Bioconjug. Chem. 19 (2008) 1813-1821
    • (2008) Bioconjug. Chem. , vol.19 , pp. 1813-1821
    • Guan, H.1    McGuire, M.J.2    Li, S.3    Brown, K.C.4
  • 18
    • 45349101921 scopus 로고    scopus 로고
    • Vitamin B12-mediated transport: a potential tool for tumor targeting of antineoplastic drugs and imaging agents
    • Gupta Y., Kohli D.V., and Jain S.K. Vitamin B12-mediated transport: a potential tool for tumor targeting of antineoplastic drugs and imaging agents. Crit. Rev. Ther. Drug Carr. Syst. 25 (2008) 347-379
    • (2008) Crit. Rev. Ther. Drug Carr. Syst. , vol.25 , pp. 347-379
    • Gupta, Y.1    Kohli, D.V.2    Jain, S.K.3
  • 19
    • 0030999750 scopus 로고    scopus 로고
    • Apoptosis and the dilemma of cancer chemotherapy
    • Hannun Y. Apoptosis and the dilemma of cancer chemotherapy. Blood 89 (1997) 1845-1853
    • (1997) Blood , vol.89 , pp. 1845-1853
    • Hannun, Y.1
  • 20
    • 0030715323 scopus 로고    scopus 로고
    • Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
    • Li P., Nijhawan D., Budihardjo I., Srinivasula S.M., Ahmad M., Alnemri E.S., and Wang X. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91 (1997) 479-489
    • (1997) Cell , vol.91 , pp. 479-489
    • Li, P.1    Nijhawan, D.2    Budihardjo, I.3    Srinivasula, S.M.4    Ahmad, M.5    Alnemri, E.S.6    Wang, X.7
  • 22
    • 37849035223 scopus 로고    scopus 로고
    • Caspase-3 activation is a critical determinant of genotoxic stress-induced apoptosis
    • Mazumder S., Plesca D., and Almasan A. Caspase-3 activation is a critical determinant of genotoxic stress-induced apoptosis. Methods Mol. Biol. 414 (2008) 13-21
    • (2008) Methods Mol. Biol. , vol.414 , pp. 13-21
    • Mazumder, S.1    Plesca, D.2    Almasan, A.3
  • 23
    • 0032939194 scopus 로고    scopus 로고
    • Intestinal absorption of acyclovir beta-glucoside: comparative study with acyclovir, guanosine, and kinetin beta-glucoside
    • Mizuma T., Masubuchi S., and Awazu S. Intestinal absorption of acyclovir beta-glucoside: comparative study with acyclovir, guanosine, and kinetin beta-glucoside. Pharm. Res. 16 (1999) 69-73
    • (1999) Pharm. Res. , vol.16 , pp. 69-73
    • Mizuma, T.1    Masubuchi, S.2    Awazu, S.3
  • 24
    • 43849084688 scopus 로고    scopus 로고
    • Synthetic polymers as drug-delivery vehicles in medicine
    • Neuse E.W. Synthetic polymers as drug-delivery vehicles in medicine. Met. Based Drugs 2008 (2008) 1-19
    • (2008) Met. Based Drugs , vol.2008 , pp. 1-19
    • Neuse, E.W.1
  • 25
    • 0029068871 scopus 로고
    • Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
    • Nicholson D.W., Ali A., and Thornberry N.A. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 376 (1995) 37-43
    • (1995) Nature , vol.376 , pp. 37-43
    • Nicholson, D.W.1    Ali, A.2    Thornberry, N.A.3
  • 28
    • 67651144014 scopus 로고    scopus 로고
    • Potential influence of β-glucosidases on in vitro cytotoxicity mediated by β-D-Glc-IPM (glufosfamide), a new tumor therapeutic agent
    • Seker H., Bertram B., Troster H., Fisher R., Trendelenburg M., and Wiessler M. Potential influence of β-glucosidases on in vitro cytotoxicity mediated by β-D-Glc-IPM (glufosfamide), a new tumor therapeutic agent. Annu. Meet. Am. Assoc. Cancer Res. 41 (2000) 602
    • (2000) Annu. Meet. Am. Assoc. Cancer Res. , vol.41 , pp. 602
    • Seker, H.1    Bertram, B.2    Troster, H.3    Fisher, R.4    Trendelenburg, M.5    Wiessler, M.6
  • 29
    • 52049105453 scopus 로고    scopus 로고
    • Recent trends in targeted anticancer prodrug and conjugate design
    • Singh Y., Palombo M., and Sinko P.J. Recent trends in targeted anticancer prodrug and conjugate design. Curr. Med. Chem. 15 (2008) 1802-1826
    • (2008) Curr. Med. Chem. , vol.15 , pp. 1802-1826
    • Singh, Y.1    Palombo, M.2    Sinko, P.J.3
  • 30
    • 51649093438 scopus 로고    scopus 로고
    • Peptide ligand-mediated liposome distribution and targeting to EGFR expressing tumor in vivo
    • Song S., Liu D., Peng J., Sun Y., Li Z., Gu J.R., and Xu Y. Peptide ligand-mediated liposome distribution and targeting to EGFR expressing tumor in vivo. Int. J. Pharm. 363 (2008) 155-161
    • (2008) Int. J. Pharm. , vol.363 , pp. 155-161
    • Song, S.1    Liu, D.2    Peng, J.3    Sun, Y.4    Li, Z.5    Gu, J.R.6    Xu, Y.7
  • 31
    • 44449085539 scopus 로고    scopus 로고
    • Paul Ehrlich's magic bullet concept: 100 years of progress
    • Strebhardt K., and Ullrich A. Paul Ehrlich's magic bullet concept: 100 years of progress. Nat. Rev. Cancer 8 (2008) 473-480
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 473-480
    • Strebhardt, K.1    Ullrich, A.2
  • 32
    • 3643085353 scopus 로고    scopus 로고
    • In vitro cytotoxicity following specific activation of amygdalin by beta-glucosidase conjugated to a bladder cancer-associated monoclonal antibody
    • Syrigos K.N., Rowlinson-Busza G., and Epenetos A.A. In vitro cytotoxicity following specific activation of amygdalin by beta-glucosidase conjugated to a bladder cancer-associated monoclonal antibody. Int. J. Cancer 78 (1998) 712-719
    • (1998) Int. J. Cancer , vol.78 , pp. 712-719
    • Syrigos, K.N.1    Rowlinson-Busza, G.2    Epenetos, A.A.3
  • 33
    • 9144219841 scopus 로고    scopus 로고
    • Open label phase II study on glufosfamide administered as a 60-minute infusion every 3 weeks in recurrent glioblastoma multiforme
    • European Organization for Research and Treatment of Cancer New Drug Development Group, European Organization for Research and Treatment of Cancer Brain Tumor Group and European Organization for Research and Treatment of Cancer (EORTC
    • van den Bent M.J., Grisold W., Frappaz D., Stupp R., Desir J.P., Lesimple T., Dittrich C., de Jonge M.J., Brandes A., Frenay M., Carpentier A.F., Chollet P., Oliveira J., Baron B., Lacombe D., Schuessler M., Fumoleau P., European Organization for Research and Treatment of Cancer New Drug Development Group, and European Organization for Research and Treatment of Cancer Brain Tumor Group and European Organization for Research and Treatment of Cancer (EORTC. Open label phase II study on glufosfamide administered as a 60-minute infusion every 3 weeks in recurrent glioblastoma multiforme. Ann. Oncol. 14 (2003) 1732-1734
    • (2003) Ann. Oncol. , vol.14 , pp. 1732-1734
    • van den Bent, M.J.1    Grisold, W.2    Frappaz, D.3    Stupp, R.4    Desir, J.P.5    Lesimple, T.6    Dittrich, C.7    de Jonge, M.J.8    Brandes, A.9    Frenay, M.10    Carpentier, A.F.11    Chollet, P.12    Oliveira, J.13    Baron, B.14    Lacombe, D.15    Schuessler, M.16    Fumoleau, P.17
  • 35
    • 0026264892 scopus 로고
    • The MTT-assay as a rapid test for cell proliferation and cell killing: application to human peripheral blood lymphocytes (PBL)
    • Weichert H., Blechschmidt I., Schröder S., and Ambrosius H. The MTT-assay as a rapid test for cell proliferation and cell killing: application to human peripheral blood lymphocytes (PBL). Allerg. Immunol. (Leipz) 37 (1991) 139-144
    • (1991) Allerg. Immunol. (Leipz) , vol.37 , pp. 139-144
    • Weichert, H.1    Blechschmidt, I.2    Schröder, S.3    Ambrosius, H.4
  • 36
    • 0030775794 scopus 로고    scopus 로고
    • Towards intelligent anticancer drug screening in the post-genome era?
    • Workman P. Towards intelligent anticancer drug screening in the post-genome era?. Anticancer Drug Des. 12 (1997) 525-531
    • (1997) Anticancer Drug Des. , vol.12 , pp. 525-531
    • Workman, P.1
  • 37
    • 34848911993 scopus 로고    scopus 로고
    • Reversal of multidrug resistance by transferrin-conjugated liposomes co-encapsulating doxorubicin and verapamil
    • Wu J., Lu Y., Lee A., Pan X., Yang X., Zhao X., and Lee R.J. Reversal of multidrug resistance by transferrin-conjugated liposomes co-encapsulating doxorubicin and verapamil. J. Pharm. Pharm. Sci. 10 (2007) 350-357
    • (2007) J. Pharm. Pharm. Sci. , vol.10 , pp. 350-357
    • Wu, J.1    Lu, Y.2    Lee, A.3    Pan, X.4    Yang, X.5    Zhao, X.6    Lee, R.J.7
  • 38
    • 44849137874 scopus 로고    scopus 로고
    • Sugar and fat - that's where it's at: metabolic changes in tumors
    • Young C.D., and Anderson S.M. Sugar and fat - that's where it's at: metabolic changes in tumors. Breast Cancer Res. 10 (2008) 202-210
    • (2008) Breast Cancer Res. , vol.10 , pp. 202-210
    • Young, C.D.1    Anderson, S.M.2


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